| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | AT1 RECEPTOR STRUCTURE AND FUNCTION |
| Discussion Leader: Kevin Catt (NICHD, NIH, Bethesda, MD, USA) |
| 7:30 pm - 8:00 pm | Ronald Stenkamp (University of Washington, Seattle, WA, USA)
"Implications of the high-resolution rhodopsin structure for GPCR conformation and function" |
| 8:00 pm - 8:30 pm | Sadashiwa Karnik (Cleveland Clinic, Cleveland, OH, USA)
"Structural determinants of AT1 receptor function" |
| 8:30 pm - 9:00 pm | Laszlo Hunyady (Semmelweis University, Budapest, Hungary)
"Structural requirements for signaling and internalization of the AT1 receptor" |
| 9:00 pm - 9:30 pm | Walter Thomas (Baker Institute, Melbourne, Australia)
"AT1 receptor-arrestin interactions" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | POST-TRANSCRIPTIONAL MECHANISMS REGULATING AT RECEPTORS |
| Discussion Leader: Kathryn Sandberg (Georgetown University, Washington,
DC, USA) |
| 9:00 am - 9:30 am | Thomas Thekkumkara (Texas Tech University, Amarillo, TX, USA)
"Regulation of angiotensin II receptor gene expression: A physiological paradigm" |
| 9:30 am - 10:00 am | Hong Ji (Georgetown University, Washington, DC, USA)
"Regulation of the AT1 receptor by the 5' leader sequence" |
| 10:00 am - 10:30 am | Georg Nickenig (University of Saarland, Hombourg, Germany)
"Protein-RNA interaction in the 3' untranslated region of the AT1 receptor mRNA: binding motifs, binding proteins and functional relevance (?)" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 12:30 pm | SIGNALLING AND FUNCTION: NEW ASPECTS OF THE AT2 RECEPTOR |
| Discussion Leader: Thomas Unger (Humboldt University, Berlin, Germany) |
| 11:00 am - 11:20 am | Clara Nahmias (Institut Cochin, Paris, France)
"Novel signaling pathways for AT2-mediated growth inhibition" |
| 11:20 am - 11:40 am | Christoph Chmurzynski (Humbolt University, Berlin, Germany)
"The function of the cytoplasmic tail of AT2 receptors in internalization and signal transduction" |
| 11:40 am - 12:00 pm | Helmy Siragy (University of Virginia, Charlottesville, VA, USA)
"AT2 and diabetic renal disease" |
| 12:00 pm - 12:20 pm | Jukka Lethonen (Harvard, MA, USA)
"Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | GENETICS OF HYPERTENSION |
| Discussion Leader: Xavier Jeunemaître (Collège de France, Paris, France) |
| 5:30 pm - 6:00 pm | Anna Dominiczak (Western Infirmary, Glasgow, UK)
"Y chromosome and hypertension: lessons learnt from rat and man |
| 6:00 pm - 6:30 pm | Gérard Ailhaud (Faculty of Sciences, University of Nice, France)
"Adipose angiotensinogen and blood pressure: a transgenic approach" |
| 6:30 pm - 7:00 pm | Mohan K. Raizada (University of Florida, Gainesville, FL, USA)
"Gene therapy for hypertension based on renin-angiotensin system antisense inhibition" |
| 7:00 pm - 7:30 pm | Xavier Jeunemaître (Collège de France, Paris, France)
"Kinases involved in humanhypertension" |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ANGIOTENSIN II RECEPTOR INTERACTING PROTEINS: SCAFFOLDS, SIGNALS AND SURPRISES |
| Discussion Leader: Bradford Berk (University of Rochester, Rochester, NY,
USA) |
| 9:00 am - 9:25 am | Eric Clauser (Institut Cochin, Paris, France)
"Activation, signaling and cellular traffic of AngII AT1 receptors" |
| 9:25 am - 9:45 am | Bradford Berk (University of Rochester,
Rochester, NY, USA)
"SOXF: Secreted oxidative stress induced factors that regulate cell growth" |
| 9:45 am - 10:05 am | Frederick A. O. Mendelsohn (Howard Florey Institute, Melbourne, Australia)
"Role of AT4 receptor/IRAP in memory"
|
| 10:05 am - 10:30 am | Tadashi Inagami, Takaaki Senbonmatsu (Vanderbilt University, Nashville, TN, USA)
"New signalling mechanisms of the angiotensin II receptor, AT2" |
| 10:30 am | Coffee Break |
| 11:00 am - 12:30 pm | NEW THERAPEUTIC APPROACHES IN CARDIOVASCULAR DISEASE |
| Discussion Leader: Gordon Williams (Harvard Medical School, Boston, MA,
USA) |
| 11:00 am - 11:30 am | Gordon Williams (Harvard medical School, Boston, MA, USA)
"Aldosterone receptor antagonist revisited" |
| 11:30 am - 12:00 am | Alessandro Cataliotti (Mayo Clinic, Rochester, NY, USA)
"Vasopeptidase inhibitors" |
| 12:00 pm - 12:30 pm | Hans Brunner (University Hospital, Lausanne, Switzerland)
"Renin inhibitors: will they achieve their therapeutic potential?" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | ANGIOTENSIN AND CARDIAC CELL GROWTH AND DEATH |
| Discussion Leader: Kenneth Baker (Texas A&M University, Temple, TX, USA) |
| 5:30 pm - 6:00 pm | Lorrie Kirshenbaum (University of Manitoba, Winnipeg, Canada)
"Molecular regulation of cardiac cell growth and cell death" |
| 6:00 pm - 6:30 pm | Richard Kitsis (Albert Einstein College of Medicine, Bronx, NY, USA)
"Manipulating apoptosis in the myocardium" |
| 6:30 pm - 7:00 pm | Roberta Gottlieb (Scripps Research Institute, La Jolla, CA, USA)
"Biochemistry of cell death in the heart" |
| 7:00 pm - 7:30 pm | David Harrison (Emory University, Atlanta, GA, USA)
"Interactions of extracellular superoxide dismutase and angiotensin II" |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TISSUE-SPECIFIC TRANSGENESIS OF RENIN-ANGIOTENSIN SYSTEM GENES |
| Discussion Leader: Martin Paul (Free University of Berlin, Germany) |
| 9:00 am - 9:30 am | Friedrich Luft (Berlin-Buch, Germany)
"Double transgenic rats as models to study angiotensin-induced end organ damage" |
| 9:30 am - 10:00 am | Curt Sigmund (University of Iowa, Iowa City, IO, USA)
"Examining the RAS in the brain using tissue-specific transgenic models" |
| 10:00 am - 10:30 am | Thierry Pedrazzini (University Hospital, Lausanne, Switzerland)
"Compensatory cardiac hypertrophy in angiotensin II-induced renovascular hypertension" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Tim Reudelhuber (Institut de Recherches Cliniques, Montreal, Canada)
"Effects of chronic and tissue-specific increases of angiotensin peptides using a novel transgenic mouse strategy" |
| 11:30 am - 12:00 pm | Yigal Pinto (Department of Cardiology, Maastricht, The Netherlands)
"Transgenic rats with targeted ACE expression in the heart as a model to study cardiac pathophysiology " |
| 12:00 am - 12:30 pm | John Mullins(University of Edinburgh, Scotland)
"Exploitation of the Cy1a1 regulatory system to study hypertensive organ damage" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | DEVELOPMENTAL ASPECTS OF THE RENIN-ANGIOTENSIN SYSTEM |
| Discussion Leader: Pierre Corvol (Collège de France, Paris, France) |
| 5:30 pm - 5:55 pm | Kenneth Gross (Roswell Park Cancer Institute, Buffalo, NY, USA)
"Renin - an immediate downstream target of class I Hox genes" |
| 5:55 pm - 6:20pm | Hiroko Nishimura (University of Tennessee, Memphis, TN, USA)
"Maturation-dependent modulation of angiotensin receptors: unique avian model" |
| 6:20 pm - 6:45 pm | Iekunii Ichikawa (Vanderbilt University, Nashville, TN, USA)
"Role of angiotensin in the urinary tract development during the transition from intra- to extra-uterine life" |
| 6:45 pm - 7:10 pm | Ariel Gomez (Charlottesville, VA, USA)
"Embryonic origin and lineage of juxtaglomerular cells" |
| 7:10 pm - 7:20 pm | Jurgen Schneermann (NIDDK, NIH, Bethesda, MD, USA)
"Phylogenetic aspects of the renin-angiotensin system" |
| 7:20 pm - 7:30 pm | Jean-Marie Gasc (Collège de France, Paris, France)
"Angiotensin Converting Enzyme : early expression in embryonic development" |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | ANGIOTENSIN II AND THE BRAIN |
| Discussion Leader: Juan Saavedra (NIMH, NIH, Bethesda, MD, USA) |
| 9:00 am - 9:25 am | Wolfgang Kuschinsky (University of Heidelberg, Heidelberg, Germany)
"Cerebral microcirculation - dynamics of brain capillary perfusion" |
| 9:25 am - 9:50 am | Barbara Crain (Johns Hopkins School of Medicine, Baltimore, MD, USA)
"Reproductive hormones: Importance in cerebral circulation and ischemia" |
| 9:50 am - 10:10 am | Olaf Paulson (Copenhagen University Hospital,
Denmark)
"The role of the renin-angiotensin system in the regulation of cerebral circulation" |
| 10:10 am - 10:30 am | Martin Lauritzen (University of Copenhagen, Copenhagen, Denmark)
"Coupling brain's electrical activity to local circulation: methods,
problems and possible solutions" |
| 10:30 am | Coffee Break |
| 11:00 am - 12:30 pm | ANGIOTENSIN II, INFLAMMATION AND ATHEROSCLEROSIS |
| Discussion Leader: Jesus Egido (Fundacion Jimenez Diaz, Madrid, Spain) |
| 11:00 am - 11:30 am | Jesus Egido (Fundacion Jimenez Diaz, Madrid, Spain)
"Emerging data on angiotensin II as a proinflammatory mediator" |
| 11:30 am - 12:00 pm | Javier Diez (Pamplona, Spain)
"Angiotensin II and oxidative stress in the pathogenesis of atherosclerosis" |
| 12:00 am - 12:30 pm | William B. Strawn (Wake Forest University, Winston-Salem, NC, USA)
"Inflammation and angiotensin blockade in atherosclerosis. Potential insights into vascular protection" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | ANGIOTENSIN II AND OXIDATIVE STRESS |
| Discussion Leader: Kathy Griendling (Emory University, Atlanta, GA, USA) |
| 5:30 pm - 5:45 pm | Kathy Griendling (Emory University, Atlanta, GA, USA)
"Overview of recent discoveries" |
| 5:45 pm - 6:15 pm | Satoru Eguchi (Vanderbilt University, Nashville, TN, USA)
"Tyrosine kinase network activated by ROS in AT1 receptor signaling" |
| 6:15 pm - 6:45 pm | TBA |
| 6:45 pm - 7:15 pm | Thomas Muenzel (University Hospital Eppendorf, Hamburg, Germany)
"Oxidative mechanisms underlying angiotensin II-induced endothelial dysfunction" |
| 7:15pm - 7:30 pm | W. Robert Taylor (Emory University, Atlanta, GA, USA)
"The role of osteopontin in angiotensin II-induced vascular hypertrophy" |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |