| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30-9:30 PM | INNATE IMMUNITY |
| Discussion Leader: Lewis Lanier (Univ. of California, San Francisco) |
| 7:30-8:15 PM | Lewis Lanier (Univ. of California, San Francisco)
Regulation of T cell and NK cell immune responses by activating and inhibitory receptors |
| 8:15-9:00 PM | Shizuo Akira (Research Institute for Microbial Diseases)
TLR family: key receptors in innate and acquired immunity |
| 9:00 PM | Reception |
| MONDAY |
| 7:30-8:30 AM | Breakfast |
| 8:30 AM | Group Photo |
| 9:00 AM-12:30 PM | LYMPHOCYTE DEVELOPMENT |
| Discussion Leader: Kristin Hogquist (University of Minnesota) |
| 9:00-9:20 AM | Kristin Hogquist (University of Minnesota)
Session overview |
| 9:20-10:00 AM | George Holländer (University of Basel)
Thymic stromal cell patterning |
| 10:00-10:30 AM | Coffee break |
| 10:30-11:10 AM | Howard Petrie (Memorial Sloan-Kettering Cancer Center)
Control of lymphopoiesis in the steady-state thymus |
| 11:10-11:50 AM | Cynthia Guidos (Hospital for Sick Children Research Institute)
Functions of the cytoplasmic tail of murine pre-Talpha |
| 11:50-12:30 PM | Bruno Kyewski (German Cancer Research Center)
Medullary epithelial cells and tolerance induction |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30-9:30 PM | ANTIGEN RECEPTORS |
| Discussion Leader: Mark Schlissel (University of California, Berkeley) |
| 7:30-8:00 PM | Mark Schlissel (University of California, Berkeley)
Regulating the activity and specificity of the V(D)J recombinase |
| 8:00-8:30 PM | Barry Sleckman (Washington University)
Developmental regulation of the V(D)J recombination reaction by RSSs |
| 8:30-9:00 PM | Timothy Behrens (University of Minnesota)
De-differentiation of immature B cells following interruption of basal Ig signaling. |
| 9:00-9:30 PM | John Kappler (National Jewish Medical & Research Center)
MHC/TCR Interactions |
| TUESDAY |
| 7:30-8:30 AM | Breakfast |
| 9:00 AM-12:30 PM | SIGNAL TRANSDUCTION IN LYMPHOCYTES |
| Discussion Leader: Gary Koretzky (Univ. of Pennsylvania) |
| 9:00-10:00 AM | Gary Koretzky (Univ. of Pennsylvania)
Role of adaptor proteins in T cell activation |
| 10:00-10:30 AM | Coffee break |
| 10:30-11:10 AM | John Monroe (University of Pennsylvania)
Signals regulating the positive and negative selection of developing B lymphocytes |
| 11:10-11:50 AM | Katherine Siminovitch (Mount Sinai Hospital)
Role of the Wiskott-Aldrich syndrome protein in coordinating lymphocyte activation |
| 11:50-12:30 PM | Susan Pierce (NIH)
The spatial organization of B cell signaling receptors |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30-9:30 PM | B CELL ACTIVATION/MEMORY |
| Discussion Leader: Janet Stavnezer (University of Massachusetts) |
| 7:30-8:00 PM | Janet Stavnezer (University of Massachusetts)
The role of mismatch repair proteins in antibody class switch recombination |
| 8:00-8:30 PM | John Kearney (University of Alabama-Birmingham)
Cellular interactions of marginal zone B cells and humoral immunity |
| 8:30-9:00 PM | Michael McHeyzer-Williams (Scripps Research Institute)
Memory B cell subsets |
| 9:00-9:30 PM | Nina Papavasiliou (Rockefeller University)
Somatic mutation |
| WEDNESDAY |
| 7:30-8:30 AM | Breakfast |
| 9:00 AM-12:30 PM | LYMPHOCYTE MIGRATION |
| Discussion Leader: Michael D. Gunn (Duke University) |
| 9:00-10:00 AM | Michael D. Gunn (Duke University)
The role of lymphoid chemokines in leukocyte migration and the regulation of immune response |
| 10:00-10:30 AM | Coffee break |
| 10:30-11:10 AM | Timothy Springer (Harvard University)
Integrin LFA-1 structure and function |
| 11:10-11:50 AM | Sergio Lira (Schering-Plough Research Institute)
Chemokine function in lymphocyte migration |
| 11:50-12:30 PM | Leo Lefrancois (University of Connecticut)
CD8 T cell migration to nonlymphoid tissues |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session 3 |
| 6:00 pm | Dinner |
| 7:30-9:30 PM | INTRAVITAL IMAGING |
| Discussion Leader: Chris Contag (Stanford University) |
| 7:30-8:10 PM | Chris Contag (Stanford University)
Immune cell trafficking studies using luciferase as an in vivo reporter |
| 8:10-8:50 PM | John Mountz (University of Alabama-Birmingham)
Imaging T cells in vivo |
| 8:50-9:30 PM | Paul Allen (Washington University)
In vivo imaging of auto-reactive antibodies and tumor-reactive T cells |
| THURSDAY |
| 7:30-8:30 AM | Breakfast |
| 9:00 AM-12:30 PM | T CELL ACTIVATION/MEMORY |
| Discussion Leader: Philippa Marrack (National Jewish Medical & Research Center) |
| 9:00-10:00 AM | Philippa Marrack (National Jewish Medical & Research Center)
Events during T cell death |
| 10:00-10:30 AM | Coffee Break |
| 10:30-11:10 AM | Rafi Ahmed (Emory University)
Memory T cell differentiation and maintenance |
| 11:10-11:50 AM | Susan Swain (Trudeau Institute)
The generation, function and persistence of CD4+ memory T cells |
| 11:50-12:30 PM | Ken Murphy (Washington University)
Regulators of inflammatory immune responses |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30-9:30 PM | IMMUNE REGULATION AND TOLERANCE |
| Discussion Leader: Anne O'Garra (NIMR, Mill Hill) |
| 7:30-8:00 PM | Anne O'Garra (NIMR, Mill Hill)
In vitro generation of regulatory T cells |
| 8:00-8:30 PM | Brigitta Stockinger (NIMR, Mill Hill)
T cell regulation: a special job or everyone's responsibility |
| 8:30-9:00 PM | Shimon Sakaguchi (Kyoto University)
Naturally arising regulatory T cells |
| 9:00-9:30 PM | Fiona Powrie (Sir William Dunn School of Pathology of Oxford)
Inflammation in the intestine: control by regulatory T cells |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |