Gordon Research Conferences
Meeting Details

Proteolytic Enzymes & Their Inhibitors
Gordon Research Conference


July 7-12, 2002


Colby-Sawyer College
New London, NH


James McKerrow

Vice Chair:
Nancy A. Thornberry

Meeting Program

2:00 pm - 9:00 pmArrival and check-in
6:00 pmDinner
7:30 pm - 9:30 pmRegulated Intermembrane Proteolysis
Bart De Strooper (K.U. Leuven/V.I.B.): Discussion Leader
APP Processing
Rob Rawson (University of Texas Southwestern Medical Center)
Nafi Kopan (Washington University)
Matthew Freeman (MRC)
9:30 Chair's Reception
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthetic Protease Inhibitors: New Tools and Drug Leads
Scott K. Thompson (GlaxoSmithKline): Discussion Leader
Ulrike Obst, Ph.D. (Roche Pharmaceuticals)
Novel, Selective Inhibitors of Factor VIIa
Brad Katz, Ph.D. (Celera)
Engineering Inhibitors Highly Selective for the S1 Sites of Ser 190 Trypsin-like Serine Protease
Scott K. Thompson, Ph.D. (GlaxoSimthKline)
New Heterocyclic Inhibitors of Methionine Aminopeptidase-2
Harold Tschesche, Ph.D. (Universitat Bielefeld, Germany)
Structure-Based Design of Potent MMP Inhibitors of the Basis of a 6H-1,3,4 -Thiadiazine Scaffold
Patty Podolin, Ph.D.(GlaxoSmithKline)
Development of Cathepsin S Inhibitors for the Treatment of Inflammatory Diseases
Peter Dragovich, Ph.D. (Pfizer)
Orally Bioavailable Human Rhinovirus 3C Protease Inhibitors
James Powers (Georgia Tech) Short Talk
New Clan CD protease inhibitors
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmProtease Specificity and Biological Function
Charles Craik (UCSF): Discussion Leader
Reverse biochemistry: Probing the function of proteases in complex biological systems
Matt Bogyo, Ph.D. (Celera)
Functional Proteomic Analysis of Proteolytic Enzymes: Application to the Cysteine Proteases of Plasmodium falciparum
Ben Turk (Harvard)
Substrate recognition by anthrax lethal factor
Ranabir Sinha Roy (Merck)
Substrate Specificity of DPPIV and Insight into Biological Function
Steve Young (Gladstone Institute)
Examining the functional role of prenylprotein endoproteases
7:30 am - 8:30 amBreakfast
9:00 am -12:30 pmStructural Basis of Protease Function
Wolfram Bode: Discussion Leader
Piet Gros (University Utrecht, The Netherlands)
Membrane protease OmpT from E. coli
Hans Brandstetter (Max-Planck-Institute)
Archaebacterial Tricorn Protease
Zongchao Jia (Queen's University)
Activated Catalytic Domain of Rat m-Calpain in the Presence of Calcium
Tim Clausen (Max-Planck-Institute)
The Heat Shock Protease HtrA from E. coli
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmMicrobial Proteases
Dan Goldberg (Washington U): Discussion Leader
Aaron Mitchell (Columbia)
A fungal proteolytic system that governs development and virulence
Bob Sauer (MIT)
Energy-Dependent Protein Unfolding
Dan Goldberg (Washington University)
Genome-wide analysis of Plasmodium hemoglobin degradation
Robert Liddington (Burnham Institute)
Structure of anthrax lethal factor
7:30 am - 8:30 amBreakfast
9:00am - 12:30 pmProteases in Cell Cycle and Cell Death
Guy Salvesen (Burnham Institute): Discussion Leader
A little death is good for you
Jean-Michael Peters (Research Institute of Molecular Pathology)
Bruce Hay (Caltech)
Drosophila Proteases
Peter Vandebabeele (University of Gent)
Hao Wu (Cornell)
Structural Studies of Caspase Inhibitors
Karin Rodberg (University of Linkoping)
Lysosomal proteases: important mediators of apoptosis
Kevin Tomaselli (IDUN Pharmaceuticals, San Diego)
Caspase inhibitor therapy
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmProteases in the Immune Response and Inflammation
Hal Chapman (UCSF): Discussion leader
Proteases and MHC class II function
Hidde Ploegh (Harvard)
MHC class II maturation and trafficking
Colin Watts (University of Dundee)
AEP activation and function
Ira Mellman (Yale)
Role of lysosomal proteases in dendritic cell maturation
Cristoph Peters (Albert-Ludwigs-Universität - Freiburg, Germany)
Legumain Knockout
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSecreted and Membrane Associated Proteases in Cancer and Endocrine Function
Bonnie Sloane (Wayne State): Discussion Leader
Johanna Joyce (UCSF)
Investigation of matrix-degrading enzymes in multistage tumorgenesis
Ed Madison (Corvas)
Structural characterization of matriptase/MT-SP-1
Thomas Bugge (PTRU/OPCB/NIH)
Matriptase/MT-SP1 in mouse development
Bonnie Sloane (Wayne State)
Tumor/Host Contribution to Proteolysis In Situ
Klaudia Brix (International University Bremen)
Thyroid hormone processing by secreted cathepsins
Lisa Coussens (UCSF)
Type I Collagen Remodeling Regulates Vascular Permeability
6:00 pmBanquet
7:30Keynote address
Zena Werb (UCSF)
"The Degradation Monologues"
8:30 pm - 9:15 pmElections and Business Meeting
9:30 pmParty
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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