| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SPATIAL SIGNALING I |
| 7:30 pm - 7:55 pm |
Jurgen Knoblich, Ph.D.
Research Institute of Molecular Pathology
Vienna, Austria
"Asymmetric cell division in neuroblasts" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Monica Gotta, Ph.D.
Institute of Biochemistry, ETH Höenggerberg
Zuerich, Switzerland
"Asymmetric cell division in C. elegans" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Orion Wiener, Ph.D.
Department of Cell Biology, Harvard Medical School
Boston, MA
"Regulation of cell polarity during neutrophil chemotaxis: the chemotactic compass" |
| 9:15 pm - 9:30 pm | Discussion |
| 9:30 pm | Welcome Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | GPCRs |
| 9:00 am - 9:25 am | Jeff Benovic, Ph.D.
Thomas Jefferson University, Department of Microbiology and Immunology
Philadelphia, PA
"Regulation of GPCRs by phosphorylation" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am |
Steven S.G. Ferguson, Ph.D.
Robarts Institute, University of Western Ontario, Department of Cell Biology Research Group
London, Canada
"Beta-arrestin-dependent signaling via small G-proteins" |
| 10:00 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Coffee Break |
| 10:35 am - 11:00 am |
Mark von Zastrow, Ph.D.
University of California-San Francisco, Department of Psychiatry
San Francisco, CA
"Molecular sorting of G protein-coupled receptors in the endocytic pathway" |
| 11:00 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am |
Jo Ann Trejo, Ph.D.
University of North Carolina, Department of Pharmacology
Chapel Hill, NC
"Role of sorting nexins in GPCR signaling and trafficking" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm |
Marc Caron, Ph.D.
Duke University Medical Center, Department of Cell Biology, HHMI
Durham, NC
"Regulation of GPCR signaling in vivo" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SPATIAL SIGNALING II |
| 7:30 pm - 7:55 pm |
Tobias Meyer, Ph.D.
Department of Molecular Pharmacology, Stanford University Medical Center
Stanford, CA
"Second messenger dynamics in mammalian chemotaxis" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:15 pm |
Carole Parent, Ph.D.
Laboratory of Cellular and Molecular Biology
National Cancer Institute, National Institutes of Health
"Adenylyl cyclase localization regulates streaming during chemotaxis" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm |
Andrey Shaw, M.D.
Department of Pathology & Immunology, Washington University
St. Louis, MO
"Structure and function of immunological synapses" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm |
Robert Deschesnes, Ph.D.
University of Iowa, Department of Biochemistry
Iowa city, IA
"Palmitoylation and the subcellular localization of Ras proteins" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | G-PROTEINS |
| |
| 9:00 am - 9:25 am |
David Siderovski, Ph.D.
University of North Carolina, Department of Pharmacology
Chapel Hill, NC
"Regulator of G-protein signaling (RGS) proteins: Myriad partners and myriad roles" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am |
Richard Neubig, M.D., Ph.D.
University of Michigan, Department of Pharmacology
Ann Arbor, MI
"Mechanism and physiological functions of RGS proteins" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am |
Heather Hess
Yale University
New Haven, CT
"RGS proteins and centrosome movements in C. elegans" |
| 10:25 am - 10:50 am | Coffee Break |
| 10:50 am - 11:15 am |
Steve Sprang, Ph.D.
University of Texas Southwestern Medical Center
Department of Biochemistry, HHMI
Dallas, TX
"G-protein regulatory interactions"
|
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am |
John Tessmer, Ph.D.
University of Texas at Austin, Department of Chemistry and Biochemistry
Institute for Cellular and Molecular Biology
Austin, TX
"The crystal structure of a complex between GRK2 and Gbeta1gamma2"
|
| 11:50 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Alan Smrcka, Ph.D.
University of Rochester, Department of Pharmacology and Physiology
Rochester, NY
"Cell permeant G ßγ binding peptides reveal a new mechanism for activation of beta/gamma subunit signaling" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE EVENING (Sponsored in part by the ASPET Division of Molecular Pharmacology) |
| 7:30 pm - 7:35 pm | Introduction |
| 7:35 pm - 8:15 pm |
Don Hunt, Ph.D.
University of Virginia Health Sciences Center, Department of Pathology
Charlottesville, VA
"Mass spectrometry and protein signaling networks"
|
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:30 pm | Introduction |
| 8:30 pm - 9:15 pm |
Anthony Pawson, Ph.D.
University of Toronto, Department of Medical Genetics and Microbiology
Toronto, Canada
"Organizing signaling pathways through protein interactions"
|
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LIPID SIGNALING |
| 9:00 am - 9:10 am |
Ken Harden, Ph.D.
University of North Carolina, Department of Pharmacology
Mary Ellen Jones Building
Chapel Hill, NC |
| 9:10 am - 9:35 am |
Peter Gierschik, M.D.
University of Ulm, Department of Pharmacology and Toxicology
Ulm, Germany
"Regulation of phospholipase C beta isoforms by Rho GTPases"
|
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am |
Tohru Kataoka, Ph.D.
Kobe University School of Medicine, Department of Physiology II
Kobe, Japan
"Regulation and function of phospholipase C epsilon" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:15 am |
John Sondek, Ph.D.
University of North Carolina, Department of Pharmacology
Chapel Hill, NC
"PLC structure"
|
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am |
John D. York, Ph.D.
Duke University Medical Center
Department of Pharmacology and Cancer Biology and Biochemistry, HHMI
Durham, NC
"Inositol polyphosphate messengers as regulators of nuclear function"
|
| 11:55 am - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm |
Denise Kenski
UCSF
"Chemical genetic inhibition of kinases"
(Sponsored in part by the ASPET Division of Molecular Pharmacology) |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELL CYCLE CHECKPOINT SIGNALING |
| 7:30 pm - 7:55 pm |
Karlene Cimprich, Ph.D.
Stanford University School of Medicine, Department of Molecular Pharmacology
Stanford, CA
"Understanding the mechanisms of DNA damage detection: Sensors and signals" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm |
Helen Piwnica-Worms, Ph.D.
Washington University School of Medicine, Department of Cell Biology and Physiology
St. Louis, MO
"Cell cycle and checkpoint control" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm |
Jean Gautier, Ph.D.
Columbia University
Department of Genetics & Development
New York, NY
"DNA damage response signaling in cell-free systems" |
| 9:15 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIGNALING IN CARDIAC DISEASE |
| 9:00 am - 9:30 am |
Tony Muslin, M.D.
Washington University School of Medicine, Department of Internal Medicine
St Louis, MO
"The role of RGS proteins in cardiovascular disease" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am |
Joan Heller Brown, Ph.D.
University of California, San Diego, Department of Pharmacology
La Jolla, CA
"GPCR signaling pathways in myocardial cell survival" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am |
Stefan Offermanns, M.D., Ph.D.
University of Heidelberg, Department of Pharmacology
Im Neuenheimer Feld 366
Heidelberg, Germany
"Gq/11 and G12/13 signaling in the cardiovascular system" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am |
Yoshi Ishikawa, M.D., Ph.D.
UMDNJ-New Jersey Medical School
Department of Cell Biology and Molecular Medicine, University Heights
Newark, NJ
"The differential roles of type 5 adenylyl cyclase in the heart and the striatum" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:15 pm |
Catherine Waters, Ph.D.
Department of Physiology and Pharmacology
SIBS, Glasgow
"GPCR signaling components in receptor tyrosine kinase activation of ERK"
|
| 12:15 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | POST RECEPTOR SIGNALING AND CANCER THERAPEUTICS |
| 7:30 pm - 7:55 pm |
Ronald Depinho, M.D.
Dana Farber Cancer Institute, Harvard Medical School
Department of Adult Oncol, Med and Genet
Boston, MA
"Modeling a path to cancer in mice" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm |
Alan D'Andrea, M.D.
Dana-Farber Cancer Institute, Department of Medicine
Boston, MA
"The Fanconi anemia/BRCA signaling pathway in the DNA damage response" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Mark Rolfe, Ph.D.
Millennium Pharmaceuticals
Cambridge, MA
"Discovery and development of VELCADE, a novel proteasome inhibitor for cancer therapy" |
| 9:15 pm - 9:25 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |