| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRUCTURE, ASSEMBLY AND BIOPHYSICS OF IFs
(in memoriam of Peter Steinert) |
| Discussion Leader: David Parry (Massey University, Palmerston North, New Zealand)
Introduction |
| Guest Speaker: Wolfgang Baumeister (Max Planck Institute of Biochemistry, Martinsried, Germany)
"Electron Tomography: towards visualizing the supramolecular architecture inside cells" |
| Harald Herrmann (German Cancer Research Center, Heidelberg, Germany)
"Mutational analysis of intermediate filament assembly: from lamins to desmin" |
| Poster oral presentation: Ken Goldie (European Molecular Biology Laboratory, Heidelberg, Germany)
"Structural investigations of intermediate filament assembly and network formation employing advanced electron microscopy methods" |
| Sergei Strelkov (M.E. Müller Institute, Biozentrum, University of Basel, Switzerland)
"Understanding the structural principles of IF assembly: from the elementary dimer to complete filaments" |
| Paul FitzGerald (School of Medicine, University of California, Davies, CA, USA)
"Site directed spin labeling and electron paramagnetic resonance as tools for defining IF structure" |
| Final discussion |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LAMIN BIOLOGY AND DISEASES |
| Discussion Leader: Roland Foisner (Vienna Biocenter, Vienna, Austria)
Introduction |
| Guest Speaker: Frank McKeon (Harvard Medical School, Boston, MA, USA)
"Less difficult than nuclear lamins but potentially solvable: p63 and epithelial stem cells" |
| Gisele Bonne (INSERM, Paris, France)
"Clinical, genetic and functional heterogeneity in laminopathies: an updated overview" |
| Colin Stewart (NCI-FCRDC, Frederick, MD, USA)
"Nuclear structure in development, aging and disease" |
| Coffee Break |
| Larry Gerace (The Scripps Research Institute, La Jolla, CA, USA)
"Integral membrane proteins of the nuclear envelope identified by a comprehensive proteomics analysis" |
| Poster oral presentation: Amy Rowat (University of Southern Denmark, Odense, Denmark)
"Getting to the core of the matter: biophysical perspectives of the nuclear envelope and lamina"
|
| Yossi Gruenbaum (Hebrew University, Jerusalem, Israel)
"Lamin-based pathways" |
| Reimer Stick (Institute for Cell Biology, University of Bremen, Germany)
"Function of B-type lamins in early development of Xenopus" |
| Final discussion |
| 12:45 pm | Lunch / Photo |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IFs AND APOPOTOSIS |
| Discussion Leader: Normand Marceau (Research Center, Laval University, Quebec, Canada)
Introduction |
| Guest Speaker: Bill Earnshaw (University of Edinburgh, UK)
"Aurora and Borealin - new levels of mitotic regulation" |
| Vincent Cryns (Northwestern University, Chicago, IL, USA)
"The deadly tango between caspases and the IF cytoskeleton" |
| Marcus Peter (Ben May Institute for Cancer Research, University of Chicago, IL, USA)
"DEDD/DEDD2 regulate caspase activation on intermediate filaments" |
| Bob Oshima (The Burnham Institute, La Jolla, CA, USA)
"Keratins in early development" |
| Poster oral presentation: Stephane Gilbert (Research Center, Laval University, Quebec, Canada)
"Keratins modulate c-Flip/ERK1/2 anti-apoptotic signaling in simple epithelial cells" |
| Final discussion |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | KERATIN REGULATION AND DISEASES |
| Discussion Leader: Jürgen Schweizer (German Cancer Research Center, Heidelberg, Germany)
Introduction |
| Guest Speaker: Dennis Roop (Baylor College of Medicine, Houston, TX, USA)
"p63 is the molecular switch for initiation of epithelial stratification and K14 expression during development" |
| Pierre Coulombe (Johns Hopkins University, Baltimore, MD, USA)
"New insight into keratin regulation and function" |
| Coffee Break |
| Lutz Langbein (German Cancer Research Center, Heidelberg, Germany)
"Keratins: pathfinders in the hair follicle compartments" |
| Irwin McLean (University of Dundee, UK)
"Keratin 7 transgenic mice - a 'not-so-simple' epithelial keratin" |
| Thomas Magin (University of Bonn, Germany)
"Analysis of mutant vimentin in fibroblasts and transgenic mice" |
| Birgit Lane (University of Dundee, UK)
"Cell stress and keratin dynamics" |
| Poster oral presentation: Nam-On Ku (Palo Alto VA and Stanford University, Palo Alto, CA, USA)
"Keratins as susceptibility genes for liver disease" |
| Final discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IFs, STRESS AND SIGNALLING |
| Discussion Leader: Kurt Zatloukal (Medical University of Graz, Austria)
Introduction |
| Guest Speaker: Ron Kopito (Stanford University, Palo Alto, CA, USA)
"Aggresomes: a cellular pathway for aggregate clearance" |
| Milos Pekny (University of Göteborg, Sweden)
"The function of intermediate filaments in astrocytes" |
| Jesus Paramio (CIEMAT, Madrid, Spain)
"New insights on K10 mediated signaling through transgenic approaches" |
| Poster oral presentation: Elke Janig (Medical University of Graz, Austria)
"The unfolded protein response to keratin aggregates"
|
| Roy Quinlan (University of Durham, UK)
"Network catastrophies and their causes as experienced by type III proteins" |
| Final discussion |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NEURONAL IF BIOLOGY AND DISEASES |
| Discussion Leader: Brian H. Anderton (King's College, London, UK)
Introduction |
| Guest Speaker: Erika Holzbaur (University of Pennsylvania, Philadelphia, PA, USA)
"The role of axonal transport in the pathogenesis of motor neuron disease" |
| Don Cleveland (Ludwig Institute for Cancer Research, University of California, San Diego, CA, USA)
"Neurofilaments as the target for the 'outside-in' signaling cascade in radial growth" |
| Coffee Break |
| Jean-Pierre Julien (Laval University, Quebec, Canada)
"The role of peripherin in motor neuron disease" |
| Albee Messing (Waisman Center, Madison, WI, USA)
"GFAP mutations and Alexander disease" |
| Christopher Miller (Department of Neuroscience, King's College, London, UK)
"Neurofilament phosphorylation and axonal transport" |
| Harish Pant (NINDS, Bethesda, MD, USA)
"Why is NF-M/H tail domain phosphorylation normally restricted to the axonal compartment of the neuron?" |
| Poster oral presentation: Ben G. Szaro (Department of Biological Sciences and the Center for Neuroscience Research, University at Albany, State University of New York, NY, USA)
"Developmentally regulated binding of KH-domain proteins to the 3' untranslated region of NF-M mRNA"
|
| Final discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IFAPs: FROM BIOLOGY TO DISEASE |
| Discussion Leader: Ronald K. Liem (Columbia University, New York, NY, USA)
Introduction |
| Guest Speaker: Fiona Watt (Keratinocyte Laboratory London Research Institute, London, UK)
"How do periplakin and envoplakin associate with the plasma membrane?" |
| Kathy Green (Northwestern University, Chicago, IL, USA)
"Working out the strength and flexibility of desmosomes" |
| Poster oral presentation: Andrew P. Kowalczyk (Emory University, Atlanta, GA)
"Pemphigus autoantibody binding to keratinocyte cell surfaces disrupts desmosomes and causes Dsg3 internalization through an endo-lysosomal pathway"
|
| Luca Borradori (Hôpital Cantonal Universitaire, Geneva, Switzerland)
"Characterization of the association between plakin family members and intermediate filaments" |
| Gerhard Wiche (Vienna Biocenter, Vienna, Austria)
"Cytolinker scaffolds as signaling platforms" |
| Final discussion |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | WHAT'S LEFT OF IFs THAT WE NEED TO KNOW? |
| Discussion Leader: Werner W. Franke (German Cancer Research Center, Heidelberg, Germany)
Introduction |
| Guest Speaker: Elaine Fuchs (Rockefeller University, New York, NY, USA)
"Cytoarchitecture in the epidermis" |
| Yassemi Capetanaki (Biomedical Research Academy of Athens and University of Patras, Greece)
"Intermediate filament-mitochondria connections - coordinating life and death" |
| Coffee Break |
| Rudolf Leube (Institute for Anatomy, Johannes Gutenberg University, Mainz, Germany)
"Keratin filament network organization in vivo" |
| John Eriksson (University of Turku, Finland)
"Intermediate filaments as signaling scaffolds" |
| Masaki Inagaki (Aichi Cancer Center Research Institute, Nagoya, Japan)
"Identification and characterization of cleavage fullow kinases" |
| Poster oral presentation: Karen M. Ridge (Northwestern University, Chicago, IL, USA)
"Mitochondrial-generated ROS promote the disassembly of keratin intermediate filaments" |
| Brian K. Kennedy (Department of Biochemistry, University of Washington, Seattle, WA, USA)
"Functional roles of A-type lamins in cell proliferation and differentiation" |
| Final discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW HORIZONS IN IF STUDIES |
| Discussion Leader: Alasdair C. Steven (NIH, Bethesda, MD, USA)
Introduction |
| Guest Speaker: Aaron Ciechanover (Israel Institute of Technology, Haifa, Israel)
"On general aspects of the ubiquitin system" |
| Christine Jacobs-Wagner (Yale University, New Haven, CT, USA)
"A bacterial IF-like cytoskeleton involved in cell shape" |
| Poster oral presentation: Linda M. Lund (University of Maryland, Baltimore, MD, USA)
"The intermediate filament protein synemin is an A-kinase anchoring protein" |
| Poster oral presentation: Stephanie Portet (The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada)
"Modeling the intermediate filament networks" |
| Poster oral presentation: Sanjay Kumar (Vascular Biology Program, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA)
"Subcellular laser nanosurgery of cytoskeletal filaments" |
| Bob Goldman (Northwestern University, Chicago, IL, USA)
"The complexities of organizing and maintaining an intermediate filament network requires mRNA, molecular motors, motility and co-translational assembly" |
| Final discussion |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Departure |