Gordon Research Conferences
Meeting Details

Cell Proliferation, Molecular & Genetic Basis of
Gordon Research Conference

Note: This conference is currently known as "Cell Growth & Proliferation".


June 26 - July 1, 2005


Colby-Sawyer College
New London, NH


Michael Tyers

Vice Chair:
Michael B. Yaffe

Meeting Description

Cell proliferation, which depends on the intimately linked processes of growth and division, is a fundamental systems-level attribute of all life forms. The precise regulation of proliferation in response to internal and external cues is critical for development, tissue renewal and evolutionary fitness, while the disregulation of proliferation underlies many human conditions, most notably cancer and aging. Historically, the breakthroughs in our understanding of cell growth and division have derived from cross-fertilization of results and ideas from researchers studying sundry model organisms, from yeast to humans. The basis for cell proliferation entails the control of key signaling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Indeed, many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This Gordon Research Conference on the Molecular and Genetic Basis of Cell Proliferation aims to provide an integrated perspective on the multitude of processes that govern cell growth and division across a spectrum of eukaryotic model systems. Many frontiers of cell division research will be covered, including fundamental cell cycle modules, checkpoints and cancer, chromosome replication and dynamics, control of cell growth and polarity, growth factors and signal transduction, ubiquitin-dependent proteolysis, gene regulation and systems-level approaches. This meeting affords an opportunity to access an interdisciplinary cross-section of cell cycle research as presented by international leaders in their respective fields. In recent past meetings, discussion has been lively as researchers exchange their diverse perspectives on cell proliferation.


Meeting Program

2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Speakers
Discussion Leader: Mike Tyers
7:30 pm - 8:30 pm Gerard Evan
"Putting the brakes on tumor cell growth"
8:30 pm - 9:30 pmSteve Elledge (Harvard Medical School)
"Adventures in mammalian genetics"
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGrowth
Discussion Leader: Bruce Edgar
9:00 am - 9:30 amBruce Edgar (Fred Hutchinson Cancer Research Center)
"Proliferation and growth control in Drosophila"
9:30 am - 10:00 amMike Hall (University of Basel)
"TOR signaling and control of cell growth in yeast and mammals"
10:00 am - 10:30 amMorris Birnbaum (HHMI/U of Pennsylvania)
"Regulation of growth and metabolism by Akt/PKB"
10:30 am Coffee Break / Photo
11:00 am - 11:30 amGeorge Thomas (U Cinncinati)
"The nutrient input to the mTOR/S6K1 signaling pathway"
11:30 am - 12:00 pmLaura Johnston (Columbia University)
"Growth, competition and size control"
12:00 pm - 12:15 pmKaren Cichowski (Harvard Medical School)
"The NF1 tumour suppressor is an indispensable regulator of TSc2 and mTOR"
12:15 pm - 12:30 pmBrendan Manning (Harvard School of Public Health)
"Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSignaling
Discussion Leader: Tony Pawson
7:30 pm - 8:00 pm Tony Pawson (Samuel Lunenfeld Research Institute)
"Reciprocal cell signaling"
8:00 pm - 8:15 pmLarry Feig (Tufts University)
"The Ral GTPase Signaling Cascade in Cellular Growth Control"
8:15 pm - 8:30 pmAnne-Claude Gingras (Institute for Systems Biology)
"Comparative protein interaction networks for the PP2A-type phosphatases"
8:30 pm - 9:00 pm Helen McNeill (Cancer Research UK)
"Drosophila tumour suppressor genes in growth & tissue organization"
9:00 pm - 9:30 pmBen Neel (Beth Israel-Deaconess Medical Center, Harvard Medical School)
"Shp2 and its binding proteins in cancer"
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Cycle
Discussion Leader: Orna Cohen-Fix
9:00 am - 9:30 am Orna Cohen-Fix (NIH)
"Yeast with nuclei bent out of shape"
9:30 am - 10:00 am Wade Harper (Harvard Medical School)
"Substrate recognition and ubiquitination by cullin-based ubiquitin ligases"
10:00 am - 10:30 amHelena Richardson (Peter Mac Cancer Institute, Australia)
"Novel regulators of G1-S phase progression revealed in a Drosophila genetic screen"
10:30 am Coffee Break
11:00 am - 11:30 amMatthias Peter (ETH, Switzerland)
"Regulation and function of cullin-based ligases"
11:30 am - 12:00 pmJoan Ruderman (Harvard Medical School)
"Aurora kinases and mitosis"
12:00 pm - 12:15 pmZhi-Chun Lai (Pennsylvania State University)
"Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats"
12:15 pm - 12:30 pmEric Weiss (Northwestern University)
"Regulation of yeast Cbk1 and its role in Ace2-driven transcriptional asymmetry"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChromosome Replication and Dynamics
Discussion Leader: Titia de Lange (The Rockefeller University)
7:30 pm - 8:00 pmTitia de Lange (The Rockefeller University)
"How telomeres tame the DNA damage response"
8:00 pm - 8:30 pm John Diffley (Cancer Research UK)
"Regulation of origin licensing in human cells by cyclin dependent kinases"
8:30 pm - 9:00 pm Dan Durocher (Samuel Lunenfeld Research Institute)
"Control of checkpoint recovery by histone H2A dephosphorylation"
9:00 pm - 9:15 pmYisong Wang (Oak Ridge National Laboratory)
"Human Cdc14B phosphatase and microtubule dynamics"
9:15 pm - 9:30 pmTBA
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCheckpoints
Discussion Leader: Helen Piwnica-Worms
9:00 am - 9:30 amHelen Piwnica-Worms (Washington University School of Medicine)
"Mammalian cell cycle and checkpoint control"
9:30 am - 10:00 amSally Kornbluth (Duke University Medical Center)
"Checkpoint regulation of Cdc25"
10:00 am - 10:30 am Carol Prives (Columbia University)
"Regulation of DNA damage mediated apoptosis by the p53 family"
10:30 am Coffee Break
11:00 am - 11:30 amSusan Lees-Miller (University of Calgary)
"Mechanisms of Activation of ATM"
11:30 am - 12:00 pmMike Yaffe (MIT)
"MAPKAP Kinase-2/Chk3 - a critical regulator of DNA damage checkpoint signaling"
12:00 pm - 12:30 pmRobert Rottapel (Ontario Cancer Institute)
"The Rho GEF Lfc Regulates Spindle Assembly in Early Mitosis"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSystematics and Mathematical Modeling
Discussion Leader: Fred Cross
7:30 pm - 8:00 pmFred Cross (The Rockefeller University)
"Modeling the cell cycle: Top-down, bottom-up or lost in the middle"
8:00 pm - 8:30 pmRavi Iyengar (Mount Sinai School of Medicine)
"Regulatory motifs in cellular networks"
8:30 pm - 9:00 pmRebecca Heald (University of California, Berkeley)
"Mechanisms and molecules of mitosis"
9:00 pm - 9:30 pmMike Snyder (Yale University)
"Regulatory networks in eucaryotes"
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGene Regulation
Discussion Leader: Dan Gottschling
9:00 am - 9:30 am Dan Gottschling (Fred Hutchinson Cancer Research Center)
"Nuclear incontinence: The effects of old age on the genome"
9:30 am - 10:00 amNick Dyson (Beth Israel-Deaconess Medical Center, Harvard Medical School)
"Varieties of E2F-mediated regulation"
10:00 am - 10:30 am Bill Tansey (Cold Spring Harbor Laboratory)
"Transcriptional control and the ubiquitin-proteasome system"
10:30 am Coffee Break
11:00 am - 11:30 amAli Shilatifard (Saint Louis University School of Medicine)
"Yeast COMPASS points the way to human MLL and its role in the regulation of gene expression as a histone methyltransferase"
11:30 am - 11:45 amStephane Larochelle (Memorial Sloan-Kettering Cancer Center)
"The dual-function Cdk7 complex: exquisite specificity and cell cycle-dependent substrate selectivity revealed through chemical genetics"
11:45 am - 12:00 pmRandal Tibbetts (University of Wisconsin)
"Mechanisms of CREB phosphorylation by ATM/ATR kinases"
12:00 pm - 12:15 pmLinda Penn (Ontario Cancer Institute)
"Cul7 cooperates with Myc in transformation by promoting p53 ubiquitination and inhibiting p53 mediated apoptosis"
12:15 pm - 12:30 pmBusiness Meeting
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCancer
Discussion Leader: Tak Mak
7:30 pm - 8:00 pm Tak Mak (Campbell Family Institute of Breast Cancer Research, Ontario Cancer Institute)
"Regulation of PTEN functions"
8:00 pm - 8:30 pmJackie Lees (MIT)
"E2F in the control of proliferation and apoptosis"
8:30 pm - 9:00 pmJean Y.J. Wang (University of California San Diego)
"Death by Abl: A matter of location and translocation"
9:00 pm - 9:30 pm Dafna Bar-Sagi (SUNY at Stonybrook)
"Ras signaling"
7:30 am - 8:30 amBreakfast
9:00 amDepart
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