| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE TALKS |
| 7:30 pm - 8:00 pm | Samuel Wilson (NIEHS)
"Mechanisms of Mutagenesis at the Cellular and Atomic Structural Levels: Lessons from Studies of Mammalian pol?" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Penny Jeggo (University of Sussex)
"DNA Non-Homologous End-Joining: The Mechanism and Interfacing Pathways" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Marc Vidal (Dana Farber Cancer Institute)
"Interactome Networks" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENOTOXICITY OF ENDOGENOUS LESIONS AND BER |
| 9:00 am - 9:35 am | Discussion Leader:
Larry Marnett (Vanderbilt University)
"Chemistry of Reactive DNA Adducts and Its Biological Consequences" |
| 9:35 am - 10:10 am | Sankar Mitra (University of Texas Medical Branch) |
| 10:10 am - 10:45 am | Coffee Break / Photo |
| 10:45 am - 11:20 am | John Essigmann (Massachusetts Institute of Technology)
"Sources and consequences of DNA Alkylation and Oxidation" |
| 11:20 am - 11:55 am | Akira Yasui (Tohoku University)
"Following Cellular Responses Induced by Oxidative DNA Damage in Human Cells" |
| 11:55 am - 12:30 pm | Leona Samson (Massachusetts Institute of Technology)
"Biological Responses to DNA Base Damage" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW DEVELOPMENTS IN EXCISION REPAIR |
| 7:30 pm - 8:00 pm | Discussion Leader:
Jean-Marc Egly (Institut de Genetiquet et Biologie Moleculaire et Cellulaire) |
| 8:00 pm - 8:30 pm | Caroline Kisker (State University of New York at Stony Brook)
"From Recognition to Incision - New insights into Nucleotide Excision Repair" |
| 8:30 pm - 9:00 pm | Kioji Tanaka (Osaka University)
"Molecular Basis for Cockayne Syndrome and Its Related Disorder" |
| 9:00 pm - 9:30 pm | Priscilla Cooper (Lawrence Berkeley National Laboratory)
"Insights for Transcription-Coupled Repair from Interactions and Dynamics of XPG" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RESPONSES TO REPLICATION BLOCKAGE |
| 9:00 am - 9:45 am | Discussion Leader:
Tom Kunkel (NIEHS)
"Replication Fidelity with Damaged Templates" |
| 9:45 am - 10:30 am | John Diffley (Cancer Research UK)
"The Initiation of DNA Replication in Yeast and Human Cells" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | Alan Lehmann (University of Sussex)
"Regulation of Translesion Synthesis by Ubiquitination of PCNA" |
| 11:45 am - 12:30 pm | Jean Wang (University of California, San Diego)
"Cell Death Response to Genotoxins" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DOUBLE BLACK DIAMONDS OF REPAIR: DNA CROSS- LINKS AND PROTEIN-DNA CROSS-LINKS |
| 7:30 pm - 8:00 pm | Discussion Leader:
Stephen Lloyd (Oregon Health and Science University)
"Cellular Responses to DNA-Protein Crosslinks" |
| 8:00 pm - 8:30 pm | Peter McHugh (University of Oxford)
"Processing of DNA Interstrand Cross-Links in Budding Yeast" |
| 8:30 pm - 9:00 pm | Laura Neidernhofer (University of Pittsburgh Cancer Institute)
"Mammalian Crosslink Repair: Unraveling a Mechanism of Aging" |
| 9:00 pm - 9:30 pm | Alan D-Andrea (Dana-Farber Cancer Institute)
"The Fanconi Anemia/BRCA Pathway and the DNA Damage Response" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DAMAGE INDUCIBLE CHECKPOINTS AND SIGNALING |
| 9:00 am - 9:45 am | Discussion Leader:
Antony Carr (University of Sussex)
"Recombination But Not Checkpoint Proteins are Required for Survival of a Site-Specific Replication Stall" |
| 9:45 am - 10:30 am | Stephen Elledge (Brigham and Women's Hospital)
"Adventures in Mammalian Genetics" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | Rodney Rothstein (Columbia University) |
| 11:45 am - 12:30 pm | Yossi Shiloh (Tel Aviv University)
"The ATM-Mediated DNA Damage Response: New Branches" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DNA DAMAGE IN VIVO AND SOMATIC MUTATION IN VIVO |
| 7:30 pm - 8:00 pm | Discussion Leader:
Andrew Collins (University of Oslo)
"DNA Oxidation in Humans: How Much and How Important" |
| 8:00 pm - 8:30 pm | Bernd Epe (Johannes Gutenberg University Mainz)
"Generation, Repair and Mutagenic Potential of Endogenous Oxidative DNA Modifications in Mice" |
| 8:30 pm - 9:00 pm | Vernon Walker (Lovelace Respiratory Research Institute)
"Transplacental Exposure to Nucleoside Analogs: DNA Damage and Fetal Health" |
| 9:00 pm - 9:30 pm | Shinya Shibutani (State University of New York at Stony Brook)
"Genotoxic Mechanism of Tamoxifen in Developing Endometrial Cancer" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MITOCHONDRIA: THE OTHER SITE OF DNA DAMAGE |
| 9:00 am - 9:45 am | Discussion Leader:
William Copeland (NIEHS)
"DNA Replication in Mitochondrial Diseases" |
| 9:45 am - 10:30 am | Susan LeDoux (University of South Alabama)
"Mitochondrial DNA Repair: A Critical Player in the Cellular Response to Genotoxic Insults" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | Ute Moll (State University of New York at Stony Brook)
"p53 Protein Has a Direct Apoptotic Role at Mitochondria" |
| 11:45 am - 12:30 pm | Takehiko Shibata (RIKEN)
"Mitochondrial DNA Replication Initiated by an Excision-Repair Enzyme and a Recombination-Protein in Yeast: A Possible Mechanism to Escape DNA Damage and to Resume Homoplasmy" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | METALS AS CO-CARCINOGENS |
| 7:30 pm - 8:00 pm | Discussion Leader
David Wilson (National Institute on Aging)
"Lead Foils DNA Repair: Inactivation of the Major Mammalian Abasic Endonuclease" |
| 8:00 pm - 8:30 pm | Andrew Kligerman (Environmental Protection Agency)
"How the Genotoxicity of Arsenic Determines Its Mode of Action as a Carcinogen" |
| 8:30 pm - 9:00 pm | Anatoly Zhitkovich (Brown University)
"Dueling Roles of Nucleotide Excision and Mismatch Repair in Chromium Toxicity" |
| 9:00 pm - 9:30 pm | James Imlay (University of Illinois at Urbana-Champaign)
"Are Endogenous Oxidants an Important Source of DNA Damage?" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |