Gordon Research Conferences
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Conference Program
Hormone Action in Development & Cancer
(This meeting is currently known as "Hormone-Dependent Cancers")
July 10-15, 2005
Mount Holyoke College
South Hadley, MA

This new Gordon Research Conference is a combination of the former Gordon Conferences on Hormone Action, Hormones and Development, and Hormonal Carcinogenesis which have been discontinued. The focus of this conference will be on the role of steroid (nuclear) hormones in development and cancer with a focus on the underlying molecular and cellular mechanisms of these processes. This new Gordon Conference will bring together cutting-edge experts in these areas with young investigators to discuss mechanistic concepts broadly across phyla and their translation to basic problems in development and cancer. The highly multidisciplinary and "transformational" environment that will be created during this meeting in formal and informal contexts is intended to result in cross-fertilization and development of significant new ideas. The program will include state-of-the-art discussions of important areas such as hormone action during early and pubertal development, steroid hormone receptors and modifiers of hormone action, steroid hormone metabolism, non-steroid nuclear receptors and non-nuclear steroid hormone receptors, the role of stromal-epithelial interactions, signaling and receptor cross-talk, non-genomic and epigenetic actions of hormones, genetic susceptibility to hormone-related cancer, environmental endocrine disrupting agents, hormonal agents in cancer prevention and therapy, and a wide range of model systems applicable to the study of hormone action in development and cancer.

This conference was made possible by support from Gordon Research Conferences, GTX, Inc., Cell Press, and the National Institutes of Health (NCI, NIDDK, and NIEHS).

2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmDiscussion Leader: John MacLachlan (Tulane University)
7:40 pm - 8:40 pmKeynote Speaker: Bruce Spiegelman (Dana Farber/Harvard)
"Regulation of metabolic pathways through transcriptional co-activation"
8:40 pm - 9:30 pmDavid Moore (Baylor)
"Nuclear receptors in liver cancer and liver growth"
7:30 am - 8:30 amBreakfast
8:45 amPhoto
9:00 am - 9:10 amDiscussion Leader: Don Brown (Carnegie Institution)
Discussant: Jim Truman (University of Washington)
9:10 am - 10:00 amKevin White (Yale)
"Gene networks in ecdysis"
10:00 amCoffee Break
10:20 am - 11:10 amAlex Schrieber (Carnegie)
"Thyroid-hormone gene programs for metamorphosis"
11:10 am - 12:00 pmCheryl Sisk (Michigan State University)
"Neuroendocrine control of puberty"
12:00 pm - 12:30 pmLate breaking presentations
Discussion Leader: Jerry Heindel (NIEHS)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #1
6:00 pmDinner
7:30 pm - 9:30 pmANIMAL MODELS
Discussion Leader: James Shull (University of Nebraska)
7:30 pm - 8:10 pmMyles Brown (Dana Farber/Harvard)
"Mammary tumors and PI3K/AKT pathway activation in AIB1 transgenic mice"
8:10 pm - 8:50 pmPricilla Furth (Georgetown University)
"How changes in ERalpha, AIB1, Brca1 and Stat5a expression in mammary epithelial cells modulate mammary gland development and breast cancer risk"
8:50 pm - 9:30 pmMargaret Jones (Prince Henry's Institute of Medical Research / Monash, Australia)
"Regulation of adiposity by estrogen - the Aromatase knockout (ArKO) mouse model"
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEPIGENETICS
9:00 am - 9:10 amDiscussion Leader: Paolo Sassone-Corsi (CNRS, Strassbourg, France)
Discussant: Cheryl Walker (MD Anderson)
9:10 am - 10:00 amGail Prins (University of Chicago) & Shuk-mei Ho (University of Massachusetts)
"Epigenetic mechanisms mediating neonatal estrogen imprinting on adult risk of prostate carcinogenesis"
10:00 amCoffee Break
10:20 am - 11:10 amDavid Jarrard (University of Wisconsin)
"Aging and cancer: Are age-related alterations in genomic imprinting susceptibility factors for cancer?"
11:10 am - 11:40 amKen Nephew (Indiana University)
"Epigenetic consequences of loss of estrogen receptor-alpha signaling on downstream target genes in breast cancer"
11:40 am - 12:20 pmMichael Skinner (Washington State University)
"Epigenetic Transgenerational Actions of Endocrine Disruptors on Male Reproduction and Disease Development"
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #1
6:00 pmDinner
7:30 pm - 7:35 pmNominations for Vice Chairs
7:35 pm - 8:10 pmDiscussion Leader: Rakesh Kumar (MD Anderson)
8:10 pm - 8:50 pmJan-Åke Gustafsson (Karolinska, Sweden)
"Antiproliferative actions of ERbeta - mechanisms and possible pharmaceutical applications"
8:50 pm - 9:30 pmEllis Levin (UC-Irvine-Long Beach VA)
"Extra-nuclear origins of estrogen receptor action"
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTHERAPY AND PREVENTION
9:00 am - 9:10 amDiscussion Leader: Ronald Ross (USC)
Discussant: Gerry Coetzee (USC)
9:10 am - 9:55 amMalcolm Pike (USC)
"Did Women's Health Initiative (WHI) teach us anything new about progestins and cancer?"
9:55 am - 10:40 amChris Haiman (USC)
"Is individualizing hormonal chemoprevention feasible based on genetic profiling?"
10:40 amCoffee Break
11:00 am - 11:45 amHoward Scher (Memorial Sloan Kettering)
"The AR as a therapeutic target for prostate cancer"
11:45 am - 12:30 pmHoward Parnes (National Cancer Institute) & Richard Cote (USC)
"The success (and failure) of the Prostate Cancer Prevention Trial (PCPT)"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #2
6:00 pmDinner
7:15 pm - 7:30 pmBusiness Meeting: Election of Vice Chairs
7:30 pm - 9:30 pmGENOMICS & PROTEOMICS
Discussion Leader: Shuk-mei Ho (University of Massachusetts)
7:30 pm - 8:10 pmSuzanne Conzen (University of Chicago)
"Beyond Gene Profiling: Using Bioinformatic Approaches to Uncover Glucocorticoid Receptor -mediated Signaling Pathways"
8:10 pm - 8:50 pmTim Huang (Ohio State)
"Methylation Profiling of Hormone-Insensitive Breast Cancer"
8:50 pm - 9:30 pmSamir Hanash (Fred Hutchinson Cancer Center)
"Contribution of proteomics to molecular analysis of disease"
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHORMONE METABOLISM
9:00 am - 9:10 amDiscussion Leader: Shiuan Chen (City of Hope)
Discussant: Rajeshwar Tekmal (UT Health Science Center at San Antonio)
9:10 am - 10:00 amJose Russo (Fox Chase)
"Estrogen and its metabolites and breast carcinogenesis"
10:00 am Coffee Break
10:30 am - 11:20 amThomas Sutter (University of Memphis)
"Estradiol hydroxylation by CYP1B1: Relevance to the treatment and prevention of breast cancer"
11:20 am - 12:00 pmRobert Brueggemeier (Ohio State)
"Aromatase and cyclooxygenases: The role of the enzymes and inhibitors in breast cancer"
12:00 pm - 12:30 pmLate breaking presentations
Discussion Leader: Jerry Heindel (NIEHS)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #2
6:00 pmDinner
7:30 pm - 9:30 pmKEYNOTE ADDRESS
7:30 pm - 7:45 pmDiscussion Leader: Donald Coffey (Johns Hopkins)
7:45 pm - 9:30 pmGerald (Jerry) Cunha (UCSF)
"Role of stroma in hormone-regulated normal development and carcinogenic progression"
7:30 am - 8:30 amBreakfast
9:00 amDepart

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