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Conference Program
 
Mycotoxins & Phycotoxins
June 19-24, 2005
Colby College
Waterville, ME

The Gordon Research Conference on Mycotoxins and Phycotoxins provides an international forum for the presentation and discussion of leading edge research on the biology, chemistry, risk assessment and toxicology of fungal, algal, and cyanobacterial toxins that are known food or water contaminants. A primary goal of the meeting is to create the critical mass of creative thinking necessary to unravel the complex food safety problem presented by naturally occurring food toxins. With this in mind, considerable effort is made to provide numerous opportunities for participants to interact in a relaxed environment that promotes the free exchange of ideas on topics vital to the future of research on the identification, toxicology, control, and regulation of natural toxins in foods. The conference is unique in that it bring together a diverse multidisciplinary group of research scientists who are all ultimately focused on solving the same practical problem: ensuring the safety and security of the food supply!


Contributors
Carl Storm Underrepresented Minority Fellowships
Frito-Lay, Inc.
General Mills
International Life Sciences Institute (ILSI), North America
National Institutes of Health, Office of Rare Diseases
National Institute of Environmental Health Sciences
Pablo Valenzuela and Bernardito Mendez Foundation
U.S. Department of Agriculture, CSREES
U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmRisk Assessment and its Role in Regulatory Decision Making
Chair: Dr. Felicia Wu, University of Pittsburgh
Discussion Leader: Dr. David Miller, Carleton University
7:30 pmWelcome
7:40 pmChair Overview
7:50 pmTerry Troxell, U.S. FDA
"Processes for Setting Regulatory Limits for Fumonisin and other Mycotoxins"
8:20 pmDr. Elaine Faustman, University of Washington, School of Public Health and Community Medicine
"Marine Toxin Risk Analysis and Risk Communication"
8:50 pmDr. Wentzel Gelderblom, Medical Research Council of South Africa
"Risk Assessment Of The Fumonisin B Mycotoxins - Perspectives On Different Regulatory Scenarios In Developing Countries"
9:20 pmDiscussion
9:30 pm Social
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmToxicogenomics and Molecular Mechanisms of Toxicity
Chair: Dr. Chris Corton, US Environmental Protection Agency, Research Triangle Park, NC
Discussion Leader: Dr. Annie Pfohl-Leszkowicz, Ecole Nationale superieure Agronomique de Toulouse, France
9:00 am Chair Overview
9:10 am Dr. Greg Mayer, School of Marine Sciences, University of Maine
"Toxicogenomic Effects of Marine Brevetoxins in Liver and Brain of Mouse"
9:40 amDr. Michael Stone, Vanderbilt University
"The Aflatoxin B1 N7-dG Formamidopyrimidine (FAPY) Adduct in DNA: Structural Perspectives on Genotoxicity"
10:10 amDiscussion
10:25 amBreak
11:00 am Dr. Ed Cleveland, USDA, New Orleans, LA
"Genomics for determination of aflatoxigenic potential of Aspergillus species"
11:30 am Dr. Wolfgang Dekant, Institute for Toxicology, University of Wuerzburg, Germany
"Ochratoxin A causes DNA-damage in target and non-target organs in rats, but does not form covalent DNA-adducts"
12:00 pm"Hot topic" - to be chosen from posters
12:10 pm Discussion
12:30 pmPhoto / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session with authors present (second hour)
6:00 pmDinner
7:30 pm - 9:30 pmNovel Toxin Variants and Synthetic Receptors
Chair: Dr. Bob Dickey, U.S. FDA
Discussion Leader: Dr. Mark Savard, Agriculture and Agri-Food Canada
7:30 pm Dr. Andrea Bordelais, University of North Carolina at Wilmington Center for Marine Science
"New Brevetoxin Variants"
8:00 pmDr. Hans-Ulrich Humpf, University of Meunster, Germany
"Structural elucidation of thermal degradation products of Fusarium mycotoxins"
8:30 pmDr. Robert Gawley, Department of Chemistry and Biochemistry, University of Arkansas
"Chemosensors for the detection of saxitoxin"
9:00 pmDr. Sergey Piletsky, Institute of BioScience and Technology, Cranfield University, UK
"Molecularly imprinted polymers for the detection of marine toxins"
9:30 pmSocial
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmToxin Induction and Biosynthesis
Chair: Dr. Gary Payne, North Carolina State University
Discussion Leader: Micheal Holmes, National University of Singapore
9:00 amChair Overview
9:10 amDr. Nancy Keller, University of Wisconsin
"Un-loxing the code: Cross Kingdom Oxylipin Signaling Mediates Aspergillus spore and mycotoxin production"
9:40 am Dr. David Sherman, University of Michigan
"Harnessing Metabolic Potential from Diverse Toxin Biosynthetic Systems"
10:10 am Discussion
10:30 amBreak
11:00 amDr. Cynthia Heil, University of South Florida, St. Petersburg, FL
"Interactions of Nitrogen Fixing Bacteria with Karenia brevis"
11:30 amDr. Samuel Lo Chun-lap, Hong Kong University
"The Use Of Differentially Expressed Protein Profiles Under Different Growth Phases And Growth Conditions For Bloom Prediction Of Prorocentrum Triestinum"
12:00 pm "Hot topic" - to be chosen from posters
12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session with authors present (second hour)
6:00 pmDinner
7:30 pm - 9:30 pmToxin Mitigation and Control
Chair: Richard Lewis, University of Queensland, Australia
Discussion Leader: Dr. Russell Molyneux, USDA, CA
7:30 pm Dr. Kevin O'Shea, Department of Chemistry and Biochemistry, Florida International University
"Oxidation and Detoxification of Microcystins using Ultrasonic Irradiation"
8:00 pmDr. Daniel Veith, University of Marburg, Germany
"Molecular tools for the analysis of fungal infection and development"
8:30 pm Dr. Anne Desjardins, USDA, Peoria, IL
"Reduced infectivity of fungal spores through spore modification"
9:00 pmDr. Mike Twiner, NOS Center for Coastal Environmental Health and Biomolecular Research
"The relationship between bacteria and harmful algae: functional... or dysfunctional"
9:30 pmSocial
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDetection Technologies for Organisms and Toxins (Focus on satellite workshop highlights)
Chair: Dr. Kelly Rein, Florida International University, Miami, FL
Discussion Leader: Dr. Ken Voss, Toxicology and Mycotoxin Research Unit, USDA, Athens, GA
9:00 amOverview of Satellite Workshop: This talk will summarize the presentations and demonstrations given at the Satellite Workshop that is to be organized by vice-Chairs Kelly Rein and Ken Voss for Friday and Saturday June 17th and 18th, 2005 at the Mount Desert Island Biological Laboratory (NIH), Bar Harbor, ME.
9:30 amDr. Kathryn Coyne, University of Delaware Graduate College of Marine Studies
"Single-tube detection of multiple harmful algal species by quantitative real-time PCR"
10:00 amDr. Kevin James, Mass Spectrometry Center for Proteomics and Biotoxin Research, Cork Institute of Technology, Cork, Ireland
"Azaspiracids and diarrhetic shellfish poisoning toxins in marine phytoplankton and shellfish determined using nano-electrospray mass spectrometric methods"
10:30 amCoffee Break
11:00 amDr. Rudolf Krska, IFA-Tulln, Austria
"Multivariate mid-IR-Spectroscopy as a promising tool to estimate the DON-level in maize and wheat"
11:30 amDr. Chris Taitt, Naval Research Laboratory, Washington
"Detection of multiple mycotoxins from various food sources using an array biosensor"
12:00 pm"Hot topic" - to be chosen from posters
12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAnimal Model Studies
Chair: Dr. Isabelle Oswald, INRA, Toulouse, France
Discussion Leader: Dr. Andrew Gordon, Old Dominion University, Virginia
7:30 pmDr. Janet Benson, Lovelace Respiratory Research Institute
"Toxicities of Inhaled Brevetoxin and Microcystin in Rodents"
8:00 pmDr. Raghu Sharma, University of Georgia
"Fumonisin signaling in livers of genetically modified mice"
8:30 pmDr. Roger Coulombe, Utah State University
"Modulation of Aflatoxin Toxicity in Poultry with Antioxidants"
9:00 pmPoster presentations (2) related topics
9:30 pmSocial
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAnimal Model Studies II
Chair: Dr. Ronald Riley, USDA
Discussion Leader: Dr. Fran Van Dolah, NOAA
9:00 amOverview
9:10 am Keynote lecture: Dr. Jerry Rice, Georgetown University Medical Center, DC
"Relating animal toxicity data to human safety"
10:10 amDiscussion
10:25 amBreak
10:45 amDr. Sven Daenicke, Insitute of Animal Nutrition, Braunschweig FAL, Germany
"Toxicokinetics and metabolism of deoxynivalenol and zearalenone"
11:15 am Dr. Julie Zaias, University of Miami
"Pathophysiology of aerosolized Florida Red Tide Toxins exposure in animals"
11:45 am"Hot topic" - to be chosen from posters
11:55 amDiscussion
12:15 pm Business meeting
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmAssessing Chronic Exposure to Toxins
Chair: Dr. Mark Poli, U.S. Army
Discussion Leader: Sarah Henry, U.S. FDA
7:30 pmDr. Robert Macphail, U.S. EPA, NC
"Anatoxin-a: Episodic Exposures, Sublethal Effects"
8:00 pmDr. J.S. Wang, Texas Tech University, TX
"Validation Of Fumonisin Biomarkers For Studying Human Cancer Risks"
8:30 pmDr. Helen Schurz-Rogers, Centers for Disease Control, USA
"Outbreak of Aflatoxicosis in Kenya, 2004"
9:00 pmDiscussion
9:15 pmClosing Remarks
9:30 pmSocial
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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