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Molecular Mechanisms in Lymphatic Function & Disease
September 3-8, 2006
Les Diablerets Conference Center
Les Diablerets, Switzerland
Chair:
Kari Alitalo

Vice Chair:
Geert Schmid-Schonbein

This conference is devoted to an in-depth exploration and discussion of lymphatic vascular research and biology, with special emphasis upon lymphatic development, involvement in human diseases such as lymphatic malformations and lymphedema with adipogenesis and tissue fibrosis, inflammation, cancer metastasis, and therapeutic lymphangiogenesis and its inhibition. The physiology and genetics of the lymphatic system will also be explored.

Lymphatic vascular biology has experienced a dramatic growth within the last several years due in large part to the availability of enhanced techniques and tools for these investigations. There is an unprecedented need for lymphatic biologists and investigators to have a forum in which to conduct a dialogue surrounding scientific developments in this field and to determine the direction of future investigative efforts. Approaches that have experienced a recent upsurge in productive lymphatic investigation include, but are not limited to: genetics, biochemistry and biophysics, cellular and molecular biology, bioengineering, physiology and pharmacology, anatomy, developmental biology, pathology, vasculogenesis and angiogenesis, tumor biology, muscle cell biology, interstitial signaling mechanisms, and others.

Contributors
Amgen
AstraZeneca
European Commission / EU Lymphangiogenemoics Integrated Program
Genentech
ImClone Systems
Lymphatic Research Foundation
National Institutes of Health
Novartis
Schering
SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:00 pmLYMPHANGIOGENESIS - BASIC MECHANISMS
Discussion Leader: Christer Betsholtz (Stockholm)
7:30 pm - 7:50 pmPeter Carmeliet (Leuven)
"Fishing and frogging for lymph-angiogenic genes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmStefan Schulte-Merker (Utrecht)
"Lymphangigogenesis in the zebrafish - dose dependent effects of VEGFR signaling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBrant M. Weinstein (Bethesda, MD)
"Lymphatic development in the zebrafish"
8:50 pm - 9:00 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHATIC ENDOTHELIUM
Discussion Leader: Tatiana Petrova (Helsinki)
9:00 am - 9:20 amElisabetta Dejana (Milan)
"The molecular organization of lymphatic intercellular junctions"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amLena Claesson-Welsh (Uppsala)
"VEGF receptor function in the lymphatic endothelium"
9:50 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:50 amHellmut Augustin (Freiburg)
"Cell biology of lymphatic endothelium"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSalvatore Oliviero (Siena)
"VEGFR-3 signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPirjo Laakkonen (Helsinki)
"Peptide targeting of lymph vessels"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPresentations selected from poster abstracts including fellowship/award presentations
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDEVELOPMENT OF THE LYMPHATIC VASCULAR SYSTEM
Discussion Leader: Peter Carmeliet (Leuven)
5:30 pm - 5:50 pmGuillermo Oliver (Memphis, TN)
"Cellular and Molecular Mechanism Regulating the Development of the Lymphatic Vasculature"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmMichael Detmar (Zurich)
"Molecular control of lymphangiogenesis"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmAnne Eichmann (Paris)
"Neural guidance genes in lymphangiogenesis"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmJan Kitajewski (New York, NY)
"Notch regulates VEGFR-3 in vascular development"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMATURATION OF THE LYMPHATIC VESSELS
Discussion Leader: Anne Eichmann (Paris)
9:00 am - 9:20 amChrister Betsholtz (Stockholm)
"Perivascular cell biology and genomics"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGavin Thurston (Tarrytown, NY)
"Angiopoietins in the growth and maintenance of blood and lymphatic vessels"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amTatiana Petrova (Helsinki)
"Transcriptional control of lymphatic vessel maturation"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amGou Young Koh (Daejon)
"Role of angiogenic factors in remodeling of blood and lymphatic vessels"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amLaura Benjamin (Boston)
"RhoB regulation of Lymphatic Development"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPresentations selected from poster abstracts including fellowship/award presentations
12:00 pm - 12:15 pm Tuomas Tammela (Helsinki)
"Engineering New Molecular Forms of VEGF-C for Optimal Treatment of Lymphedema"
12:15 pm - 12:30 pm Joseph Rutkowski (Lausanne)
"Secondary Lymphedema in the Mouse Tail: Lymphatic Hyperplasia, VEGF-C Upregulation and the Protective Role of MMP-9"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTHE INTERSTITIUM, LYMPH FORMATION AND PROPULSION
Discussion Leader: David Bates (Bristol)
5:30 pm - 5:50 pmMelody Swartz (Lausanne)
"Autologous chemotaxis: How lymphatic function helps drive cell homing into lymphatics"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmGeert Schmid-Schönbein (San Diego, CA)
"What needs to be carried: The inflammatory side of lymphatic fluid"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmDavid Zawieja (College Station, TX)
"Mechanisms regulating lymphatic contraction and lymph flow"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmHelge Wiig (Bergen)
"Role of the interstitium and lymphatics in fluid volume regulation"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHATIC METASTASIS
Discussion Leader: Michael Detmar (Zurich)
9:00 am - 9:20 am Marc Achen (Melbourne)
"Molecular control of lymphatic metastasis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 am Gerhard Christofori (Basel)
"Distinct Mechanisms of Tumor Metastasis"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 am Rakesh Jain (Boston, MA)
"Dissecting steps of lymphatic metastasis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 am Yihai Cao (Stockholm)
"Regulation of lymphangiogenesis by multiple growth factors"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 am Mihaela Skobe (New York, NY)
"Lymphatic metastasis and its inhibition"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pm Alanna Ruddell (Seatlle, WA)
"Functional expansion of lymph node lymphatics in the formation of metastatic tumors"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pm Judith Varner (San Diego, CA)
"Integrin a4b1 mediated lymph node lymphangiogenesis promotes tumor metastasis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmLYMPHATIC VESSELS IN INFLAMMATION
Discussion Leader: Elisabetta Dejana (Milan)
5:30 pm - 5:50 pmDontscho Kerjaschki (Vienna)
"How inflammatory lymphangiogenesis is orchestrated"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmDonald McDonald (San Fransisco, CA)
"Cellular actions of inhibitors of lymphangiogenesis and angiogenesis"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMasabumi Shibuya (Tokyo)
"Involvement of VEGFR-1 in lymphangiogenesis in vivo"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmDavid Jackson (Oxford)
"Regulating cellular traffic in inflamed lymphatics"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPATHOGENESIS OF LYMPHATIC VASCULAR DISEASE
Discussion Leader: Dontscho Kerjaschki (Vienna)
9:00 am - 9:20 amMiikka Vikkula (Brussels)
"Phenotypic variability in VEGFR3-caused lymphedema"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPeter Mortimer (London)
"Refining the phenotype and mechanisms of oedema in genotyped lymphoedema"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amStanley Rockson (Stanford, CA)
"From Bedside to Bench: Molecular Pathogenesis in Experimental Acute Lymphedema"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDavid Bates (Bristol)
"Mechanisms underlying lymphatic pathologies in cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJoerg Wilting (Goettingen)
"Development and Malformation of Lymph Vessels"
11:50 am - 12:00 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTHERAPEUTIC ASPECTS
Discussion Leader: Donald McDonald (San Francisco)
5:30 pm - 5:50 pmBronek Pytowski (New York, NY)
"In vivo effects of antagonist monoclonal antibodies to VEGFR-3"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmSeppo Yla-Herttuala (La Jolla, CA)
"Possibilities to grow lymphatic vessels in vivo with local gene transfer"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmSirpa Jalkanen (Turku)
"Targeting mechanisms of cell traffic within the lymphatics"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pm Achim Hoerauf (Bonn)
"Targeting of Wolbachia Endosymbionts in Filarial Worms with Doxycycline Reduces Plasma VEGF-C/sVEGFR-3 and Improves Pathology in Lymphatic Filariasis"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pm Claus Cursiefen (Erlangen)
"Inhibition of inflammatory lymphangiogenesis in the cornea by blocking integrin alpha 5"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
 
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