| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments |
| 7:40 pm - 9:30 pm | Endocytosis and Signal Transduction |
| Discussion Leader: Paolo Di Fiore (Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy) |
| 7:45 pm - 8:05 pm | Sara Sigismund (Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy)
"Endocytosis and signaling of the Epidermal Growth Factor Receptor" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Ivan Dikic (Goethe University Medical School, Frankfurt, Germany)
"Regulation of endocytic Ub receptors by monoubiquitylation" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Gerry Weinmaster (UCLA School of Medicine)
"DSL-ligand endocytosis provides a force to physically separate the Notch1 heterodimer and allow proteolytic activation" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:27 pm | David Bilder (University of California, Berkeley)
"Endocytic control of Notch activation and cell proliferation" |
| 9:27 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Endocytosis in Cell Physiology and Development |
| Discussion Leader: Pietro De Camilli (Yale University School of Medicine) |
| 9:00 am - 9:20 am | Pietro De Camilli (Yale University School of Medicine)
"New insights into dynamin function" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Timothy Ryan (Weill Medical College, Cornell University)
"The coupling of Exocytosis and Endocytosis at Nerve Terminals" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Marco Gonzalez-Gaitan (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany)
"Morphogenesis and mitosis: budgeting signaling cargo in endosomal carriers" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Tom Kirchhausen (Harvard University Medical School)
"Regulation of cell size during cell division" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Ciara Gallagher (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria)
"The conserved C2 domain protein Lethal (2) giant discs regulates protein trafficking in Drosophila" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Jennifer Lippincott-Schwartz (NICHD, NIH)
"Organization of exocytic and endocytic pathways in the Drosophila syncytial embryo" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structure of Trafficking Machinery Components |
| Discussion Leader: Frances Brodsky (UCSF) |
| 7:30 pm - 7:50 pm | Frances Brodsky (UCSF)
"Hierarchy of clathrin interactions with binding proteins during coated vesicle assembly" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | David Owen (CIMR, Cambridge University, UK)
"More tales of AP2" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | James Hurley (NIDDK, NIH)
"Ubiquitin recognition and ubiquitin-dependent sorting" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | David Lambright (University of Massachusetts Medical School)
"TBC domain GAPs for Rab GTPases supply two catalytic fingers in trans" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Transport and Sorting in the TGN/Endosome Network |
| Discussion Leader: Marino Zerial (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany) |
| 9:00 am - 9:20 am | Marino Zerial (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany)
"Quantitative analysis of endosome dynamics" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Juan Bonifacino (NICHD, NIH)
"Mechanisms of CD4 downregulation by the Nef protein of primate immunodeficiency viruses" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Kathleen Collins (University of Michigan School of Medicine)
"Targeting of MHC-I and CD4 to lysosomes in HIV infected cells" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Liz Conibear (Medical Genetics Centre for Molecular Medicine and Therapeutics, University of British Columbia, Canada)
"Regulating transport at the yeast late Golgi" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Mara Duncan (UCLA School of Medicine)
"Inhibitors of Membrane Traffic Identified by Compound Synthetic Lethal Screening" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Harald Stenmark (Norwegian Radium Hospital, Montebello, Oslo, Norway)
"Degradative protein sorting: the roles of phosphoinositides and ubiquitin" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Endocytosis, Lysosomes, and the Cytoskeleton |
| Discussion Leader: Sandra Lemmon (University of Miami) |
| 7:30 pm - 7:50 pm | Sandra Lemmon (University of Miami)
"Dynamics of Clathrin Dependent Endocytosis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Sanja Sever (Harvard University Medical School)
"Processing of the GTPase dynamin by extralysosomal cathepsin L defines a mechanism for nephrotic syndrome" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Gillian Griffiths (Oxford University, UK)
"Cytotoxic T Lymphocytes: On Target for the Kill" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Sylvain Loubéry (Curie Institute, Paris, France)
"Magnetic endosomes to study microtubule based movements of early and late endocytic compartments" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanisms of Transport Carrier Formation, Targeting, and Fusion |
| Discussion Leader: Margaret Robinson (MRC, Cambridge, UK) |
| 9:00 am - 9:20 am | Margaret Robinson (MRC, Cambridge, UK)
"Adaptors and sorting signals for clathrin-coated vesicles" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Peter McPherson (McGill Univ., Montreal, Canada)
"Clathrin-light chains are dispensable for endocytosis but are critical for intracellular membrane trafficking" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Harvey McMahon (MRC, Cambridge, UK)
"BAR domains as markers of vesicle budding pathways" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Josh Kaplan (Mass. Gen. Hospital/Harvard)
"Mechanisms regulating synaptic transmission in C. elegans" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Chris Burd (University of Pennsylvania School of Medicine)
"Endocytic recycling by sorting nexins" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Christian Ungermann (University of Osnabrueck, Germany)
"Dynamics of tethering complexes during yeast endosome-vacuole biogenesis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Cell Biology of Pathogen Infection |
| Discussion Leader: Jorge Galan (Yale University School of Medicine) |
| 7:30 pm - 7:50 pm | Jorge Galan (Yale University School of Medicine)
"Modulation of host-cell functions by a bacterial pathogen" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Raphael Valdivia (Duke University Medical Center)
"Bacterial co-option of mammalian lipid droplets" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | XiaoXiao Pan (Yale University School of Medicine)
"A Legionella pneumophila Dot/Icm substrate protein that interferes with vesicular transport" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Xiaowei Zhuang (Harvard University)
"Entry mechanisms of influenza and polio viruses" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Biogenesis and Disorders of Lysosomes and Lysosome-related Organelles |
| Discussion Leader: Esteban Dell'Angelica (UCLA School of Medicine) |
| 9:00 am - 9:20 am | Esteban Dell'Angelica (UCLA School of Medicine)
"Functional interaction between protein complexes involved in the biogenesis of lysosome-related organelles" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Matsinori Fukuda (RIKEN, Saitama, Japan)
"Rab27A effectors and their roles in melanosome transport" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Mickey Marks (University of Pennsylvania School of Medicine)
"A novel pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle biogenesis" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Paul Saftig (University of Kiel, Germany)
"New insights into functions of lysosomal membrane proteins" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Judith Klumperman (University Medical Center and Institute for Biomembranes, Utrech, The Netherlands)
"Transport carriers of the lysosomal pathway" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Lois Weisman (University of Michigan)
"Fig4, a lipid phosphatase, activates the Fab1 lipid kinase" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 8:30 pm | Novikoff Lecture |
| Sandra Schmid (Scripps Research Institute)
"Dynamin and clathrin-mediated endocytosis: The more I learn, the less I know" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |