| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOST-PATHOGEN INTERACTIONS AND BACTERIAL PATHOGENESIS |
| 7:30 pm - 7:40 pm | Discussion Leader: Erol Fikrig (Yale Univ., New Haven, CT) |
| 7:40 pm - 8:05 pm | Magnus Höök (Texas A & M University, Houston, TX)
"MSCRAMMs of Bacterial Pathogens Including Spirochetes" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Jon Skare (Texas A&M University, College Station, TX)
"The Role of bbk32 in Borrelia burgdorferi Infectivity" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Linden Hu (Tufts Univ., Boston, MA)
"The Role of Matrix Metalloproteinases in the Pathogenesis of Lyme Arthritis" |
| 9:15 pm - 9:25 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SPIROCHETES: THE GENOMIC PERSPECTIVE |
| 9:00 am - 9:10 am | Discussion Leader: Tom Schwan (NIAID, Rocky Mountain Labs, Hamilton, MT) |
| 9:10 am - 9:30 am | Sherwood Casjens (Univ. Utah, Salt Lake City, UT)
"Comparative Analysis of Borrelia Genomes" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Wolfram Zückert (Univ. Kansas, Kansas City, KS)
"Spirochetal Protein Export Pathways" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 11:00 am | Coffee Break / Photo Session |
| 11:00 am - 11:20 am | Richard Zuerner (National Animal Disease Center, Ames, IA)
"The Papillomatous Digital Dermatitis Treponeme - Genomic Insights" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Arturo Centurion-Lara (Univ. Washington, Seattle, WA)
"The tprK System of Treponemal Species and Subspecies" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | David Šmajs (Masaryk University, Brno, Czech Republic)
"Comparative Genomics of Treponemes" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | SPIROCHETE GENETICS AND GENETIC MANIPULATION |
| 5:30 pm - 5:40 pm | Discussion Leader: Patti Rosa (NIAID, Rocky Mountain Labs, Hamilton, MT) |
| 5:40 pm - 6:05 pm | Mathieu Picardeau (Pasteur Inst., Paris, France)
"Genetic Manipulation of Leptospires" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:40 pm | Philip Stewart (NIAID, Rocky Mountain Labs, Hamilton, MT)
"Molecular Genetic Manipulation of Borrelia burgdorferi" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:15 pm | Chris Fenno (Univ. Michigan, Ann Arbor, MI)
"Strategies for Genetic Manipulation of Treponema denticola" |
| 7:15 pm - 7:25 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HOST IMMUNE RESPONSE AND BACTERIAL PERSISTENCE |
| 9:00 am - 9:10 am | Discussion Leader: Sheila Lukehart (Univ. Washington, Seattle, WA) |
| 9:10 am - 9:55 am | Staffan Normark (Karolinska Institute, Stockholm, Sweden)
"Host and Microbial Factors Determining Disease Outcome: Carriage Versus Acute or Persistent Infection" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Alan Barbour (UC Irvine, Irvine, CA)
"Programming of Antigenic Variation in Relapsing Fever" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 11:20 am | Coffee Break |
| 11:20 am - 11:45 am | Janis Weis (Univ. Utah, Salt Lake City, UT)
"Host Genetic Loci that Regulate the Outcome of Borrelia burgdorferi Infection" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Linda Bockenstedt (Yale Univ., New Haven, CT)
"Genesis and Control of Lyme Borreliosis by Innate Immunity" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | INVASIVE STRATEGIES OF SPIROCHETAL PATHOGENS |
| 5:30 pm - 5:40 pm | Discussion Leader: Rich Ellen (Univ. Toronto, Toronto, Canada) |
| 5:40 pm - 6:05 pm | Jenifer Coburn (Tufts Univ., Boston, MA)
"Determinants of Borrelia burgdorferi Tissue Tropism" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:40 pm | Jarlath Nally (University College Dublin, Belfield, Ireland)
"Adaptation of Pathogenic Leptospires to the Host Environment" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:15 pm | Annette Moter (Charité University Medicine, Berlin, Germany)
"FISHing for Spirochetes: Treponemes in periodontitis and digital dermatitis" |
| 7:15 pm - 7:25 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SPIROCHETE BIOLOGY AND DIVERSITY |
| 9:00 am - 9:10 am | Discussion Leader: Isabelle Saint Girons (Pasteur Inst., Paris, France) |
| 9:10 am - 9:30 am | Nyles Charon (West Virginia Univ., Morgantown, WV)
"Spirochete Motility and Chemotaxis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Steve Norris (Univ. Texas, Houston, TX)
"Treponema pallidum: Physiology of an Obligate Parasite" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Jared Leadbetter (Caltech, Pasadena, CA)
"Metabolic Transformation of Plant Biomass by Termite Gut Spirochetes" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Jonas Bunikis (UCI, Irvine, CA)
"The Enzootic Cycle of Lyme Borreliosis, Diversity and Maintenance" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Darren Trott (Univ. Queensland, Brisbane, Australia)
"The Outer Membrane of Brachyspira Species" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | COMPLEMENT EVASION STRATEGIES OF SPIROCHETES |
| 5:30 pm - 5:40 pm | Discussion Leader: Marina Cinco (Univ. Trieste, Trieste, Italy) |
| 5:40 pm - 6:05 pm | Sakari Jokiranta (National Public Health Inst., Helsinki, Finland)
"Complement Evasion by Relapsing Fever Borreliae" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:40 pm | Peter Kraiczy (Univ. Hospital of Frankfurt, Frankfurt, Germany)
"Complement Regulator-Acquiring Surface Proteins (CRASPs) of Borrelia burgdorferi" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:15 pm | Rich Marconi (Medical College of Virginia, Richmond, VA)
"Structure-Function Analysis of Spirochetal Complement Binding Proteins" |
| 7:15 pm - 7:25 pm | Discussion |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENE REGULATION AND EXPRESSION IN SPIROCHETES |
| 9:00 am - 9:10 am | Discussion Leader: Darrin Akins (Univ. of Oklahoma, Oklahoma City, OK) |
| 9:10 am - 9:55 am | Lalita Ramakrishnan (Univ. Washington, Seattle, WA)
"The Dynamic Nature of Mycobacterium-Macrophage Interactions" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:25 am | Ben Adler (Monash Univ., Melbourne, Australia)
"Leptospiral Transcriptional Responses to Environmental Stimuli" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Brian Stevenson (Univ. Kentucky, Lexington, KY)
"Molecular Mechanisms of Borrelia burgdorferi Gene Regulation" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Scott Samuels (Univ. Montana, Missoula, MT)
"Engineering Borrelia burgdorferi Gene Regulation" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Frank Yang (Indiana Univ., Indianapolis, IN)
"Function and regulation of Borrelia burgdorferi outer surface protein OspA" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | LATE BREAKING SESSION |
| Discussion Leaders: Caroline Cameron (Washington Univ., Seattle, WA) & James Matsunaga (UCLA / VA, Los Angeles, CA) |
| 5:30 pm - 5:40 pm | Douglas Botkin (Univ. Texas, Houston, TX)
"Identification of Potential Virulence Determinants by Himar1 Transposition of Infectious Borrelia burgdorferi B31" |
| 5:40 pm - 5:45 pm | Discussion |
| 5:45 pm - 5:55 pm | Mary Brinkman (Baylor College of Medicine, Houston, TX)
"Antigen Identification and Characterization in Treponema pallidum" |
| 5:55 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:10 pm | Melissa Caimano (Univ. Connecticut Health Center, Farmington, CT)
"RpoS Coordinates the Reciprocal Upregulation and Repression of a Subset of Differentially Expressed Borrelial Genes Associated with the Mammalian and Tick Phases of the Enzootic Cycle" |
| 6:10 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:25 pm | Caroline Bamford (Univ. Bristol, Bristol, UK)
"Fibrinogen-binding by Treponema denticola is Mediated by the Chymotrypsin-like Protease Complex" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:40 pm | Michael Miller (West Virginia Univ., Morgantown, WV)
"Identification of Defined Chemoattractants for Borrelia burgdorferi Using a Modified Capillary Tube Assay" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 6:55 pm | Christer Larsson (UMEA Universitet, Sweden)
"Latent Infection in the Brain Facilitate Immune Evasion and Disease Reactivation by the Relapsing Fever Spirochete Borrelia duttonii" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:10 pm | Helene Louvel (Pasteur Inst., Paris, France)
"Iron Regulation by a Two-Component System in Leptospira" |
| 7:10 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Volker Fingerle (Univ. Munich, Munich, Germany)
"Complementation of an European Borrelia afzelii Mutant Lacking Outer Surface Protein C Highlights the Crucial Role of OspC for Dissemination of Borrelia afzelii in Ixodes ricinus" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |