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Conference Program
 
Molecular & Cellular Bioenergetics
(This meeting is currently known as "Bioenergetics")
June 17-22, 2007
Proctor Academy
Andover, NH
Chair:
Fevzi Daldal

Vice Chair:
David G. Nicholls

The Molecular and Cellular Bioenergetics Conference meets annually, with a rotating emphasis on one of three areas: electron transport (respiratory complexes I to IV), ATP synthases-ATPases, and cellular bioenergetics. The 2007 meeting will emphasize electron transport and respiratory complexes I to IV. While the program contains sessions centered on the structure, function and biogenesis of respiratory complexes, it also covers F-ATP syntases/V-ATPases and aspects of cellular bioenergetics, including cancer, aging and mitochondrial therapeutics, in order to convey an integrated view of current molecular and cellular bioenergetics. The traditional interest of the Conference on structure and function of membrane proteins is augmented with sessions covering theoretical considerations and sessions dealing synthetic and analytical approaches to large membrane protein complexes. The Wednesday morning session where selected posters in all areas are presented is an all-time favorite. In addition, a highlight of the 2007 meeting is a session, dealing with most recent findings on "omics, imaging and bio-nano" frontiers pertinent to energy transduction, dedicated to Dr. Britton Chance, a legendary hero of Bioenergetics. Young investigators, postdoctoral fellows and graduate students are especially invited to apply, and all applicants to the Conference are encouraged to submit abstracts and prepare brief oral presentations for poster discussions.


Contributors
DEPARTMENT OF ENERGY
UNITED MITOCHONDRIAL DISEASE FOUNDATION
NATIONAL INSTITUTES OF HEALTH

UNIVERSITY OF PENNSYLVANIA
DREXEL UNIVERSITY

GENENTECH, INC.
SEAHORSE BIOSCIENCE INC.
AMGEN, INC.
SANOFI-AVENTIS DEUTSCHLAND GMBH
BRISTOL-MYERS SQUIBB COMPANY
PFIZER, INC.
ON-LINE INSTRUMENT SYSTEMS, INC.
BRUKER BIOSPIN CORPORATION
CELL PRESS
NEW ENGLAND BIOLABS, INC.

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmElectron Transfer, Proton Transfer, Role of Water in Proteins
7:40 pm - 7:55 pm Discussion Leader: Marilyn Gunner (CUNY, NY, US)
7:55 pm - 8:20 pm P. Leslie Dutton (University of Pennsylvania, PA, US)
"Natural Selection and Variance in Engineering Electron Transfer Chains and Oxidation-reduction Catalysis"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:50 pm Sharon Hammes-Schiffer (Penn State, PA, US)
"Proton-Coupled Electron Transfer in Proteins: Dynamics and Kinetic Isotope Effects"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm David Beratan (Duke University, NC, US)
"Bridges and Switches: Protein Motion and Electron Transfer"
9:20 pm - 9:30 pm General Discussion (Colin Wraight)
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAssembly of Multi-subunit, Multi-cofactor Membrane Proteins
9:00 am - 9:30 am Discussion Leader: Sabeeha Merchant (UCLA, CA, US)
9:30 am - 9:55 am Michael K. Johnson (University of Georgia, GA, US)
"Iron-sulfur Cluster Biosynthesis"
9:55 am - 10:00 am Discussion
10:00 am - 10:25 am Stuart J. Ferguson (University of Oxford, UK)
"The Thioether Bonds in c-type Cytochromes; the Puzzles of Why and How"
10:25 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:25 am H-Georg Koch (Albert-Ludwigs University, Freiburg, Germany)
"Membrane Protein Assembly in Bacteria: Defining the Route from the Ribosome to the Formation of Oligomeric Complexes"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Egbert J. Boekema (University of Groningen, Netherlands)
"Structure of Plant Mitochondrial Supercomplexes by Electron Microscopy"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:30 pm General Discussion (Bernd Ludwig)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmF0-F1 ATP Synthase: Structure and Function
7:30 pm - 7:50 pm Discussion Leader: Wolfgang Junge (University of Osnabruck, Germany)
7:50 pm - 8:15 pm John E. Walker (MRC, Cambridge, UK)
"Inhibitors of ATPase as an Aid to Understanding Function"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Stanley D. Dunn (University of Western Ontario, Canada)
"Structure and Function of the ATP Synthase Peripheral Stalk"
8:45 pm - 8:50 pm Discussion
8:45 pm - 9:10 pm Paola Turina (University of Bologna, Italy)
"The H+/ATP Ratio and its Subtleties"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm General Discussion (Wayne Frasch)
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmComplex II and Complex IV: Structure-Function and Biology
9:00 am - 9:15 am Discussion Leader: Hartmut Michel (Max Planck Institute, Germany)
9:15 am - 9:40 am Gary Cecchini (VA Medical Center, CA, US)
"The Heme of Complex II - What is it Good for?"
9:40 am - 9:45 am Discussion
9:45 am - 10:10 am Marten Wikstrom (University of Helsinki, Finland)
"Proton Translocation by Cytochrome c Oxidase"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:00 am Discussion Leader: Bob Gennis (University of Illinois, IL, US)
11:00 am - 11:25 am Jon Hosler (University of Mississippi, MS, US)
"Subunit III as the Anti-inactivation Component of Cytochrome c Oxidase"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Maik Huttemann (Wayne State University, MI, US)
"Regulation of Cell Respiration through Cell Signaling"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:30 pm General Discussion (Roy Lancaster)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMitochondrial Links to Apoptosis, Cancer and Aging
7:30 pm - 7:50 pm Discussion Leader: Takao Yagi (Scripps Research Institute, CA, US)
7:50 pm - 8:15 pm Craig B. Thompson (University of Pennsylvania, PA, US)
"The Bioenergetics of Cell Growth"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Paul M. Hwang (NHLBI/NIH, MD, US)
"Cytochrome c Oxidase Regulation by p53"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Lenny Guarente (MIT, MA, US)
"Sirtuins, Disease and Aging"
9:15 pm - 9:30 pm General Discussion (Bernard D. Lemire)
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPoster discussion / Workshop sessions
9:00 am - 10:30 amElectron Transport and Redox
Discussion Leaders: Tony Crofts (University of Illinois, IL, US) & Blanca Barquera (Rensselear Polytech. Inst., NY, US)
ATPase
Discussion Leader: Stephan Wilkens (SUNY Upstate Medical Univ, NY, US)
10:30 am - 11:00 amCoffee Break
11:00 am - 12:30 pmMolecular and Cellular Bioenergetics Workshop
Discussion Leader: Shelagh Ferguson Miller (MSU, East Lansing, MI, US)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmV-ATPase Structure-Function and Cell Biology
7:30 pm - 7:50 pm Discussion Leader: Patricia M. Kane (SUNY Upstate Medical Univ., NY, US)
7:50 pm - 8:15 pm Michael D. Forgac (Tufts University, MA, US)
"Structure, Function and Regulation of the Vacuolar ATPases"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Tom H. Stevens (University of Oregon, OR, US)
"Assembly and Sorting of the Yeast V-ATPase"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm G.H. Sun-Wada (Doshisha Women College, Kyoto, Japan)
"Tissue-specific Subunit Isoforms of Proton Pump V-ATPase"
9:15 pm - 9:20 pm Discussion
9:20 pm - 9:30 pm General Discussion (Nathan Nelson)
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmComplex I and Complex III: Structure-Function and Biology
9:00 am - 9:15 am Discussion Leader: Tomoko Ohnishi (University of Pennsylvania, PA, US)
9:15 am - 9:35 am Leo Sazanov (MRC, Cambridge, UK)
"The Structures of the Hydrophilic and Membrane Domains of Respiratory Complex I"
9:35 am - 9:40 am Discussion
9:40 am - 9:55 am Judy Hirst (MRC, Cambridge, UK)
"New Insights into the Iron-sulfur Clusters of Complex I from EPR Spectroscopy"
9:55 am - 10:10 am Uli Brandt (University of Frankfurt, Germany)
"Structural and Functional Insights into Mitochondrial Complex I"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:00 am Discussion Leader: William A. Cramer (Purdue University, IN, US)
11:00 am - 11:25 am Di Xia (NIH/NCI, MD, US)
"Cytochrome bc1 Structures and Implication for Function"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Akhil Vaidya (Drexel University, PA, US)
"Electron Transport in the Minimalist Mitochondrion of Malaria Parasites"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:30 pm General Discussion (Carola Hunte)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrom Omics and Imaging to Mitochondrial Frontiers
7:30 pm - 7:50 pm Discussion Leader: Britton Chance (University of Pennsylvania, PA, US)
7:50 pm - 8:15 pm Vamsi K. Mootha (Harvard Medical School, MA, US)
"Mitochondrial Systems Biology"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Orian Shirihai (Tufts University, MA, US)
"Photoactivatable GFP: a Window into the Social Life of Mitochondria within the Individual Cell"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Terry G. Frey (San Diego State University, CA, US)
"Correlated Light and Electron Microscopy in Four Dimensions Reveals Structural Changes in Mitochondria During Apoptosis"
9:15 pm - 9:20 pm Discussion
9:20 pm - 9:30 pm General Discussion (Roger C. Prince)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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