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Conference Program
 
Bioorganic Chemistry
June 10-15, 2007
Proctor Academy
Andover, NH

The Gordon Research Conference on Bioorganic Chemistry was founded in 1992 to bring together scientists from a range of disciplines to present and discuss cutting-edge research at the interface between chemistry and biology. Both fundamental and applied research relevant to academia and industry are highlighted. To maintain a balance between these areas, the conference is organized by two co-chairs, one from academia and one from industry. We emphasize the presentation of techniques or approaches that are broadly applicable across multiple areas of chemical and biological research. Traditionally, small molecules that probe, modulate, or mimic cellular components or processes as well as studies of biology at the molecular level have been of particular interest.

In this 16th year of the meeting, the conference will be held at Proctor Academy, Andover, New Hampshire during the week of June 10-15, 2007. This venue was chosen to facilitate the free and open exchange of ideas in a friendly and informal environment. We will continue the tradition of emphasizing hard-hitting interdisciplinary research that draws from the areas of organic chemistry, bioorganic chemistry, medicinal chemistry, chemical biology, biotechnology, biophysics, biochemistry, and molecular / cellular biology. Both the seminars and poster presentations should, to the greatest possible extent, emphasize unpublished work. All conferees are encouraged to present posters.


Contributors
Abbott Laboratories
ACS Chemical Biology, A Publication of the ACS
ARIAD Pharmaceuticals Inc.
AstraZeneca
Biogen Idec, Inc.
Biological Chemistry Division of ACS
Bristol-Meyers Squibb
Cambridge Antibody Technology
Cell Press
Genentech, Inc.
Givaudan
GlaxoSmithKline
Eli Lilly and Company
Infinity Pharmaceuticals
Merck Research Laboratories
Nature Chemical Biology
New England Biolabs
Novartis Institutes for Biomedical Research
Pfizer/GRC Chemistry Student Fellowships
Royal Society of Chemistry
Schering-Plough
Sunesis Pharmaceuticals, Inc
Wyeth Laboratories

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmSINGLE MOLECULES AND BIOPHYSICAL METHODS
Discussion Leader: Claudio Chuaqui (AstraZeneca)
7:35 pm - 8:05 pm Maria Pellegrini (Biogen Idec)
"Weak and Weaker: NMR Methods for Characterization, Validation, and Promotion of Early Lead Candidates"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Robert Singer (Yeshiva)
"Watching Single mRNAs"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Sunney Xie (Harvard)
"Actions on DNA: Lessons from Real-Time Movies, In Vitro and In Vivo"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMODEL SYSTEMS
Discussion Leader: Sergey Savinov (Purdue)
9:00 am - 9:30 am Matthew Francis (Berkeley)
"New Chemical Reactions for Site-Selective Protein Modification"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Indraneel Ghosh (Arizona)
"Sequence Enabled Reassembly of Proteins for Seeing Native DNA"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Jacqueline Barton (Caltech)
"DNA Charge Transport: Oxidative Damage and Repair"
11:10 am - 11:20 am Discussion
11:20 am - 11:50 am William DeGrado (Penn)
"De Novo Design of Proteins, Peptides, and Peptide Mimetics"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Poster Talk I: Bobby Arora (NYU)
"Structure and Function in Hydrogen Bond Surrogate Based Helices"
12:15 pm - 12:30 pm Poster Talk II: Jeff Keillor (Montreal)
"Development of a Dimaleimide-Based Protein Labelling Method"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMOLECULAR AND CELLULAR PROBES
Discussion Leader: Jeffrey Bode (Santa Barbara)
7:30 pm - 8:00 pm Gregor Zlokarnik (Vertex)
"Creativity in design or validation? Enabling techniques versus single-use probes"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Paul Hergenrother (Illinois)
"Small Molecules as Tools to Identify Novel Anti-Cancer Targets"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Milan Mrksich (Chicago)
"Tailored Substrates for Cell Adhesion"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDRUG DESIGN AND DISCOVERY
Discussion Leader: John Starrett (Bristol-Meyers Squibb)
9:00 am - 9:30 am Jay Grobler (Merck)
"Directed Discovery of New Antiretroviral Agents"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Stewart Fisher (AstraZeneca)
"Murl as a Druggable Target"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Andrea Cochran (Genentech)
"Inhibitors and Mechanism in the Aurora Kinase Family"
11:10 am - 11:20 am Discussion
11:20 am - 11:50 am Timothy Willson (GlaxoSmithKline)
"Lipids as Ligands for Orphan Nuclear Receptors"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Poster Talk III: Rami Hannoush (Genentech)
"Reversible Small Molecule-Induced Fragmentation of the Mammalian Golgi Apparatus"
12:15 pm - 12:30 pm Poster Talk IV: James Chen (Stanford)
"Chemical Tools for the Spatiotemporal Control of Zebrafish Gene Expression"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I (continued)
6:00 pmDinner
7:30 pm - 9:30 pmTRANSCRIPTION FACTORS AND DNA REPAIR
Discussion Leader: Orlando Schaerer (Stony Brook)
7:30 pm - 8:00 pm John Koh (Delaware)
"Chemical Rescue of Nuclear Receptor Mutants"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm John Essigmann (MIT)
"Design of DNA Damaging Agents that Hijack Transcription Factors and Block DNA Repair"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Gregory Verdine (Harvard)
"Finding a Needle in a Haystack: The Challenge of Lesion Searching by DNA Glycosylases"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVISUALIZING CELLULAR BIOLOGY
Discussion Leader: James Chen (Stanford)
9:00 am - 9:30 am Jennifer Lippincott-Schwartz (NIH)
"Use of photoactivatable fluorescent proteins for studying protein and organelle dynamics in living cells"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Kai Johnsson (Lausanne)
"Chemical Approaches for Visualizing Protein Function"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Peter Sorger (Harvard)
"Systems-Level Analysis of Anti-ErbB Therapeutics"
11:10 am - 11:20 am Discussion
11:20 am - 11:50 am Tom Kirchhausen (Harvard)
"Chemical Biology of Membrane Traffic"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmFRONTIERS IN ENZYMOLOGY
Discussion Leader: Lizbeth Hedstrom (Brandeis)
7:30 pm - 8:00 pm Robert Copeland (GlaxoSmithKline)
"Drug-Target Residence Time, A Different Perspective on Compound Optimization"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Donald Hilvert (ETHZ)
"Molecular Diversity and Catalysis"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Stephen Benkovic (Penn State)
"Perspectives on Biological Catalysis"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEMERGING AREAS IN CHEMICAL BIOLOGY
Discussion Leader: Jason Gestwicki (Michigan)
9:00 am - 9:30 am Helen Blackwell (Wisconsin-Madison)
"Synthetic Ligands that Disrupt Bacterial Quorum Sensing Pathways and Outcomes"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Nicole Sampson (Stony Brook)
"ROMPing with ADAM: Polymer Probes of Fertilization"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am James Wells (UCSF)
"Site-Directed Chemical Approaches to Caspase Signaling"
11:10 am - 11:20 am Discussion
11:20 am - 11:50 am Gerald Crabtree (Stanford)
"Designing small molecules to make and break protein-protein interactions"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Poster Talk V: Jennifer Kohler (Stanford)
"Cooperation among glycosylation enzymes"
12:15 pm - 12:30 pm Poster Talk VI: Elizabeth Boon (Stony Brook)
"Determining a Molecular Basis for NO Signaling in Bacterial Biofilms"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (continued)
6:00 pmDinner
7:30 pm - 9:30 pmNEW PARADIGMS IN BIOORGANIC AND MEDICINAL CHEMISTRY
Discussion Leader: Brian Blagg (Kansas)
7:30 pm - 8:00 pm Dale Boger (Scripps)
"Chemistry at the Chemistry-Biology Interface"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Andrew Hamilton (Yale)
"Synthetic Approaches to Disrupting Protein-Protein Interactions"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm François Diederich (ETHZ)
"Structure-Based Design of Non-Peptidic Enzyme Inhibitors: New Targets in the Treatment of Infectious Diseases"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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