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Carbohydrates
Gordon Research Conference

Dates

June 17-22, 2007

Location

Tilton School
Tilton, NH

Organizers

Chairs:
Todd L. Lowary & Peng George Wang

Vice Chairs:
Peter H. Seeberger & Stephen G. Withers

Meeting Description

Carbohydrates, particularly those found on cell surfaces, play critical biological roles. For example, glycoconjugates are involved in the development and differentiation of cells, cell adhesion and cell signaling, and cell-matrix interactions. It is also well documented that changes either in the structures of these glycans, or in the expression of carbohydrate-binding proteins, are associated with an ever-increasing number of diseases, include human genetic diseases such as muscular dystrophy or congenital disorders of glycosylation, viral and bacterial infections, parasite invasion and survival as well as metastasis and tumor progression. Recently published studies have demonstrated that glycoconjugates are also regulators of the immune system. The main goal of the Gordon Research Conference (GRC) on Carbohydrates is to bring together a diverse group of scientists who work in the broad area of glycoscience (carbohydrate chemistry, carbohydrate biochemistry, and glycobiology) to discuss recent progress and future challenges in the field. The meeting will have talks organized into six focus areas in nine sessions. Three full day symposia will anchor the meeting: 1.) synthetic carbohydrate chemistry, 2.) glycopharmaceuticals and 3.) structure/function studies of carbohydrate processing-enzymes. In addition, three half-day symposia will be held on: 1.) carbohydrate structure, 2.) conformational analysis/NMR spectroscopy and 3.) glycoengineering.

Contributors

Meeting Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:25 pm Glycotherapeutics I
Discussion Leader: A. Stewart Campbell (Ancora Pharmaceuticals, Inc., USA)
7:40 pm - 8:05 pmLinda Hsieh-Wilson (California Institute of Technology, USA)
"Decoding structure-activity relationships of glycosaminoglycans"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Geert-Jan Boons (Complex Carbohydrate Research Center, University of Georgia, USA)
"Synthetic compounds to probe biological functions of complex carbohydrates"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Chi-Huey Wong (Scripps Research Institute, USA)
"Post-translational glycosylation: challenges and opportunities"
9:15 pm - 9:25 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:15 pm Glycotherapeutics II
Discussion Leader: Peng George Wang (The Ohio State University, USA)
9:00 am - 9:25 amZhongwu Guo (Wayne State University, USA)
"A new cancer immunotherapy"
9:25 am - 9:35 am Discussion
9:35 am - 9:45 am Poster Highlight Presentation: Jeff Gildersleeve (National Cancer Institute, USA)
"Application of carbohydrate microarrays to basic and translational cancer research"
9:45 am - 9:50 am Discussion
9:50 am - 10:15 am Chitrananda Abeygunawardana (Merck Inc, USA)
"Challenges in analytical characterization of carbohydrate based vaccines"
10:15 am - 10:25 am Discussion
10:25 am Coffee Break
10:50 am - 11:00 amPoster Highlight Presentation: Pavel Kitov (The University of Alberta, Canada)
"Multifunctional multivalency: a novel concept capable of delivering one billion fold avidity gains"
11:00 am - 11:05 am Discussion
11:05 pm - 11:15 pmPoster Highlight Presentation: Andrew J. Fisher (University of California - Davis, USA)
"Crystal structures of a sialyltransferase complexed with donor analogs and acceptor reveal substrate binding sites and catalytic mechanism"
11:15 pm - 11:20 pm Discussion
11:20 am - 11:30 amPoster Highlight Presentation: Tom Wennekes (Leiden University, The Netherlands)
"Hydrophobic iminosugars as selective inhibitors glucosylceramide metabolism: Synthesis, biological evaluation and therapeutic applications"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pmShin-Ichiro Nishimura (Hokkaido University/AIST Hokkaido, Japan)
"Mechanism-based drug design: novel strategy toward highly selective therapeutic reagents"
12:00 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Conformational Analysis and NMR Spectroscopy
Discussion Leader: C. Allen Bush (University of Maryland, Baltimore County, USA)
7:30 pm - 7:55 pm Robert Woods (Complex Carbohydrate Research Center, University of Georgia, USA)
"Computational docking and free energy calculations applied to carbohydrate-protein interactions"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmThomas Peters (University of Lübeck, Germany)
"NMR experiments reveal virus-carbohydrate interactions at atomic resolution"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Highlight Presentation: Frank Schweizer (University of Manitoba, Canada)
"Effects of glycosylation of (2S,4R)-hydroxyproline on the conformation, kinetics and thermodynamics of prolyl amide isomerization"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Andrew Almond (University of Manchester, United Kingdom)
"Using NMR and computer modeling to determine the solution structure of glycosaminoglycans"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:15 pm Structure and Bioinformatics
Discussion Leader: Mary Cloninger (Montana State University, USA)
9:00 am - 9:25 amJohn Klassen (University of Alberta, Canada)
"Quantifying protein-carbohydrate interactions using electrospray ionization mass spectrometry"
9:25 am - 9:35 am Discussion
9:35 am - 9:45 am Poster Highlight Presentation: Mark Nitz (University of Toronto, Canada)
"Designing fluorescent heparin binding motifs"
9:45 am - 9:50 am Discussion
9:50 am - 10:15 am Claus-Wilhelm von der Lieth (DKFZ - Heidelberg, Germany)
"Informatics for glycobiology and glycomics: recent progress and future challenges"
10:15 am - 10:25 am Discussion
10:25 am Coffee Break
10:50 am - 11:15 am Kay-Hooi Khoo (Academia Sinica, Taiwan)
"MALDI CID MS/MS sequencing of mycobacterial arabinans: defining new structural variants and biosynthetic models"
11:15 am - 11:25 am Discussion
11:25 am - 11:35 am Poster Highlight Presentation: Claudio J. Margulis (University of Iowa, USA)
"Sugar folding: a novel structure prediction tool for oligosaccharides and polysaccharides in solution"
11:35 am - 11:40 am Discussion
11:40 am - 12:05 pmChristine Szymanski (National Research Council, Canada)
"Investigating the bacterial glycome: novel techniques and applications for glycobiology"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Glycoengineering
Discussion Leader: Steven Withers (University of British Columbia, Canada)
7:30 pm - 7:55 pmXi Chen (University of California - Davis, USA)
"Towards an understanding of sialic acid post-glycosylational modifications"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Tillman Gerngross (GlycoFi, USA)
"The use of humanized yeast to explore the glyco-design space - a novel discovery platform for biotherapeutics"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Highlight Presentation: Goncalo Bernardes (Oxford University, United Kingdom)
"Novel methods for precisely glycosylated proteins"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Suzanne Walker (Harvard University, USA)
"Glycosyltransferase inhibitors"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:15 pm Carbohydrate Synthesis I
Discussion Leader: Jacquelyn Gervay-Hague (University of California - Davis, USA)
9:00 am - 9:25 am Yasuhiro Kajihara (Yokohama City University, Japan)
"Chemical synthesis of glycoproteins having intact and homogeneous complex type oligosaccharides"
9:25 am - 9:35 am Discussion
9:35 am - 9:45 am Poster Highlight Presentation: Xuefei Huang (University of Toledo, USA)
"Pre-activation based one-pot synthesis of complex oligosaccharides"
9:45 am - 9:50 am Discussion
9:50 am - 10:15 am David Crich (University of Illinois - Chicago, USA)
"Diastereoselective glycosylation: lessons from the mannose/glucose conundrum, and others"
10:15 am - 10:25 am Discussion
10:25 am Coffee Break
10:50 am - 11:15 amShang-Cheng Hung (National Tsing Hua University, Taiwan)
"Regioselective one-pot protection of carbohydrates"
11:15 am - 11:25 am Discussion
11:25 am - 11:35 am Poster Highlight Presentation: Susanne Striegler (Auburn University, USA)
"Carbohydrate oxidation with dinuclear metal complexes"
11:35 am - 11:40 am Discussion
11:40 am - 12:05 pm Mikael Bols (University of Copenhagen, Denmark)
Stereoelectronic substituent effects and their influence on reactivity of carbohydrates"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair(s); Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair(s))
7:30 pm - 9:30 pm Carbohydrate Synthesis II
Discussion Leader: Xuefei Huang (University of Toeldo, USA)
7:30 pm - 7:55 pm Makato Kiso (Gifu University, Japan)
"Di-tert-butylsilylene (DTBS)-directed alpha-glycosidation of galactose/galactosamine toward the assembly of various glycosides"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Robert Field (John Innes Centre, United Kingdom)
"Particles and chips"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Highlight Presentation: Haibing Guo (West Virginia University, USA)
"De novo asymmetric synthesis of the anthrax tetrasaccharide via a palladium-catalyzed glycosylation reaction"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm France-Isabelle Auzanneau (University of Guelph, Canada)
"Glycosylations at O-4 of N-acetylglucosamine"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:15 pm Carbohydrate Processing Enzymes I
Discussion Leader: Nicola Pohl (Iowa State University, USA)
9:00 am - 9:25 am Warren Wakarchuk (National Research Council, Canada)
"Bacterial glycosyltransferases: versatile catalysts for glycoconjugate synthesis (2007 edition)"
9:25 am - 9:35 am Discussion
9:35 am - 9:45 am Poster Highlight Presentation: Mario Feldman (The University of Alberta, Canada)
"A new family of bacterial oligosaccharyltransferases involved in protein O-linked glycosylation"
9:45 am - 9:50 am Discussion
9:50 am - 10:15 am James Naismith (St Andrews University, United Kingdom)
"Carbohydrate export in bacteria"
10:15 am - 10:25 am Discussion
10:25 am Coffee Break
10:50 am - 11:15 am Martin Tanner (University of British Columbia, Canada)
"Enzymes in the biosynthesis of sialic acid and related compounds"
11:15 am - 11:25 am Discussion
11:25 am - 11:35 am Poster Highlight Presentation: Jian Liu (University of North Carolina)
"Engineering the specificity of sulfotransferases to synthesize specific heparan sulfate structures"
11:35 am - 11:40 am Discussion
11:40 am - 12:05 pmLai-Xi Wang (University of Maryland, USA)
"Convergent chemoenzymatic synthesis of glycopeptides and glycoproteins"
12:05 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Carbohydrate Processing Enzymes II
Discussion Leader: Todd Lowary (University of Alberta, Canada)
7:30 pm - 7:55 pm David Vocadlo (Simon Fraser University, Canada)
"Mechanism of action and development of O-GlcNAcase inhibitors"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmPaul DeAngelis (University of Oklahoma, USA)
"Chemoenzymatic synthesis of glycosaminoglycans: Monodisperse polymers and unnatural structures"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Highlight Presentation: Chun-Hung Lin (Academia Sinica, Taiwan)
"Structure and mechanism of Helicobacter pylori fucosyltransferase: A basis to develop potent inhibitors"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Gideon Davies (York University, United Kingdom)
"Enzymatic mannoside hydrolysis: conformational pathways and mimicry of the transition-state"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The project described was supported by Grant Number 1 R13 RR024093-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.
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