Conference Program
 
Cardiac Arrhythmia Mechanisms
March 18-23, 2007
Ventura Beach Marriott
Ventura, CA

Cardiac arrhythmias are the major cause of mortality and morbidity in the developed world. Yet, the mechanisms of deadly arrhythmias remain to be elucidated. The main goal of the biannual conference is to explore the fundamental mechanisms of the most complex arrhythmias, including atrial and ventricular fibrillation. New approaches to diagnosis, treatment, and prevention of cardiac arrhythmias will require the use of highly sophisticated tools that, in many cases, would consist of combinations of multiple technologies including novel imaging modalities, genetics, molecular and structural biology, tissue engineering, immunochemistry, patch-clamping, optical and high density electrode mapping of electrical wave propagation, and computer modeling. This field is represented by outstanding investigators at the forefront of research and experts in molecular biology, cellular electrophysiology, biomedical engineering, mathematics and clinical cardiology. This conference will provide a forum to interact and share ideas about the role of numerous factors in the mechanisms of complex cardiac arrhythmias and sudden cardiac death.

Program Committee

Igor Efimov (Chair), Natalia Trayanova (Co-Chair), Robert Gilmour, Raymond Ideker, Jose Jalife, Andre Kleber, Barry London, Michael Rosen, Yoram Rudy, Guy Salama, Douglas P. Zipes.

Poster Sessions

Gordon Research Conferences are all about inclusiveness and the use of posters will permit many of the conferees, including graduate students and postdocs, to actively participate in the meeting. The Vice-Chair of the Conference, Natalia A. Trayanova will be responsible for the poster sessions. Efforts will be made to ensure that poster sessions are organized so that the overall program of the Conference retains a coherent nature.


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmImaging Arrhythmias
Discussion Leader: Igor R. Efimov (Washington University, St. Louis, MO)
7:35 pm - 8:00 pm Arkady Pertsov (State University of New York, NY)
"3D Fluorescent Imaging"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pm Guy Salama (University of Pittsburgh, Pittsburgh, PA)
"Genetically encoded fluorescent probes"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pm Yoram Rudy (Washington University, St. Louis, MO)
"Imaging Arrhythmias in Humans: ECGi"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAtrial arrhythmias
Discussion Leader: Jose Jalife (State University of New York, Syracuse,NY)
9:00 am - 9:40 am Craig Henriquez (Duke University, NC)
"Models of AF"
9:40 am - 10:00 amDiscussion
10:00 am Coffee Break
10:15 am - 10:55 am Barry London (University of Pittsburgh Medical Center Pittsburgh, PA)
"AF in mice"
10:55 am - 11:15 amDiscussion
11:15 am Group Photo
11:30 am - 12:10 pm Omer Berenfeld (State University of New York, Syracuse, NY)
"AF in humans"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanoelectric interaction
Discussion Leader: Natalia Trayanova (Johns Hopkins University, Baltimore, MD)
7:30 pm - 7:55 pm Peter Kohl (Oxford University, Oxford, UK)
"Mechanoelectric basis of arrhythmias"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Max Lab (Imperial College, London, UK)
"Microvolt T Wave Alternans and Arrhythmia: A Mechanoelectric Contribution"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Andrew McCulloch (University of California San Diego, La Jolla, CA)
"From protein to organ: putting mechanoelectric interactions together"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVentricular fibrillation
Discussion Leader: James N. Weiss (University of California, Los Angeles, CA)
9:00 am - 9:40 am Peng-Sheng Chen (Cedars-Sinai Heart Center, Los Angeles, CA)
"Nerves matter in VF"
9:40 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 11:10 am Peter Taggart (University College Hospital, London, UK)
"Mapping VF in humans"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pm Raymond Ideker (University of Alabama, Birmingham, AL)
"Postshock initiation of VF"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of electrotherapy
Discussion Leader: John Wikswo (Vanderbilt University, Nashville, TN)
7:30 pm - 7:55 pm Vladimir Fast (University of Alabama, Birmingham, AL)
"The role of local heterogeneities"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Blanca Rodriguez (Oxford University, Oxford, UK)
"Modeling defibrillation: role of ventricular structure in shock failure"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Leslie Tung (Johns Hopkins University, Baltimore, MD)
"Electrical control of reentry in cell culture"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTissue engineering & arrhythmia
Discussion Leader: David Sedmera (Institute of Animal Physiology and Genetics, Prague, Czech Republic)
9:00 am - 9:40 am Nenad Bursac (Duke University, Durham, NC)
"Design of 2-D and 3-D cardiac tissues with controllable architecture and function"
9:40 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 11:10 am Kit Parker (Harvard University, Boston, MA)
"Myocardial tissue engineering"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pm Michael Rosen (Columbia University, New York, NY)
"Engineering a biopacemaker"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell-to-cell communications
Discussion Leader: Mario Delmar (State University of New York, Syracuse, NY)
7:30 pm - 7:55 pm Feliksas Bukauskas (Albert Einstein College of Medicine, New York, NY)
"Novel connexin 30.2"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Roselle Abraham (Johns Hopkins University, Baltimore, MD)
"Cell types mismatch"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Eric Beyer (The University of Chicago, Chicago, IL)
"Diversity of connexins"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmConduction system
Discussion Leader: Andre Kleber (University of Bern, Bern, Switzerland)
9:00 am - 9:40 am Greg Morley (New York University School of Medicine, New York, NY)
"The development of the conduction system"
9:40 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 11:10 am Vadim Fedorov (Washington University, St. Louis, MO)
"Pacemaking and conduction system of the rabbit heart"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmRobert Gourdie (Medical University of South Carolina, Charleston, SC)
"Patterning of the conduction system"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPathophysiologic substrates of arrhythmia
Discussion Leader: Douglas P. Zipes (University of Indiana, Indianapolis, IN)
7:30 pm - 7:55 pm David S. Rosenbaum (Case Western Reserve University, Cleveland, OH)
"Molecular control of cardiac alternans"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Miguel Valderrábano (UCLA, Los Angeles, CA)
"Rescaling the dynamics of ischemia-reperfusion arrhythmias"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Tom Hund (Washington University, St. Louis, MO)
"The role of calcium in ischemia and heart failure"
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart