| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Welcome Reception (Ware Campus Center) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Collagens: Molecular Structure & Assembly |
| 7:40 pm - 7:50 pm | Discussion Leader: Billy Hudson (Vanderbilt University) |
| 7:50 pm - 8:10 pm | Barbara Brodsky (Robert Wood Johnson Medical School)
"Self recognition in the assembly of collagens at the supramolecular level" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Jamshid Khoshnoodi (Vanderbilt University School of Medicine)
"Mechanism of Collagen IV Assembly" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Shireen Lamande (Murdoch Childrens Research Institute)
"Collagen VI: Mutations, assembly and quality control" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jamie Fitzgerald (Oregon Health and Science University)
"Three new collagen VI chains: Implications for collagen VI assembly" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of Collagen: Transcription, Splicing and Translation |
| 9:00 am - 9:10 am | Discussion Leader: Linda Sandell (Washington University) |
| 9:10 am - 9:35 am | Audrey McAlinden (Washington University)
"Alternative splicing of type II procollagen: multiple levels of regulation during cartilage development and disease" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Heather Yeowell (Duke University)
"Alternative splicing of lysyl hydroxylase 2: role of TIA factors in regulation of transcript expression" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 10:55 am | Branko Stefanovic (Florida State University)
"Post-transcriptional regulation of type I collagen expression and coordinated translation of alpha 1(I) and alpha 2(I) mRNAs" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Roberto Civitelli (Washington University)
"Control of Osteoblast Gene Expression by Gap Junctions" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Joy Lincoln (University of Miami)
"Sox9 is required for expression and organization of cartilage-associated genes during mouse heart valve development" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Matthew Layne (Boston University School of Medicine)
"Coactivator dependent induction of collagen and ECM gene expression" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Sherrill Adams (University of Pennsylvania)
"Integration of signaling by T3, retinoids and BMPs regulates collagen X gene expression during endochondral bone formation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Collagen-Protein Interactions |
| 7:30 pm - 7:45 pm | Discussion Leader: Magnus Hook (Texas A&M University System) |
| 7:45 pm - 8:05 pm | Sylvie Ricard Blum (CNRS, Lyon)
"The extracellular interactome: focus on collagen-protein interactions" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Birgit Leitinger (Imperial College London)
"Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Francisco Borrego (NIH/NIAID)
"Characterization of the interaction between LAIR-1 and collagens" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | James San Antonio (Thomas Jefferson University)
"Cell and matrix interaction domains on the collagen fibril" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Uwe Hansen (University Hospital Of Muenster)
"Opticin binding to collagen II containing collagen fibrils in vivo and in vitro" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Supramolecular Assemblies & Interactions in the Matrix |
| 9:00 am - 9:10 am | Discussion Leader: Peter Bruckner (University of Münster) |
| 9:10 am - 9:40 am | Jean Schwarzbauer (Princeton University)
"Assembly of fibronectin fibrils in tissues" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Russell Fernandes (University of Washington)
"Collagen XI Chain Misassembly in Cartilage of the Chondrodysplasia (cho) Mouse" |
| 10:05 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:30 am - 11:00 am | Daniela Villone (University of Münster)
"Supramolecular interactions of anchoring fibrils within the dermo-epidermal junction zone" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | Johanna Myllyharju (University of Oulu)
"Tissue-specific changes in the hydroxylysine content and crosslinks of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Elena Makareeva (NIH, NICHD)
"Do type I collagen homotrimers cause pathology by altering tissue remodeling?" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Markus Ruegg (Biocenter)
"Molecular mechanisms involved in the assembly of the vertebrate neuromuscular junction" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genetics and Collagens |
| 7:30 pm - 7:40 pm | Discussion Leader: Kathryn Cheah (The University of Hong Kong) |
| 7:40 pm - 8:00 pm | Pui-Yan Kwok (University of California, San Francisco)
"Natural variation in human collagen genes" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Danny Chan (The University of Hong Kong)
"Genetic risk factors for intervertebral disc degeneration" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:50 pm | Dale Bodian (Stanford University)
"Linking Collagen Genotypes to Molecular Phenotypes" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:05 pm | Stephanie Carleton (University of Missouri-Columbia)
"Role of genetic background in determining phenotypic severity in col1a2 deficient mice (oim)" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Doug Gould (University of California, San Francisco)
"AMD-Relevant Phenotypes in Col4a1 Mutant Mice Are Genetic Context Dependent" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Extracellular Matrix Processing and Turnover |
| 9:00 am - 9:10 am | Discussion Leader: Daniel Greenspan (University of Wisconsin) |
| 9:10 am - 9:35 am | Suneel Apte (Cleveland Clinic Foundation)
"ADAMTS metalloproteases: Key participants in extracellular networks" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:00 am | Claus Franzke (Hospital for Special Surgery)
"New insights for the ectodomain shedding of collagen XVII" |
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:35 am - 11:00 am | Karl Kadler (University of Manchester)
"Trafficking of collagen fibrils" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | William Wu (Henry Ford Hospital)
"The role of a type II collagen peptide fragment (matrikine) in cartilage turnover" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:50 am | Amy Bradshaw (Medical University of South Carolina)
"SPARC regulates procollagen processing and collagen fibrillogenesis" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Efrat Kessler (Tel Aviv University)
"Interaction of PCPE-1 with cells" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Linda Sandell (Washington University)
"Integrin mediated functions of col II N propeptide" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Cell-Matrix Interactions |
| 7:30 pm - 7:40 pm | Discussion Leader: Donald Gullberg (University of Bergen) |
| 7:40 pm - 8:00 pm | Beate Eckes (University of Cologne)
"Direct links to collagen: collagen-binding integrins" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:20 pm | Sergio Carracedo (University of Bergen)
"Regulation of integrin alpha11beta1 expression in vitro" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Wolfgang Vogel (University of Toronto)
"Building and rebuilding the ECM: new insights in DDR collagen receptor function" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Taina Pihlajaniemi (University of Oulo)
"Transmembrane and shed forms of collagen XIII have distinct roles in cell-matrix adhesion" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Collagen Diseases & Animal Models |
| 9:00 am - 9:10 am | Discussion Leader: John Bateman (Murdoch Childrens Research Institute) |
| 9:10 am - 9:35 am | Francesco Ramirez (Robert Wood Johnson Medical School)
"Microfibrils in development and disease" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:00 am | Joan Marini (NIH)
"Bone dysplasia and type I collagen mutations: Insights into mechanism from human mutations and the Brtl mouse" |
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:35 am - 10:45 am | Charlotte Phillips (University Of Missouri-Columbia)
"Osteogenesis Imperfecta: Use of mechanotransduction approaches to enhance bone integrity" |
| 10:45 am - 10:50 am | Discussion |
| 10:50 am - 11:15 am | Roy Morello (Baylor College of Medicine)
"Prolyl 3-hydroxylation: a novel paradigm for recessive osteogenesis imperfecta" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Manuel Koch (Cologne University)
"Collagen XII and XIV: Modulators of the extracellular matrix stability" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Ray Boot-Handford (University of Manchester)
"Functional characterization of collagen XXVII" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Michael Fox (Harvard University or Virginia Commonwealth University)
"Collagens IV are critical for the formation and maintenance of motor nerve terminals" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Tissue Engineering & Regenerative Medicine |
| 7:30 pm - 7:40 pm | Discussion Leader: Vladimir Mironov (Medical University of South Carolina) |
| 7:40 pm - 8:00 pm | Nicolas L'Heureux (Cytograft Tissue Engineering)
"Engineering human vascular grafts" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Peter Lelkes (Drexel University)
"Electrospining of collagen in tissue engineering" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:50 pm | Varun Gauba (Rice University)
"Thermal stability of heterotrimeric collagen mimics" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Richard Visconti (Medical University of South Carolina)
"Role recruited circulated stem cells in collagen synthesis in infacted myocardium" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Katja Schenke-Layland (University of California, Los Angeles)
"Multiphoton microscopy of collagen in heart valve tissue engineering" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |