Gordon Research Conferences
Meeting Details
Search:
  GO

Combinatorial Chemistry
Gordon Research Conference

Accelerating Drug Discovery
Note: This conference is currently known as "High Throughput Chemistry and Chemical Biology".

Dates

June 3-8, 2007

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
Daryl R. Sauer

Vice Chair:
Paul R. Hanson

Meeting Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNew Technologies and Drug Discovery
Discussion Leader: Daryl Sauer (Abbott Labs)
7:40 pm - 8:00 pm Tom Beattie (TRB Associates)
"Combinatorial Chemistry: Past, Present and Future"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Anabella Villalobos (Pfizer)
"Chemical Efficiencies and Changing the Way We do Medicinal Chemistry"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Jim Summers (Abbott Labs)
"Meeting the Challenges of the Pharmaceutical Industry - The Role of Technology in a Winning R&D Strategy"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOrganic / Bio-organic Chemistry
Discussion Leader: Oliver Kappe (Karl-Franzens University)
9:00 am - 9:45 am Stephen Martin (University of Texas-Austin)
"Aspects of Protein-Ligand Interactions: What are the Energetic Consequences of Ligand Preorganization?"
9:45 am - 9:55 am Discussion
9:55 am Coffee Break / Group Photo
10:30 am - 11:00 am Bruce Lipshutz (University of California-Santa Barbara)
"Enabling Technologies Based on the Chemistry of Coenzyme Q10"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Valery Fokin (Scripps Research Institute)
"Catalytic Dipolar Cycloadditions: Diversity and Function"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Ohyun Kwon (UCLA)
"Phosphine Catalysis of Allenes in Diversity-Oriented Synthesis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnabling Technologies in Drug Discovery
Discussion Leader: Tom Sowin (Abbott Labs)
7:30 pm - 8:00 pm Andrew Combs (Incyte)
"A Pragmatic Approach to Increasing Productivity in Discovery Chemistry"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Craig Lindsley (Vanderbilt University)
"Preclinical Drug Discovery in an Academic Setting - It is Possible"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Steve Haswell (University of Hull)
"Intelligent Drug Design Through the Application of Micro Fluidic Technology"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructural Approaches and Drug Design
Discussion Leader: Philip Hajduk (Abbott Labs)
9:00 am - 9:35 am Marc Jacobs (Vertex Pharmaceuticals)
"Leveraging X-ray Structural Information in Gene-family Based Drug Discovery: Protein Kinases"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Rod Hubbard (Vernalis)
"Experiences in fragment-based discovery"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:35 am Philip Hajduk (Abbott Labs)
"A Statistical Analysis of Chemical Substituents Utilized in Lead Optimization"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Maurizio Pellecchia (Burnham Institute)
"Structure and NMR-Based Approaches to Protein Kinase Inhibition"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMedicinal Chemistry Case Studies
Discussion Leader: Craig Lindsley (Vanderbilt)
7:30 pm - 8:00 pm Scott Wolkenberg (Merck)
"Selective Agonists of Somatostatin Receptor Subtype 2 (sstr2): Application of an Iterative Analogue Library Approach"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Alice Rodriguez (Vanderbilt)
"From HTS to lead optimization using technology enabled synthesis: Development of novel allosteric potentiators of mGluR5"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Joe Salvino (Cephalon)
"Practical Approaches Toward Lead Finding and Lead Optimization Library Synthesis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLibraries for Chemical Biology
Discussion Leader: Kip Guy (St. Jude)
9:00 am - 9:35 am Ben Cravatt (Scripps Research Institute)
"Mapping enzyme active sites in complex proteomes"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Doron Greenbaum (University of Pennsylvania)
"A Chemical Biology Approach to Understand Protease Function in the Malarial Parasite"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:35 am Jack Taunton (UCSF)
"New Chemical Tools for Exploring the Kinomes of People and Parasites"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Jeremy Mallari (St. Jude)
"Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Discuss future Site & Scheduling preferences; Discuss Conference Name Change)
7:30 pm - 9:30 pmNIH CMLD Projects
Discussion Leader: Jeff Aube (University of Kansas)
7:30 pm - 7:55 pm James Panek (Boston University)
"Expanding stereochemical and skeletal diversity using chiral organosilanes"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Jeff Aube (University of Kansas)
"Application of Domino Reactions to Library Synthesis"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Jared Shaw (Broad Institute of Harvard and MIT)
"New strategies for high throughput synthesis and target identification"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Peter Wipf (University of Pittsburgh)
"Parallel Synthesis of Heterocycles - Something Old, Something New, Something Borrowed, Something Blue"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Vice Chair Candidate Presentations)
9:00 am - 12:30 pmAcademic Combichem / Library Generation
Discussion Leader: Jared Shaw (Broad Institute of Harvard and MIT)
9:00 am - 9:35 am Ian Baxendale (Cambridge University)
"Multi-step flow synthesis: Training to be a plumber"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Sergey Kozmin (University of Chicago)
"From Practical High-Throughput Synthesis of Pure Small-Molecule Libraries to Discovery of New Cell-Modulators"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:35 am Dave Bergbreiter (Texas A&M University)
"Separation Strategies for Synthesis and Catalysis that Use Soluble Polymers"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Nikki Pohl (Iowa State University)
"Automated Solution-phase Iterative Oligosaccharide Synthesis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Fill out Conference Evaluation Forms; Election of the next Vice Chair)
7:30 pm - 9:30 pmMedicinal Chemistry Case Studies
Discussion Leader: Joe Salvino (Cephalon)
7:30 pm - 8:00 pm James Leahy (Exelixis Pharmaceuticals)
"High Throughput Methodology in Kinase Inhibitors"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Chris Sarko (Boehringer-Ingelheim)
"Hit to Lead Evaluation of Benzimidazole Inhibitors of ITK: From General Screening Library to Lead Series"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Roland Dolle (Aldolor)
"New Reagents for N-Heterocyclization of Primary Amines"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter