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Dendrites: Molecules, Structure and Function
Gordon Research Conference

Dates

March 18-23, 2007

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chairs:
Nelson Spruston & Michael Haeusser

Vice Chairs:
Greg J. Stuart & Anirvan Ghosh

Meeting Description

Dendrites are the highly complex neuronal structures that receive and integrate synaptic input from other cells. Although dendrites were discovered over a century ago, the past decade has seen a dramatic resurgence of interest in the function of these remarkable structures. This has been spurred by several new technical developments - including advances in imaging, electrophysiology, and molecular approaches - which have made the structure and function of dendrites relatively accessible. As a consequence, dendrites are now viewed as a field of study in and of themselves, and promise to unite and shed new light on disparate fields such as membrane trafficking, synaptic plasticity, and neuronal excitability. This Gordon Conference will crystallize the latest developments across the entire range of dendritic research, from their morphology and development, through to the electrical and computational properties of dendrites. The conference should be of interest to researchers and students in neuroscience, as well as to anyone who is interested in how the brain works.

Related Meeting

This GRC was held in conjunction with the "Dendrites: Molecules, Structure and Function" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMOLECULAR DETERMINANTS OF DENDRITIC SHAPE
Discussion Leader: Linda Van Aelst (Cold Spring Harbor Laboratory)
7:40 pm - 8:05 pmHaitao Zhu (Stanford University)
"Mechanisms of dendritic pruning during development"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmBonnie Firestein (Rutgers University)
"Intrinsic regulation of dendrite number and branching"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmYuh Nung Jan (UC San Francisco)
"Regulation of dendritic branching patterns"
9:20 pm - 9:30 pmDiscussion
9:30 pm - 11:30 pmInformal Social
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPROTEIN SYNTHESIS AND MOLECULAR TRAFFICKING IN DENDRITES
Discussion Leader: Zoltan Nusser (Budapest)
9:00 am - 9:25 amMike Ehlers (Duke University)
"Positioning endocytic machinery in dendrites and spines"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amOswald Steward (UC Irvine)
"Messenger RNA trafficking in dendrites"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amShort Talk: TBA
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amErin Schuman (Caltech)
"Regulation of dendritic protein synthesis by activity"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmJames Trimmer (UC Davis)
"Dendritic distribution of K channels"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk: TBA
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSTRUCTURAL PLASTICITY OF DENDRITES
Discussion Leader: Erin Schuman (Caltech)
7:30 pm - 7:55 pmHolly Cline (Cold Spring Harbor)
"Dendritic development and synaptogenesis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmElly Nedivi (MIT)
"Plasticity of interneuron dendritic arbors in visual cortex"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmWenbiao Gan (New York University)
"Spine motility in visual cortex in vivo"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: TBA
9:25 pm - 9:30 pmDiscussion
9:30 pm - 11:30 pmInformal Social
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSIGNAL INTEGRATION IN DENDRITES
Discussion Leader: Rodolfo Llinas (NYU)
9:00 am - 9:25 amJeff Magee (Janelia Farm / HHMI)
"Initiation and propagation of dendritic spikes"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amMatthew Larkum (University of Bern)
"Coincidence detection by dendrites"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amShort Talk: TBA
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amFritjof Helmchen (University of Zurich)
"Calcium signals in vivo"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmJackie Schiller (Technion University)
"Functional subcompartments in dendrites"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJohann Bollmann (Harvard)
"Functional imaging of dendritic activity in the optic tectum of larval Xenopus laevis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:15 pm - 5:00 pmWhale Watching
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmCOMPUTATIONAL PROPERTIES OF DENDRITES
Discussion Leader: Dan Johnston (Univ. Texas, Austin)
7:30 pm - 7:55 pmDmitri Chklovskii (Janelia Farm / HHMI)
"What determines the shape of dendrites?"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmArnd Roth (University College London)
"Links between morphology and dendritic function"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmBartlett Mel (University of Southern California)
"Dendrites as multi-layer networks"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: TBA
9:25 pm - 9:30 pmDiscussion
9:30 pm - 11:30 pmInformal Social
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDENDRITES AND SYNAPTIC PLASTICITY
Discussion Leader: Julian Jack (University College London)
9:00 am - 9:25 amKristen Harris (University of Texas, Austin)
"Ultrastructure of dendritic spine plasticity during LTP"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amRoger Nicoll (UC San Francisco)
"How does a spine control its AMPA receptors?"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amShort Talk: TBA
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amJesper Sjöström (University College London)
"A dendritic switch for synaptic plasticity"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmArthur Konnerth (Technical University, Munich)
"Dendritic Ca spikes and synaptic plasticity"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk: TBA
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmINTRINSIC PLASTICITY OF DENDRITES
Discussion Leader: David Linden (Johns Hopkins)
7:30 pm - 7:55 pmDan Johnston (University of Texas, Austin)
"Synaptic plasticity and dendritic excitability"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmMu-ming Poo (UC Berkeley)
"Long-term enhancement of dendritic excitability"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmDominique Debanne (University of Marseille, France)
"Intrinsic plasticity in pyramidal neurons"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: TBA
9:25 pm - 9:30 pmDiscussion
9:30 pm - 11:30 pmInformal Social
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDENDRITES AND DISEASE
Discussion Leader: Kristen Harris (University of Texas, Austin)
9:00 am - 9:25 amJohn Morrison (Mt. Sinai University)
"Effects of steroids and aging on spines and synapses"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTerry Robinson (University of Michigan)
"Structural plasticity associated with exposure to drugs of abuse"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amShort Talk: TBA
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amBrad Hyman (Mass. General Hospital)
"Multiphoton imaging of dendritic processes in models of Alzheimer's disease"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmBill Greenough (Univ. Illinois Urbana-Champaign)
"Failure of synaptic and dendritic pruning in the mouse model of fragile X syndrome"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk: TBA
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:10 pm - 5:00 pmWine Tour or Getty Villa
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmDENDRITES AS PRESYNAPTIC ELEMENTS
Discussion Leader: Roger Nicoll (UC San Francisco)
7:30 pm - 7:55 pmNathan Urban (Carnegie Mellon University)
"Transmitter release from mitral cell dendrites"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmBrad Alger (University of Maryland)
"Dendritic cannabinoids and inhibition"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmWade Regehr (Harvard Medical School)
"Dendritic cannabinoid release"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: TBA
9:25 pm - 9:30 pmDiscussion
9:30 pm - 11:30 pmInformal Social
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
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