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Enzymes, Coenzymes & Metabolic Pathways
July 8-13, 2007
University of New England
Biddeford, ME
Chairs:
Squire J. Booker & Nigel G. Richards

Vice Chairs:
Lizbeth Hedstrom & Nicole S. Sampson

There will be a strong focus at this conference on the broader biological aspects of enzyme action, the discovery of new enzymatic chemistries and the impact of enzymology in obtaining engineered natural products with interesting biological activity and in environmental bioremediation. Lectures discussing the role of complex co-factors in catalysis, including transition metal clusters, will also be a feature of the meeting. In addition, there will be focused sessions on: (i) the chemical mechanisms by which enzymes activate molecular oxygen, (ii) how substrates are channeled between multiple active sites within complex enzymes, (iii) the chemistry of transition metal and other co-factors, (iv) the role of enzymes in disease and methods for identifying novel drug targets, and (v) studies at the frontiers of enzymology, including methods for enzyme characterization within living cells.

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pm IN VIVO APPROACHES TO MONITORING ENZYME ACTION AND METABOLIC PATHWAYS
Discussion Leader: Paul Adams (University of Arkansas-Fayetteville)
7:35 pm - 8:05 pm Sunney Xie (Harvard University)
"Probing Biochemical Reactions of Single Molecules in Living Cells"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Erin O’Shea (Harvard Medical School)
"Cellular Nutrient Homeostasis"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm David Wemmer (University of California-Berkeley)
"How Can NMR Contribute to Understanding Chemistry in Cells?"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm NOVEL METABOLIC PATHWAYS
Discussion Leader: Kevin Walker (Michigan State University)
9:00 am - 9:30 am John Cronan (University of Illinois)
"Strange Happenings in Sulfur Insertions of Lipoic Acid and Biotin"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 amAlessandra Eustaquio (University of California-San Diego)
"Discovery of a Novel Chlorination Pathway in Nature"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am Joseph P. Noel (The Salk Institute)
"Traversing Evolutionary Pathways in Three Dimensions: Divergent Substrate and Product Specificities in Specialized Metabolism"
11:00 am - 11:10 am Discussion
11:10 am - 11:25 pmBrian Miller (Florida State University)
"From Promiscuous Enzymes to New Metabolic Pathways (TIM Complementation)"
11:25 am - 11:30 am Discussion
11:30 am - 11:45 amSheryl Tsai (University of California-Irvine)
"Structural and Enzymological Analyses of Polyketide Synthase: Towards ‘Unnatural’ Natural Products"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pmJonathan Spencer (University of Cambridge)
"Polyketide Biosynthesis on Land and at Sea"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm MECHANISMS OF POST-TRANSLATIONAL MODIFICATION
Discussion Leader: Philip Cole (Johns Hopkins University School of Medicine)
7:30 pm - 8:00 pm Raymond Trievel (University of Michigan)
"Structural Basis for the Dynamic Regulation of Protein Lysine Methylation"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Stuart Licht (Massachusetts Institute of Technology)
"Substrate Translocation by the Processive Protease ClpAP"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Dorothy Beckett (University of Maryland-College Park)
"Transcriptional Sensing of Biotin Status and Regulation of Biotin Protein Ligase Function"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ENZYMOLOGY OF OXYGEN ACTIVATION
Discussion Leader: David Ballou (University of Michigan)
9:00 am - 9:30 am Justine Roth (Johns Hopkins University)
"Structures and Reactivity Patterns of Activated Oxygen Intermediates in Metalloenzymes"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 amSteven Bruner (Boston College)
"Structural Basis for Cofactor-Independent Dioxygenation in Vancomycin Biosynthesis"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am John Lipscomb (University of Minnesota)
"Making Oxygenase Enzyme Mechanisms Crystal Clear"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Astrid Gräslund (University of Stockholm)
"Ribonucleotide Reductase: Metal-Oxygen Reactions and Free Radicals"
11:40 pm - 11:50 am Discussion
11:50 am - 12:20 pm Wilson Francisco (Arizona State University)
"Mechanistic Studies on Eukaryotic and Prokaryotic Flavonol 2,3-Dioxygenases"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm METALLO-COFACTORS IN ENZYME REACTIONS
Discussion Leader: Anne-Frances Miller (University of Kentucky)
7:30 pm - 7:45 pmCraig Townsend (Johns Hopkins University)
"Reflections on the contributions of Dr. Ian Scott to natural product biosynthesis"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pmJohn Gerlt (University of Illinois-Urbana-Champaign)
"Reflections on the contributions of Dr. Frank Westheimer to the field of enzymology"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmMarkus Ribbe (University of California-Irvine)
"Nitrogenase: A Paradigm for Metallocluster Assembly"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmJoseph Martin Bollinger Jr (The Pennsylvania State University)
"Formation and Function of a Radical-Initiating Mn(IV)/Fe(III) Cofactor in Ribonucleotide Reductase from Chlamydia trachomatis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ENZYMES IN COFACTOR BIOSYNTHESIS, AND MECHANISMS OF COFACTOR ACTION
Discussion Leader: W. W. Cleland (University of Wisconsin-Madison)
9:00 am - 9:30 am Vahe Bandarian (University of Arizona)
"Insights into Functional Evolution from Studies of Intragenomic Homologs"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 amKaren Allen (Boston University)
"The Structure of Acetoacetate Decarboxylase: The Electrostatic Hypothesis Revealed"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am Bruce Palfey (University of Michigan)
"Flavoprotein-Catalyzed Redox Reactions in Pyrimidine Metabolism"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Marie Alda Gilles-Gonzalez (University of Texas Southwestern Medical School)
"Oxygen-Sensing Kinases in Bacterial-Host Interactions"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Dieter Jahn (Technische Universität Braunschweig)
"Structure and Function of Enzymes for the Biosynthesis of Tetrapyrroles"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm TUNNELS HOLES AND SUBSTRATE CHANNELING
Discussion Leader: Frank Raushel (Texas A&M University)
7:30 pm - 8:00 pm Thomas Leyh (Albert Einstein College of Medicine)
"Overcoming Catalytic Inefficiency: Lessons from Sulfur Metabolism"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Osnat Herzberg (Center for Advanced Research in Biotechnology)
"Swiveling Domains in Phosphotransfer Reactions"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Dieter Söll (Yale University)
"From One Glutamine to Another: The Circuitous Route to Gln-tRNA"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ENZYMES IN DISEASE
Discussion Leader: Barbara Gerratana (University of Maryland-College Park)
9:00 am - 9:30 am Peter Tummino (GlaxoSmithKline)
"Impact of Drug-Enzyme Target Residence Time on the Pharmacological Properties of Novel Cancer Therapeutics"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 amRobert Hondal (University of Vermont)
"Selenium vs. Sulfur Thioredoxin Reductases: A Conformation Switching Mechanism Explains Differences in the Catalytic Mechanisms"
9:45 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am Clifton Barry (National Institutes of Health)
"A Novel F420-Dependent Nitroreductase Involved in the Activation of Nitroimidazole Prodrugs in Mycobacterium tuberculosis"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 am Dave Percival (Merck-Frosst)
"A Novel Cathepsin K Inhibitor for the Treatment of Osteoporosis"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Craig Townsend (Johns Hopkins University)
"Fatty Acid Synthase, Hypoxia and Cancer"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm FRONTIERS IN ENZYMOLOGY
Discussion Leader: JoAnne Stubbe (Massachusetts Institute of Technology)
7:30 pm - 8:20 pm Tadhg Begley (Cornell University)
"Thiamin: A Simple Cofactor with a Complex Biosynthetic Pathway"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pm Christopher Walsh (Harvard Medical School)
"Novel Aspects of Assembly Line Enzymes: Biosynthesis of the Antibiotic Andrimid"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by 5 R13 GM079040-02 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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