| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 9:30 pm | EPIGENOMICS |
| Discussion Leader: Steve Jacobsen (HHMI, UCLA) |
| 7:35 pm - 7:55 pm | Brad Bernstein (Broad Institute, USA)
"Chromatin state maps of pluripotent and lineage committed cells" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Bing Ren (Ludwig Institute, UCSD)
"Genome annotation using a conserved genetic code" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Peter Jones (USC/Norris Comprehensive Cancer Center)
"The cancer epigenome" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:00 pm | Short Talk: Suhua Feng (HHMI - UCLA)
"Epigenetic profiling in Arabidopsis" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Vincenzo Pirrotta (Rutgers University)
"Alternative chromatin states of Polycomb target genes" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | DNA METHYLATION |
| Discussion Leader: John Greally (Albert Einstein College of Medicine) |
| 9:00 am - 9:20 am | Eric Selker (University of Oregon)
"Advances in understanding the control of DNA methylation in Neurospora" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Judith Bender (Johns Hopkins University)
"A histone-dependent DNA methylation pathway" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Hiro Sasaki (NIGR, Mishima, Japan)
"Genome imprinting mechanisms in the mouse germline and early embryos" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 10:55 am | Short Talk: Fred Berger (Temasek Life Science Laboratory, Singapore)
"Epigenetic control of resource allocation to the Arabidopsis embryo involves DNA methylation and trans-silencing" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Tim Bestor (Columbia University)
"Interactions of histone methylation and DNA CpG methylation" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Xiaodong Cheng (Emory University)
"Structure of mammalian Dnmt3a-Dnmt3L complex" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Taiping Chen (Novartis)
"Lsd1 mutation leads to embryonic lethality and genome-wide hypomethylation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short Talk: Hidetoshi Saze (National Institute of Genetics, Japan)
"Genetic dissection of DNA methylation at the BONSAI locus" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HISTONE MODIFICATIONS AND VARIANTS |
| Discussion Leader: Sarah Elgin (Washington University, St Louis) |
| 7:30 pm - 7:50 pm | Karolin Luger (Colorado State University)
"Nucleosomes and their chaperones" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Steve Henikoff (Fred Hutchinson Cancer Research Center)
"Histone variant dynamics and epigenetics" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Justin Goodrich (University of Edinburgh)
"Whole genome screens for novel Polycomb group gene targets" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Terry Magnuson (UNC - Chapel Hill)
"Epigenetic mechanisms of X inactivation" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Short Talk: Juan Casas-Mollano (University of Nebraska, Lincoln)
"Histone H3 Threonine 3 Phosphorylation (H3T3ph) as an inheritable mark for silenced euchromatin in Chlamydomonas" |
| 9:20 pm - 9:25 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IMPRINTING, DOSAGE COMPENSATION & CHROMOSOMAL MECHANISMS |
| Discussion Leader: Emma Whitelaw (Queensland Institute of Medical Research) |
| 9:00 am - 9:20 am | Ueli Grossniklaus (University of Zurich)
"Regulation of genomic imprinting in Arabidopsis" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Marisa Bartolomei (University of Pennsylvania)
"Mechanism of genomic imprinting at the H19/Igf2 locus" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Jeannie Lee (Massachussetts General Hospital, Harvard University)
"X inactivation: sex, heterochromatin, pairing and more" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Barbara Meyer (HHMI - UC Berkeley)
"Regulation of X chromosome-wide repression and recombination" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Jim Birchler (University of Missouri)
"Studies on the function of the male specific lethal (MSL) complex in Drosophila" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Asifa Akhtar (EMBO labs, Heidelberg)
"Dosage compensation in Drosophila: MSLs and beyond" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Ting Wu (Harvard University)
"Ultra-conserved elements - sentinels of genome integrity?" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ROLES OF RNA I |
| Discussion Leader: Anne Ferguson-Smith (University of Cambridge) |
| 7:30 pm - 7.50 pm | Philip Zamore (University of Massachusetts Medical School, Worcester)
"Small silencing RNA pathways" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Rob Martienssen (Cold Spring Harbor Laboratories)
"Silent running: heterochromatin and RNAi in plants and fission yeast" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Olivier Voinnet (CNRS Strasbourg) |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Craig Pikaard
"Roles of RNA polymerase IV and nuclear siRNAs in heterochromatin organization and gene regulation" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Short Talk: Elissa Lei (NIDDK, NIH)
"Identification of noncoding RNAs associated with the gypsy chromatin insulator" |
| 9:20 pm - 9:25 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:45 am | ROLES OF RNA II |
| Discussion Leader: Bill Kelly (Emory University) |
| 9:00 am - 9:20 am | Denise Barlow (CEMM - Research Center for Molecular Medicine, Austria)
"Gene silencing in imprinted gene clusters by long ncRNAs" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Marjori Matzke (Gregor Mendel Institute, Austria)
"Genetic analysis of RNA-directed DNA methylation" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Vicki Chandler (BIO5 Institute, University of Arizona)
"Paramutation: RNA mediated meiotically-heritable silencing" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 12:30 pm | REGULATION OF CHROMATIN |
| 10:45 am - 11:05 am | Shiv Grewal (NCI - NIH)
"Heterochromatin: a versatile platform of the genome" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:20 am | Short Talk: Sriharsa Pradhan (New England Biolabs, Mass)
"G9a automethylation imply wider substrate specificity and HP1 binding" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Short Talk: Gerhard Rank (Royal Melbourne Hospital, Australia)
"The protein methyltransferase PRMT5 links histone H4 methylation to Dnmt3a-dependent DNA methylation and transcriptional silencing" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Hiten Madhani (UCSF)
"Determinants of promoter chromatin architecture in S. cerevisiae" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:25 pm | David Spector (Cold Spring Harbor Laboratory)
"Nuclear organization and gene silencing" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | EPIGENETICS IN DEVELOPMENT |
| Discussion Leader: John McCarrey (University of Texas, San Antonio) |
| 7:30 pm - 7:50 pm | Petra Hajkova (Gurdon Institute, University of Cambridge)
"Epigenetic reprogramming of the early mouse germ cell lineage" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:05 pm | Short Talk: David Katz (Emory University, Georgia)
"H3K4me2 Demethylase Activity Guards the Immortality of the Germline by Preventing Epigenetic Inheritance" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Wolf Reik (Babraham Institute, Cambridge)
"Regulation of imprinting and epigenetic programming in mammalian development" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Renato Paro (ETH Zurich, Switzerland)
"The epigenetic control of tissue regeneration in Drosophila" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Rudolph Jaenisch (Whitehead Institute, MIT)
"Stem cells, pluripotency and epigenetic programming" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| (Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences) |
| 9:00 am - 12:30 pm | DISEASE, ENVIRONMENT, EVOLUTION |
| Discussion Leader: Amar Klar (NCI, Frederick) |
| 9:00 am - 9:20 am | Steve Baylin (Johns Hopkins University)
"The cancer epigenome and its role in tumor initiation and progression" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Mike Higgins (Roswell Park Cancer Institute)
"Imprinted expression of Cdkn1c, overgrowth and Beckwith Wiedemann Syndrome" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Short Talk: Art Petronis (CAMH, University of Toronto)
"Epigenomic studies of major psychosis" |
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| Discussion Leader: Jean Finnegan (CSIRO, Canberra) |
| 10:35 am - 10:55 am | Phil Avner (Pasteur Institute, France)
"Plasticity and evolution in the X inactivation process" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Rick Amasino (University of Wisconsin)
"Vernalization: remembering winter with an epigenetic switch" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Eric Richards (Washington University, St Louis)
"Mining natural epigenetic variation" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Short Talk: Vincent Colot (INRA-CNRS, France)
"Transgenerational inheritance patterns of DNA methylation in Arabidopsis" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:15 pm | Short Talk: Catherine Suter (Victor Chang Cardiac Research Institute, Sydney)
"Germline epimutations in human" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DYNAMIC NUCLEUS |
| Discussion Leader: Jasper Rine (UC - Berkeley) |
| 7:30 pm - 7:40 pm | Short Talk: Pedro Crevillen (John Innes Centre, Norwich)
"Epigenetic regulation of flowering time" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 8:05 pm | Peter Fraser (Babraham Institute, Cambridge)
"3-D transcriptional networks" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Edith Heard (Institut Curie, France)
"The nuclear choreography underlying initiation of X inactivation" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Stephane Ronsseray (Institut Jacques Monod, Paris)
"P element repression in Drosophila by epigenetic telomeric trans-silencing involving heterochromatin formation and the rasiRNA silencing pathway" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Short Talk: Sylvia Erhardt (UC Berkeley and LBNL)
"Epigenetic regulation of centromeres" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Meeting Closure |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |