| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 7:45 pm | Welcome: G. Paolo Dotto (Dept. of Biochemistry, U. of Lausanne, Switzerland, and Mass. Gen. Hosp., Charlestown, MA) |
| 7:45 pm - 9:30 pm | GLOBAL APPROACHES |
| Discussion Leader: Elaine Fuchs (Howard Hughes Medical Institute, The Rockefeller University, New York) |
| 7:45 pm - 8:10 pm | Elaine Fuchs (Howard Hughes Medical Institute, The Rockefeller University, New York)
"Multifaceted approaches to unraveling skin morphogenesis" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Stuart L. Schreiber (Howard Hughes Medical Institute, Harvard University, Cambridge, MA)
"Small Molecules and Disease Biology" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Norbert Perrimon (Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston)
"Functional genomic approaches to tissues formation" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | DEVELOPMENT AND CANCER |
| Discussion Leader: Fiona Watt (Cambridge Research Institute, Cambridge, UK) |
| Co-Leaders: Shadmehr Demehri (Washington University, St Louis) and Rehan Villani (University of Queensland, AU) |
| 9:00 am - 9:20 am | Yosef Yarden (Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel)
"EGFR and HER2: network biology in normal and malignant epithelia" |
| 9:20 pm - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Paul A. Khavari (Stanford University School of Medicine, Stanford)
"Ras/MAPK Signaling in Epithelial Homeostasis and Neoplasia" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Anna Mandinova (Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown)
"EGFR - Notch - p53: an integrated switch for differentiation in keratinocytes and squamous cell carcinomas" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Fiona Watt (Cambridge Research Institute, Cambridge, UK)
"Contribution of stem cells and differentiated cells to epidermal tumour formation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Andrzej A. Dlugosz (Department of Dermatology and Comprehensive Cancer Center, University of Michigan)
"Hedgehog signaling in tumor initiation and maintenance" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Allan Balmain (Cancer Research Institute, San Francisco)
"The Genetics of Mouse Skin Tumor susceptibility" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Group A) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STEM CELLS |
| Discussion Leader: George Cotsarelis (University of Pennsylvania Hair and Scalp Clinic, Philadelphia) |
| Co-Leader: Valerie Horsley (Rockefeller University, NY) |
| 7:30 pm - 7:50 pm | George Cotsarelis (University of Pennsylvania Hair and Scalp Clinic, Philadelphia)
"Hair Follicle Stem Cells and Wound Healing: What's the Connection" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Daniel Aberdam (Faculty of Medicine, Nice, France)
"A multipotent ectodermal cell population derived from human embryonic stem cells" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Sendurai Mani (Whitehead Institute for Biomedical Research, Cambridge, Mass)
"The epithelial-mesenchymal transition generates cells with stem-like properties" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Weimin Zhong (Dept of Molecular, Cellular & Developmental Biology, Yale University, New Haven)
"Asymmetric Cell Division and Stem-Cell Homeostasis" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSCRIPTION |
| Discussion Leader: Dennis R. Roop (Department of Dermatology, University of Colorado, Aurora) |
| Co-Leader: Mike Fessing (University of Bradford, UK) |
| 9:00 am - 9:20 am | Myles Brown (Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston)
"Deciphering the Enhancer Code" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Howard Y. Chang (Stanford University School of Medicine, Stanford)
"Programming positional identities by long noncoding RNAs" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Stephen Blacklow (Harvard Medical School, Boston)
"Structural and Biochemical Studies of Notch Transcription Complexes" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:10 am - 11:20 am | Raphael Kopan (Department of Molecular Biology and Pharmacology, Washington University, St Louis)
"Non cell-autonomous responses to loss of Notch signaling in the skin impact follicular size and animal survival" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Dennis R. Roop (Department of Dermatology, University of Colorado, Aurora)
"p63 regulates key target genes required for epidermal morphogenesis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Walter Wahli (Center of Integrative Genomics, University of Lausanne, Switzerland)
"Role of PPAR-β in tissue repair" |
| 12:00 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Group A) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ISSUE RISING SESSION I |
| Discussion Leaders: Vladimir Bothckarev (Boston University) and Caterina Missero (Center for Genetic Engineering, Naples, Italy) |
| 7:30 pm - 7:40 pm | Vladimir Bothckarev (Boston University, Boston, MA, & U. of Bradford, Bradford, UK)
"Global microarray analysis of follicular and glandular types of epidermal differentiation: A role for BMP signaling in suppressing trans-differentiation of the foot pad epidermis towards folliculogenesis" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Caterina Missero (Center for Genetic Engineering, Naples, Italy)
"p63 regulates commitment to the keratinocyte cell lineage via a BMP-dependent pathway" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Masatake Osawa (Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown)
"Notch signaling mediates both differentiation and undifferentiation program in suprabasal keratinocytes" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Beatrice Howard (Institute for Cancer Research, London, UK)
"Neuregulin3 alters cell fate in the epidermis and mammary gland" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Philip Jones (MRC Cancer Cell Unit, Cambridge, UK)
"A single type of progenitor cells maintains normal epidermis: cell kinetic and spatial implications" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Jackie Bickenbach (Cell Biology Dept., Iowa U.)
"Harnessing and directing the multipotency of epidermal stem cells" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Rebecca Morris (Columbia University, NY)
"Skin tumor formation from hair follicle bulge keratinocytes in Krt1-15CrePR1;R26R mice" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Yinling Hu (MD Anderson U., Smithville, TX)
"IKKα in postnatal skin development and skin tumor development in mice" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DIFFERENTIATION AND SIGNALING |
| Discussion Leader: Pierre A. Coulombe (Johns Hopkins University School of Medicine, Baltimore) |
| Co-Leader: Xunwei Wu (Harvard Medical School) |
| 9:00 am - 9:20 am | Daniel Constam (ISREC - Swiss Federal Institute of Technology, Lausanne, Switzerland)
"Mechanism of Smad2/3 activation by Cripto governing cell fate in the early mouse embryo" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Toni Oro (Stanford University, School of Medicine)
"Hedgehog controls hair follicle regeneration through a novel dermal signaling pathway" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Manolis Pasparakis (Department of Mouse Genetics & Inflammation, University of Cologne, Germany)
"IKK/NF-kappaB signalling in the regulation of epidermal development and homeostasis" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Pierre A. Coulombe (Johns Hopkins University School of Medicine, Baltimore)
"Keratins in skin epithelia: Tinkering with translation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Reinhard Fässler (Department of Molecular Medicin, Martinsried, Germany)
"Kindler syndrome proteins in adhesion signalling" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Howard P. Baden (Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown)
"30 yrs of Gordon Conference and Skin Research: From the clinics to the bench and back" (Lecture in honor of Irwin Freedberg) |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Group B) |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | ISSUE RISING SESSION II |
| Discussion Leader: James Rheinwald (Harvard Medical School) |
| 7:30 pm - 7:40 pm | Meei-Hua Lin (Washington University School of Medicine, St. Louis, MO)
"Functions of Fatty Acid Transport Protein 4 in the Developing Skin" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | John M. Cunningham (U. of Chicago, Chicago)
"Grainy head-like 2 is a pivotal regulator of epithelial-mesenchymal transition in vertebrates" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Stephen M. Jane (Bone Marrow Research Laboratories, Melbourne, Australia)
"Defective wound healing in mice lacking planar cell polarity genes" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | James Rheinwald (Harvard Medical School, Boston)
"A wound and tumor suppressor response of hypermotility and growth arrest, shared by keratinocytes and many other epithelial cell types" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Carolyn R. Byrne (Barts and London, Inst. Cell and Mol. Science, London)
"AKT signaling in epidermal differentiation/barrier formation, and disregulation during carcinogenesis" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Rebecca J. Richardson (Faculty of Life Sciences, Manchester, UK)
"The periderm is required to prevent abnormal epithelial attachment" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Juan Guinea-Viniegra (IMP, Vienna, Austria)
"Epidermis-specific deletion of Jun proteins causes a TNF dependent disease" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Julie A. Segre (NHGRI, NIH, Bethesda, MD)
"The Skin Microbiome" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CELL ADHESION AND MORPHOGENESIS |
| Discussion Leader: Angela Christiano (Department of Dermatology, Columbia University, New York) |
| Co-Leaders: Emma Delva (Emory University, Atlanta, GA) and John Lamar (Albany Medical College, Albany, NY) |
| 9:00 am - 9:20 am | Cheng Ming Chuong (Department of Pathology, University of Southern California, Los Angeles)
"Different strategies of integument follicle morphogenesis and regeneration" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sarah E. Millar (Department of Dermatology, University of Pennsylvania, Philadelphia)
"Wnt signaling in ectodermal appendage development" |
| 9:50 am -10:00 am | Discussion |
| 10:00 am - 10:20 am | Angela Christiano (Department of Dermatology, Columbia University, New York)
"The unexpected consequences of P-cadherin mutations" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11.20 am | Arnoud Sonnenberg (Netherlands Cancer Institute, Amsterdam)
"The role of the integrin alpha6beta4 and plectin in the formation and breakdown of hemidesmosomes" |
| 11:20 am - 11.30 am | Discussion |
| 11:30 am - 11:50 am | Kathleen J. Green (Departments of Pathology & Dermatology, Northwestern University Medical School, Chicago)
"Desmosome Armadillo Proteins -- In and out of Junctions" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Andrew P. Kowalczyk (Emory University, Atlanta, GA)
"Mechanisms of Desmosome Disassembly in the Skin Disease Pemphigus Vulgaris" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | William G. Carter (Fred Hutchinson Cancer Research Center, Seattle, WA)
"Gp140/CDCP1 responds to wounding by regulating Src Family Kinases, Rac, Tiam 1 and cell adhesion in epidermis" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Group B) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SKIN AS AN INTEGRATED ORGAN |
| Discussion Leader: Meenhard Herlyn (Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia) |
| Co-Leader: Hisham Bazzi (Columbia University, NYC) |
| 7:30 pm - 7:50 pm | Meenhard Herlyn (Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia)
"Keratinocytes control melanocytes" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Lisa M. Coussens (Cancer Research Institute, University of California, San Francisco)
"Regulating Vascular Homeostasis with TGFbeta Antagonists" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Sabine Werner (Institute of Cell Biology, ETH Zürich, Switzerland)
"Cytoprotective signalling pathways in tissue repair and skin cancer" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Bruce Morgan (Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown)
"Building better blondes - a novel mechanism by which the Dermal Papilla regulates pigment production" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Jonathan Garlick
"Perspective and Prospects, 'Rapping Up' the Meeting" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |