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Mechanisms of Membrane Transport
June 10-15, 2007
Tilton School
Tilton, NH
Chair:
Peter C. Maloney

Vice Chair:
Amy L Davidson
Contributors
Funding for this conference was made possible by the National Institute of General Medical Sciences and the National Institute of Diabetes, Digestive and Kidney Diseases, for which the organizers are grateful. This conference is also indebted to Merck Research Laboratories for their continued financial support. We would also like to acknowledge with thanks a gift from Cell Press.
SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Biophysical and Biological Principles
Discussion Leader: P. Maloney (Johns Hopkins Medical School)
7:40 pm - 8:10 pmShimon Schuldiner (Hebrew University of Jerusalem)
"When biochemistry meets structural biology: the story of EmrE"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmWerner Kuhlbrandt (Max Planck Institute for Biophysics, Frankfurt)
"EM and X-ray studies of the mechanism of ammonia transport in prokaryotes"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmRon Kaback (University of California, Los Angeles)
"Up and down and in and out with LacY"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pm ABC Transporters
Discussion Leader: A. Davidson (Purdue University)
9:00 am - 9:35 amHeather Pinkett (California Institute of Technology)
"An inward-facing conformation of a putative metal-chelate type ABC transporter"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amJue Chen (Purdue University)
"Crystal structure of the E. coli maltose transporter"
10:20 am - 10:30 amDiscussion
10:20 am - 10:30 amCoffee Break
11:00 am - 11:35 amKaspar Locher (Institute of Molecular Biology and Biophysics, ETH Zurich)
"Structure and mechanism of bacterial ABC transporters"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmMarwan Al-Shawi (University of Virginia)
"Kinetic models of ABC function"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Crossing the Bilayer
Discussion Leader: S. White (University of California, Irvine)
7:30 pm - 8:00 pmDon Engleman (Yale University)
"A translocating peptide that targets tumors and other acidic tissues in vivo"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmSteve White (University of California, Irvine)
"Folding proteins at membrane interfaces"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMilton Saier (University of California, San Diego)
"Evolution of transmembrane transport proteins"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Gating and Conduction
Discussion Leader: D. Gadsby (Rockefeller University)
9:00 am - 9:35 amYouxing Jiang (University of Texas, Southwestern Medical Center)
"Ion selectivity of a NaK channel"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amRod MacKinnon (Rockefeller University)
"Gating of voltage-dependent K channels"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amGary Yellen (Harvard Medical School)
"Reversed gating of hyperpolarization-gated HCN channels"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmTom DeCoursey (Rush Medical College)
"The voltage-gated proton channel"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm New and Notable
Discussion Leader: C. Miller (Brandeis University)
7:30 pm - 8:00 pmAndrew Ferguson (Merck Research Laboratories)
"Crystal structure of human 5 lipoxygenase-activating protein in complex with leukotriene biosynthesis inhibitors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmTravis Barnard (NIDDK, NIH)
"Post-cleavage structure of EspP, an E. coli O157:H7 autotransporter"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAnna Levine (University of Pennsylvania Medical School)
"Crystal structure of the transmembrane domain of the M2 proton channel from influenza A virus"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Ion, Solute and Water Channels
Discussion Leader: R. Stroud (University of California, San Francisco)
9:00 am - 9:35 amMichael Maguire (Case Western Reserve University)
"The CorA Mg2+ channel and its role in salmonella virulence"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amAlan Finkelstein (Albert Einstein College of Medicine)
"Protein translocation through the anthrax toxin channel"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amTamir Gonen (University of Washington)
"The structure of the aquaporin-0 mediated membrane junction"
11:35 am - 11:45 amDiscussion
11:45 am - 12:20 pmDavid Gadsby (Rockefeller University)
"The ion pathway through the Na,K-ATPase"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Selected Poster Talks
Discussion Leader: TBA
Presenter 1: TBA
Presenter 2: TBA
Discussion
Presenter 3: TBA
Presenter 4: TBA
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Transporters and Facilitators
Discussion Leader: H.R. Kaback (University of California, Los Angeles)
9:00 am - 9:30 amChris Miller (Brandeis University)
"Slogging through the CLC transporter mechanism"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amEtana Padan (Hebrew University of Jerusalem)
"NhaA: structure-driven studies of function and regulation of an Na+/H+ antiporter"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amCoffee Break
10:30 am - 11:00 amRajini Rao (Johns Hopkins Medical School)
"Human orthologs of bacterial antiporters: phylogeny, physiology and homology modeling"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amDaxiong Fu (Brookhaven National Laboratories)
"Structure and mechanism of a zinc transporter"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmEdmund Kunji (MRC Cambridge)
"Substrate recognition and transport mechanism of mitochondrial carriers"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Future Challenges
Discussion Leader: R. MacKinnon (Rockefeller University)
7:30 pm - 8:00 pmAnjana Rao (Harvard Medical School)
"The ER store-operated CRAC calcium channel"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmLukas Novotny (University of Rochester)
"Ion exchange proteins studied by sp-FRET"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAnn McDermott (Columbia University)
"NMR of membrane proteins"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by (1 R13 GM080816-01) from the National Institute of General Medical Sciences and the National Institute of Diabetes, Digestive and Kidney Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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