| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Chair's Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcoming Remarks / Introductory Comments by GRC Site Staff and Co-Chairs, C.S. Raman and Ben Van Houten |
| 7:40 pm - 9:30 pm | Special Keynote lectures in Oxidative Stress |
| Discussion Leader: C.S. Raman (University of Texas - Medical School, Houston) |
| 7:40 pm - 8:25 pm | Tracey Rouault (NICHD, NIH)
"Iron homeostasis and neurodegeneration: role of iron regulatory proteins" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Douglas Wallace (University of California, Irvine)
"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | Session 1. Oxidative Stress and Neurodegeneration |
| Discussion Leader: Jeffrey Rothstein (Johns Hopkins University School of Medicine) |
| 9:00 am - 9:30 am | Jeffrey Rothstein (Johns Hopkins University School of Medicine)
"Glial contributions to neurodegeneration and therapeutic strategies" |
| 9:30 am - 9:50 am | Julie Andersen (Buck Institute for Age Research)
"Iron chelation: ironing out its potential for a therapeutic treatment for Parkinson's disease" |
| 9:50 am - 10:10 am | Ted Dawson (Johns Hopkins University School of Medicine)
"Identification of a novel oxidative stress signaling pathway opens up new therapeutic modalities for Parkinson's disease" |
| 10:10 am - 10:30 am | Leo Pallanck (University of Washington)
"Oxidative stress is a common etiological factor in Drosophila models of Parkinson's disease" |
| 10:30 am - 10:50 am | Discussion |
| 10:50 am - 11:20 am | Coffee Break / Group Photo |
| 11:20 am - 12:30 pm | Session 2. Stem cell survival and oxidative stress |
| Discussion Leader: John Sedivy (Brown University) |
| 11:20 am - 11:50 am | John Sedivy (Brown University)
"Signaling networks of stress-induced cellular aging" |
| 11:50 am - 12:10 pm | Toshio Suda (Keio University School of Medicine, Japan)
"Niche regulation of hematopoietic stem cells by ROS" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Session 3. Diabetes and Oxidative Stress |
| Discussion Leader: Michael Brownlee (Albert Einstein College of Medicine) |
| 7:30 pm - 8:00 pm | Michael Brownlee (Albert Einstein College of Medicine)
"A radical explanation for diabetic complications" |
| 8:00 pm - 8:20 pm | Evan Rosen (Harvard Medical School)
"A role for ROS in the etiopathogenesis of insulin resistance" |
| 8:20 pm - 8:40 pm | Gerald Shulman (Yale University School of Medicine)
"Mitochondrial dysfunction and type 2 Diabetes" |
| 8:40: pm - 9:00 pm | Mary Loeken (Harvard Medical School)
"Molecular causes of birth defects induced by diabetic pregnancy and oxidative stress" |
| 9:00 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | Session 4. Oxidative Stress and Lung Injury |
| Discussion Leader: Brooke Mossman (University of Vermont College of Medicine) |
| 9:00 am - 9:30 am | Brooke Mossman (University of Vermont College of Medicine)
"Inhaled particulates and ROS: the Good, the Bad, and the Ugly" |
| 9:30 am - 9:50 am | Steven Kleeberger (NIEHS, NIH)
"Differential Susceptibility to Oxidative Stress or 'Why Me?" |
| 9:50 am - 10:10 am | Anne-Laure Perraud (National Jewish Medical and Research Center)
"TRPM2, an intriguing chimeric ion channel gated by ADP-ribose, a novel messenger of oxidative stress: Its potential role in the etiology of asthma" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:40 am | Coffee Break |
| 10:40 am - 12:30 pm | Session 5. Biomarkers of Oxidative Stress and Inflammation |
| Discussion Leader: Ned Porter (Vanderbilt University) |
| 10:40 am - 11:10 am | Ned Porter & Jason Morrow (Vanderbilt University)
"Insights into lipid peroxidation - from basic mechanisms to clinical relevance" |
| 11:10 am - 11:30 am | Francisco Schopfer (University of Pittsburgh School of Medicine)
"Cell signaling actions of nitrated fatty acids" |
| 11:30 am - 11:50 am | Valeria Culotta (Johns Hopkins University Bloomberg School of Public Health)
"Metals and oxidative stress: Tales from yeast" |
| 11:50 am - 12:10 pm | Kelvin Davies (University of Southern California)
"The RCAN1 gene in health and disease: Too much of a good thing can be bad for you" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Session 6. Biology of iron and iron overload diseases |
| Discussion Leader: James Imlay (University of Illinois at Urbana-Champaign) |
| 7:30 pm - 8:00 pm | James Imlay (University of Illinois at Urbana-Champaign)
"Molecular explanations for the toxicity of hydrogen peroxide" |
| 8:00 pm - 8:20 pm | Jill Waalen (The Scripps Research Institute)
"From iron to bronze diabetes: Hemochromatosis and other diseases of iron overload" |
| 8:20 pm - 8:40 pm | Matthias Hentze (European Molecular Biology Laboratory, Germany)
"Molecular control and diseases of iron metabolism" |
| 8:40 pm - 9:00 pm | Nicholas DiProspero (NINDS, NIH)
"Biologic and therapeutic effects of a high-dose antioxidant in Friedreich's ataxia" |
| 9:00 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:45 am | Session 7. Cancer and Oxidative Stress |
| Discussion Leader: Jan Vijg (Buck Institute for Age Research) |
| 9:00 am - 9:30 am | Jan Vijg (Buck Institute for Age Research)
"Genome instability, transcriptional deregulation and aging" |
| 9:30 am - 9:50 am | Nathalie Mazure (CNRS, Université de Nice)
"Hypoxia signaling and cell death in the tumor microenvironment. Role of BNIP3?" |
| 9:50 am - 10:10 am | Paul Schumacker (Northwestern University)
"Mitochondrial oxidant stress and cancer: When good signals turn bad" |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Yousin Suh (University of Texas Health Science Center at San Antonio)
"Premature aging transcriptomes" |
| 10:50 am - 11:10 am | Virpi Launonen (University of Helsinki, Finland)
"Fumarate hydratase: Linking mitochondrial dysfunction and cancer" |
| 11:10 am - 11:45 am | Discussion |
| 11:45 am - 12:30 pm | Session 8. Cardiovascular disease and oxidative stress |
| Discussion Leader: Ajay Shah (King's College London) |
| 11:45 am - 12:05 pm | Ajay Shah (King's College London, U.K.)
"NADPH oxidases in cardiac remodelling" |
| 12:05 pm - 12:25 pm | Joshua Hare (Johns Hopkins University School of Medicine)
"Pivotal role of nitric oxide in ROS signaling" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Hot Topics Session |
| Discussion Leader: Ben Van Houten (NIEHS, NIH) |
| 7:30 pm - 7:45 pm | Hot Topics Presenter 1 |
| 7:50 pm - 8:05 pm | Hot Topics Presenter 2 |
| 8:10 pm - 8:25 pm | Hot Topics Presenter 3 |
| 8:30 pm - 8:45 pm | Hot Topics Presenter 4 |
| 8:50 pm - 9:05 pm | Hot Topics Presenter 5 |
| 9:10 pm - 9:25 pm | Hot Topics Presenter 6 |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Session 9. Mitochondria and oxidative stress |
| Discussion Leader: Michael Murphy (MRC Dunn Human Nutrition Unit, U.K.) |
| 9:00 am - 9:30 am | Michael Murphy (MRC Dunn Human Nutrition Unit, U.K.)
"Targeting antioxidants to mitochondria as a potential therapy" |
| 9:30 am - 9:50 am | William Copeland (NIEHS, NIH)
"Lessons from the bench, deciphering diseases of mitochondrial DNA replication" |
| 9:50 am - 10:10 am | Rod Capaldi (University of Oregon)
"Quantitating oxidative damage from arrays of mitochondrial proteins" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:10 am | Gerald Shadel (Yale University School of Medicine)
"Mitochondrial gene expression in disease and aging" |
| 11:10 am - 11:30 am | Massimo Zeviani (National Neurological Institute "Carlo Besta", Italy)
"Modelling human mitochondrial disorders in yeast, flies and mice" |
| 11:30 am - 11:50 am | Paul Hwang (NHLBI, NIH)
"Metabolic control by tumor suppressor p53"
|
| 11:50 am - 12:10 pm | Christopher Baines (Cincinnati Children's Hospital Medical Center)
"Dissecting the mitochondrial pore" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Session 10. Aging and Oxidative Stress |
| Discussion Leader: Holly Van Remmen (University of Texas Health Sciences Center, San Antonio) |
| 7:30 pm - 8:00 pm | Holly Van Remmen (University of Texas Health Sciences Center at San Antonio)
"Superoxide mediated oxidative stress induces accelerated age related skeletal muscle atrophy" |
| 8:00 pm - 8:20 pm | Tomas Prolla (University of Wisconsin)
"The Role of mtDNA Mutations in Oxidative Stress, Apoptosis and Aging in Mammals" |
| 8:20 pm - 8:40 pm | Boudewijn Burgering (University Medical Center Utrecht, The Netherlands)
"Forkheads, p53 and the control of cellular oxidative stress" |
| 8:40 pm - 9:10 pm | Azad Bonni (Harvard Medical School)
"MST regulation of oxidative stress responses and longevity" |
| 9:10 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |