Conference Program
 
RNA Editing
January 14-19, 2007
Ventura Beach Marriott
Ventura, CA
Chairs:
Kenneth D. Stuart & Mary O'Connell

Vice Chairs:
Juan D. Alfonzo & Marie Ohman

The biannual GRC on RNA Editing is the only regularly scheduled meeting on this subject. It will convene a relatively small group of established leaders and junior scientists in a casual setting for five days of morning and evening presentations with afternoons reserved for poster sessions, informal discussions, and recreation. The GRC on RNA Editing provides scientists investigating these diverse processes with a unique opportunity to interact at a single meeting and discuss new hypotheses and mechanistic paradigms, exchange information about experimental strategies, and initiate collaborations.

Contributors
Dharmacon Inc.
New England Biolabs, Inc.
NIH
OyaGen, Inc.
RNA Society
Taisho Pharmaceutical Company, Ltd.
USB Corporation
SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
4:00 pm - 6:00 pmReception
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDIVERSITY IN EDITING
Discussion Leader: Robert Reenan (Brown University)
7:40 pm - 8:00 pm Robert Reenan (Brown University, USA)
"Regulation of the Drosophila Phenome by ADAR"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pm Henri Grosjean (CNRS, France)
"The Various Strategies of Codon Decoding in Organisms of the 3 Domains of Life"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pm Jonatha M. Gott (Case Western Reserve University, USA)
"New forms of editing in Physarum mitochondria"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pm Nicholas Davidson (Washington University, USA)
"RNA targets for apobec-1 and its complementation factor ACF"
9:15 pm - 9:20 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSNO AND OTHER STABLE RNA MODIFICATIONS
Discussion Leader: Eric Phizicky (University of Rochester)
9:00 am - 9:20 am Eric Phizicky (University of Rochester School of Medicine, USA)
"tRNA modification in yeast"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 am Michael W. Gray (Dalhousie University, Canada)
"Biochemistry of Mitochondrial 5' tRNA Editing"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 am YiTao Yu (University of Rochester Medical Center, USA)
"RNA modification and pre-mRNA splicing regulation"
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 am Maurille (Skip) Fournier (University of Massachusetts, USA)
"SnoRNP-mediated modifications in rRNA influence several aspects of ribosome activity"
10:35 am - 10:40 amDiscussion
10:45 am - 11:15 am Coffee Break
11:15 am Group Photo
11:30 am - 11:50 am Michael P. Terns (University of Georgia, USA)
"RNA-guided Pseudouridylation by H/ACA RNPs"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pm Tom Meier (Albert Einstein College of Medicine, USA)
"Molecular dissection of complex mammalian pseudouridine synthases: H/ACA ribonucleoproteins"
12:05 pm - 12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmINNATE IMMUNE RESPONSE AND HOST DEFENSE
Discussion Leader: Bryan Cullen (Duke University)
7:30 pm - 7:50 pm Bryan Cullen (Duke University, USA)
"Intrinsic immunity to retroviruses and retrotransposons mediated by the APOBEC3 protein family"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pm Reuben Harris (University of Minnesota, USA)
"Mechanisms of retroelement inhibition by APOBEC3 proteins"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pm Nina Papavasiliou (The Rockefeller University, USA)
"DNA deamination in adaptive and innate immunity"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pm Charles Samuel (University of California Santa Barbara, USA)
"Expression and Function of ADAR1 in Response to Pathogen Infection in the Mouse Model"
9:05 pm - 9:10 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMACROMOLECULES MACHINES AND FUNCTIONAL INTERACTIONS
Discussion Leader: Barbara Sollner-Webb (The Johns Hopkins University)
9:00 am - 9:20 am Barbara Sollner-Webb (The Johns Hopkins University, USA)
"Insights into the action of the T. brucei RNA editing complex, from analyzing component proteins"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 am Maureen Hanson (Cornell University, USA)
"Recognition of C targets of editing in chloroplasts"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 am Harold C. Smith (University of Rochester, USA)
"Cytoplasmic compartmentalization and function of C to U editing factors"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Larry Simpson (University of California Los Angeles, USA)
"Uridine insertion/deletion editing in trypanosomes: Functional interactions between L-complex proteins"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 am Laurie Read (SUNY Buffalo School of Medicine, USA)
"Modulation of trypanosome RNA editing by the RNA binding protein, RBP16"
11:30 am - 11:35 amDiscussion
11:35 am - 11:55 am Juan Alfonzo (Ohio State University, USA)
"Global and local determinants of tRNA editing in trypanosomatids"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pm Steve Hajduk (Marine Biological Laboratory, USA)
"Alternative Editing of mRNA Generates Protein Diversity in Trypanosomes"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmEDITING AND RNA INTERFERENCE
Discussion Leader: Kazuko Nishikura (Wistar Institute)
7:30 pm - 7:50 pm Kazuko Nishikura (Wistar Institute, USA)
"Regulation of microRNA processing and expression through RNA editing by ADAR deaminases"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pm Gordon Carmichael (University of Connecticut Health Center, USA)
"The role of vigilins in connecting ADAR editing to heterochromatic gene silencing"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pm Brenda Bass (University of Utah, USA)
"Modulation of gene expression by Adenosine deaminases that act on RNA"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pm Erez Levanon (Harvard Medical School, Boston, USA)
"Analysis of A-to-I RNA editing in human and mouse genomic repeats"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pm Tao Pan (University of Chicago, USA)
"Toward studies of RNA modifications at the genomic scale"
9:10 pm - 9:15 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmENZYME-SUBSTRATE RECOGNITION
Discussion Leader: Joshua Rosenthal (University of Puerto Rico)
9:00 am - 9:20 am Joshua Rosenthal (Institute of Neurobiology, University of Puerto Rico, USA )
"SqADAR: a precocious cephalopod editor"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 am Peter Beal (University of Utah, USA)
"Structure/activity relationships for A to I RNA editing by ADARs"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 am Marie Öhman (Stockholm University, Sweden)
"A method to find novel sites of selective A to I editing"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Warner Greene (University of California San Francisco, USA)
"The Complexities of APOBEC3G Complexes"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 am Donna Koslowsky (Michigan State University, USA)
"Kinetic and thermodynamic studies of gRNA/mRNA interaction"
11:30 am - 11:35 amDiscussion
11:35 am - 11:55 am Axel Brennicke (ULM Universitaet, Germany)
"Analysis of trans-factors in plant mitochondrial RNA editing"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pm Miguel Holmgren (NIH/NINDS, Washington DC, USA)
"RNA editing of the internal cavity of Kv channels alters fast inactivation"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmSTRUCTURE
Discussion Leader: Wim Hol (University of Washington)
7:30 pm - 7:50 pm Wim Hol (Howard Hughes Medical Institute, University of Washington, USA)
"Crystallographic and Biochemical Studies of the Editosome from Trypanosoma brucei"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pm Frédéric Allain (Institute of Molecular Biology and Biophysics, Switzerland)
"Structure-specific recognition of RNA by ADAR2 dsRBMs"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pm Juli Feigon (University of California Los Angeles, USA)
"Structural studies of telomerase and H/ACA snoRNAs"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pm Adrian R. Ferre-D'Amare (Fred Hutchinson Cancer Research Center, USA)
"Pseudouridine synthases: Use of RNA rigidity and flexibility for recognition"
9:05 pm - 9:10 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMEDICAL CONSEQUENCES
Discussion Leader: Ron Emeson (Vanderbilt University)
9:00 am - 9:20 am Ron Emeson (Vanderbilt University, USA)
"Physiological roles of edited serotonin 2C receptor isoforms"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 am Peter Seeburg (Max-Planck Institute of Medical Research, Germany)
"ADAR2, a role in sporadic ALS?"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 am Shin Kwak (University of Tokyo, Japan)
"ADAR2 underactivity and death of motor neurons in ALS"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:05 am Youming Lu (University of Central Florida)
"RNA editing of AMPA receptor GluR2 subunit in neuronal degeneration"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 am Ingo Greger (The Medical Research Council Laboratory of Molecular Biology, UK)
"RNA editing modulates AMPA receptor biogenesis"
11:30 am - 11:35 amDiscussion
11:35 am - 11:55 am Michael Jantsch (University of Vienna, Austria)
"An RNA-sensor for nucleo-cytoplasmic transport of ADAR1"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pm Nathaniel Landau (The Salk Institute for Biological Studies, USA)
"The role of APOBEC3 cytidine deaminases in suppression of exogenous and endogenous viruses"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 4
6:00 pmDinner
7:30 pm - 9:30 pmHOT TOPICS
Discussion Leader: Mark Macbeth (University of Utah, USA)
7:30 pm - 7:45 pmYong Liu (Shanghai Institute of Biological Sciences, China)
"Metabolic Regulation of RNA Editing by ADAR2 in Pancreatic Islets and b-Cells"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmAngela Gallo (Ospedale Pediatrico 'Bambino Gesù', Rome, Italy)
"RNA editing deregulation in pediatric astrocytomas and GBMs"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmEdward Steele (Australian National University, Canberra,AUSTRALIA)
"The antibody somatic hypermutation pattern contains key features of the A-to-I RNA editing signature"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMark Stapleton (Lawrence Berkeley Labs, USA)
"Re-coding of mRNA transcripts in Drosophila: new targets and functional consequences"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJason Carnes (Seattle Biomedical Research Institute, USA)
"The Architecture of Three Distinct T. brucei Editosomes
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJoseph E. Wedekind (University of Rochester, USA)
"Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this Gordon Research Conference conference was made possible by # R13 MH73163 from NIMH. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.