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Stress Proteins in Growth, Development and Disease
Gordon Research Conference

Dates

August 19-24, 2007

Location

Magdalen College
Oxford, United Kingdom

Organizers

Chair:
Peter Walter

Vice Chair:
Bernd Bukau

Meeting Description

All organisms are exposed to stressful conditions including environmentally imposed stresses such as elevated temperatures and irradiation, physiological stress such as rapid cellular proliferation, oxidative stress due to metabolic reactions, or pathophysiological stresses such as pharmacological agents, infection and inflammation. Even normal developmental or nutritional changes exert stresses as systems temporarily depart from and try to re-establish homeostasis. If unmitigated, such stressful conditions lead to protein misfolding, aggregation, cellular dysfunction and cell death. Recent studies strongly suggest that the ability to sense and respond to stress signals, through the activation of signal transduction pathways, transcription factors and gene products that function in protein homeostasis is critical for normal growth, development and in the protection against diseases that include cancer, cardiovascular disease and protein folding diseases such as Alzheimer’s, Huntington’s and prion-based disease. Furthermore, studies in model systems have established a strong correlation between longevity and the ability to mount robust stress responses. The meeting will highlight the many cutting-edge advances in the field, including the mounting appreciation of the importance of autophagy pathways to remodel cells under stress conditions and the increasing emphasis on using modeling approaches to understand stress regulation at a systems level. This GRC will emphasize vigorous discussions of recent exciting developments related to stress sensing, signaling and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathopysiological states, the cell biology of stress and the roles of stress in aging. Many opportunities will be provided for both established and new investigators, graduate students and postdoctoral fellows to engage in detailed but informal discussions to enhance the dissemination of new information and the formation of collaborations to advance and broaden our understanding of the role of stress proteins in human health, in aging and in disease.

Contributors

Beckman Coulter
Cell Signaling Technology, Inc.
Elsevier
Garland Science
Genentech, Inc.
The National Institutes of Health
Pfizer, Inc.

Meeting Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Opening Session
7:40 pm - 8:00 pmWelcome / Introductory Comments by Meeting Chair & Vice Chair:
Peter Walter (University of California, San Francisco)
Bernd Bukau (Universität Heidelberg)
8:00 pm - 9:00 pmR. Morimoto (Northwestern University)
"Protein Misfolding in Stress, Aging, and Neurodegenerative Disease"
9:00 pm - 9:30 pm Discussion
MONDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm Immunity, Infection and Cancer
Discussion Leader: Jonathan Weissman (UCSF)
9:00 am - 9:20 amC. Nicchitta (Duke University)
"GRP94: Chaperoning the gateway to multicellularity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amA. Cuervo (Albert Einstein College of Medicine)
"Chaperone-mediated autophagy in stress, aging and neurodegeneration"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:50 amD. Ron (New York University School of Medicine)
"Compartment-specific cellular adaptation to unfolded protein load"
10:50 am - 11:00 amDiscussion
11:00 am - 11:15 amA. Nakai (Yamaguchi University)
"HSF1 plays a role in feedback regulation of the febrile response"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amI. Benjamin (University of Utah)
"New biosignatures for protein aggregation diseases"
11:40 am - 11:50 am Discussion
11:50 am - 12:10 pmJ. Weissman (Univ. of California, San Francisco)
"Telling right from wrong: quality control in the ER"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pm Aging and Longevity
Discussion Leader: Bernd Bukau (Universität Heidelberg)
7:30 pm - 7:50 pmT. Nystrom (Göteborg University)
"Segregation of damages proteins during asymmetrical and symmetrical cytokinesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmL. Guarente (MIT)
"Sirtuins, calorie restriction and aging"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:45 pmS. Korenblit (Univ. of California, San Francisco)
"IGF-1 pathway mutants"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmK. Blackwell (Harvard)
"Regulation of longevity factor SKN-1"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmA. De Maio (University of California, San Diego)
"HSP70 secretion"
9:25 pm - 9:30 pm Discussion
TUESDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm Cell Biology and Mechanism
Discussion Leader: Jeff Brodsky (University of Pittsburg)
9:00 am - 9:20 amY. Ohsumi (National Institute for Basic Biology)
"Critical Questions on the molecular mechanism of autophagy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amA. Kimchi (Weizmann Institute of Science)
"Switching between different forms of cell death - Systems level view of stress responses"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:45 amA. Mogk (Universität Heidelberg)
"Protein disaggregation of hybrid proteins consisting of labile and tightly folded domains"
10:45 am - 10:50 amDiscussion
10:50 am - 11:10 amK. Nagata (Kyoto University)
"Thiol reductase ERdj5 accelerates the ER-associated degradation by cleaving intermolecular disulfide bonds of misfolded proteins"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amS. Bernales (Fundacion Ciencia para la Vida, Santiago)
"Autophagy counterbalances ER expansion during the UPR"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amM. Niwa (University of California, San Diego)
"UPR regulation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJ. Brodsky (University of Pittsburgh)
"Diverse functions of molecular chaperones during the polyubiquitination and degradation of aberrant membrane proteins in the ER"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pm Oxidative and Metal-catalyzed Damage
Discussion Leader: Dennis Thiele (Duke University)
7:30 pm - 7:50 pmU. Jakob (University of Michigan)
"Hsp33-Activation by Redox-Induced Protein Unfolding"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmS. Merchant (Univ. of California, Los Angeles)
"Iron sparing mechanisms and metabolic remodeling in Fe-deficient Chlamydomonas"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:35 pmE. Nudler (New York University School of Medicine)
"Eukaryotic RNA Thermometer"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmK. Kohno (Nara Institute of Science and Technology)
"How Ire1 sees unfolded proteins"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmD. Thiele (Duke University Medical Center)
"Stress responses due to over- and under-accumulation of essential metals"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm Stress Sensing and Response
Discussion Leader: Lea Sistonen (Turku Centre for Biotechnology)
9:00 am - 9:20 amE. Deuerling (ZMBH Heidelberg)
"Molecular guardians for newborn proteins: ribosome-associated chaperones and their role in protein folding"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJ. Lis (Cornell University)
"Dissecting mechanisms of heat shock gene transcription and regulation"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amJ. Brickner (Northwestern University)
"DNA localization confers memory of previous transcriptional state"
10:50 am - 11:00 am Discussion
11:00 am - 11:15 amH. El Samad (Univ. of California, San Francisco)
"Control strategies in the cytoplasmic heat shock response of E. coli: Balancing unfolded proteins and the cost of folding them"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amE. Vierling (University of Arizona)
"Probing the sHSP structure and substrate interactions"
11:40 am - 11:50 am Discussion
11:50 am - 12:10 pmL. Sistonen (Turku Centre for Biotechnology)
"Multi-site post-translational regulation of heat shock transcription factors"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Role of Stress Proteins
Discussion Leader: Betty Craig (University of Wisconsin)
7:30 pm - 7:50 pmK. Morano (University of Texas Medical School, Houston)
"The Hsp110/Hsp70 partnership in yeast"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmM. Kuehn (Duke University)
"Outer Membrane Vesicles: A stress response pathway involved in bacterial virulence"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmZe’ev Ronai (The Burnham Institute)
"JAMP for (ER) stress"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmE. Craig (University of Wisconsin)
"Hsp70s and J-proteins: Versatile chaperone machines"
9:20 pm - 9:30 pmDiscussion
THURSDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm Protein Conformation Diseases
Discussion Leader: Jeff Kelly (Scripps Research Institute)
9:00 am - 9:20 amJ. Frydman (Stanford University)
"Pathways of misfolded protein quality control in the eukaryotic cytosol"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amW. Balch (Scripps Research Institute)
"Folding and misfolding space in protein trafficking disease"
9:50 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 10:50 amJ. Buxbaum (Scripps Research Institute)
"Extracellular deposition disease"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amA. Bertolotti (MRC Laboratory of Molecular Biology)
"Protein misfolding: Influence of the cellular environment"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 amM. Heikenwälder (Inst for Neuropathology, Zürich)
"Mammalian prions: The role of the immune system in prion pathogenesis"
11:45 am - 11:50 amDiscussion
11:50 am - 12:10 pmJ. Kelly (Scripps Research Institute)
"Understanding & ameliorating age onset neurodegenerative diseases"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
5:30 pm Reception, Cloisters Lawn
6:00 pmDinner
7:30 pm - 9:30 pm Metabolic and Nutritional Stress
Discussion Leader: C. Rodrigues-Pousada (Universidade Nova de Lisboa)
7:30 pm - 7:50 pmK. Ashrafi (University of California, San Francisco)
"Energy regulatory circuits in C. elegans"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmB. Tu (University of Texas Southwestern Medical Center)
"Logic of a metabolic cycle: Insights into the life of a yeast cell during nutrient-limited growth"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmJi-Sook Hahn (Seoul National University)
"Yak1 kinase, a bridge between nutrient signaling and stress response in S. cerevisiae"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmC. Rodrigues-Pousada (Universidade Nova de Lisboa)
"Yeast activator proteins and stress response in S.cerevisiae"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pm B. Bukau (Universität Heidelberg)
Concluding Remarks
FRIDAY
8:00 am - 9:00 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13AG030760-01 from the National Institute of Aging (NIA). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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