Gordon Research Conferences
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Conference Program
 
New Antibacterial Discovery & Development
March 9-14, 2008
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Robert E.W. Hancock

Vice Chair:
Jutta Heim

This Gordon Research Conference will bring together industry, academic and government leaders involved in the discovery and development of novel antibacterial agents. Antibacterial resistance has spread worldwide at an alarming rate, continues to increase, and presents a tremendous global health challenge. Multi-drug resistance has become commonplace in many disease-causing bacteria. Infections that were once easy to treat are becoming difficult, and in some cases, impossible to treat and people are suffering severe illness or dying as a consequence.

There is an acute need for novel antibacterials to combat this growing resistance. Therapeutically, antibacterials are unique compared to most other classes of drugs, due to the fact that resistance eventually renders these agents less efficacious with continued use. New effective antibacterial agents and therapies will therefore be needed on a continuing basis. Unfortunately, this new generation of antibacterials has proven extremely difficult to discover and develop. The pipeline of new antibacterials is drying up, industry has been exiting the field, and regulatory issues have made it harder and more expensive to get approvals. Future progress in the discovery and development of efficacious antibacterials will require the intense collaboration of researchers from many disciplines in academia, and the biotech and pharma industries, as well as the involvement of policy makers and regulators. This Conference will focus on the problems that stand in the way of successful sustained antibacterial discovery and development, as well as the innovation necessary to deliver these much needed new drugs to patients.


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome: Bob Hancock, Chair (University of British Columbia) / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmThe Picture Today and Tomorrow - Keynote Addresses
7:35 pm - 7:45 pm Discussion Leader: Trevor Trust (Astra Zeneca)
7:45 pm - 8:30 pm Julian Davies (University of British Columbia)
"Resistance: Lessons to learn"
8:30 pm - 9:15 pm Karen Bush (Johnson and Johnson)
"What is in the future for antibiotics?"
9:15 pm - 9:30 pm General Discussion
9:30 pm Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmConventional Targets
Discussion Leader: Lynn Silver (LL Silver Consulting)
9:00 am - 9:25 am Prabhavathi Fernandes (Cempra Pharmaceuticals Inc)
"What makes a good antibiotic target"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Roy Kishony (Harvard)
"Antibiotic interactions to discourage resistance development"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Hans Georg Sahl (U. Bonn)
"Cell Walls as a target"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break / Group Photo
11:20 am - 11:45 am Ann Eakin (Astra Zeneca)
"DNA synthesis as a target"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Roger C. Levesque (U. Laval)
"Cell Division as a target"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:15 pmPoster Session 1
5:30 pm - 7:30 pmScreening Strategies and Hit Generation
Discussion Leader: Tim Falla (Helix Biomedix)
5:30 pm - 5:55 pm Jay Hinton (Inst. Food Research, UK)
"Differences between in vitro and in vivo lifestyle"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:30 pm Dieter Habich (Bayer)
"Reversed genomics and chemical post-evolution of natural products - Sources for new antibacterials"
6:30 pm - 6:40 pm Discussion
6:40 pm - 7:05 pm Jennifer Leeds (Novartis)
"New screening strategies"
7:05 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Selected Poster Talk: Jonathan Swoboda (Harvard Medical School)
"Genetic analysis of Staphylococcus aureus Wall Teichoic Acid (WTA) biosynthesis and an in vivo high throughput screen for inhibitors targeting this pathway"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
9:15 pm - 11:00 pmPoster Session 1 (continued); Beverages available
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAlternative Antibacterial Approaches
Discussion Leader: William Shafer (Emory U. School of Medicine)
9:00 am - 9:25 am James Mond (BioSynexus)
"Therapeutic Antibodies"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Oreola Donini (Inimex Pharma)
"Selective Immunomodulators"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Vincent Fischetti (Rockefeller University)
"Using phage lytic enzymes to control pathogenic bacteria"
10:35 am - 10:45 am Discussion
10:45 am - 11:25 am Coffee Break
11:25 am - 11:50 am Alan Bocking (Mt. Sinai Hospital)
"Probiotics and Perinatal Health"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Selected Poster Talk: Anna Maria Pirttila (University of Oulu)
"Endophytic fungi as a source of new antimicrobials"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Selected Poster Talk: Elizabeth Moritz (University of Illinois)
"The prevalence of toxin-antitoxin systems in clinical isolates and investigation into their tractability as novel antimicrobial targets"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:15 pmPoster Session 2
5:30 pm - 6:30 pmPre-Clinical and Clinical Considerations
Discussion Leader: Julian Davies (University of British Columbia)
5:30 pm - 5:55 pm John Rex (Astra Zeneca)
"Clinical considerations for a new antibiotic"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:25 pm Keith Rodvold (PharmD)
"Infection site antibiotic concentrations and their meaning"
6:25 pm - 6:30 pm Discussion
6:30 pm - 7:30 pmCell Division and Antibiotic Signatures
6:30 pm - 6:40 pm Selected Poster Talk: Remco Kort (TNO Quality of Life)
"The fingerprints that antibiotics leave in the transcriptome of Staphylococcus aureus"
6:40 pm - 6:45 pm Discussion
6:45 pm - 6:55 pm Selected Poster Talk: Elizabeth Harry (University of Technology Sydney)
"Targeting cell division: The Z Ring assembles from a dynamic helical-like structure"
6:55 pm - 7:00 pm Discussion
7:00 pm - 7:10 pm Selected Poster Talk: Neil Stokes (Prolysis Limited)
"CDI-936 series of novel cell division inhibitors with potent and selective anti-staphylococcal activity"
7:10 pm - 7:15 pm Discussion
8:00 pmDinner
9:15 pm - 11:00 pmPoster Session 2 (continued); Beverages available
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGram Negative Active Drugs
Discussion Leader: Laura Piddock (Birmingham Medical School)
9:00 am - 9:25 am Matthew E. Falagas (Alfa Institute of Biomedical Sciences)
"Revival of the Polymyxins"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Tim Falla (Helix Biomedix)
"The evolution of the innate immunity antibiotic"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Dirk Buman (Hannover Medical School)
"Identifying new targets for Salmonella through in vivo screening"
10:35 am - 10:45 am Discussion
10:45 am - 11:25 am Coffee Break
11:25 am - 11:50 am Natalie Strynadka (Univ of British Columbia)
"Structural biology approaches to understanding antibiotic mechanisms and resistance"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Selected Poster Talk: Kristen Schurek (University of British Columbia)
"Identification of novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Selected Poster Talk: Ruslan Tsivkovski (MPEX Pharmaceuticals)
"Efflux pump inhibitors (EPIs): Multiple ways to inhibit a single pump"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:15 pmPoster Session 3
5:30 pm - 7:30 pmNovel Targets and Overcoming Resistance
Discussion Leader: Jared Silverman (Cubist Pharmaceuticals)
5:30 pm - 5:55 pm Patricia Bradford (Wyeth)
"Where are we with Resistance?"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:25 pm Sheo Singh (Merck)
"New strategies to develop novel targets: Platensimycin, a selective FabF inhibitor"
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:55 pm Satoshi Murakami (Institute of Scientific and Industrial Research, Osaka University)
"Structure and mechanism of bacterial multi-drug efflux systems"
6:55 pm - 7:00 pm Discussion
7:00 pm - 7:25 pm Eric Brown (McMaster U)
"Probing uncharted physiology in bacteria with new (and old) small molecules"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
9:15 pm - 11:00 pmPoster Session 3 (continued); Beverages available
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:10 amSelected Topics & Late Breakers
Discussion Leaders: Patrice Courvalin (Institut Pasteur)
9:00 am - 10:40 amSelected Topics and Late Breakers: Attendees are invited to discuss topics of interest in less than 5 minutes with 5 slides (strictly regulated). Presenters will be selected at the Gordon Conference by the Chair.
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
11:30 am - 12:30 pmRecent Experience with Clinical Trials
Discussion Leader: Patricia Bradford (Wyeth)
11:30 am - 11:55 am Jutta Heim (Basilea)
"Anti-resistance; ceftobiprole, an anti-MRSA broad-spectrum cephalosporin antibiotic"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pm Bruce Montgomery (Gilead Sciences)
"Inhaled antibiotics"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmTowards More Efficient Antibacterial Development
Discussion Leader: Keith Poole (Queens U)
5:30 pm - 5:55 pm Jacques Schrenzel (U Hospitals Geneva)
"Combined proteomics and transcriptomics approach for the identification of resistance-related markers: glycopeptide-resistance in Staph. aureus"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:30 pm Rod Hubbard (York U)
"Fragment-based drug discovery"
6:30 pm - 6:40 pm Discussion
6:40 pm - 7:05 pm Rudolf Then (Consultant)
"Multiple mode of action antibiotics: some lessons from nature and application in antibiotic design"
7:05 pm - 7:15 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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