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Conference Program
 
Autophagy in Stress, Development & Disease
January 6-11, 2008
Ventura Beach Marriott
Ventura, CA
Chair:
Ana Maria Cuervo

Vice Chair:
Noboru Mizushima

Autophagy is a catabolic process involved in a wide array of cellular events including development, aging, immunity and cell death. It is evolutionarily conserved and ubiquitous among eukaryotic cells. In higher eukaryotes, autophagic dysfunction has been associated with cancer, certain muscular diseases and neurodegeneration. Autophagic pathways differ in the way that cytosolic components and organelles are delivered to the lysosome or vacuole. In recent years, morphological, genetic, biochemical and cell biological approaches have begun to provide insight into the molecular mechanisms underlying autophagy.

This Gordon Research Conference is an ideal venue for both experts and newcomers to the field of autophagy research. Given recent development that have placed autophagy at the frontiers of science, this conference is extremely timely. The conference will bring together leading international scientists with a broad range of interests related to diverse aspects of autophagy, with the goal that their presentations and interactions will promote the evolution of new concepts and research directions.

The goals of this meeting are to facilitate an integrated approach to defining the role of autophagy in physiological and pathological processes and to elucidate the mechanism of the autophagic pathways in various organisms. International experts studying autophagy in model systems will discuss the most recent results in this rapidly emerging field.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:45 pmWelcome / Introductory Comments by GRC Site Staff
Chair: Ana Maria Cuervo (Albert Einstein College of Medicine)
Vice-Chair: Noboru Mizushima (Tokyo Medical and Dental University)
7:45 pm - 9:30 pm AUTOPHAGY: TWO YEARS LATER…
7:45 pm - 9:15 pm Keynote Speakers
7:45 pm - 7:50 pm Introduction: Patrice Codogno (INSERM, University of Paris)
7:50 pm - 8:20 pmBeth Levine (University of Texas Southwestern)
"Autophagy in stress, development and disease: past, present and future directions"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:35 pm Introduction: William Dunn (University of Florida)
8:35 pm - 9:05 pmJames Fred Dice (Tufts University)
"Chaperone-mediated autophagy"
9:05 pm - 9:15 pm Discussion
9:30 pm - 11:30 pm Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MOLECULAR DISECTION OF MACROAUTOPHAGY
9:00 am - 9:05 amDiscussion Leader: Suresh Subramani (University of California)
9:05 am - 9:25 amYoshinori Ohsumi (National Institute for Basic Biology)
"Mechanism of autophagosome formation in yeast"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amSharon Tooze (London Research Institute)
"Role of COPI in autophagosome formation and maturation"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 amTamotsu Yoshimori (Osaka University)
"Where they come from?: Mechanistic insight into autophagosome formation in mammals"
10:25 am - 10:35 am Discussion
10:35 am - 10:55 amZvulun Elazar (Weizmann Institute of Science)
"Involvement of mammalian Atg8s in early stages of autophagosomes biogenesis"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Coffee Break / Group Photo (11:15 am)
11:30 am - 11:50 amEeva-Liisa Eskelinen (Univeristy of Helsinki)
"Formation and maturation of autophagosomes in mammalian cells"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Francesco Cecconi (University of Rome Tor Vergata)
"Regulation of Ambra1-dependent autophagy by the microtubular dynein motor complex"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Poster Session I - Briefing (Odd Numbers)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I / Reception
6:00 pmDinner
7:30 pm - 9:30 pm MACROAUTOPHAGY: FROM COMPONENTS TO REGULATION AND BACK
7:30 pm - 7:35 pmDiscussion Leader: Alfred J. Meijer (University of Amsterdam)
7:35 pm - 7:55 pmMichael Thumm (Georg August University)
"Looking into the molecular mechanism of autophagy in S. cerevisiae"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pmMaria Isabel Colombo (Universidad Nacional de Cuyo)
"Interaction between the autophagic and endocytic pathways: molecular components"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pmTomas Neufeld (University of Minnesota)
"Nutrient-dependent control of autophagy in Drosophila: forward and feedback signaling in a TOR-Vps34 network"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:20 pmSatoshi Tsukamoto (Tokyo Medical and Dental University)
"Role of autophagy in early embryogenesis in mice"
9:20 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm General Discussion / Burning questions
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:25 am MACROAUTOPHAGY AND ORGANELLE DEGRADATION
9:00 am - 9:05 amDiscussion Leader: John Lemasters (University of North Carolina)
9:05 am - 9:25 amRod Devenish (Monash University)
"Uncovering non-canonical autophagy in yeast?"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amVictor Shengkan Jin (UMDNJ - Robert Wood Johnson Medical School)
"The role of autophagy in mitochondria degradation"
9:55 am - 10:05 am Discussion
10:05 am - 10:20 am Hagai Abeliovich (Hebrew University of Jerusalem)
"Role of mitochondrial fission in the regulation of mitophagy"
10:20 am - 10:25 am Discussion
10:25 am - 11:00 am Coffee Break
11:00 am - 12:30 pm SPECIALIZED AUTOPHAGY I: SOLUBLE PROTEINS
11:00 am - 11:05 amDiscussion Leader: James Fred Dice "Paulo" (Tufts University)
11:05 am - 11:25 amHui-Ling Chiang (Penn State College of Medicine)
"Coatomers and the vacuole import and degradation pathway"
11:25 am - 11:35 am Discussion
11:35 am - 11:55 amE. Knecht (Instituto de Investigaciones Principe Felipe)
"Regulation of lysosomal pathways different from macroautophagy in mammalian cells"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Marco Sandri (Venetian Institute of Molecular Medicine)
"FoxO3 coordinates ubiquitin-proteasome and autophagy-lysosome systems during muscle wasting"
12:20 pm - 12:25 pm Discussion
12:25 pm - 12:30 pm General Discussion / Burning questions
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Activities: Whale Watching Trip, Soccer Game
4:00 pm - 6:00 pmPoster Session I / Reception
6:00 pmDinner
7:30 pm - 9:30 pm SPECIALIZED AUTOPHAGY II: ORGANELLES
Discussion Leader: James Fred Dice "Paulo" (Tufts University)
7:30 pm - 7:50 pmDavid Goldfarb (University of Rochester)
"Linking the inner and outer nuclear membranes during microautophagy of the nucleus in S. cerevisiae"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmWilliam Dunn (University of Florida)
"Dissecting the molecular events of micropexophagy and macropexophagy"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmSuresh Subramani (University of California)
"The role of selective Atg-proteins in macropexophagy of the peroxisomes in P. pastoris"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmIda van der Klei (University of Groningen)
"Peroxisome degradation in the yeast Hansenula polymorpha"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm AUTOPHAGY: NATIVE AND ADQUIRED IMMUNITY
9:00 am - 9:05 amDiscussion Leader: Marisa Colombo (Universidad Nacional de Cuyo)
9:05 am - 9:25 amVojo Deretic (University of New Mexico)
"Autophagy and immunity: from tuberculosis to Crohn's disease and beyond"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 amChristian Munz (The Rockefeller University)
"Antigen presentation on MHC class II molecules after autophagy"
9:55 am - 10:05 am Discussion
10:05 am - 10:20 am Miguel A. Sanjuan (St. Jude Children’s Research Hospital)
"Toll-Like Receptor Signaling in Macrophages Links the Autophagy Pathway to Phagocytosis"
10:20 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:15 amAkiko Iwasaki (Yale University)
"Autophagy and antiviral immunity"
11:15 am - 11:25 am Discussion
11:25 am - 11:45 amHebert Virgin (University of Washington)
"Role of ATG5 in innate and adaptive immunity and ATG16 in ileal innate immune cell functions"
11:45 am - 11:55 am Discussion
11:55 am - 12:15 pmMartine Biard-Piechaczyk (CPBS, Montpellier, France)
"Role of HIV-1 envelope proteins in autophagy and apoptosis of uninfected CD4 T cells"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Poster Session II - Briefing (Even Numbers)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II / Reception
6:00 pmDinner / Announcement Winning Posters (4)
7:30 pm - 9:30 pm AUTOPHAGY, POLYUBIQUITIN AND AGGREGOPATHIES
Discussion Leader: Charleen T. Chu (University of Pittsburgh School of Medicine)
7:30 pm - 7:50 pmTerje Johansen (University of Tromsøe)
"Role of p62/SQSTM1 in autophagic degradation of polyubiquitinated protein aggregates"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmDavid Rubinsztein (University of Cambridge)
"Helping autophagy enhance clearance of aggregate-prone intracytosolic proteins"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmMasaaki Komatsu (Juntendo University)
"Role of p62/SQSTM1 degradation by autophagy in cytoplasmic inclusion formation"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmRalph Nixon (New York University)
"Autophagy dysfunction in Alzheimer's disease and AD mouse models"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm AUTOPHAGY AND DISEASE
9:00 am - 9:05 amDiscussion Leader: Ralph Nixon (New York University)
9:05 am - 9:25 amAndrew Thorburn (University of Colorado)
"Targeted therapy-induced autophagy and the control of tumor cell death mechanisms"
9:25 am - 9:35 am Discussion
9:35 am - 9:50 am Zhenyu Yue (Mount Sinai School of Medicine)
"Neuronal Autophagy in Axons and the Implication of Dysfunctional Autophagy in Axonopathy"
9:50 am - 9:55 am Discussion
9:55 am - 10:15 amPatrice Codogno (INSERM, University of Paris)
"Canonical and noncanonical macroautophagy in cancer cells"
10:15 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:10 am Paul Taylor (University of Philadelphia)
"HDAC6 facilitates autophagic degradation of misfolded protein aggregates"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 amEileen P. White (The Cancer Institute of New Jersey)
"Role of autophagy in cancer"
11:35 am - 11:45 am Discussion
11:45 am - 12:30 pm Winning Poster Presentations (4 talks 5 min + 3 min questions)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Activities: Wine Trip, Softball game, Beach Volleyball
4:00 pm - 6:00 pmPoster Session II / Reception
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm AUTOPHAGY, CELL DEATH AND AGING
7:30 pm - 7:35 pmDiscussion Leader: Ettore Bergamini (University of Pisa)
7:35 pm - 7:50 pmSusmita Kaushik (Albert Einstein College of Medicine)
"Impaired chaperone-mediated autophagy in aging"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pmJayanta Debnath (University of California)
"Autophagy and cell survival during extracellular matrix detachment"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:45 pmKevin M. Ryan (Beatson Institute for Cancer Research)
"Identifying the factors that determine specificity in the autophagic response"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmAdi Kimchi (Weizmann Institute of Science)
"Cross-talk between autophagy and apoptosis"
9:15 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Closing Remarks
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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