Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
 
 
QUICK SEARCH
GO
[ advanced search ]
 
 
 
Basement Membranes
June 22-27, 2008
University of New England
Biddeford, ME
Chair:
Jeffrey H. Miner

Vice Chair:
Monique M. Aumailley

The 2008 Basement Membranes Gordon Research Conference will be the fourteenth in a highly successful series of biannual meetings that have been major international forums for dissemination of new concepts regarding the structure and function of basement membranes and their receptors. Basement membranes are complex extracellular structures that play crucial roles in the organization and function of most tissues and organs, including muscle, skin, blood vessels, brain, heart, lung, eye, kidney, and peripheral nerves. This conference has traditionally attracted both senior and junior scientists from a wide range of fields, including protein structure, cell and developmental biology, pathology, and neurobiology. In addition, it has been attended by clinicians and scientists involved in research and/or treatment of human disorders involving basement membranes. The 2008 Conference will present a diverse mixture of sessions on basement membrane protein structure, biosynthesis, assembly, receptors, and function during development and in disease. The meeting will feature an exciting program that includes a keynote lecture by Joan Brugge.

In addition to invited speakers, there will be numerous opportunities throughout the conference for oral presentations by graduate students, postdocs, and junior faculty based on submitted abstracts.

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:45 pmWelcome / Introductory Comments by GRC Site Staff and
Conference Chair, Jeff Miner
7:45 pm - 9:30 pm STRUCTURAL ASPECTS OF BASEMENT MEMBRANE PROTEINS
Discussion Leader: Billy Hudson (Vanderbilt University Medical Center, Nashville)
7:45 pm - 8:10 pmBilly Hudson (Vanderbilt University Medical Center, Nashville)
"Glomerular basement membrane: assembly, novel crosslinks, and auto- and allo-epitopes of the α3α4α5 collagen IV network"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmKiyotoshi Sekiguchi (Osaka University, Osaka)
"Molecular basis of basement membrane recognition by integrins"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmMats Paulsson (University of Cologne, Cologne)
"Structure and interactions of laminin short arms"
9:20 pm - 9:30 pm Discussion
9:30 pm Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm BASEMENT MEMBRANES: GENETICS AND ROLES IN DEVELOPMENT
Discussion Leader: Lynn Sakai (Shriners Hospital for Children, Portland)
9:00 am - 9:25 amDavid Sherwood (Duke University, Durham)
"Breaching the basement membrane: anchor cell invasion in C. elegans"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amJean Schwarzbauer (Princeton University, Princeton)
"Regulation of C. elegans gonadal leader cell migration by integrins and extracellular matrix"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amSunita Kramer (Robert Wood Johnson Medical School/UMDNJ, Piscataway)
"Genetics of heart tube assembly in Drosophila"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 amLynn Sakai (Shriners Hospital for Children, Portland)
"Extracellular regulation of growth factor signaling by fibrillin microfibrils"
11:40 am - 11:50 am Discussion
11:50 am - 12:05 pm Short Talk: Dong-Hua Yang (UMDNJ/RWJMS, Piscataway)
"A generalized reduction of laminin gamma1 subunit causes a lelective peripheral nerve myelination defect"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Short Talk: Karolina Rasi (University of Oulu)
"Mice lacking type XV collagen and laminin alpha4 show developmental alterations of sciatic nerves"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm BASEMENT MEMBRANES IN NEURAL DEVELOPMENT AND FUNCTION
Discussion Leader: Joshua Sanes (Harvard University, Cambridge)
7:30 pm - 7:55 pmJoshua Sanes (Harvard University, Cambridge)
"Synaptic organizing molecules of the basal lamina"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmUli Mueller (Scripps Research Institute, La Jolla)
"Integrin functions in neural stem and precursor cells"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmJames Fawcett (Cambridge University, Cambridge)
"Extracellular matrix structures in the control of plasticity"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Short Talk: Xianhua Piao (Children’s Hospital/Harvard Medical School, Boston)
"GPR56 regulates pial basement membrane integrity and cortical lamination"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm THE DISH AND BEYOND: NOVEL INSIGHTS INTO BASEMENT MEMBRANE BIOLOGY
Discussion Leader: Monique Aumailley (University of Cologne, Cologne)
9:00 am - 9:25 amDennis Discher (University of Pennsylvania, Philadelphia)
"Matrix elasticity directs stem cell lineage specification"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amStephen Weiss (University of Michigan, Ann Arbor)
"Membrane-tethered MMPs and the regulation of basement membrane cellular traffic"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amArnoud Sonnenberg (The Netherlands Cancer Institute, Amsterdam)
"Roles of the integrins alpha3beta1 and alpha6beta4 in keratinocyte migration"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 amMonique Aumailley (University of Cologne, Cologne)
"Laminin signaling in the skin"
11:40 am - 11:50 am Discussion
11:50 am - 12:05 pm Short Talk: Normand Pouliot (Peter Maccallum Cancer Centre, East Melbourne)
"Combined in vitro and in vivo strategies to isolate bone metastatic breast tumor variants identify laminin-511 as a potent pro-metastatic substrate"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Short Talk: Erhard Hohenester (Imperial College, London)
"Structural basis of sequence-specific collagen recognition by SPARC"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm PROTEOGLYCANS
Discussion Leader: Renato Iozzo (Thomas Jefferson University, Philadelphia)
7:30 pm - 7:55 pmRenato Iozzo (Thomas Jefferson University, Philadelphia)
"Key roles for perlecan in skeletal muscle and cardiovascular development"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmYoshi Yamada (National Institute of Dental and Craniofacial Research, Bethesda)
"Multiple roles of perlecan in development and adult tissue functions"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmRob Burgess (The Jackson Laboratory, Bar Harbor)
"Partial loss of function caused by a point mutation in the SEA domain of agrin"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Short Talk: Markus Rüegg (University of Basel, Biozentrum)
"Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm BASEMENT MEMBRANES AND DISEASE
Discussion Leader: Ulrike Mayer (University of East Anglia, Norwich)
9:00 am - 9:25 amLeena Bruckner-Tuderman (University Medical Center, Freiburg)
"Collagen VII hypomorphic mouse: a model for cell therapy for dystrophic epidermolysis bullosa"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amUlrike Mayer (University of East Anglia, Norwich)
"Integrin function in heart and skeletal muscle"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amKevin Campbell (HHMI/University of Iowa, Iowa City)
"Molecular insights into dystroglycan function"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 amDoug Gould (University of California at San Francisco, San Francisco)
"Pleiotropy of the Col4a1 phenotypic spectrum includes neuronal lamination defects"
11:40 am - 11:50 am Discussion
11:50 am - 12:05 pm Short Talk: Eileen Hwang (UMDNJ RWJMS, Piscataway)
"Folding renucleation after a sequence interruption in type IV collagen"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Short Talk: Maria Luisa Oppizzi (California Pacific Medical Center, San Francisco)
"Beta-dystroglycan trafficking to the nucleus points to functional diversification enabled by SEA autoproteolysis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:15 pm - 7:45 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:45 pm - 9:30 pm BASEMENT MEMBRANES AND ORGANOGENESIS
Discussion Leader: Matthew Hoffman (National Institute of Dental and Craniofacial Research, Bethesda)
7:45 pm - 8:10 pmNguyet Nguyen (Washington University, St. Louis)
"Laminin alpha5 and the lung: the plot thickens"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmMatthew Hoffman (National Institute of Dental and Craniofacial Research, Bethesda)
"Basement membrane remodeling during branching morphogenesis"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmPeter Yurchenco (Robert Wood Johnson Medical School/UMDNJ, Piscataway)
"Role of gamma1 laminins and their receptors in renal collecting duct epithelial cell polarization and proliferation"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MATRIX RECEPTORS AND SIGNALING
Discussion Leader: Reinhard Faessler (Max Planck Institute for Biochemistry, Martinsried)
9:00 am - 9:25 am Reinhard Faessler (Max Planck Institute for Biochemistry, Martinsried)
"Genetic analysis of integrin signaling"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Erica Golemis (Fox Chase Cancer Center, Philadelphia)
"Coordinated deregulation of cell adhesion and cell cycle in NEDD9-induced metastasis"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 am Alexander Bershadsky (Weizmann Institute of Science, Rehovot)
"Mechanical and signaling aspects of crosstalk between cell adhesions and the cytoskeleton"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Ohad Medalia (The Ben Gurion University, Beer-Sheva)
"The molecular architecture of integrin-mediated focal adhesion revealed by cryo-electron tomography"
11:40 am - 11:50 am Discussion
11:50 am - 12:05 pm Short Talk: Corinne Albiges-Rizo (Inserm U823, Grenoble)
"Cell adaptive response to extracellular matrix is controlled by ICAP-1-dependent beta1-integrin affinity"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Short Talk: Xi Zhang (Vanderbilt University, Nashville)
"Beta1 integrin plays a critical role in ureteric bud branching morphogenesis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pm KEYNOTE PRESENTATION AND HOT TOPICS
Discussion Leader: Charles Streuli (University of Manchester)
7:30 pm - 8:15 pmJoan Brugge (Harvard Medical School, Boston)
"Live free or die: Extracellular matrix control of epithelial cell viability"
8:15 pm - 8:30 pm Discussion
8:30 pm - 9:30 pmHot Topics: Four short talks from submitted abstracts
8:30 pm - 8:40 pmDixie Pinke (University of Ottawa)
"Control of three-dimensional breast morphogenesis through the protein elongation factor eEF1A2"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmJenny Kruegel (University of Goettingen)
"Nidogen-1 and nidogen-2 - the basement membrane-equivalent in the pericellular matrix of human chondrocytes"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmGerman Pinzon-Duarte (State University of New York Downstate Medical Center, Brooklyn)
"Laminin ablation from ILM induces progressive retinal ganglion cell loss and abnormal axonal trajectories"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmJenne Relucio (State University of New York, Stony Brook)
"Fyn dysregulation accompanies delayed oligodendrocyte differentiation in laminin-deficient brains"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by R13AR056151 from the National Institute of Arthritis And Musculoskeletal and Skin Diseases (NIAMS), Office of the Director, National Institutes of Health (OD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and National Institute of Child Health and Human Development (NICHD), and the Office of Rare Diseases (ORD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
© 2013 Gordon Research Conferences. All Rights Reserved. Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter