Gordon Research Conferences
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Conference Program
 
Bioelectrochemistry
July 20-25, 2008
University of New England
Biddeford, ME
Chair:
Ann M. Rajnicek

Vice Chair:
Julie Gehl

Conference Theme:
Bioelectrical control of cells and tissues: its potential for novel clinical therapies

The conference will focus on electric field interactions with cells, from the scale of tissue and whole cell behaviour to the molecular and nanoscale processes underpinning electrical effects. Sessions will emphasize the latest advances in understanding of the biology and biophysics of electric field interactions with cells, with contributions from dynamic speakers and discussion leaders from the international scientific community and industry.

Relevance and Aim
The ability to control cell behaviour electrically offers exciting opportunities to develop novel clinical therapies for wound healing, tissue regeneration, stem cell therapies, control of nervous system function, and electroporation-based delivery of genes or drugs. These concepts are emerging clinically but will only reach their potential with better understanding of the basic processes underpinning their effects. The major aim of the conference will be to understand how electric fields control cell function and therefore establish a basis on which to develop further biomedical applications. Since the process of tissue repair often reiterates normal development, discussion topics will incorporate understanding how electrical stimuli control normal development as well as wound healing, cell migration, stem cell differentiation, and tissue regeneration. In the context of clinical use of DNA electrotransfer for gene therapy, discussions will explore the mechanisms by which DNA enters cells and the conditions for optimal gene expression.

Target Audience
This cross-disciplinary conference is suitable for cell biologists, developmental biologists, biophysicists, electrochemists, neurobiologists, cancer biologists, membrane biologists, and medical doctors dedicated to translational research. Industrial participation is encouraged. The ability to cross-fertilise ideas between disciplines is a particular strength of the conference. Time is built into the schedule for networking via informal discussion and social interaction.

Attendees are encouraged to present posters that stimulate additional discussions. The conference provides an excellent opportunity for junior researchers (e.g. graduate students or postdocs) to present their work to leaders in the field within a uniquely constructive atmosphere.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Control of cell function and differentiation by extracellular electric fields
Discussion Leader: Raphael C. Lee (University of Chicago Medical Center, USA)
7:40 pm - 8:20 pmHoracio Cantiello (Massachusetts General Hospital, USA)
"Electrodynamic properties of cytoskeletal elements and their potential role in cell function"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmMichael Cho (University of Illinois, USA)
"Facilitated stem cell differentiation mediated by non-invasive electrical stimulation and tissue engineering applications"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm Using electric fields for cancer detection and therapy
Discussion Leader: Dietmar Rabussay (Genetronics Inc, USA)
9:00 am - 9:40 amAnarosa Arcangeli (University of Firenze, Italy)
"Unconventional ion channel signalling in cancer cells: interaction between K+ channels, adhesion receptors and metastasis"
9:40 am - 10:00 am Discussion
10:00 amCoffee Break
10:30 am - 11:10 amMustafa Djamgoz (Imperial College, UK)
"Tumor detection by changes in tissue electrical potential and control of metastasis with electric fields"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmRichard Nuccitelli (BioElectroMed Corp, USA)
"Detection and treatment of malignant skin lesions using electric fields"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Gene electrotransfer to cells and tissues
Discussion Leader: Pernille Hojman (Copenhagen University Hospital, Denmark)
7:30 pm - 8:10 pmLluis Mir (CNRS, France)
"Gene electrotransfer to muscle: a view with future prospects"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmHanne Gissel (Aarhus University, Denmark)
"Muscle function and integrity after DNA electrotransfer: mechanistic roles of ion pores and pumps"
9:10 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Electrical control of stem cell differentiation and regeneration
Discussion Leader: Joachim Wegener (Muenster, Germany)
9:00 am - 9:40 amMichael Levin (Forsyth Institute, USA)
"Bioelectric signals link cellular and embryo-wide polarity in left-right patterning"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amDany Adams (Forsyth Institute, USA)
"Hydrogen ion gradients control regeneration and development"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmNestor Oviedo (Forsyth Institute, USA)
"Bioelectric control of regeneration and stem cell regulation"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Electric field effects at the membrane
Discussion Leader: Discussion Leader: Eberhard Neumann (University of Bielefeld, Germany)
7:30 pm - 8:10 pmYasushi Okamura (Okazaki Center for Integrative Bioscience, Japan)
"Mechanisms of voltage-sensing phosphoinositide phosphatases: linking electrical signals and phosphoinositide signals"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmLeslie Loew (University of Connecticut Health Center, USA)
"New Optical Probes for imaging membrane potential"
9:10 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Electrical control of CNS function and repair
Discussion Leader: Colin McCaig (University of Aberdeen, UK)
9:00 am - 9:40 amSteven Schiff (Penn State University, USA)
"Towards spatiotemporal control of brain cortex with feedback electrical fields"
9:40 am - 10:00 am Discussion
10:00 amCoffee Break
10:30 am - 11:10 amJed Hartings (University of Cincinnati, USA)
"Cortical spreading depolarizations following acute injury to the human brain"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmJorge Collazos-Castro (Hospital Nacional de Paraplejicos, Spain)
"Development of an electrochemical device for stimulation of mammalian spinal cord repair"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Post electrotransfer of genes: DNA transport to the nucleus
Discussion Leader: Richard Heller (University of South Florida, USA)
7:30 pm - 8:10 pmMarie-Pierre Rols (IPBS-CNRS, France)
"DNA/membrane interaction: a key step in gene electrotransfer"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmDavid Dean (University of Rochester, USA)
"Augmenting post electrotransfer of DNA to the nucleus: mechanisms and applications"
9:10 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Controlling cell responses to electric fields: wound healing
Discussion Leader: Frank Hart (USA)
9:00 am - 9:40 amAnn Rajnicek (UK)
"Guiding nerves and epithelial cells with electrical and mechanical cues"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amRomana Kucerova (UK)
"Electrical control of mouse wound healing by the transcription factor Pax6"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmChristine Pullar (Leicester University, UK)
"Cellular mechanisms that control guidance of keratinocyte migration and re-epithelialisation by electric fields"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Hot Topics
Discussion Leader: Julie Gehl (Copenhagen University Hospital, Denmark)
7:30 pm - 8:10 pmRaoul Kopelman (University of Michigan, USA)
"Voltage-sensing in living cells with ‘Nanopebbles’"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Thomas Heimburg (Niels Bohr Institute, University of Copenhagen, Denmark)
"The action potential as a propagating density pulse"
9:10 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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