Gordon Research Conferences
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Conference Program
 
Cancer Models & Mechanisms
July 27 - August 1, 2008
Bryant University
Smithfield, RI
Chair:
Gerard I. Evan

Vice Chair:
Andreas Trumpp

Cancer is a bewilderingly complex ensemble of diseases all sharing, at their heart, various genetic dysfunctions in pathways that regulate cell growth, proliferation, differentiation, survival and interactions with the somatic microenvironment. Advances in the molecular anatomy of cancers has indicated a plethora of potential targets that are either directly mutated in cancers or act as downstream effectors of mutated pathways. Already, the number of new therapeutics greatly exceeds the capacity for clinical trials, necessitating the increasing use of pre-clinical models. Fortunately, the remarkable conservation of signaling and regulatory pathways within metazoans means that the whole repertoire of model organisms can be gainfully enlisted in the identification, functional elucidation and pharmacological validation of targets. Each type of model systems has unique advantages and disadvantages – some excel in experimental, biochemical and genetic tractability, others lend themselves to large scale and rapid throughput screens, while others more closely emulate their cognate human pathologies.

This conference is unique in bringing together leading authorities working with yeast, worms, flies, frogs, mice and, increasingly, human patients – all of whom share the overarching aim of understanding the mechanisms underpinning genesis, evolution and maintenance of cancers. Both basic and translational cancer research stands to gain much from the breadth of insights that such diverse model systems offer. This conferencewill acquaint participants from academia and industry with the diverse set of tools now available with which to understand cancers and work out how best to treat them.


SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Keynote Lectures
7:40 pm - 8:25 pmDavid Tuveson (CRI, University of Cambridge, UK)
"Using the mouse to model pancreatic cancer"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20pmMike Tyers (University of Ediburgh)
"Computational deconvolution of signaling networks"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm Ras and its motley crew
Discussion Leader: Celeste Simon (U. Penn)
9:00 am - 9:50 amJulian Downward (CR UK, London)
"Oncogenic signaling by Ras"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:20 amPhilippe Bastiaens (Max Planck Institute of Molecular Physiology)
"Spatial organisation of Ras signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 12:20 pmJeffrey Settleman
"Addiction to Oncogenic Kinases in Human Cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursions
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOncogenesis and tumor suppression I
Discussion Leader: Alan Clarke (Cardiff University, Wales)
7:30 pm - 8:20 pmRene Bernards (Netherlands Cancer Institute)
"Genome-wide screens for novel oncogenes and tumor suppressors"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmJacqueline Lees (MIT)
"The Rb tumor suppressor - new functions and tumor models"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Oncogenesis and tumor suppression II
Discussion Leader: William Kaelin Jnr (Dana Farber Cancer Inst.)
9:00 am - 9:50 amAndreas Trumpp (ISREC)
"Modeling Myc oncogenesis in vivo"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:20 amDean Felsher (Stanford)
"Switchable mouse models of human cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 am Scott Cameron (UT Southwestern)
"Transcriptional control of programmed cell death in cell lineages and in cancer"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmMonica Boyle (Salk Institute)
"Stem Cell-Niche Cell interactions during Tumorigenesis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursions
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOncogenesis and tumor suppression III
Discussion Leader: Jaqueline Lees (MIT)
7:30 pm - 8:20 pmAlan Clarke (U. Cardiff, Wales, UK)
"Dissecting oncogenic signaling in the GI tract"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmKaren Cichowski (Brigham & Women's Hospital, Boston)
"Unexpected mechanisms of Ras activation in tumorigenesis and metastasis"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Tumors and their microenvironments
Discussion Leader: Andreas Trumpp (ISREC)
9:00 am - 9:50 amCeleste Simon (U. Penn)
"How cells cope with hypoxia"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:20 amWilliam Kaelin Jnr (DFCI)
"Hypoxic signaling in tumors"
11:20 am - 11:30 amDiscussion
11:30 am - 12:20 pmMartin Oft (Scherring-Plough Research Institute, Palo Alto)
"IL-23 induces the Flip Flop from tumor immune surveillance to tumor promoting inflammation"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursions
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmThe mouse as a cancer model
Discussion Leader: Leisa Johnson (Genentech Inc.)
7:30 pm - 8:20 pmLeisa Johnson (Genentech)
"Genetically Engineered Mouse Models of Oncology: A New Frontier in Translational Medicine"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmGerard Evan (UCSF)
"Modeling cancer therapies of the future in vivo"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Understanding and killing cancer cells I
Discussion Leader: Dean Felsher (Stanford)
9:00 am - 9:50 amClodagh O’Shea (Salk Institute)
"Designing and optimizing oncolytic viruses"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:20 amGalit Lahav (Harvard Medical School)
"Deconstructing the p53 signaling network"
11:20 am - 11:30 am Discussion
11:30 am - 12:20 pmMarcus Peter (U. Chicago)
"The role of microRNAs in tumor progression"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursions
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Understanding and killing cancer cells II
Discussion Leader: Julian Downward (CR UK, London)
7:30 pm - 8:20 pmNavdeep Chandel (Northwestern University)
"The role of mitochondria in cellular homeostasis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmJohn Abrams (UTSW)
"Communal cell death and p53 response networks in Drosophila"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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