Gordon Research Conferences
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Conference Program
 
Cardiac Regulatory Mechanisms
July 20-25, 2008
Colby-Sawyer College
New London, NH

The unifying theme of the conference will be "Ca" as a modulator of contractility, electrical properties, and pathological phenotypes. This is an exciting time in cardiac research and we will highlight scientists advancing basic knowledge and also translating findings in molecular and cellular biology to the prevention and treatment of cardiac pathology. We will explore how cardiac myocytes regulate global and local Ca and how these changed are transduced into changes in signaling pathways and gene expression. Cell death and repair will also be considered. A goal will be to bring together talented scientists using different approaches to explore far ranging aspects of cardiac regulation. There will be presentations and discussion of specific molecular mechanisms regulating cardiac function with a balance between functional properties of the heart (rate, rhythm and contractility) and signaling mechanisms that control myocyte growth and hypertrophy.


Contributors
Boehringer Ingelheim Pharmaceuticals, Inc.
Boston Scientific Corporation
Cairn Research Ltd.
Cardiac Muscle Society
Carl Zeiss, Inc.
Chroma Technology Corporation
CV Therapeutics
Cytokinetics, Inc.
Medtronic, Inc.
Merck & Co., Inc.
National Institutes Of Health
Omega Engineering, Inc.
Pacer Scientific Instruments
Pfizer, Inc.
Sophion Bioscience, Inc.
St. Jude Medical

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmThe Surface Membrane
Discussion Leaders: Donald Bers (University of California, Davis) & Katharine Dibb (University of Manchester, UK)
7:35 pm - 8:03 pm Robert S. Kass (Columbia University)
"Regulatory roles of the KCNE1 subunit in arrhythmias linked to the IKs potassium channel"
8:03 pm - 8:13 pm Discussion
8:13 pm - 8:41 pm Kenneth Philipson (University of California, Los Angeles)
"Sodium-calcium exchange: A tale of two sites"
8:41 pm - 8:51 pm Discussion
8:51 pm - 9:20 pm Stanley Nattel (Montreal Heart Institute, Canada)
"Molecular mechanisms of atrial arrhythmogenesis"
9:20 pm - 9:30 pm Discussion
9:30 pm Opening Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSERCA
Discussion Leaders: W. Jonathan Lederer (University of Maryland Biotechnology Institute) & Aarif Khakoo (University of Texas)
9:00 am - 9:30 am Larry R. Jones (Indiana University)
"Phospholamban and molecular regulation of SERCA"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Ole Sejerstedt (University of Oslo, Norway)
"Life without SERCA in the heart"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break / Group Photo
10:50 am - 11:20 am Alicia Mattiazzi (National University of La Plata, Buenos Aires, Argentina)
"Acidosis CaMKII and SERCA"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Dmitry Terentyev (Ohio State University, Columbus)
"MicroRNA miR-1 overexpression enhances Ca release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CAMKII-dependent hyperphosphorylation of RyR2"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Alan Smrcka (University of Rochester)
"Adrenergic regulation of cardiac calcium through an epac and phospholipase C epsilon-dependent pathway"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Jolanda van der Velden (VU University Medical Centre, Amsterdam, Netherlands)
"Impaired myofilament contractility in post-infarct remodeled myocardium is restored by beta-adrenergic stimulation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmSignaling
Discussion Leaders: Susan F. Steinberg (Columbia University) & Mark Ziolo (Ohio State University)
7:30 pm - 8:00 pm Joan Heller Brown (University of California, San Diego)
"CaMKII in cardiomyocyte survival and heart failure"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Patrick Most (Thomas Jefferson University)
"S100A1 regulation of cardiomyocyte calcium handling: inotropic, antiapoptotic and antiarrhythmic effects"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Howard Rockman (Duke University)
"Biased Signaling by GPCRs"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Ryanodine Receptor in Heart
Discussion Leaders: Steven Houser (Temple University) & Julio Altamirano (University of Maryland Biotechnology Institute)
9:00 am - 9:30 am Godfrey Smith (University of Glasgow, UK)
"Spontaneous SR Ca2+ release"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Mark Cannell (University of Auckland, NZ)
"Spatial control of Ca2+ signaling"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Paul Allen (Harvard, MA)
"RyR2 interactions with calcium release unit proteins"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Rebecca Sitsapesan (University of Bristol, UK)
"Phosphorylation and the cardiac ryanodine receptor"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmHeart Failure
Discussion Leaders: Martin Morad (Georgetown University) & Chris Loughrey (University of Glasgow)
7:30 pm - 8:00 pm Leslie Leinwand (University of Colorado)
"How diet and sex modify the genetic landscape of the heart"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Jeffrey Molkentin (University of Cincinnati)
"T-type calcium entry is anti-hypertrophic and cardioprotective"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Karin Sipido (University of Leuven, Belgium)
"EC coupling in heart failure"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRhythms and Arrhythmias
Discussion Leaders: James Weiss (University of California, Los Angeles) & Alexey Glukhov (University of Washington, Saint Louis)
9:00 am - 9:30 am Edward Lakatta (NIH, Gerontology Research Center, Baltimore)
"Autonomic modulation of normal pacemaker automaticity linked to constitutively active adenylyl cyclase and PKA-dependent spontaneous SR calcium cycling"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Dario DiFrancesco (University of Milan, IT)
"HCN-based pacemaking: rhythm and dysrhythmia"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:20 am Ken Laurita (Case Western Reserve University, Cleveland, OH)
"Alternans"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pm Igor R. Efimov (Washington University, St. Louis, Missouri)
"Optical Imaging of Rhythms and Arrhythmias"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Leighton Izu (University of Kentucky, Lexington)
"The Spatial Distribution of Ca2+ release channels affects Ca2+ dynamics: insights into the origins of arrhythmias"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmSarcomeric Proteins: Normal and Abnormal
Discussion Leaders: John Solaro (University of Illinois, Chicago) & Ye Chen-Izu (University of Kentucky, Lexington)
7:30 pm - 8:00 pm Beata Wolska (University of Illinois, Chicago)
"Interventions in Ca regulation as a therapeutic target for rescuing the FHC phenotype"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Richard Moss (University of Wisconsin)
"Force modulation by stretch of myocardium during systole"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Henk Granzier (University of Arizona)
"The giant elastic protein titin--role in cardiac function and disease"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cells, Development, Death, and Repair
Discussion Leaders: Elizabeth Murphy (National Institutes of Health, Bethesda, MD) & Junko Kurokawa (Tokyo Medical and Dental University, Japan)
9:00 am - 9:30 am Christine Mummery (University of Leiden, Netherlands)
"Heart repair and embryonic stem cells"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Michael Rosen (Columbia University)
"Bioengineering the pacemaker"
10:10 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:20 am Charles Murry (University of Washington)
"Stem cell signaling in the heart"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pm Mark Sussman (San Diego State University)
"Cardiac Stem Cells: Engineered to Enhance Regeneration"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Fernando Santana (University of Washington, Seattle)
"Excitation-Contraction Coupling in Human Embryonic Stem Cell-Derived Cardiomyocytes"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Speaker
Discussion Leader: David Eisner (University of Manchester, UK)
7:30 pm - 8:15 pmSilvia Priori (University of Pavia, IT)
"Calcium mediated arrhythmogenesis and cardiac channelopathies"
8:15 pm - 8:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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