Gordon Research Conferences
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Conference Program
 
Chemotactic Cytokines
September 21-26, 2008
Centre Paul Langevin
Aussois, France
Chair:
Amanda E. Proudfoot

Vice Chair:
Gerry Graham

Chemokines are a family of approximately 50 proteins that differ from other cytokines in that they possess a distinctive biochemical hallmark in the form of conserved cysteine residues and act on G protein-coupled seven transmembrane (7TM) spanning receptors. Their principal role is that of directing leukocyte trafficking in the body, and they are thus pivotal to development and the establishment of the immune system. However their excessive activity results in the establishment of inflammation and through studies in animal models using tools such as genetically modified mice, neutralizing antibodies and receptor antagonists, chemokines have been shown to play a role in diseases such as asthma, atherosclerosis, multiple sclerosis, inflammatory bowel disorder and arthritis, as well as many others. They have also been shown to play a role in diseases such as cancer and infectious diseases such as AIDS, where they appear to play complex roles beyond inflammation. Since 7TM receptors are one of the cornerstones of the pharmaceutical industry, they provide a very attractive target for therapeutic intervention, and chemokine-focused programs are now moving into the clinic. Importantly 2007 witnessed the first approval by the FDA for a chemokine receptor antagonist for the prevention of HIV infection. They are also suitable targets for biological therapeutics, and again monoclonal antibodies are currently under testing in man. Thus the chemokine field attracts scientists from both academia and industry, and the Gordon Research Conference on Chemotactic Cytokines provides an ideal forum for direct exchange of ideas, and challenging discussion.

The conference is scheduled to be held in Aussois, France, from 21-26 September 2008. It will be limited to 160 participants, and speakers are selected to provide a forum for innovative discussion. In addition the conference will allow students and postdoctoral fellows the opportunity to expose their work and to have informal discussions with leading scientists in this area. This will be achieved, in part, through the dedicated poster sessions and the daily social program. Since the conference is held in Europe, we expect a large European attendance, but we hope to attract a substantial participation from the US. We therefore request support to cover the costs for travel and registration at the European venue.


Contributors
ALMAC SCIENCES
CELL PRESS
CHEMOCENTRYX
IDURON LTD
KONTAKTGRUPPE FUR FORSCHUNGSFRAGEN
MERCK & CO., INC.
MERCK SERONO INTERNATIONAL SA
NATIONAL INSTITUTES OF HEALTH
NOVIMMUNE
PEPROTECH EC LTD.
PFIZER, INC.
PHARMACOPEIA, INC.
POLYPHOR LTD.
PROTAFFIN BIOTECHNOLOGIE AG
UNIVERSITY OF CALIFORNIA

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKEYNOTE LECTURES
7:40 pm - 7:50 pm Discussion Leader: Amanda Proudfoot (Merck Serono Geneva Research Centre)
"Welcome and Introduction"
7:50 pm - 8:30 pm Luke O'Neill (Trinity College, Dublin)
"Toll-like receptors: the ignition of the inflammatory response"
8:30 pm - 9:10 pm Polly Matzinger (NIH)
"Danger Signal: re-igniting the inflammatory response"
9:10 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDRUG DEVELOPMENT
9:00 am - 9:10 am Discussion Leader: Christine Power (Merck Serono International S.A, Geneva)
"Introduction"
9:10 am - 9:30 am Daniel Obrecht (Polyphor)
"Discovery and development of clinically validated CXCR4 inhibitors applying Protein Epitope Mimetics (PEM) Technology"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Marcello Allegretti (DOMPE)
"Results of Reparaxin Phase II clinical trials"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break / Group Photo
10:40 am - 11:00 am Tom Schall (ChemoCentryx Inc Santa Clara, CA)
"CCR9 Phase III results"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Mette M. Rosenkilde (Copenhagen University)
"A molecular glimpse of the chemical evolution from bicyclam to oral non-cyclan CXCR4 antagonists"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Andreas Kungl (Protaffin)
"A glycan switch to generate chemokine-based therapeutics"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Orly Eizenberg (Biokine)
"Development of Novel Promiscuous Chemokine Antagonists"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCHEMOKINES AND HUMAN DISEASE
5:30 pm - 5:35 pm Discussion Leader: Barrett Rollins (Dana Farber, Harvard Medical School, Boston, MA)
"Introduction"
5:35 pm - 5:55 pm Fran Balkwill (London, UK)
"Chemokines in tumour:/stroma interactions"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Antonella Viola (Milan)
"Chemokine modification in the tumor microenvironment"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pm David Adams (Birmingham, UK)
"Chemokines and T cell recruitment to the human liver"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Christian Weber (Aachen,Germany)
"Structural basis and in vivo relevance of chemokine heteromerization"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Gali Soria (Tel Aviv)
"The pro-malignancy chemokine RANTES: Regulation of intracellular expression and release in breast tumor cells"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCHEMOKINES IN ANIMAL MODELS OF DISEASE
9:00 am - 9:10 am Discussion Leader: Nick Lukacs (Ann Arbor, Michigan)
"Introduction"
9:10 am - 9:30 am Mark Swain (Calgary Canada)
"Of mice and men: chemokines, T cells, and mouse liver"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Mauro Teixeira (Belo Horizonte, Brazil)
"PI3Kgamma modulates CXCR1/2 function in sepsis"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:00 am Sara Rankin (London, UK)
"Selective mobilisation of stem cell subsets from the bone marrow"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Christophe Combardiere (Paris)
"A link between atherosclerosis, cancer and AMD"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Don Cook (NIH)
"Allergic sensitization through the airway primes IL-17-dependent immune responses to subsequent allergen challenge"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Santos Manes (Madrid)
"Statins induce regulatory T cell recruitment via a CCL1-dependent Pathway"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCHEMOKINES IN HOMEOSTASIS
5:30 pm - 5:35 pm Discussion Leader: Martin Lipp
"Introduction"
5:35 pm - 5:55 pm Andy Luster (Harvard, Boston)
"Moving in a new direction: RNAi screen identifies a novel pathway required for chemotaxis"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Peter Lane (MRC Birmingham, UK)
"Organising memory CD4 responses"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pm Sergio Lira (Mount Sinai, NY)
"Chemokines in intestinal homeostasis"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Ronen Alon (Weizmann, Israel)
"A new dimension in chemokine triggered lymphocyte motility across endothelial barriers"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Reina Mebius (Amsterdam)
"Lymph node stromal cells regulate dendritic cell-induced gut-homing of T cells"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCHEMOKINES AND THE IMMUNE RESPONSE
9:00 am - 9:10 am Discussion Leader: Steve Kunkel (Ann Arbor, Michigan)
"Introduction"
9:10 am - 9:30 am Federica Sallusto (Bellinzona)
"Memory T cell subsets: function and trafficking"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Rheinhold Foster (Germany)
"Consitutive chemokine receptor control of the adaptive immune response"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:00 am Joshua Farber (NIH)
"Chemokine Receptors in the Differentiation and Function of CD4+ Effector/Memory T Cells"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Dan Campbell (Benaroya Research Institute, Seattle)
"Homing and homeostasis of Foxp3+ regulatory T cells"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Gudrun Debes (Philiadelphia)
"Chronicity of inflammation determines the relative importance of CCR7 in lymphocyte egress from inflamed extralymphoid tissues"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Bei-Chang Yang (National Cheng-Kung University)
"Tracking T cell migration in a three-dimensional collagen matrix: on motility and directionality"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmATYPICAL BINDERS AND BIOLOGY
5:30 pm - 5:35 pm Discussion Leader: Antal Rot (Novartis, Vienna)
"Introduction"
5:35 pm - 5:55 pm Alberto Mantovani (Fondazione Humanitas per la Ricerca, Milan)
"Chemokine decoy receptors in tuning activation and resolution of inflammation"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Gerry Graham
"Toll-like receptors and chemokine receptors: 2 interconnected arms of the innate immune system"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pm Bijan Boldajipour
"Control of chemokine-directed primordial germ cell migration in zebrafish"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Phil Murphy (NIH)
"Misbehavior in the absence of chemoattractant receptors"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Maud Deruaz (Geneva, Switzerland)
"Ticks produce chemokine binding proteins with stringent and broad specificities"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmCHEMOKINES AND THE CNS
9:00 am - 9:10 am Discussion Leader: William Rostene (INSERM, Paris)
"Introduction"
9:10 am - 9:30 am Christine Dambly-Chaudiere (Montpelier, France)
"Chemokines and cell migration in the fish lateral line"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Helene Boudin (Nancy, France)
"Axon differentiation mediated by CXCR4"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:00 am Jeff Harrison (Gainesville, FL)
"CXCR3 and malignant glioma"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Richard Ransohoff (Cleveland Clinic)
"CXCR2 control of oligodendrocyte migration"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Cristina Limatola (Rome, Italy)
"Fractalkine reduces migration of immature neurons through soluble factors"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Dayanindhi Raman (Vanderbilt University Medical Center)
"Elucidation of the neuroprotective pathway operating through the chemokine receptors in Alzheimer’s disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSTRUCTURE FUNCTION AND SIGNALING
5:30 pm - 5:35 pm Discussion Leader: Peter Nelson (Munich)
"Introduction"
5:35 pm - 5:55 pm Paul Proost (Leuven)
"Natural non-proteolytic posttranslational modification of chemokines reduces in vitro and in vivo activity"
5:55 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Ann Richmond (USA)
"Characterizing the CXCR2 Chemosynapse"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pm Marc Parmentier (Belgium)
"Receptor oligomerization: does it matter practically"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Brian Volkman
"Functional requirement for interconversion between two unrelated protein folds in the lymphotactin native state"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Karin Larsson (Lund, Sweden)
"ADC-1004: a potent C5a receptor block"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible, in part, by 1R13AI79893-01 from the National Institute of Allergy and Infection Diseases (NIAID). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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