Gordon Research Conferences
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Conference Program
 
Chromatin Structure & Function
May 11-16, 2008
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Peter B. Becker

Vice Chair:
Robert Kingston

The Chromatin Structure and Function Gordon Conference covers all aspects of chromatin organization and its impact on nuclear processes, such as gene expression and DNA repair. Themes include:

  • The folding of nucleosomal arrays into higher order structures and the role of linker histones and of core histone variants
  • Chromatin assembly at the replication fork, in association with repair of damaged DNA and within highly transcribed genes where chromatin is disrupted by the passage of RNA polymerase
  • Energy-dependent transitions of nucleosome structure, the relocation and disassembly of nucleosomes and the ATP-dependent exchange of histone variants
  • Signals that converge in a combinatorial pattern of chemical histone modifications and their interpretation by interacting factors
  • The requirements for transcription initiation as well as elongation in a chromatin context
  • The generation of silent states by reinforcing positive feed-back loops, as a hallmark of heritable, epigenetic gene silencing that occurs normally during development, but also erroneously in some tumours
  • Dosage compensation systems that coordinate the expression of all individual genes of a complex eukaryote through modulation of chromatin structure
  • The rules that govern the arrangements of chromosomes within the nucleus and the compartmentalisation of nuclei into functional domains

Contributors
Funding for this conference was made possible by grants from the National Cancer Institute and the National Human Genome Research Institute, as well as by contributions from the following companies: Nimblegen Systems, Active Motif, BayerSchering Health Care, Millipore, New England Biolabs, Promega, Sangamo Biosciences, Kontaktgruppe für Forschungsfragen (Ciba, Novartis, F. Hoffmann-La Roche, Merck Serono, Syngenta), Leica, Imagenes.

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNucleosomal arrays
Discussion Leader: Karolin Luger (Colorado State University, Fort Collins)
7:40 pm - 8:00 pm Tim Richmond (ETH, Zürich)
"Chromatin Structure/Remodeling"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Daniela Rhodes (Laboratory of Molecular Biology, MRC, Cambridge)
"Chromatin Higher Order Structure"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm John van Noort (University of Leiden)
"Single-Molecule Force Spectroscopy Reveals a Highly Compliant Solenoidal Structure for the 30 nm Chromatin Fiber"
8:45 pm - 8:50 pm Discussion
8:55 pm - 9:15 pm David Tremethick (John Curtin School of Medical Research, Canberra)
"Linking histone variant chromatin structure with function"
9:15 pm - 9:20 pm Discussion
9:30 pm Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin assembly and repair
Discussion Leader: Daniela Rhodes (Laboratory of Molecular Biology, MRC, Cambridge)
9:00 am - 9:20 am Karolin Luger (Colorado State University, Fort Collins)
"Nucleosomes and their chaperones"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Jon Widom (Northwestern University, Evanston)
"The genomic code for nucleosome positioning"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Oliver Rando (University of Massachusetts, Worcester)
"Static and dynamic genome-wide views of yeast chromatin"
10:10 am - 10:15 am Discussion
10:15 am - 10:35 am Genevieve Almouzni (Institut Curie, Paris)
"When Histone chaperones meet the replication fork"
10:35 am - 10:40 am Discussion
10:40 am - 11:20 am Coffee Break / Group Photo
11:20 am - 11:40 am Craig Peterson (University of Massachusetts, Worcester)
"Chromatin dynamics at a DNA double strand break"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Jacques Coté (Laval University Cancer Research Center, Quebec)
"Functional dissection of HAT complexes playing an essential role during DNA replication"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Xuetong Shen (M. D. Anderson Cancer Center, University of Texas)
"Involvement of INO80 in DNA replication"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session (A - G)
5:30 pm - 7:30 pmDynamic chromatin transitions
Discussion Leader: Craig Peterson (University of Massachusetts, Worcester)
5:30 pm - 5:50 pm Geeta Narlikar (University of California, San Francisco)
"Mechanisms of ATP-dependent Chromatin Remodeling Complexes"
5:50 pm - 5:55 pm Discussion
5:55 pm - 6:10 pm Blaine Bartholomew (Southern Illinois University School of Medicine, Carbondale)
"Structural and Functional Insights into ATP-dependent Chromatin Remodeling"
6:15 pm - 6:20 pm Discussion
6:20 pm - 6:40 pm Toshio Tsukiyama (Fred Hutchinson Cancer Center, Seattle)
"Functions of ATP-dependent chromatin remodeling in vivo"
6:40 pm - 6:45 pm Discussion
6:45 pm - 7:05 pm Tom Owen-Hughes (University of Dundee)
"What happens when nucleosomes collide?"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm Colin Logie (Center for Molecular Life Sciences, Nijmegen)
"Nucleosome stepsize of ATP-dependent chromatin remodelling enzymes"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHistone modifications and signalling
Discussion Leader: Jane Mellor (University of Oxford)
9:00 am - 9:20 am David Allis (Rockefeller University, New York)
"Beyond the Double Helix: Writing and Reading the 'Histone Code'"
9:20 am - 9:25 am Discussion
9:25 am - 9:40 am Dinshaw Patel (Sloan Kettering Cancer Center, New York)
"PHD Fingers: Structure-function studies of a methyl-lysine reader module in leukemic and oncogenic systems"
9:40 am - 9:45 am Discussion
9:45 am - 10:05 am Tony Kouzarides (The Gurdon Institute, Cambridge)
"Functional analysis of chromatin modifications"
10:05 am - 10:10 am Discussion
10:10 am - 10:25 am Marc Fiedler (LMB, MRC, Cambridge)
"Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex"
10:25 am - 10:30 am Discussion
10:30 am - 11:10 am Coffee Break
11:10 am - 11:30 am Jerry Workman (Stowers Institute, Kansas City)
"Protein complexes that modify histones for transcription"
11:30 am - 11:35 am Discussion
11:35 am - 11:50 am Kiyoe Ura (University of Osaka)
"A defect in histone H3 lysine 36 tri-methyltransferase causes a human disease through the disruption of developmental transcription"
11:50 am - 11:55 am Discussion
11:55 am - 12:15 pm Shelley Berger (The Wistar Institute, Philadelphia)
"Histone post translational modifications during gametogenesis and replicative cellular aging"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session (H - N)
5:30 pm - 7:30 pmActive chromatin
Discussion Leader: Jerry Workman (Stowers Institute, Kansas City)
5:30 pm - 5:50 pm Jane Mellor (University of Oxford)
"TOR and AMPK control lysine 14 acetylation and trimethylation of lysine 4 on histone H3"
5:50 pm - 5:55 pm Discussion
5:55 pm - 6:15 pm Ali Shilatifard (Stowers Institute, Kansas City)
"Molecular Implementation of Histone H3 Lysine 4 (H3K4) Methylation"
6:15 pm - 6:20 pm Discussion
6:20 pm - 6:40 pm Danny Reinberg (NYU, Smilow Research Center, New York)
"Chromatin and Its Impact on Gene Expression and Cellular Memory"
6:40 pm - 6:45 pm Discussion
6:45 pm - 7:05 pm Ingrid Grummt (German Cancer Research Center, Heidelberg)
"Intergenic and antisense transcripts regulate promoter methylation and silencing of rRNA genes"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm Andreas Ladurner (EMBL, Heidelberg)
"The 'peptidase' domain of FACT subunit Spt16 is a histone H3-H4 binding module"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSilent chromatin
Discussion Leader: Jeannie Lee (Massachusetts General Hospital, Boston)
9:00 am - 9:20 am Robin Allshire (University of Edinburgh)
"Chromatin at fission yeast centromeres"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Shiv Grewal (NIH, Bethesda)
"Epigenetic genome control by RNAi and transposon-derived proteins"
9:45 am - 9:50 am Discussion
9:50 am - 10:05 am Ann Ehrenhofer-Murray (Zentrum für Molekulare Biotechnologie, Essen)
"Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate"
10:05 am - 10:10 am Discussion
10:10 am - 10:30 am Susan Gasser (Friedrich Miescher Institut, Basel)
"Assembling heterochromatin: cooperative binding and the role of non-histone tail contacts"
10:30 am - 10:35 am Discussion
10:35 am - 11:10 am Coffee Break
11:10 am - 11:30 am Ramin Shiekhattar (CRG, Barcelona)
"Regulation of transcription through histone demethylation"
11:30 am - 11:35 am Discussion
11:35 am - 11:55 am Renato Paro (ETH Zentrum für Biosysteme, Basel)
"Molecular link between epigenetics and phenotypic plasticity"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Luciano DiCroce (CRG, Barcelona)
"Mechanisms of epigenetic silencing in normal and cancer cells"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmBalancing the genome
Discussion Leader: Bryan Turner (University of Birmingham)
5:30 pm - 5:50 pm Mitzi Kuroda (Harvard University, Boston)
"Targeting the X chromosome for dosage compensation in Drosophila"
5:50 pm - 5:55 pm Discussion
5:55 pm - 6:15 pm Barbara Meyer (University of California, Berkeley)
"Chromosome-Wide Repression"
6:15 pm - 6:20 pm Discussion
6:20 pm - 6:40 pm Edith Heard (Institut Curie, Paris)
"Initiating and spreading the silence during X-chromosome inactivation"
6:40 pm - 6:45 pm Discussion
6:45 pm - 7:05 pm Jeannie Lee (Harvard University, Boston)
"Dosage compensation by X-inactivation in the mammal"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm Asifa Akhtar (EMBL, Heidelberg)
"MOF histone acetyl transferase is a key regulator of dosage compensation and gene expression in Drosophila"
7:25 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProgramming and reprogramming functional states
Discussion Leader: Ingrid Grummt (German Cancer Research Center, Heidelberg)
9:00 am - 9:20 am Bryan Turner (University of Birmingham)
"Think globally, act locally: the multi-layered relationship between histone modifications and gene expression"
9:20 am - 9:25 am Discussion
9:25 am - 9:40 am Siavash Kurdistani (David Geffen School of Medicine at UCLA, Los Angeles)
"Epigenetic Reprogramming for Oncogenic Transformation"
9:40 am - 9:45 am Discussion
9:45 am - 10:05 am Jürg Müller (EMBL, Heidelberg)
"Mechanisms of Polycomb/trithorax chromatin regulation"
10:05 am - 10:10 am Discussion
10:10 am - 10:30 am Sharon Dent (M.D. Anderson Cancer Center, Houston)
"Functions and Regulation of Histone Modifying Complexes"
10:35 am - 10:40 am Discussion
10:40 am - 11:10 am Coffee Break
11:10 am - 11:25 am Antoine Peters (Friedrich Miescher Institute, Basel)
"Establishing chromatin states in the early embryo: integrating parental specific contributions"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Amanda Fisher (Imperial College, London)
"Epigenetics and pluripotency"
11:50 am - 11:55 am Discussion
11:55 am - 12:15 pm Brad Cairns (University of Utah, Salt Lake City)
"Distinctive chromatin structures reside at the promoters of embryonic transcription factors in human sperm"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session (O - Z)
5:30 pm - 7:30 pmChromosomes and nuclear organization
Discussion Leader: Genevieve Almouzni (Institut Curie, Paris)
5:30 pm - 5:50 pm Thomas Cremer (University of Munich)
"Chromosome territories and nuclear organization: structural, functional and evolutionary aspects"
5:50 pm - 5:55 pm Discussion
5:55 pm - 6:15 pm Wendy Bickmore (MRC Human Genetics Unit, Edinburgh)
"Polycomb complexes regulate chromatin condensation at Hox loci"
6:15 pm - 6:20 pm Discussion
6:20 pm - 6:40 pm Peter Fraser (Babraham Institute, Cambridge)
"Transcription Factories and Spatial Transcription Networks"
6:40 pm - 6:45 pm Discussion
6:45 pm - 7:05 pm Bas van Steensel (Netherlands Cancer Institute, Amsterdam)
"Genome - nuclear lamina interactions in mammalian cells"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm Patrick Heun (Max Planck Institute for Immunobiology, Freiburg)
"Centromere identity and neocentromere formation in Drosophila"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmFarewell Get-Together
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible in part by 1 R13 CA132255-01 from the National Cancer Institute and the National Human Genome Research Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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