Gordon Research Conferences
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Conference Program
 
DNA Damage, Mutation & Cancer
March 9-14, 2008
Ventura Beach Marriott
Ventura, CA
Chair:
John B. Hays

Vice Chair:
Joann B. Sweasy

A major premise of this GRC series, now titled DNA Damage, Mutation, and Cancer, has been that much of the cancer associated with environmentally-induced and endogenous DNA damage is linked to damage-dependent mutagenesis. Cells use a network of interconnected pathways to suppress such mutagenesis and thus avoid carcinogenesis. They repair damaged DNA and bypass DNA-replication-blocking lesions by processes that balance efficiency and fidelity. Damage-triggered signaling pathways delay cycling of genetically-compromised cells and may eventually eliminate them. The 2008 conference will place a major emphasis on consequences for human health. A pair of keynote talks that describe "genetic landscapes" of cancer will set the stage for subsequent sessions concerned with specific genetic alternations in cancer cells and with the genetic epidemiology of sporadic cancer. Two additional sessions concerned with health endpoints will focus on cellular responses to chemotherapy-induced DNA damage that may induce secondary cancers, and consider consequences of processing of damaged DNA for tissue growth and development and for aging. Some of these talks will emphasize the value of new model systems - Arabidopsis and zebrafish - to the DNA repair and mutagenesis community. Two sessions will be concerned with molecular starting points of damage-processing pathways: the structural biology and theory of DNA-damage recognition and effects of sequence context and consequences of novel structures in lesion-free DNA. One session aims at biochemical understanding of the balance between error-prone vs. high-fidelity responses to blocked replication forks. One will consider multi-step processing pathways initiated by specific DNA lesions.


Contributors
NATIONAL INSTITUTES OF HEALTH
OXFORD BIOMEDICAL RESEARCH, INC.
CARL STORM UNDERREPRESENTED MINORITY FELLOWSHIPS

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm KEYNOTE ADDRESSES
Discussion Leader: John Hays (Oregon State University)
7:40 pm - 8:25 pmLarry Loeb (University of Washington)
"How Mutations Cause Cancer"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:20 pmMax Wicha (University of Michigan)
"Cancer Stem Cells"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm GENETIC LANDSCAPES OF CANCER
Discussion Leader: Christoph Klein (University of Regensburg)
9:00 am - 9:25 amChristoph Klein (Regensburg)
"Mutation and selection during systemic cancer progression"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amLaura Wood (The Johns Hopkins University)
"Genomic Analyses of Human Cancer"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amFred Alt (Harvard University)
"IgH Class Switching, DNA End-Joining, Translocation, and Cancer"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Group Photo
11:35 am - 12:00 pmToshiyasu (Toshi) Taniguchi (University of Washington)
"The Fanconi-Anemia-BRCA Pathway and chemosensitivity of human cancer"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Christophe Cazaux (CNRS, Toulouse)
"The Roles of Replication/Recombination/Repair TLS Polymerases in Replicative Stress and Cancer"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm POPULATION CANCER RISKS FROM DNA-REPAIR DEFICIENCIES AND ABERRANT DNA STRUCTURES
Discussion Leader: Harvey Mohrenweiser (Oregon Health and Sciences University)
7:30 pm - 7:45 pmHarvey Mohrenweiser (OHSU)
"Contribution to Cancer Risk of the Extensive Population Variation in DNA Repair-Gene Sequences"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:15 pmXifeng Wu (U.T. Texas M.D. Anderson Center, Houston)
"Personalized Prediction of Cancer Risk and Outcome: Markers of Genetic Instability"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:50 pmDavid Wilson (National Institute of Aging, NIH, Baltimore)
"Base Excision Repair Variation in the Human Population"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmPhyllis Strauss (Northeastern University)
"How AP Endonuclease Controls Embryonic Survival in Zebrafish"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm NOVEL MECHANISMS OF GENOMIC INSTABILITY
Discussion Leader: Joann Sweasy (Yale University)
9:00 am - 9:20 amJoann Sweasy (Yale)
"Introduction"
9:20 am - 9:45 amKaren Vasquez (U. Texas M. D, Anderson, Smithville)
"DNA-structure-induced Genetic Instability"
9:45 am - 9:55 am Discussion
9:55 am - 10:10 am Faye Rogers (Yale Medical School)
"Altered Helical Structures in DNA Repair and Induction of Apoptosis"
10:10 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee break
10:45 am - 11:10 amPeter Glazer (Yale University)
"Down-regulation of DNA Repair in Hypoxia"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amBarbara Hohn (Friedrich-Miescher Institute, Basel)
"Transgenerqtional Memory of Hyper-rec Phenotype in Plants"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pmRobert Wells (Texas A. and M. University)
"Non-B DNA Conformations, Genomic Rearrangements, and Human Disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm CHEMOTHERAPY: DNA-REPAIR AND DAMAGE=SIGNALING IMPLICATIONS
Discussion Leader: Peter Karran (Cancer Research U.K., Clare Hall)
7:30 pm - 7:50 pmPeter Karran (Clare Hall)
"Therapeutic DNA Damage: Implications for Cancer"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:20 pmMark Kelley (Indiana University School of Medicine)
"AP Endonuclease Ape1/Ref-1: A DNA-repair and Redox Signaling Target for Chemotherapy"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:55 pmPeter McHugh (Cancer Research UK, Oxford)
"Mechanisms of Repair of DNA Inter-strand Cross-links"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmAnne Britt (U. Calif. Davis)
"Identification of New Checkpoint Regulators in an Arabidopsis Model System"
9:55 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EVENTS AT STALLED REPLICATION FORKS
Discussion Leader: Alan Lehmann (University of Sussex, UK)
9:00 am - 9:25 amAlan Lehmann (Sussex)
"Ubiquitination of PCNA and Polymerases in Response to DNA Damage"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amPeter Burgers (Washington University, St. Louis)
"An Essential Role for Rev1 Binding to Ubiquitinated PCNA during Mutagenesis"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 amLajos Haracska (Hungarian Academy of Sciences, Szeged)
"Role of Yeast Rad5 and its Human Ortholog SHPRH in Postreplication Repair"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 amAgnes Cordonnier (INSERM, CNRS, Illkirch, France)
"Regulation and Role of PCNA Monoubiquitination in Eukaryotic Cell Extracts"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmKyungjae Myung (NHGRI, NIH)
"Suppression of DNA-damage-induced Chromosomal Rearrangements by Damage Avoidance and Other Pathways"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Martin Cohn (Harvard Medical School)
"Regulation of the Fanconi Anemia Pathway by a DAF1-contaning Multi-subunit Protein Complex"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm PATHWAYS THAT PROCESS DAMAGED DNA
Discussion Leader: Ed Loechler (Boston University)
7:30 pm - 7:55 pmEd Loechler (BU)
"Evidence for Two Active Sites in Y-Family Polymerases: Biological Implications?"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pmNick Geacintov (New York University)
"Structure-Function Relationships in the Recognition and Excision of Bulky Lesions"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:00 pmRobert Fuchs (CNRS, Marseilles)
"Mechanisms of Mutagenesis without Semi-conservative DNA Replication"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Zvi Livneh (Weizmann Institute)
"The Role of DNA Polymerase Zeta in Mammalian TLS: Evidence for a Two Polymerase Mechanism"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm RECOGNITION OF DNA DAMAGE
Discussion Leader: Wei Yang (NIDDK, NIH)
9:00 am - 9:25 amWei Yang (NIH)
"Finding Needles in a Haystack"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amJames Stivers (The Johns Hopkins University)
"Linking Dynamics of Damaged Base Pairs to Recognition by Enzymes"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 amLorena Beese (Duke University)
"DNA-lesion-recognition Complexes"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 amJennifer Brodbelt (University of Texas at Austin)
"Novel Mass Spectrometric Strategies for Analysis of DNA Adducts"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pmStephen Chaney (University of North Carolina)
"Selective Recognition of Cisplatin and Oxaliplatin-GG Adducts by Cellular Proteins: Importance of Differential Conformational Dynamics"
12:00 pm - 12:05 pm Discussion
12:05 am - 12:25 pmVeronica Maher (Michigan State University)
"DNA-damage-induced Mutagenesis, Then and Now"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm REPAIR AND TOLERATION OF DNA DAMAGE IN DEVELOPMENT AND AGING
Discussion Leader: Laura Niedernhofer (University of Pittsburgh)
7:30 pm - 7:55 pmLaura Niedernhofer (Pittsburgh)
"Aging-associated Degenerative Diseases Driven by Endogenous DNA Damage"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:15 pm Marc Curtis (Oregon State University)
"Roles of Pol Eta and Pol Zeta in Orderly Development of UVB-irradiated Plant Tissues"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmLarry Marnett (Vanderbilt University)
"In Vivo Metabolism of Deoxynucleoside Adducts and the Development of Non-Invasive Biomarkers of Endogenous DNA Damage"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmJudy Campisi (Lawrence Berkeley Lab)
"Linkage of the DNA-Damage Response to Cancer and Aging"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by grant 1R13CA133995-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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