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Conference Program
 
Drug Carriers in Medicine & Biology
August 24-29, 2008
Big Sky Resort
Big Sky, MT

The GRC conference on “Drug Carriers in Medicine and Biology” will take place in the beautiful, mountain setting of the Big Sky Resort during August 24-29th 2008. For three decades this biennial meeting has brought prominent senior and younger scientists in all aspects of biology, medicine, physico-chemical and pharmaceutical fields to meet the common interests and goals of better drug therapy using novel strategies of drug delivery and drug carriers. The 2008 meeting will focus on several areas of drug delivery including protein and oligonucleotide/gene delivery, polymers and lipid particles, nano-materials, antibody drug-conjugates and cellular carriers, directed to various targets at multiple levels, as well as multimodal molecular imaging applied to monitoring delivery and therapeutic efficacy. This meeting will also include the approaches of chemical biology and nanotechnology to target and achieve enhanced delivery and therapeutic outcomes. Young investigators are particularly encouraged to attend and join in open discussions on these important, exciting areas and other subjects. Additionally the organizers encourage poster presentations of emerging work, with one evening reserved for short presentations from the selected posters followed by open lively discussions. Prof. David Scheinberg (Sloan-Kettering Inst.) and Prof. Kyung-Dall Lee (Univ. of Michigan) invite researchers and students from academia, pharma and biotech to attend this unique meeting on drug delivery of wide scope at Big Sky Montana in 2008. This GRC site offers the additional attraction of the outdoor activities promoting interactions at various levels and the close proximity of the Yellowstone National Park.


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:45 pmWelcome / Introductory Comments by GRC Site Staff and Conference Chairs
7:45 pm - 9:30 pmDrugging the Undruggable
7:45 pm - 7:55 pmDiscussion Leaders: Kyung-Dall Lee (Univ. of Michigan, Ann Arbor) & David Scheinberg (MSKCC)
7:55 pm - 8:40 pm Gregory Verdine (Harvard University)
"Enabling Cell Uptake of alpha-Helical Peptides Through Hydrocarbon Stapling"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:15 pm Theresa Allen (Univ. of Alberta)
"Stealth Liposomes"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSelf-Assembling Drug Carriers, Polymers, and Lipidic Particles
9:00 am - 9:10 am Discussion Leader: Frank Szoka (Univ. of California, San Francisco)
9:10 am - 9:35 am Jean Fréchet (Univ. of California, Berkeley)
"Novel Polymeric Constructs"
9:35 am - 9:50 am Discussion
9:50 am - 10:15 am Mark Grinstaff (Boston University)
"A Very Short Synopsis on PGLSA Dendrimers and a New Story on Functional Nanoparticles"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 am Paula Hammond (Massachusetts Institute of Technology)
"Patchy Particles: Linear-Dendritic Micellar Assembly for Ligand Variable Targeted Delivery"
11:25 am - 11:40 am Discussion
11:40 am - 12:05 pm David Thompson (Purdue University)
"Design & Performance of Bioresponsive Carrier Systems for Drug & Gene Delivery"
12:05 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmVasculature, Lymphatics, and Barriers
7:30 pm - 7:40 pm Discussion Leader: Philip Thorpe (Univ. of Texas Southwestern Medical Center)
7:40 pm - 8:00 pm Vladimir Muzykantov (U. Penn)
"Targeting anti-thrombotic and anti-inflammatory prodrugs to endothelium"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Bronek Pytowski (ImClone, Inc.)
"Therapeutic targeting of lymphatic endothelium"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:10 pm David Lyden (Weill Cornell Medical College)
"Preparing the Soil: The Pre-Metastatic Microenvironment"
9:10 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNanomaterial-Based Agents
9:00 am - 9:10 am Discussion Leader: Henry Kopecek (Univ. of Utah)
9:10 am - 9:30 am Shiladitya Sengupta (Massachusetts Institute of Technology)
"Pathophysiology-inspired engineering of hybrid nanoparticles"
9:30 am - 9:45 am Discussion
9:45 am - 10:05 am Joseph DeSimone (Univ. of North Carolina, Chapel Hill)
"Opportunities Associated with the Control of Size, Shape, Surface Chemistry and Modulus of Carriers for Use in Medicine"
10:05 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:10 am Kimberly Hamad-Schifferli (Massachusetts Institute of Technology)
"Interfacing Nanoparticles to Biology: Multifunctional Nanoparticles"
11:10 am - 11:25 am Discussion
11:25 am - 11:35 am Omolola E. Adefeso (U.Mich.)
"Fabrication of nanoparticles for vasculature"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amKristy Ainslie (UCSF)
"Microfabricated oral delivery vehicle"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmJinming Gao (UTSouthwestern)
"Non spherical nanomedicines platforms"
12:05 pm - 12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Last Names A-K)
6:00 pmDinner
7:30 pm - 9:30 pmGenetic and Cell-Based Therapies
7:30 pm - 7:40 pm Discussion Leader: Kyung-Dall Lee (Univ. of Michigan)
7:40 pm - 8:00 pm Martin Brown (Stanford University)
"Anaerobic bacteria as tumor specific drug targeting agents"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Neil Forbes (Univ. of Massachusetts, Amherst)
"Spatial and temporal control of delivery to tumors using engineered S. typhimurium"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Adrian Krainer (Cold Spring Harbor Laboratory)
"Splicing Correction as a Therapeutic Approach in Spinal Muscular Atrophy"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Agents, Pharmacogenomics
9:00 am - 9:10 am Discussion Leader: Peter Senter (Seattle Genetics, Inc.)
9:10 am - 9:30 am Michael Shuler (Cornell University)
"A Body-on-a Chip for Testing Pharmaceuticals"
9:30 am - 9:45 am Discussion
9:45 am - 10:05 am Yana Reshetnyak (Univ. of Rhode Island)
"pHLIP Nanotechnology platform for cancer imaging and therapy"
10:05 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:10 am Kathy Giacomini (Univ. of California, San Francisco)
"Pharmacogenetics of Transporters: From SNP Discovery to Drug Therapy"
11:10 am - 11:25 am Discussion
11:25 am - 11:35 amYoung Investigator Presentation (TBA)
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amAnu Puri (NCI-Frederick)
"Radiosensitive liposomes"
11:50 am - 12:00 pmStavroula Sofou (Polytech U)
"pH sensitive liposomes"
12:00 pm - 12:10 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Last Names L-Z)
6:00 pmDinner
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pm - 9:30 pmStudent, Post Doc, Young Investigator Presentations
Discussion Leaders: Philip Low (Purdue University) & Patrick Stayton (Univ. of Washington)
(Presentations selected from Poster Session: All poster presenters should be prepared to give a short talk (ppt file) if selected)
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAntibodies and Conjugates
9:00 am - 9:10 am Discussion Leader: David Scheinberg (MSKCC)
9:10 am - 9:35 am Ira Pastan (NCI)
"Immunotoxins in 2008: Successes and Challenges"
9:35 am - 9:50 am Discussion
9:50 am - 10:15 am Oliver Press (Univ. of Washington)
"Pretargeted Radioimmunotherapy for Hematologic Malignancies"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 am Ezio Bonvini (MacroGenics, Inc.)
"Exploiting Fc-Receptors for Therapeutic Purposes"
11:25 am - 11:40 am Discussion
11:40 am - 12:05 pm Allen Ebens (Genentech, Inc.)
"Antibody-Drug Conjugates: Principles of Safety and Efficacy, Promising Candidates for Treatment of Lymphoma"
12:05 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Imaging
7:30 pm - 7:40 pm Discussion Leaders: David Scheinberg (MSKCC) & Oliver Press (Univ. of Washington)
7:40 pm - 8:00 pm Brian Ross (Univ. of Michigan, Ann Arbor)
"Imaging Biomarkers of Cancer Drug Response"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Dwight Seferos (Northwestern University)
"Nano-Flares for Intracellular Imaging"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:10 pm David Piwnica-Worms (Washington University in St. Louis)
"Dynamic Imaging of Signal Transduction Pathways and Target-Specific Drug Pharmacodynamics In Vivo"
9:10 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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