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Conference Program
 
Environmental Endocrine Disruptors
June 8-13, 2008
Waterville Valley Resort
Waterville Valley, NH

The Sixth Gordon Research Conference (GRC) on Environmental Endocrine Disruptors (EED) will be held June 8-13, 2008, in a beautiful and comfortable resort setting; Waterville Valley Resort, New Hampshire. This conference will mark the 10th anniversary of the first GRC on EED. We will highlight the important advances over the past ten years and hope to help shape the next decade of research. Speakers will include leading scientists from the US, Japan and Europe, as well as young scientists who have recently reported exciting findings.

The 2008 conference is framed around five Specific Aims:

  1. To bring together national and international leaders in EED research in a meeting format that promotes learning and open discussion of hypotheses and knowledge gaps and that encourages collaborative research;
  2. To highlight the important milestones in EED research since the first GRC on EED in 1998, emphasizing new developments that may guide research in this area over the next ten years;
  3. To focus on effects of EED across the lifespan (prenatal, early childhood, puberty, midlife and old age) in a range of model systems;
  4. To highlight novel mechanisms, new endpoints and new environmental agents currently being investigated as potential EEDs, and to expand EED exposure assessment;
  5. To encourage participation of trainees and other young scientists in EED research.

This GRC will have a strong emphasis on reproductive science and clinical translation of new science. The conferences will highlight the most up-to-date science through discussions of new and proposed mechanisms of action (Monday morning’s session discusses classical and novel mechanisms of EED), new endpoints under investigation as targets of EED (Classical and novel endpoints for EED, Monday afternoon’s session), and new methods for evaluating human health risk from EED exposure (Wednesday morning’s session is on mixtures and other challenges to risk assessment). We encourage trainees and other young scientists to apply, and are seeking funds to support these emerging scientists.


SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm GRCs on Environmental Endocrine Disruption
Discussion Leader: Shanna Swan (University of Rochester)
7:40 pm - 8:10 pmDevra Davis (University of Pittsburgh Cancer Institute, Center for Environmental Oncology)
"Ten years of EED research: Views from human epidemiology"
8:10 pm - 8:40 pmJoe Thornton (University of Oregon)
"Nuclear receptor evolution: implications for endocrine disruption"
8:40 pm - 9:10 pmDavid Crews (University of Texas at Austin)
"Ten years of EED research: Views from evolutionary biology"
9:10 pm - 9:30 pm Panel discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Classical and Novel Mechanisms of Environmental Endocrine Disruption
Discussion Leader: Andrea Gore (University of Texas at Austin) and Rex Hess (University of Illinois)
9:00 am - 9:30 amMichael E. Baker (University of California at San Diego)
"Nuclear receptors, steroidogenic enzymes and metabolism"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amDouglas M. Ruden (Wayne State University)
"Epigenetics: hsp90, epigenetics and evolution"
10:15 am - 10:30 am Discussion
10:30 amCoffee Break / Group Photo
11:00 am - 11:30 amCheryl S. Watson (University of Texas Medical Branch)
"Membrane steroid receptors and xenoestrogen responses"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmHeather Patisaul (North Carolina State University)
"Disruption of sexually-dimorphic brain regions"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Classical and Novel Endpoints of Environmental Endocrine Disruption
Discussion Leader: Fred vom Saal (University of Missouri-Columbia)
7:30 pm - 8:00 pmBernard Jegou (University of Rennes)
"New approaches to study the mechanism of action of phthalates on the fetal testis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmWalter Lichtensteiger (University of Zurich)
"The brain as a target of EED: PBDEs and UV filters"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmLinda Titus-Ernstoff (Dartmouth Medical School)
"The third generation: Studies of sons and daughters of mothers exposed prenatally to diethylstilbestrol (DES)"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Environmental Endocrine Disruption Across the Lifespan
Discussion Leader: Bernie Weiss (University of Rochester)
9:00 am - 9:30 amBrian Petroff (U. Kansas)
"Early TCDD exposure effects on reproductive cyclicity and early reproductive senescence"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amPaolo Mocarelli (University of Milano-Bicocca)
"Dioxin exposure in Seveso: its effects on second generation of males"
10:15 am - 10:30 am Discussion
10:30 amCoffee Break
11:00 am - 11:30 amB. Paige Lawrence (U. Rochester)
"AhR agonists as modulators of immune programming"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmPaul Stewart (SUNY Oswego)
"Prenatal exposure to PCBs: neurobehavioral effects traced from infancy to preadolescence"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm New Opportunities and Challenges in Exposure Assessment for Environmental Endocrine Disruptors
Discussion Leader: Russ Hauser (Harvard University)
7:30 pm - 8:00 pmAntonia Calafat (Center for Disease Control and Prevention)
"Trends in EED biomarkers: Data from the NHANES across time"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmHanne Frederiksen (Rigshospitalet, Denmark)
"Urinary excretion of phthalate metabolites in Danish children"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmMary Wolff (Mt Sinai School of Medicine)
"EED concentrations in young girls"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Mixtures and Other Challenges to Risk Assessment of Environmental Endocrine Disruptors
Discussion Leader: Lou Guillette (University of Florida) and Andreas Kortenkamp (University of London)
9:00 am - 9:30 amUlla Hass (Danish Technical University)
"Combining anti-androgens: From in utero to adulthood"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amKevin Crofton (USEPA)
"Thyroid disrupting chemicals: Characterizing hazards from multiple targets"
10:15 am - 10:30 am Discussion
10:30 amCoffee Break
11:00 am - 11:30 amRichard Stahlhut (University of Rochester)
"Bisphenol A data in NHANES suggest long half-life and/or continuous non-food exposure"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmRolf Altenburger (Helmholtz Centre for Environmental Research)
"Complex environmental mixtures"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Emerging Issues in Research on Environmental Endocrine Disruptors
Discussion Leader: Margret Schlumpf (University of Zurich)
7:30 pm - 8:00 pmSuzanne Fenton (USEPA)
"EED alters gene targets in the mammary gland"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmDavid Jacobs (U. Minnesota) and Duk-Hee Lee (Kyungpook National University, South Korea)
"Mixed background exposure to POPs, diabetes, and other conditions"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmBjørn Munro Jenssen (Norwegian Technical University, Trondheim)
"Assessment of environmental toxins in arctic mammals: Relation to behavioral changes and climate change"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pm Environmental Endocrine Disruption in Wildlife
Discussion Leader: Jörg Oehlmann (University of Frankfurt am Main)
9:00 am - 9:30 amCharles Tyler (University of Exeter)
"Estrogens and anti-androgens in surfaces waters and their impacts on fish and fish populations"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amRachel Benstead (Brunel University)
"Exposure to estrogenic compounds commonly found in treated sewage effluents disrupts the seasonal reproductive cycle of freshwater snails"
10:15 am - 10:30 am Discussion
10:30 amCoffee Break
11:00 am - 11:30 amKaren Kidd (University of New Brunswick)
"Is the birth control pill an effective form of contraception for wild fishes? Results from a whole lake experiment"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmPatricia Holm (University of Basel)
"EED effects in fish: Extrapolation from organism to population"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:00 pm Poster Session
6:00 pmDinner
7:30 pm - 9:30 pm New Directions and New Funding Opportunities for Research on Environmental Endocrine Disruption
Discussion Leader: Shanna Swan (University of Rochester)
7:30 pm - 8:00 pm Panel discussion: Jerrold Heindel (NIEHS), Elaine Francis (USEPA), Taisen Iguchi (NIBB, Japan)
"New directions for EED research"
8:00 pm - 8:30 pmLinda Birnbaum (USEPA)
"Conference overview"
8:30 pm - 9:00 pm Andreas Kortenkamp (University of London)
"Thoughts for the next GRC on EED"
9:00 pm - 9:30 pm Closing Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The project described was supported by Grant Number R13ES016703 from the National Institute of Environmental Health Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Institute of Environmental Health Sciences of the National Institutes of Health.

 
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