| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 9:30 pm | NATURAL PRODUCT BIOSYNTHESIS |
| Discussion Leader: Richard Armstrong (Vanderbilt University) |
| 7:35 pm - 8:05 pm | David Sherman (U. Michigan)
"Structural diversity and metabolic versatility in natural product biosynthesis" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Sarah O'Connor (MIT)
"Alkaloid biosynthesis" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:25 pm | Carsten Krebs (Penn State)
"Oxygen activation by isopenicillin N synthase" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | NEW APPROACHES TO METABOLIC PATHWAYS |
| Discussion Leader: Jason Sello (Brown) |
| 9:00 am - 9:30 am | John Shanklin (DOE)
"Understanding unusual fatty acid biosynthesis: mechanism of allylic hydroxy fatty acid production by a mutant soluble desaturase" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Poster Talk 1: Thomas Magliery (Ohio State University)
"Statistical, combinatorial and rational engineering of enzymes for improved physical properties" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Oliver Thimm (Metanomics)
"Understanding the message from metabolic pathways. A major challenge and opportunity in current biotechnology research" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Joseph Kappock (Wash U)
"Life in Acid, A Metabolic Pickle" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Jay Keasling (UC Berkeley)
"Metabolic pathway engineering for drugs and fuels" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEINS ON THE MOVE |
| Discussion Leader: Ann McDermott (Columbia) |
| 7:30 pm - 8:00 pm | Vishva Dixit (Genentech)
"IAP antagonists induce auto-ubiquitination of c-IAPs, NF-κB activation and TNFα-dependent apoptosis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Jeff Gelles (Brandeis University)
"Walking with one lame leg: plasticity of kinesin-1 mechanochemical coupling mechanisms" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Patrick Loria (Yale)
"Flexible loops involved in enzyme function" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ADVANCES IN MEDICINAL ENZYMOLOGY |
| Discussion Leader: Hening Lin (Cornell) |
| 9:00 am - 9:30 am | Anne Eakin (AstraZeneca)
"Novel DNA gyrase inhibitors: fragment-based NMR screening to antibacterial agents" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Poster Talk 2: Steven Rothman (DuPont)
"Type II Isopentenyl Diphosphate Isomerase: Mechanistic Studies with Substrate Analogs" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Sara Thrall (GSK)
"The mechanism of a cysteine protease as revealed by integration of steady-state and pre-steady-state solvent kinetic isotope effects" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Ron Raines (U Wisconsin)
"Ribonucleases as chemotherapeutic agents" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Sharon Cload (Archemix)
"Therapeutic aptamers: applications in hemostasis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOST-PATHOGEN INTERACTIONS |
| Discussion Leader: Kate Carroll (Michigan) |
| 7:30 pm - 8:00 pm | C. Erec Stebbins (Rockefeller)
"A molecular syringe full of enzymes: how bacteria modulate host cell biology" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Poster Talk 3: Deborah Perlstein (Harvard Medical School)
"New substrate analogs to probe the mechanism of the peptidoglycan glycosyltransferases" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Poster Talk 4: Barbara Gerratana (U of Maryland)
"Kinetic and Structural Characterization of Glutamine-dependent NAD+ Synthetase" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Laura Kiessling (U Wisconsin)
"Understanding carbohydrate biosynthetic pathways in Mycobacterium tuberculosis" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NUCLEIC ACID ENZYMOLOGY |
| Discussion Leader: Martha Fedor (Scripps) |
| 9:00 am - 9:30 am | Chris Francklyn (U Vermont)
"Substrate facilitated catalysis by aminoacyl-tRNA synthetases: creating the essential precursors of protein synthesis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Poster Talk 5: Quamrul Hassan (M.I.T.)
"Methodology to probe subunit interactions in ribonucleotide reductases" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Geeta Narlikar (UC San Francisco)
"Mechanisms of ATP-dependent chromatin remodeling complexes" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Carlos Catalano (U Washington)
"Assembly of an infectious virus in vitro and mechanistic studies on a DNA packaging motor" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Poster Talk 6: Audrey Lamb (U Kansas)
"Transient kinetic evidence for a novel reaction mechanism by the ornithine hydroxylase from Pseudomonas aeruginosa" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk 7: Lin JIang (U Washington)
"De novo Computational Enzyme Design of Novel Catalysts" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SIGNALLING PATHWAYS |
| Discussion Leader: Elizabeth Boon (Stony Brook) |
| 7:30 pm - 8:00 pm | Phillip Cole (Johns Hopkins)
"Chemical approaches to sorting out histone modifying enzymes" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Keith Moffat (Chicago)
"How do signaling photoreceptors work? Static and time-resolved crystallography" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:00 pm | Susan Taylor (UC San Diego)
"PKA: dynamic scaffold for catalysis and docking" |
| 9:00 pm - 9:10 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | REGULATED ENZYMOLOGY |
| Discussion Leader: Kenny Wong (Merck Research Labs) |
| 9:00 am - 9:30 am | Shou-ou Shan (Cal Tech)
"Towards a new paradigm for GTPase regulation of intracellular protein transport" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Poster Talk 8: Stefanie Jonas (Cambridge)
"Structural and kinetic analysis of a highly catalytically promiscuous enzyme with seven activities" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Michael Wolfe (Harvard)
"Intramembrane aspartyl proteases" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Kim Orth (UT Southwestern)
"Yop and Vop play ping-pong" |
| 11:40 am - 11:50 am | Discussion |
| 12:00 pm - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FRONTIERS IN ENZYMOLOGY |
| Discussion Leader: Daniel Herschlag (Stanford U) |
| 7:30 pm - 8:00 pm | TBA |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Dan Tawfik (Weizmann)
"The makings of new enzymatic catalysts" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jack Szostak (MGH)
"Selection and evolution of enzymes from a partially randomized non-catalytic scaffold" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |