Gordon Research Conferences
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Conference Program
 
Mechanisms of Epilepsy & Neuronal Synchronization
Neuroplasticity in Epilepsy
August 3-8, 2008
Colby College
Waterville, ME
Chair:
Douglas Coulter

Vice Chair:
John Huguenard

The main goals of the study of epilepsy are to 1) to understand the underlying injury- or genetic-induced changes in brain function linking a brain perturbation to the subsequent processes that generate an increase in seizure predisposition (epileptogenesis), as well as 2) identify the mechanisms underlying synchronous electrical discharges in neuronal networks (seizure generation). Both of these processes involve plastic changes in neuron and/or circuit behavior, which is the theme of the 2008 Conference, Neuroplasticity in Epilepsy. A better understanding of both epileptogenesis and seizure generation are necessary in order to develop more effective and less toxic treatments and cures for epilepsy. A unique, intellectually challenging aspect of epilepsy research arises from the fact that it encompasses virtually all major levels of biological organization, from genes and ion channels to circuits and behavior. The major purpose of this Gordon conference is to bring together neurophysiologists, molecular biologists, geneticists, developmental neuroscientists, and neuroanatomists working on basic mechanisms related either directly or indirectly to seizure generation to synthesize current advances and to set the stage for future discoveries.

In addition to our invited speakers at the main meeting, 8 short talks will be selected from submitted abstracts, one to two weeks prior to the start of the meeting.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 7:45 pmWelcome / Introductory Comments by Douglas Coulter and John Huguenard, Chair and Vice-Chair
7:45 pm - 9:30 pmGlial Dysfunction in Epilepsy
7:45 pm - 7:50 pm Discussion Leader: John Huguenard (Stanford University Medical Center)
"Introduction"
7:50 pm - 8:15 pm Harald Sontheimer (University of Alabama Birmingham)
"Glutamate release from gliomas facilitates tumor growth and triggers peritumoral seizures"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:50 pm Ken McCarthy (University of North Carolina Chapel Hill)
"GPCR-mediated increases in astrocytic calcium are not sufficient to stimulate glutamate release in situ"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Philip Haydon (Tufts University)
"Astrocytes modulate neuronal network activity in vivo"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAcquired Channelopathies in Epilepsy
9:00 am - 9:05 am Discussion Leader: Yehezkel Ben-Ari (INSERM / INMED U29)
"Introduction"
9:05 am - 9:30 am Nicholas Poolos (University of Washington)
"Multiple mechanisms of acquired HCN channelopathy in epilepsy"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Albert Becker (University of Bonn)
"Functional consequences of transcriptional upregulation of CaV3.2 in epiletogenesis"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Dane Chetkovich (Northwestern University)
"Post-translational HCN channelopathy in temporal lobe epilepsy"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Tallie Z. Baram (University of California, Irvine)
"Multiple levels and time-scales of activity-dependent regulation of the HCN channels"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Valerie Crepel (INSERM / INMED U29)
"Aberrant Kainate Receptor-Operated Synapses on Dentate Granule Cells from Chronic Epileptic Rats"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Beatrice Marcelin (INSERM, Marseilles)
"Alterations of h current underlie a deficit of theta oscillation resonance and phase shifts in a rat model of temporal lobe epilepsy"
12:15 pm - 12:30 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic and Genomic Approaches in Epilepsy
7:30 pm - 7:35 pm Discussion Leader: Daniel Lowenstein (University of California, San Francisco)
"Introduction"
7:35 pm - 7:55 pm Wayne Frankel (Jackson Laboratories)
"Why we study novel mouse mutations that cause epilepsy"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Guy Rouleau (Université de Montreal)
"Genomic Approaches to understanding Epilepsy"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Peter Crino (University of Pennsylvania)
"Molecular Pathogenesis of Focal Brain Malformations"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Thomas Ferraro (University of Pennsylvania)
"Genomic strategy identifies a new seizure susceptibility mechanism in common strains of mice that is relevant to human epilesy"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Channelopathies in Epilepsy
9:00 am - 9:05 am Discussion Leader: Miriam Meisler (University of Michigan)
"Introduction: Ten years of channel mutations, 1998-2008"
9:05 am - 9:30 am Robert Macdonald (Vanderbilt University Medical Center)
"GABAA receptor subunit mutations associated with IGEs produce defects in subunit expression and assembly and receptor trafficking and function"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am William Catterall (University of Washington)
"Hyperexcitability, Ataxia, and Febrile Seizure in a Mouse Model of Severe Myoclonic Epilepsy of Infancy"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Bin Wang (University of Texas HSC, San Antonio)
"Understanding the mechanisms underlying a human BK potassium channel epilepsy mutation"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Edward Cooper (University of Pennsylvania)
"Neonatal seizures: From genes to mechanisms to therapy"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Matthew Anderson (Harvard Medical School)
"Defective Circuit Development in Autosomal Dominant Lateral Temporal Lobe Epilepsy"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Joy Sebe (University of California, San Francisco)
"Transplantation of Interneuron Progenitor Cells Suppresses Seizures in a Mouse Model of Epilepsy"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEarly Post-Translational Events in Epileptogenesis
7:30 pm - 7:35 pm Discussion Leader: James McNamara (Duke University School of Medicine)
"Introduction"
7:35 pm - 7:55 pm Frances Jensen (Children's Hospital & Harvard Medical School)
"Seizure induced post-translational changes in neurotransmitter receptors in the immature brain"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Jaideep Kapur (University of Virginia)
"Modulation of GABA A receptor trafficking by seizures"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Stephen Moss (Tufts University)
"Status eplitepticus decreases the phosphorylation and functional expression of gabaa receptors and kcc2"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Richard Huganir (Johns Hopkins University)
"Regulation of Glutamate Receptor Function in the Brain"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGABAergic Signaling and Epileptogenesis
9:00 am - 9:05 am Discussion Leader: David Prince (Stanford University)
"Introduction"
9:05 am - 9:30 am Kevin Staley (Massachusetts General Hospital / Harvard Medical School)
"Long-term modulation of ion transport and GABA signaling"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Matthew Walker (University College London)
"The regulation of neuronal excitability by tonic GABA(A) receptor mediated inhibition"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Jokubas Ziburkus (University of Houston)
"Dynamics and neuromodulation of excitation and inhibition during in vitro seizure-like events"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Carolyn Houser (David Geffen School of Medicine at UCLA)
"Remaining GABA Neurons in Temporal Lobe Epilepsy: What are they doing"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Amy Brooks-Kayal (University of Colorado HSC)
"Mechanisms of GABA(A) Receptor Subunit Gene Regulation during Epileptogenesis"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Wolfgang Mueller (University of New Mexico)
"Progressive changes in GABAergic inhibition during development of Temporal Lobe Epilepsy"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmImaging Approaches in Epilepsy
7:30 pm - 7:35 pm Discussion Leader: Peter Saggau (Baylor College of Medicine)
"Introduction"
7:35 pm - 7:55 pm Greg Carlson (University of Pennsylvania)
"Imaging epilepsy and hyperexcitability in developmental disorders"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Andrew Trevelyan (University of Newcastle)
"Visualizing the inhibitory surround in vitro: Inhibitory restraints on epileptiform activity"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Rosa Cossart (INSERM / INMED U29)
"Watching how synchrony is orchestrated in cortical networks: identification of 'circuit hubs'"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Karl Deisseroth (Stanford University)
"Optogenetics: development and application"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Epilepsy Models: Infantile Spasms, Cortical Dysplasias
9:00 am - 9:05 am Discussion Leader: John Swann (Baylor College of Medicine)
"Introduction"
9:05 am - 9:30 am Jeffrey Golden (Children's Hospital of Philadelphia)
"Arx, interneurons, and epilepsy"
9:30 am - 9:40 am Discussion
9:40 am -10:05 am William Dobyns (University of Chicago)
"Where has all the GABA gone? ARX, malformations, epilepsy, mental retardation and pleiotropy"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 am Coffee Break
10:40 am - 10:50 am Aristea Galanopoulou (Albert Einstein College of Medicine)
"A model of symptomatic infantile spasms"
10:50 am - 10:55 am Discussion
10:55 am - 11:20 am Stewart Anderson (Weill Medical College of Cornell University)
"Embryonic determination of interneuron fate: implications for models of interneuronopathies and the development of a cell based therapy for seizures"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Joseph LoTurco (University of Connecticut)
"Stop and go migration: regression of cortical heterotopia by re-expression of DCX"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:15 pm Julia Brill (Stanford University Medical Center)
"Enhanced IPSCs from fast spiking interneurons onto pyramidal cells in a model of focal cortical dysplasia and epilepsy"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCircuit Mechanisms of Epilepsy
7:30 pm - 7:35 pm Discussion Leader: Tom Sutula (University of Wisconsin)
"Introduction"
7:35 pm - 7:55 pm Paul Buckmaster (Stanford University)
"Hippocampal Unit Activity Before and During Spontaneous Seizures in a Model of Temporal Lobe Epilepsy"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Helen Scharfman (Nathan Kline Institute for Psychiatric Research)
"The role of neurogenesis in the dentate gyrus in temporal lobe epilepsy"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Ivan Soltesz (University of California, Irvine)
"Major role for nonrandom microcircuits in epilepsy"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Jozsef Csicsvari (Oxford University, UK)
"Behavioural state-dependent regulation of network excitability by hippocampal interneuron classes"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by NS062439 from the National Institute of Neurological Disorders and Stroke (NINDS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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