Gordon Research Conferences
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Conference Program
 
Fibroblast Growth Factors in Development & Disease
March 2-7, 2008
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chairs:
Dave Fernig & Gail Martin

Vice Chair:
Sabine Werner

FGFs and FGF receptors represent an information network that is essential for the elaboration of the metazoan body plan and the normal development of virtually every organ in the body. They are also essential for maintaining tissue homeostasis by contributing to tissue repair and metabolic regulation. Dysregulation of FGF activity underlies a variety of pathologies. For example, mutations in FGF receptors cause skeletal growth defects in newborns and cancers in adults; altered expression of FGF ligands is associated with functional brain disorders such as depression. The breadth and depth of the field is illustrated by the fact that in 2005-2006 alone, >3500 papers (PubMed), covering 86 different disciplines (ISI's Web of Knowledge) were published on FGF biology.

Recognising the field's importance and diversity, The 2nd Gordon Research Conference on FGFs in Health and Disease will showcase the timeliest research, and promote interdisciplinary exchange between scientists studying all aspects of FGF biology. Topics will cover FGF biochemistry, structure, signalling, development, physiology and pathology and a unifying theme of the conference will be the integration of our understanding of FGF function at different levels of biological organisation (molecular to the organism).

This conference places a strong emphasis on discussion and has an extended poster time. The inclusive policy on acceptance of applications ensures a strong mix of established investigators, junior PIs, postdocs and graduate students.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmFGF SIGNALING: AN OVERVIEW
Discussion Leader: Claudio Basilico (New York University, USA)
7:40 pm - 8:20 pm Moosa Mohammadi (New York University, USA)
"Structural basis for FGF receptor activation in human diseases"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm David Ornitz (Washington University, USA)
"FGF-WNT gene regulatory network regulates lung mesenchyme development"
9:15 pm - 9:30 pm Discussion
9:30 pm Poster Session
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFGF FUNCTION IN ORGANOGENESIS
Discussion Leader: Gail Martin (University of California, San Francisco, USA)
9:00 am - 9:20 am Matthew Hoffman (NIH, Bethesda, USA)
"Heparan sulfate regulation of FGF10-mediated submandibular gland branching morphogenesis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Tom Kornberg (University of California, San Francisco, USA)
"The roles of Drosophila FGF in organ induction and mitogenesis"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:50 am Angelike Stathopoulos (CalTech, USA)
"The coordination of cell movements during Drosophila gastrulation: the role of FGF signaling"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Suzi Mansour (University of Utah, USA)
"FGF signaling in inner ear development"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Nobuyuki Itoh (University of Kyoto)
"The role of FGF16 in heart development"
11.50 am -12:00 pm Discussion
12:00 pm - 12:10 pm Mark Lewandoski (National Cancer Institute, USA)
"The vertebrate limb is patterned by BMP-mediated modulation of FGF signals via Sprouty expression"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Beat Trueb (University of Bern, Switzerland)
"Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDEVELOPMENT OF THE NERVOUS SYSTEM
Discussion Leader: Ivor Mason
5:30 pm - 5:50 pm Ann Calof (University of California, Irvine, USA)
"FGFs, neurogenesis in the primary olfactory system, and the origin of GnRH-expressing neurons in the mouse"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Albert Basson (King's College London, UK)
"FGF signalling in cerebellar morphogenesis"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Hisashi Umemori (University of Michigan, USA)
"Specific Synapse Formation by FGFs"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Jean Hebert (Albert Einstein College of Medicine, USA)
"FGF signaling acts as an organizer for the telencephalon"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:15 pm Poster Session
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSKELETAL BIOLOGY
Discussion Leader: David Ornitz (Washington University, USA)
9:00 am - 9:20 am William Horton (University of Oregon Heath Science campus and Shriners Hospital for Children, USA)
"Strategies to counter excessive FGFR3 signals"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Victor Nurcombe (Institute of Molecular and Cell Biology, Singapore)
"Regulation of FGF/BMP loops by heparans during osteogenesis"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Irene Hung (University of Utah, USA)
"FGF Signaling in Skeletal Development"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Janet Henderson (McGill University, Canada)
"FGF18 to promote bone regeneration and repair"
11:20 am - 11:30 am Discussion
11.30 am - 11:50 am Claudio Basilico (New York University, USA)
"Key events determine the growth-inhibitory response of chondrocytes to FGF signaling"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Christoph Ladel (Merck Serono Research, Italy)
"FGF18 as therapeutic for osteoarthritis: Efficacy of rhFGF18 in preclinical models of osteoarthritis"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Tonia Vincent (Kenedy Institute, London)
"FGF2 is an intrinsic chondroprotective agent, which suppresses the proteinase ADAMTS5, and delays cartilage degradation in osteoarthritis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmNERVOUS SYSTEM FUNCTION AND REPAIR
Discussion Leader: Klaus Unsicker (University of Heidelberg, Germany)
5:30 pm - 5:50 pm Oliver von Bohlen und Halbach (University of Heidelberg, Germany)
"FGF-2 in an animal model of depression"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Marco Riva (University of Milan, Italy)
"FGF2 regulation in drug abuse and stress response"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Claudia Grothe (University of Hannover, Germany)
"Regenerative potential of endogenous and cell-based applied FGF-2 in two animal models, Parkinson's disease and peripheral nerve regeneration"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Mitchell Goldfarb (City University, New York, USA)
"FHF control of sodium channel physiology and neuronal function: insights from mutant mice"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:15 pm Poster Session
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTUMORIGENESIS
Discussion Leader: Victor Nurcombe (Institute of Molecular and Cell Biology, Singapore)
9:00 am - 9:20 am François Radvanyi (Institut Curie, France)
"Role of FGFR3 in tumours"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Richard Grose (Institute of Cancer, UK)
"Epithelial FGFR2: oncogene or tumour suppressor?"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Michael Seckl (Imperial College, UK)
"FGF-2 triggers a novel signaling machine enhancing translation of anti-apoptotic proteins and driving chemoresistance in lung cancer"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Dina Ron (Technion, Israel)
"Sef regulation in normal and cancer cells"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Marco Presta (University of Brescia, Italy)
"FGF2 as a damage-associated molecular pattern (DAMP) proangiogenic cytokine"
11.50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Igor Prudovsky (Maine Medical Centre, USA)
"Repression of CBF1-mediated Notch signaling results in FGF1 export and cell transformation"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Soo Hyun Kim (University College, UK)
"Anosmin-1 mediates crosstalk between TGF-beta 1 and FGFR1 signal pathways in development and tumourigenesis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmHOMEOSTASIS
Discussion Leader: Sabine Werner
5:30 pm - 5:50 pm Toru Imamura (National Institute of Advanced Industrial Science and Technology)
"BetaKlotho is required for FGF21 signaling"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Itaru Urakawa (Kirin Brewery Co, Japan)
"Role of FGF23 in phosphate homeostasis"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Makoto Kuro-o (University of Texas, USA)
"Interaction between the Klotho and FGF19 family members"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Alexei Kharitonenkov (Lilly Research Laboratories, USA)
"Metabolic actions of FGF21"
7:20 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
9:15 pm Poster Session
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSTEM CELLS, REGENERATION AND TISSUE REPAIR
Discussion Leader: Janet Henderson (McGill University, Canada)
9:00 am - 9:20 am Sabine Werner (Eidgenössische Technische Hochschule Zurich, Switzerland)
"Fibroblast growth factors in epithelial morphogenesis and tissue repair"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Gerald de Haan (University Medical Center Groningen, Netherlands)
"Culturing hematopoietic stem cells with FGFs"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Bradley Olwin (University of Colorado, USA)
"A critical role for FGFR4 in regeneration of skeletal muscle"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Robert Friesel (Maine Medical Centre, USA)
"Overexpression of Spry1 in Chondrocytes Results in Attenuated FGFR Ubiquitinylation and Sustains ERK activation Results in Chondrodysplasia"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am John Whitelock (University of New South Wales, Australia)
"HS on perlecan determines the fate of chondorcytes via its interactions with FGFs"
11.45 am - 11:53 am Discussion
11:53 am - 12:03 pm Shinya Murakami (Osaka University, Japan)
"Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2:Randomized Controlled Phase II Clinical Trial8Randomized Controlled Phase II Clinical Trial"
12:03 pm - 12:08 pm Discussion
12:08 pm - 12:22 pm Saverio Bellusci (Children's Hospital Los Angeles, USA)
"Induction of FGF10 in the ileal crypt epithelium after massive small bowel suggests a role for FGF10 in gut adaptation"
12:22 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmREGULATING THE FGF SIGNAL
Discussion Leader: Moosa Mohammedi (New York University, USA)
5:30 pm - 5:50 pm Jeremy Turnbull (University of Liverpool, UK)
"Decoding the chemical biology of heparan sulfate: an ES-MS sequencing strategy reveals specific modulation of FGF signalling"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:10 pm Helen Makarenkova (The Neurosciences Institute, USA)
"A molecular basis for FGF gradient formation and regulation of branching morphogenesis"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:25 pm Ugo Cavallaro (IFOM-IEO, Italy)
"The NCAM/FGFR cross talk: a novel paradigm in FGFR signalling"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pm Fen Wang (Texas A&M, USA)
"FGF signaling in prostate development and tumorigenesis"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Antoni Wiedlocha (Institute for Cancer Research, Oslo, Norway)
"Role of p38 MAPK in translocation of FGF-1 into cells"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:15 pm Poster Session
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by Grant # 1 R13 HD057651-01 co-funded by the National Institute of Child Health and Human Development (NICHD) and the National Institute of Neurological Disorders and Stroke (NINDS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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