Gordon Research Conferences
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Conference Program
 
Glycolipid & Sphingolipid Biology
February 17-22, 2008
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Gerrit Van Meer

Vice Chair:
Lina M. Obeid

The Gordon Research Conference on Glycolipid and Sphingolipid Biology, the tenth in this series, promises to be an exciting and instructive meeting. One challenge is to understand how the chemical structure of glycolipids and sphingolipids dictates their physical behavior in membrane organization and dynamics during transport and signaling. Another challenge is to find out how the local glyco/sphingolipid concentration is regulated by transport proteins and metabolic enzymes, including their regulation at the level of gene expression and post-translational modification. Finally, we need to find out how our knowledge of these processes can be used to understand celluar (patho)physiology and interfere with disease. With the help of all attendants we'll try to cover the significant developments and perspectives all the way from biophysics/structure, genetics, metabolism/sphingolipidomics/novel techniques, transport/toxin, signaling/immunology, to cancer/Alzheimer disease/mouse models. Next to the invited presentations by leaders in the field, exciting posters will be selected for oral presentation. We will have ample discussion after each talks, during the poster sessions and at our Italian meals.


Contributors
Gordon Research Conferences
National Institutes of Health
Beiersdorf AG
Genzyme Corporation
LPath Therapeutics, Inc.
Mizutani Foundation for Glycoscience
Sanofi-Aventis
Avanti Polar Lipids, Inc.
The Center for Cell, Gene and Vaccine Therapy, MUSC
Otsuka America Pharmaceutical, Inc.
Progress in Lipid Research at Elsevier
Keystone Nano
Echelon Research Laboratories

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmSphingolipid microdomains in transport and signaling
Discussion Leader: Erwin London (Stony Brook University, Stony Brook, NY)
7:40 pm - 8:20 pm Kai Simons (MPI-CBG, Dresden, Germany)
"Membrane rafts up and floating" [Lecture in honor of Steven Pfeiffer]
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:00 pm Jerry Feigenson (Cornell Univ., Ithaca, NY)
"Do phase domains that are too small to see really exist? Some answers from a 4-component phase diagram"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Alessandro Prinetti (Univ. of Milan, Segrate, Italy)
"Non-caveolar caveolin-1-enriched sphingolipid microdomains in the control of tumor cell motility"
9:25 pm - 9:30 pm Discussion
9:30 pm Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiophysics and transport of (glyco)sphingolipids and cholesterol
Discussion Leader: Alicia Alonso (Univ. of the Basque Country, Bilbao, Spain)
9:00 am - 9:30 am Sandro Sonnino (Univ. of Milan, Segrate, Italy)
"The amphiphilic properties of glycosphingolipids, the membrane organization and the cell signaling"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Bodil Ramstedt (Åbo Akademi Univ., Turku, Finland)
"Is there a specific interaction between sphingolipids and cholesterol? - What studies of mixed model membranes reveal"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break / Group Photo
10:50 am - 11:20 amRamandeep Singh Takhter (Mayo Clinic, Rochester, MN)
"Microdomains at the plasma membrane: Determinants for caveolar endocytosis"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Liana Silva (Instituto Superior Tecnico, Lisbon, Portugal)
"Comparing glucosylceramide and ceramide effects in membrane biophysical properties"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm L. Ashley Cowart (Medical Univ. of South Carolina, Charleston, SC)
"Palmitic-acid induced remodeling of sphingolipid profiles by Serine Palmitoyltransferase dependent and independent mechanisms"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm M. Cameron Sullards (Georgia Institute of Technology, Atlanta, GA)
"Imaging mass spectrometry: a powerful 'lipidomic' tool to determine the localization of sphingolipids directly from tissues"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 1
5:30 pm - 7:30 pmSphingolipids and immunology
Discussion Leader: Hugh Willison (Univ. of Glasgow, Glasgow, UK)
5:30 pm - 6:00 pm Gennaro De Libero (Univ. Hospital Basel, Basel, Switzerland)
"Molecular mechanisms of lipid antigen presentation to T cells"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:25 pm Laura Allende (NIH, Bethesda, MD)
"Sphingosine-1-phosphate metabolism, a regulator of inflammation and immunity"
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:45 pm Susumu Kusunoki (Kinki Univ. School of Medicine, Osaka, Japan)
"Antibodies to gangliosides and ganglioside complexes in immune-mediated neuropathies"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:05 pm Reiji Kannagi (Aichi Cancer Center, Nagoya, Japan)
"Immunogenic GM2 ganglioside antigen on cancer cells"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm Usha Acharya (Univ. of Massachusetts Medical School, Worcester, MA)
"Cell non-autonomous function of ceramidase in photoreceptor homeostasis"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStorage diseases and diabetes
Discussion Leader: Yusuf Hannun (Medical Univ. of South Carolina, Charleston, SC)
9:00 am - 9:30 am Konrad Sandhoff (Univ. of Bonn, Bonn, Germany)
"Principles of lysosomal sphingolipid catabolism and membrane digestion"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Hans Aerts (Univ. of Amsterdam, Amsterdam, The Netherlands)
"Role for glycosphingolipids in insuline resistance and type 2 diabetes"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 am Fran Platt (Univ. of Oxford, Oxford, UK)
"Sphingosine storage in Niemann-Pick disease type C: implications for therapy"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Seng H. Cheng (Genzyme Corporation, Framingham, MA)
"Impact of Modulating Glycosphingolipids on Type 2 Diabetes"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Makoto Ito (Kyushu University, Fukuoka, Japan)
"Novel catabolic pathway of GlcCer involving Klotho-related protein"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Monica M. Palcic (Carlsberg Laboratory, Copenhagen, Denmark)
"Tools for monitoring glycolipid metabolism in single cells"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 2
5:30 pm - 7:30 pmNovel techniques; sphingolipidomics
Discussion Leader: James A. Shayman (University of Michigan, Ann Arbor, MI)
5:30 pm - 6:00 pm Akemi Suzuki (Tokai University, Kanagawa, Japan)
"TLC-MS of neutral glycosphingolipids and its application"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:40 pm Howard Riezman (Univ. of Geneva, Geneva, Switzerland)
"Sterol-sphingolipid interactions in yeast"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:20 pm Jasna Peter-Katalinic (Univ. of Münster, Münster, Germany)
"Emerging glycosphingolipidomics technologies: Toward understanding topology and function"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:50 amSphingolipid metabolism and transport
Discussion Leader: Yoshio Hirabayashi (RIKEN, Saitama, Japan)
9:00 am - 9:30 am Joost Holthuis (Utrecht Univ., Utrecht, The Netherlands)
"A sphingomyelin synthase-related family of ceramide sensors with a role in early secretory pathway organization"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Thorsten Hornemann (Univ. Hospital Zürich, Zürich, Switzerland)
"What is wrong with SPT in HSN1?"
9:55 am - 10:00 am Discussion
10:00 am - 10:15 am Tony Futerman (Weizmann Inst., Rehovot, Israel)
"Mammalian ceramide synthases: What do they all do?"
10:15 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 12.30 pmPoster Talks
10 x 10 minute talks will be chosen at the meeting on the basis of those posters which generate the most interest during the afternoon and evening Poster Sessions
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 3
5:30 pm - 7:30 pmSphingolipid signaling and autophagy
Discussion Leader: Julie Saba (CHORI, Oakland, CA)
5:30 pm - 6:00 pm Patrice Codogno (Univ. Paris - Sud, Châtenay-Malabry, France)
"Regulation of macroautophagy by ceramide"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:40 pm Tim Hla (Univ. of Connecticut Health Center, Farmington, CT)
"S1P receptor-dependent control of vascular phenotype"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:05 pm Walter M. Holleran (UCSF, San Francisco, CA)
"Ceramide regulates ABCA12 transporter expression in human keratinocytes"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pm Elsa Lauwers (Université Libre de Bruxelles, Gosselies, Belgium)
"Coupled biosynthesis of sphingolipids and the yeast Gap1 permease"
7:25 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSphingolipids and cancer/skin
Discussion Leader: Richard Kolesnick (MSKCC, New York, NY)
9:00 am - 9:30 am Amy Paller (Northwestern Univ., Chicago, IL)
"Ganglioside modulation in squamous cell carcinomas: Effects on signaling and biologic behavior"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Jim Norris (Medical Univ. of South Carolina, Charleston, SC)
"The role of acid ceramidase in tumor progression and therapeutic resistance in cancer"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 am Mark Kester (Penn State College of Medicine, Hershey, PA)
"Nano 'Solutions' for Ceramide"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am Alexander Carpinteiro (Univ. of Duisburg-Essen, Essen, Germany)
"Role of the acid sphingomyelinase in tumor metastasis"
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm Charles Swanton (Cancer Research UK London Research Institute, London, UK)
"Functional genomic identification of CERT as a regulator of multidrug sensitivity in cancer"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Roger Sandhoff (German Cancer Research Center, Heidelberg, Germany)
"Male germ cells require ceramide synthase-3-derived polyenoic sphingolipids with complex glycosylation for completion of meiosis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 4
5:30 pm - 7:30 pmMouse models for sphingolipid defects/cancer and diet
Discussion Leader: Yasu Igarashi (Hokkaido Univ., Sapporo, Japan)
5:30 pm - 6:00 pm Koichi Furukawa (Nagoya University School of Medicine, Nagoya, Japan)
"Novel mechanisms for the neurodegeneration in the mutant mice lacking gangliosides"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:40 pm Ron Schnaar (Johns Hopkins School of Medicine, Baltimore, MD)
"Ganglioside functions in axon protection and axon regeneration"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:20 pm Åke Nilsson (Lund University Hospital, Lund, Sweden)
"Digestion of sphingomyelin in the gut and its potential role in cancer prevention"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner / Farewell Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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