Gordon Research Conferences
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Conference Program
 
Hemostasis
June 29 - July 4, 2008
Waterville Valley Resort
Waterville Valley, NH
Chair:
Peter J. Newman

Vice Chair:
Nigel Mackman

The Gordon Research Conference on Hemostasis is widely considered to be the premiere small meeting on the topics of blood coagulation, platelet biology, and anticoagulant pathways, enjoying both national and international reputation. First organized by hemostasis pioneers Earl W. Davie and Oscar Ratnoff in 1973, the meeting has been held biennially since then. The Hemostasis Gordon Conference has a unique focus, bringing together scientists interested in the biology, biochemistry and genetics of platelets and coagulation proteins, physicians involved in the treatment of bleeding and thrombotic diseases and biotechnologists from small and large pharma focused on the development of new therapies to address hemostatic problems.

The next conference will be held on June 29th - July 4th, 2008 at Waterville Valley Conference Center, Waterville Valley, New Hampshire, a new, comfortable, and inviting location that should provide an excellent venue for all participants. This Conference Center, surrounded by the White Mountains of New Hampshire, received the Pinnacle Award from Successful Meetings magazine in 2000, and provides over 15,000 square feet of flexible, highly functional space. Recreational facilities include ready access to biking hiking, golf, tennis, boating, and the Waterville Valley Arts Center. Waterville Valley is only two hours north of Boston, making travel to and from convenient for speakers and attendees from the US and overseas alike. All accommodations, dining hall, poster areas and meeting rooms are accessible to handicapped persons.

It is the goal of the conference organizers that nearly every person attending the conference participates either as a speaker, discussion leader, or poster presenter. At Waterville Valley, the venue for the 2008 Conference, there is space available for 30-40 posters at a session, and four poster sessions are scheduled. The conference Vice-Chair, Nigel Mackman, will be responsible for organizing the posters into sessions that are related to the meeting agenda.

Afternoons will be open for informal discussion among attendees and leisure activities aimed at increasing further interactions and intellectual exchange – traditionally a unique and important part of all Gordon Conferences. Poster presentations will be held before dinner on four of the five days. These are always very well-attended, and provide a dedicated, informal forum for interaction between junior and more senior scientists in the field.

The current draft program of the meeting is shown below. All attendees not currently on the Program who apply to the conference will be encouraged to submit an abstract for presentation at one of our four scheduled Poster Sessions, scheduled to be held in the afternoon Monday-Thursday.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:45 pmIntroductory Comments by GRC Site Staff
Welcome: Peter Newman (Blood Research Institute, BloodCenter of Wisconsin)
7:45 pm - 9:30 pm HISTORICAL VIEWS OF THROMBOSIS AND HEMOSTASIS
Discussion Leader: Nigel Mackman (University of North Carolina - Chapel Hill)
7:45 pm - 8:15 pm Barry Coller (Rockefeller University)
"From the Rivers of Babylon to the Coronary Blood Stream: Vignettes form the αIIbβ3 Story"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pm Charles Esmon (Oklahoma Medical Research Foundation)
"Toward an Understanding of the Physiological Regulation of Blood Coagulation"
9:00 pm - 9:15 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm BIOLOGY OF VON WILLEBRAND FACTOR
Discussion Leader: Zaverio Ruggeri (Scripps Research Institute)
9:00 am - 9:25 am Robert Montgomery (Blood Research Institute and Medical College of Wisconsin)
"The platelet and endothelial cell as targets for drug delivery in hemophilia"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am José Lopez (Puget Sound Blood Center)
"Shear Hell: VWF and Oxidative Stress"
10:05 am - 10:20 amDiscussion
10:20 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:25 am J. Evan Sadler (Washington University, St. Louis)
"Assembly, Storage and Structure of von Willebrand Factor"
11:25 am - 11:40 amDiscussion
11:40 am - 12:05 pm Karen Vanhoorelbeke (Catholic University of Leuven, Campus Kortrijk)
"von Willebrand Factor and its Processing by ADAMTS13"
12:05 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A
6:00 pmDinner
7:30 pm - 9:30 pm BASIC AND CLINICAL DEVELOPMENTS IN ANTI-THROMBOTICS
Discussion Leader: Wolfgang Eisert (Boehringer Ingelheim GmbH, Germany)
7:30 pm - 7:55 pm J. Anthony Ware (Eli Lilly)
"Prasugrel and the Patient Determinants of Drug Response"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Robert Schaub (Archemix Corp)
"The Evaluation of an Anti-von Willebrand Factor Therapeutic Aptamer"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Pamela Conley (Portola)
"Mechanistic Distinctions of Reversible and Irreversible P2Y12 Antagonists"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm BLOOD COAGULATION FACTORS AND HEMOSTASIS
Discussion Leader: Sriram Krishnaswamy (University of Pennsylvania)
9:00 am - 9:25 am Shannon Meeks (Emory University School of Medicine)
"Uncovering the Diversity of Structural and Functional Epitopes on the C2 Domain of Factor VIII"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am Susan Lord (University of North Carolina at Chapel Hill)
"Defining Residues Critical to Fibrin Clot Structure"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Paula Tracy (University of Vermont)
"Physical Modifications and Functional Characteristics Unique to Platelet-Derived Factor Va"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 am John McVey (Imperial College London)
"The X Factor in Adenovirus Liver Infection"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:20 pmJacky Chi Ki Ngo (Beth Israel Deaconess, Harvard)
"Crystal Structure of B-Domain Deleted Factor VIII"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A (continued)
6:00 pmDinner
7:30 pm - 9:30 pm ATHEROTHROMBOSIS
Discussion Leader: Susan Smyth (University of Kentucky)
7:30 pm - 7:55 pm Willem Ouwehand (Cambridge University, United Kingdom)
"Genome-wide Association Study Meets Systems Biology"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Susan Smyth (University of Kentucky)
"Regulation of platelet function and atherothrombosis by lysophosphatidic acid and autotaxin/lysophospholipase D"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Eugene Podrez (Lerner Research Institute, Cleveland Clinic)
"Platelet Scavenger Receptors Class B, Oxidative Stress and Atherothrombosis"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm PLATELET SIGNALING - What turns ‘em on, what turns ‘em off
Discussion Leader: Sanford Shattil (University of California - San Diego)
9:00 am - 9:25 am Lawrence Brass (University of Pennsylvania)
"Novel Regulators of Thrombus Growth and Stability"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am Jane Freedman (Boston University)
"Thrombosis and the Platelet Transcriptome"
10:05 am - 10:20 amDiscussion
10:20 am - 10.50 am Coffee Break
10:50 am - 11:15 am Joel Bennett (University of Pennsylvania)
"Interactions of Integrin Transmembrane and Cytoplasmic Domains"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 am Mark Kahn (University of Pennsylvania)
"Regulation of Thrombopoiesis and Platelet Function by Collagen Receptors"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:20 pm Donna Woulfe (Thomas Jefferson University)
"The Akt/GSK3 Pathway: Regulating Platelet Responses to Agonist"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm HOT TOPICS
Discussion Leader: Edward Plow (Lerner Research Institute, Cleveland Clinic)
7:30 pm - 7:40 pmTy Adams (University of Cambridge)
"Crystal structure of thrombin and TM"
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pmEd Conway (University of Leuven)
"Regulation of complement by TM"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:10 pmSimon De Meyer (Catholic University of Leuven)
"Gene therapy for severe VWD"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pmKaren Fong (University of Pennsylvania)
"Microfluidic analysis of mouse platelets"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pmGuillermina Girardi (Hospital for Special Surgery)
"Role of TF:FVIIa-PAR-2 signaling in PMNs"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmStephen Lam (University of Illinois-Chicago)
"Activation of integrin alphaIIb/beta3 in platelets"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmToshiyuki Miyata (National Cardiovascular Research Institute, Osaka)
"Binding of ADAMTS13 to Lys-plasminogen"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmYan-Quing Ma (Cleveland Clinic)
"Kindkin-2 is a cofactor of integrin activation"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm NOVEL TIES BETWEEN HEMOSTASIS AND INFLAMMATION
Discussion Leader: John Griffin (Scripps Research Institute)
9:00 am - 9:25 am Mark Ginsberg (University of California - San Diego)
"Endogenous Stabilizers of Endothelial Cell-Cell Junctions"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am David Ginsburg (University of Michigan)
"Hemostasis in Host Defense from Microbial Pathogens"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:15 am Cheryl Hillery (Medical College of Wisconsin)
"Sickle Cell Disease as an Inflammatory Disorder"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 am Wolfram Ruf (Scripps Research Institute)
"PAR Signaling in Sepsis"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:20 pm Anil Chauhan (CBR Institute for Biomedical Research)
"ADAMTS13- a New Link Between Thrombosis and Inflammation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B (continued)
6:00 pmDinner
7:30 pm - 9:30 pm PLATELET POLYMORPHISMS AND PLATELET IMMUNOLOGY
Discussion Leader: Gow Arepally (Duke University Medical College)
7:30 pm - 7:55 pm Paul Bray (Cardeza and Thomas Jefferson University)
"Genetic Variations and Platelet Reactivity"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Morty Poncz (University of Pennsylvania)
"New Models/New Thinking on the Pathophysiology of Heparin-induced Thrombocytopenia"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Richard Aster (Blood Research Institute)
"Drug-induced Immune Thrombocytopenia: Molecular Mechanisms"
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by Grant # 1 R13HL092626-01 co-funded by the National Institute of Child Health and Human Development (NICHD) and the National Institute of Neurological Disorders and Stroke (NINDS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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