Gordon Research Conferences
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Conference Program
 
Heterocyclic Compounds
June 15-20, 2008
Salve Regina University
Newport, RI
Chair:
Karin Briner

Vice Chair:
Christopher J. Moody

The GRC on Heterocyclic Compounds is one of the longest running Gordon Research Conferences, which reflects the vitality and importance of the subject matter. The field of heterocyclic organic chemistry provides the strategies and chemical reactions that enable the preparation of structurally complex, heterocycle-containing natural products, new pharmaceutical agents, and organic materials. The continued evolution of this field is crucial to achieving efficient, cost-effective solutions to increasingly complex problems in organic synthesis and to accessing unexplored structural space. Through formal research lectures from outstanding scientists, poster sessions and informal discussions, this conference presents an excellent opportunity to any scientist who is interested in gaining knowledge of the most recent advances in the field.


SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Conference Chair, Karin Briner
7:40 pm - 9:30 pm New Reactions and Ideas for the Synthesis of Heterocyclic Compounds (Part 1)
Discussion Leader: Christopher Moody (University of Nottingham)
7:40 pm - 8:10 pm Keith Fagnou (University of Ottawa)
"Methods for the Catalytic Functionalization of Aromatic Heterocycles"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:30 pm Short Talk: Regan Thomson (Northwestern University)
"Silicon Keeps it Together: Oxidative Transformations of Silyl Bis-Enol Ethers"
8:30 pm - 8:35 pm Discussion
8:35 pm - 9:20 pmWilliam R. Roush (Scripps Florida)
"Applications of New Chiral Allylmetallating Agents Towards the Synthesis of Oxygen Heterocycles"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Innovative Concepts for Constructing Complex Heterocyclic Compounds and Natural Products
Discussion Leader: Jason Herr (Albany Molecular Research, Inc.)
9:00 am - 9:30 amThomas Pettus (University of California, Santa Barbara)
"Diastereoselective Synthesis of the Tetrahydrofuran, Benzopyran, and Isobenzopyran Rings of Berkelic Acid"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amAlison Frontier (University of Rochester)
"Nazarov Cyclizations of Heterocycles for Natural Product Synthesis"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Group Photo (10:20 am) / Coffee Break
11:00 am - 11:25 amJ. Ramon Vargas (Kodak)
"Novel Heterocyclic Compounds for Use in Organic Light Emitting Displays"
11:25 am - 11:35 am Discussion
11:35 am - 12:20 pmTohru Fukuyama (Tokyo University)
"Synthetic Studies on Heterocyclic Natural Products"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #1 (Moderator: Christopher Moody)
6:00 pmDinner
7:30 pm - 9:30 pm Catalysis in Heterocyclic Chemistry
Discussion Leader: David Lathbury (AstraZeneca)
7:30 pm - 8:00 pmHelma Wennemers (University of Basle)
"Catalytically Active Peptides"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Simon Blakey (Emory University)
"Catalytic Metallonitrene / Alkyne Metathesis: A Powerful Cascade Process for the Synthesis of Nitrogen Containing Molecules"
8:30 pm - 8:35 pm Discussion
8:35pm - 9:25 pm Andrew Evans (University of Liverpool)
"New Asymmetric Rhodium-Catalyzed Allylic Substitution Reactions for the Total Synthesis of Complex Bioactive Natural Products"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm New Reactions and Ideas for the Synthesis of Heterocyclic Compounds (Part 2)
**NOTE**:
Please go upstairs to Room 260 in the O'Hare Academic Center for this morning’s session ONLY.
Discussion Leader: Stacy Keding (Eli Lilly & Co.)
9:00 am - 9:40 am Marisa Kozlowski (University of Pennsylvania)
"Catalytic Asymmetric Oxidative Napththol Coupling and Claisen Rearrangement Reactions"
9:40 am - 9:50 am Discussion
9:50 am - 10:20 am Lawrence Kolaczkowski (Abbott Laboratories)
"Synthesis of a PARP Inhibitor Utilizing a Scalable Memory of Chirality Cyclization"
10:20 am - 10:30 am Discussion
10:30 am - 10:40 amBusiness Meeting: (Part I)
(Nominations for the next Vice Chair)
10:40 am - 11:00 am Coffee Break
11:00 am - 11:30 am Xiaohu Deng (Johnson & Johnson)
"Versatile, regioselective pyrazole synthesis from hydrazones and nitroolefins"
11:30 am - 11:40 am Discussion
11:40 am - 12:20 pmChristina White (University of Illinois)
"Streamlining Synthesis via C-H Oxidation"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Syntheses of Complex Natural Products and Pharmaceutical Agents (Part 1)
Discussion Leader: Jared Shaw (University of California, Davis)
7:30 pm - 8:00 pm Margaret Faul (Amgen)
"Discovery and Development of a Scaleable Route to an 11Β HSD1 Inhibitor"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Short Talk: Jon Tryggvi Njardarson (Cornell University)
"Study and Applications of Small Strained Heterocyclic Synthons"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:20 pmJef DeBrabander (University of Texas, Southwestern Medical Center)
"Natural Products: Opportunities for Discovery"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm New Reactions and Ideas for the Synthesis of Heterocyclic Compounds (Part 3)
Discussion Leader: Michael Miller (Bristol-Myers Squibb)
9:00 am - 9:45 am Jeffrey Bode (University of Pennsylvania)
"Reinventing Peptide Synthesis"
9:45 am - 9:55 am Discussion
9:55 am - 10:15 amTobias Ritter (Harvard University)
"Carbon-Fluoride Bond Formation"
10:15 am - 10:25am Discussion
10:25 am - 11:00 am Coffee Break
11:00 am - 11:35 am Michael Coghlan (Eli Lilly & Co.)
"Methods for the Improved Synthesis of Heterocyclic Modulators of Nuclear Hormone Receptors"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Andrew Degnan (Bristol-Myers Squibb)
"Unnatural Heterocyclic Amino Acids as the Basis of a Novel Therapeutic for Migraine"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #2 (Moderator: Christopher Moody)
6:00 pmDinner
7:30 pm - 9:30 pm Syntheses of Complex Natural Products and Pharmaceutical Agents (Part 2)
Discussion Leader: George Sheppard (Abbott Laboratories)
7:30 pm - 7:40 pmBusiness Meeting: (Part II)
(Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences)
7:40 pm - 8:10 pm Mark McLaughlin (Merck & Co.)
"Development of a Manufacturing Route for a CGRP Antagonist Clinical Candidate"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:30 pm Short Talk: Teshik Yoon (University of Wisconsin)
"New Reactions of Oxaziridines"
8:30 pm - 8:35 pm Discussion
8:35 pm - 9:20 pm Gary Sulikowski (Vanderbilt University)
"Studies on the Synthesis of Heterocyclic Natural Products"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Methodology for the Synthesis of Heterocyclic Compounds
Discussion Leader: James Stambuli (Ohio State University)
9:00 am - 9:25 amWei Wang (University of New Mexico, Albuquerque)
"Enantioselective Organocatalytic Tandem Reactions"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amJulianne Hunt (Merck)
"Design and Synthesis of Novel Heterocyclic Inhibitors of Cholesteryl Ester Transfer Protein"
10:00 am - 10:10 am Discussion
10:10 am - 10:25 am Short Talk: Chris Vanderwal (University of California, Irvine)
"New Applications of the Zincke Ring-Opening of Pyridines"
10:25 am - 10:30 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:10 amPaul Lobben (Bristol-Myers Squibb)
"Strategies for the Efficient Construction of Pyrrolotriazines"
11:10 am - 11:20 am Discussion
11:20 am - 12:05 pm Peter Wipf (University of Pittsburgh)
"Recent Progress in Indole Synthesis"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:30 pmBusiness Meeting: (Part III)
(Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 6:00 pmFree Time / Optional Wine Tasting Social (4:00 pm)
6:00 pmDinner
7:30 pm - 9:30 pm Perspective on Heterocyclic Chemistry
Discussion Leader: Karin Briner (Eli Lilly & Co.)
7:30 pm - 7:45 pm Special Announcements
7:45 pm - 8:40 pm Andrea Vasella (ETH Zurich)
"Novel Oligoribonucleosides and the Fascination of Heterocycles"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:00 pmChristopher Moody (University of Nottingham)
"Vice-Chair’s Remarks"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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