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Conference Program
 
Ion Channels
July 6-11, 2008
Tilton School
Tilton, NH
Chair:
John P. Adelman

Vice Chair:
Ramon R. Latorre

The Ion Channels Gordon Conference of 2008 will continue the strong tradition of exploring the structure and function of all classes of ion channels, and strives to bring together scientists with diverse backgrounds to share insights of scientific as well clinical importance about the family of ion channel proteins. In addition to biophysically oriented structure and function, the meeting will offer sessions that will provide the latest information on the molecular composition and regulation of ion channels, the emerging roles and importance of the lipid environment in which the channels function, the consequences of mutations that underlie pathological states ('channelopathies') and their potential as therapeutic targets, and the integrated biological roles of ion channels.

The agenda and speakers for the GRC on ion channels is being formulated on the basis of detailed discussions leaders in the field of ion channel biology. In addition to the platform sessions, there will also be many outstanding posters scheduled for presentation, and the speakers will review all posters. Several posters will be selected as short talks. The Tilton School provides a venue that promotes one of the main goals of the meeting that is to stimulate detailed discussions among all attendees, giving rise to new ideas and directions for the field.

The Tilton School is within easy driving distance from Boston's Logan Airport and a shuttle bus will provide transportation prior to and at the conclusion of the meeting. Travel awards may be available for selected postdoctoral fellows, students, and minority participants.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 7:40 pmChair Welcome: John Adelman
7:40 pm - 9:30 pmMolecular Basis for Ion Channel Regulation
7:40 pm - 7:50 pmDiscussion Leader: Ligia Toro (UCLA)
7:50 pm - 8:10 pm Bernd Fakler (University of Freiberg)
"The molecular microdomain of Cav2 channels - a view by functional protemics"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Amy Lee (Emory University)
"Ca2+- and voltage-dependent facilitation of Ca2+ channels"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Breaking News: Gisela Wilson (University of Michigan)
"Voltage-dependent, conductance-independent signaling activity of EAG potassium channels"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Breaking News: Nathan Dascal (Tel Aviv University)
"Regulation of GIRK channels by Gβγ and Gα subunits of G proteins"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSplit Personalities
9:00 am - 9:15 amDiscussion Leader: Chris Miller (Brandeis University)
9:15 am - 9:55 am Criss Hartzell (Emory University)
"Bestrophins are chloride channels and regulate Cav channels"
9:55 am - 10:05 am Discussion
10:05 am Coffee Break
10:50 am - 11:30 am Michael Kavanaugh (University of Montana)
"Ions moving in glutamate transporters, there and back again"
11:30 am - 11:40 am Discussion
11:40 am - 12:20 pm Merritt Maduke (Stanford University)
"H+-coupled gating in CLC channels"
12:20 pm - 12:30 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLigand-gated Channels
7:30 pm - 7:45 pmDiscussion Leader: Steven Sine (Mayo Clinic)
7:45 pm - 8:10 pm Cecilia Bouzat (Universidad Nacional del Sur-Consejo Nacional de Investigaciones Científicas y Técnicas)
"Gating and Desensitization in Homomeric Cys-loop Receptors: Role of the Binding-Pore Interface"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Kenton Swartz (NIH)
"Gating the pore of P2X receptor channels"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Bill Zagotta (University of Washington)
"Molecular Mechanisms for regulation of ion channels by cyclic nucleotides"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTRPs and CRACs
9:00 am - 9:10 amDiscussion Leader: Miguel A. Valverde (Universitaet Pompeu Fabra)
9:10 am - 9:45 am Richard Lewis (Stanford University)
"A molecular mechanism for CRAC channel activation"
9:45 am - 9:55 am Discussion
9:55 am - 10:30 am Shmuel Muallem (University of Texas, Southwestern)
"Gating of TRPC and Orai channels by STIM1"
10:30 am - 10:40 am Discussion
10:40 am Coffee Break
11:10 am - 11:40 am Ardem Patapoutian (Scripps)
"ThermoTRPs as sensors of temperature and pain"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Feng Qin (SUNY Buffalo)
"Phosphoinositides and Adaptation of Pain Receptors"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBiological Roles
7:30 pm - 7:45 pmDiscussion Leader: Lily Jan (UCSF)
7:45 pm - 8:10 pm Dejian Ren (University of Pennsylvania)
"NALCN channel function"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Richard Tsien (Stanford University)
"Local Ca channel-CaM kinase cross-talk and its role in signaling to the nucleus"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Lori Isom (University of Michigan)
"Sodium channel β subunits regulate electrical excitability through channel modulation and cell adhesion"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructure
9:00 am - 9:10 amDiscussion Leader: Francisco Bezanilla (University of Chicago)
9:10 am - 9:40 am Eric Gonzales (OHSU)
"Structure and mechanism of acid sensing ion channels"
9:40 am - 9:50 am Discussion
9:50 am - 10:20 am Raimond Dutzler (University of Zurich)
"X-ray structure of a prokaryotic pentameric ligand gated ion channel"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:35 am Youxing Jiang (University of Texas, Southwestern)
"Structural study of non-selective tetrameric cation channel"
11:35 am - 11:45 am Discussion
11:45 am - 12:20 pm Mark Mayer (NIH)
"Structural analysis of allosteric ion binding sites in glutamate receptor ion channels"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGating and Permeation
7:30 pm - 7:55 pm Discussion Leader: Eduardo Perozo (University of Chicago)
"Structural basis for activation and inactivation gating in KcsA"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Ehud Isacoff (UC Berkeley)
"Voltage gating variations"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Crina Nimigean (Cornell University)
"Molecular mechanism of pH sensing in KcsA potassium channels"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Poster Presentation: Robert French (University of Calgary)
"Selectivity of the bacterial sodium channel, NaChBac, studied by experiment and simulation"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Poster Presentation: Jorge Contreras (NIH)
"Voltage drop along the pore of cation channels: from theory to experimental evidence"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmChannelopathies
9:00 am - 9:25 amDiscussion Leader: Frances Ashcroft (Oxford University)
"KATP channel mutations and neonatal diabetes: of men and mice"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Steve Cannon (University of Texas, Southwestern)
"An anomalous gating pore resulting from S4 mutations contributes to periodic paralysis"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am Mark Baker (Barts and The London School of Medicine)
"Human Na+ channel mutations and insights into pain mechanisms"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Jim Maylie (OHSU)
"Cellular physiology of episodic ataxia type 1 (EA1) induced by mutations in the delayed rectifier potassium channel, Kv1.1"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm Stanislav Sokolov (University of Washington)
"Sodium Channel Gating and Neurological Disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLipids and Channels
7:30 pm - 7:40 pmDiscussion Leader: Ching Kung (University of Wisconsin)
7:40 pm - 8:05 pm Don Hilgemann (University of Texas, Southwestern)
"PIP2 & the Regulation of Membrane and Membrane Transporter Turnover"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Zhe Lu (University of Pennsylvania)
"Ion channel function and membrane lipids"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Breaking News: Eric Honore (IPMC-CNRS)
"Regulation of mechano-gated K2P channels by lipids"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Breaking News: Stephen Long (Memorial-Sloan Kettering Cancer Center)
"Crystal structure of a voltage-dependent potassium channel in a lipid membrane-like environment"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by NS062460 from the National Institute of Neurological Disorders and Strokes (NINDS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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