Gordon Research Conferences
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Conference Program
 
Lipoprotein Metabolism
June 22-27, 2008
Waterville Valley Resort
Waterville Valley, NH
Chairs:
Robert A. Hegele & Murray W. Huff

Vice Chair:
Ira Tabas

The Gordon Research Conference on Lipoprotein Metabolism is one of the longest standing conferences in the GRC's 75 year history. The scientific content of our conference has continually evolved since the first meeting held in 1955. It is traditionally the forum in our discipline for the presentation of high impact leading edge science. The program for the 2008 Conference on Lipoprotein Metabolism will communicate new and exciting advances in the field bringing together a range of established investigators, new investigators and trainees from around the world to present and discuss a spectrum of topics related to lipoprotein metabolism. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. Additional Oral Sessions (“TBA”) will be selected from among submitted abstracts.


Contributors
AstraZeneca Canada, Inc.
ISIS Pharmaceuticals, Inc.
Merck Research Laboratories
Merck Frosst/Schering Canada
National Institutes of Health
ResVerlogix Corpororation, Canada
Wyeth Research

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:45 pmWelcome / Introductory Comments by GRC Site Staff
7:45 pm - 9:30 pm HDL Structure and Function
Discussion Leader: Mary Sorci-Thomas (Wake Forest University)
7:45 pm - 8:05 pmStan Hazen (Lerner Research Institute, Cleveland Clinic)
"Structural insights into HDL maturation and dysfunction"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmMary Sorci-Thomas (Wake Forest University)
"Three dimensional models of high density lipoprotein apo A-I: Implications for its assembly, maturation and function"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Michael N. Oda (Children’s Hospital of Oakland Research Institute)
"Structure of apo A-I on HDL subclasses"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmJay W. Heinecke (University of Washington)
"The protein universe of lipoproteins"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Genomics of Lipoprotein Metabolism
Discussion Leader: Helen H. Hobbs (University of Texas Southwestern Medical Center)
9:00 am - 9:25 amHelen Hobbs (University of Texas Southwestern Medical Center)
"Rare mutations in complex diseases: not so rare and not so complex"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amJonathan C. Cohen (University of Texas Southwestern Medical Center)
"Population-based resequencing: covering all the bases"
10:05 am - 10:20 am Discussion
10:20 am Coffee Break / Group Photo
10:50 am - 11:10 amLen A. Pennacchio (Lawrence Berkeley National Laboratory)
"Insights from deep resequencing in humans"
11:10 am - 11:20 am Discussion
11:20 am - 11:40 amSekar Kathiresan (Massachusetts General Hospital and Broad Institute)
"Common DNA sequence variants, blood lipids, and myocardial infarction"
11:40 am - 11:50 am Discussion
11:50 am - 12:10 pmA. Jake Lusis (University of California Los Angeles)
"A network-centered view of cardiovascular traits"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Lipoproteins and Atherosclerosis
Discussion Leader: Alan Daugherty (University of Kentucky)
7:30 pm - 7:50 pmAlan Daugherty (University of Kentucky)
"Interactions of hypercholesterolemia and the renin angiotensin system"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmAlyssa H. Hasty (Vanderbilt University Medical Center)
"Macrophage TLR4 expression modulates macrophage accumulation in both atherosclerotic lesions and white adipose tissue"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmMiranda van Eck (University of Leiden)
"Role of macrophage cholesterol transporters in atherosclerosis"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmLarry Chan (Baylor College of Medicine)
"Adipose differentiation related protein: foam cell formation and atherosclerosis"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Lipoproteins and Cell Biology of the Vessel Wall
Discussion Leader: Ira Tabas (Columbia University)
9:00 am - 9:20 amIra Tabas (Columbia University)
"Macrophage apoptosis in advanced atherosclerosis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amJan Borén (University of Göteborg)
"Subendothelial lipoprotein retention"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 am J. Mark Brown (Wake Forest University)
"Inhibition of SCD-1 dissociates insulin resistance & obesity from atherosclerosis"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amEdward A. Fisher (New York University School of Medicine)
"The regression of atherosclerosis: roles of lipid efflux, LXR and foam cell migration from plaques"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 amCatherine C. Hedrick (University of Virginia)
"Lipid Signaling in Cells of the Arterial Wall"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Patrick C. Rensen (Leiden University Medical Center)
"Torcetrapib and atherosclerosis in the APOE*3-Leiden.CETP mouse"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmShobha Ghosh (Virginia Commonwealth University)
"Macrophage cholesterol homeostasis at the cross roads of Atherosclerosis and Inflammation"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pm Regulation of Adipocyte Function
Discussion Leader: Karen Reue (University of California Los Angeles)
7:30 pm - 7:50 pmKaren Reue (University of California Los Angeles)
"The lipin family: bi-functional proteins in adipogenesis and metabolism"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Miklos Péterfy (Cedars-Sinai Medical Center)
"LMF1, a new gene in hypertriglyceridemia"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmRuth McPherson (Ottawa Heart Institute)
"Genetics of Adiposity & Leanness"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmDawn L. Brasaemle (Rutgers University)
"Lipid droplet-associated proteins and triacylglycerol metabolism"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Intestinal Lipoprotein Metabolism and Processing
Discussion Leader: Stephen Young (University of California Los Angeles)
9:00 am - 9:20 amStephen G. Young (University of California Los Angeles)
"GPIHBP1, a new player in lipolysis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Lawrence L. Rudel (Wake Forest University)
"Molecular events of intestinal cholesterol metabolism"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 amErin E. Mulvihill (The University of Western Ontario)
"Naringenin corrects diet-induced metabolic disturbances in Ldlr-/- mice"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amRobert O. Ryan (Children's Hospital Oakland Research Institute)
"Apolipoprotein mediated regulation of plasma lipid homeostasis"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Jay D. Horton (University of Texas Southwestern Medical Center)
"PCSK9 and lipoprotein metabolism"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 amTimothy S. Fisher (Merck Research Laboratories)
"Functional analysis of sites within PCSK9 responsible for hypercholesterolemia"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmNabil G. Seidah (Clinical Research Institute of Montreal)
"Furin, PC5/6 and PCSK9 in health and disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Hot Topics in Lipoprotein Metabolism
Discussion Leader: Joyce J. Repa (University of Texas Southwestern Medical Center)
7:30 pm - 7:50 pmJoyce J. Repa (University of Texas Southwestern Medical Center)
"LXR and ChREBP: Bridging glucose and lipid homeostasis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Gary F. Lewis (University of Toronto)
"Intestinal lipoprotein overproduction in insulin resistant states: Focus on human studies"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pmMaroun Bou Khalil (University of Ottawa)
"Lipin-1 expression controls assembly and secretion of hepatic VLDL"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Henry N. Ginsberg (Columbia University)
"Endoplasmic reticulum stress, VLDL secretion, and hepatic steatosis"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmCheryl L. Wellington (University of British Columbia)
"High density lipoproteins in the central nervous system"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Molecular Targets and New Therapeutics
Discussion Leader: Daniel J. Rader (University of Pennsylvania)
9:00 am - 9:20 amDaniel J. Rader (University of Pennsylvania)
"New therapies for dyslipidemia"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Richard Lee (ISIS Pharmaceuticals)
"Antisense oligonucleotide-mediated inhibition of apolipoprotein B"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 amKevin Fitzgerald (Alnylam)
"RNAi therapeutics targeting PCSK9"
9:55 am - 10:00 am Discussion
10:00 am - 10:20 amHarry R. Davis (Schering-Plough Pharmaceuticals)
"Role of NPC1L1 in cholesterol trafficking and atherosclerosis"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amJohn S. Parks (Wake Forest University)
"Macrophage ABCA1, inflammation, and insulin resistance"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amJacques Genest Jr (McGill University)
"A novel compound, RVX208 raises HDL-C and apo A-I"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmMichael R. Hayden (University of British Columbia)
"From genes to therapy - LPL to the rescue"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Special State-of-the art and future vision session
Discussion Leaders: Alan R. Tall (Columbia University) and Jan Breslow (The Rockefeller University)
7:30 pm - 8:00 pmAlan R. Tall (Columbia University)
"ABC transporters, sterol efflux and atherogenesis"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmJan Breslow (The Rockefeller University)
"State-of-the-art and future of research in lipoprotein metabolism"
8:45 pm - 9:00 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The views expressed in written conference materials or publication and by speakers and moderators do not necessarily reflect the official materials or policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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