Gordon Research Conferences
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Conference Program
 
Macromolecular Organization & Cell Function
Cellular Systems Biology
July 27 - August 1, 2008
Magdalen College
Oxford, United Kingdom

The Gordon Research Conference on Macromolecular Organization and Cell Function: Cellular Systems Biology has met biannually. This year the co-chairs of the program are Robert S. Balaban from the NIH and Loranne Agius from the University of Newcastle. The conference continues to focus on internal organization of the living cell to provide a systems level understanding of how interactions between specific molecular constituents contribute to basic cell function. Subcellular organization often is transient, as in the dynamic interactions of molecular motors with the cytoskeleton, of macromolecules in signal transduction pathways, or of the enzymic components of metabolic pathways. Many of these interactions depend on the unique conditions and compartmentation that exist within the intact cell that are disturbed or even destroyed using conventional in vitro approaches. Emphasis is placed on interpretation of biochemical and structural data in the light of known intracellular conditions including the spatial distribution of proteins and metabolites. Discussed are studies on macromolecular assemblies, non-invasive imaging, cellular topology of second messenger signaling pathways, and the global analysis of cellular proteins and metabolites. In addition, theoretical modeling, including the development and testing of mechanisms for handling large amounts of bioinformatics data, is a major emphasis of the conference based on the recognition that complex interactions are very difficult to study without computational tools. The conference is traditionally attended by scientists with a wide range of interests and expertise, ranging from experimentalists to theorists interested in sharing views and approaches. There is active cross-disciplinary discussion that has been greatly stimulating and valuable to the participants, and which has also fostered numerous collaborations.

This year our evening keynote speaker will be Dr. John Scott HHMI Investigator from Oregon Health and Sciences University on the four dimensional aspects of cell signaling in the heart. His lecture is in memory of Dr. Paul Srere. Paul was one of the first scientists to realise the importance of the microenvironment of the protein to its cellular function. Through his major research contributions to this field, Paul was a major driving force in convincing reductionist scientists the importance of studying protein and enzyme function in its correct macromolecular environment rather than through the conventional approaches. The Gordon Conference that Paul started on Macromolecular Organisation and Cell was one of the ways by which this concept developed and gained momentum. This year, as in previous years, we chose the speaker for the closing session with Paul's work and ideas in mind. John Scott has established that cAMP in the cell shows microcompartmentation based on the association of specific isoforms of both adenylate cyclase and cAMP phosphodiesterases with specific binding proteins, thus generating microcompartmentation of cAMP within the cell so that spatially separated pathways can be regulated independently.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
5:30 pm Reception / Mixer
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Conference Co-Chairs Robert S. Balaban (Bethesda) and Loranne Agius (Newcastle University)
7:40 pm - 9:30 pm MITOCHONDRIAL SYSTEMS BIOLOGY
Discussion Leader: Paul Brookes (University of Rochester)
7:40 pm - 8:10 pmAndrew Halestrap (University of Bristol)
"Signaling to and from the mitochondria in ischaemic preconditioning"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmKieran Clarke (University of Oxford)
"Mitochondrial metabolism in cardiovascular disease"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmPaul Brookes (University of Rochester)
"Modeling mitochondrial responses to oxygen tension"
9:20 pm - 9:30 pm Discussion
MONDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm METABOLOMICS IN SYSTEMS BIOLOGY
9:00 am - 9:10 amOfficial Welcome / Introductory Comments: Bob Balaban and Loranne Agius
9:10 am - 9:15 amDiscussion Leader: Douglas Kell (University of Manchester)
9:15 am - 9:45 amSerge Rezzi (Nestle, Lausanne)
"Metabotyping and nutrimetabolomics: non-invasive approaches to predict individual human health trajectories"
9:45 am - 9:55 am Discussion
9:55 am - 10:25 am Matej Oresic (Tech Res Centre Finland)
"Reconstruction of lipid pathways at cellular and systems levels"
10:25 am - 10:35 am Discussion
10:35 am - 11:05 am Coffee Break / Group Photo
11:05 am - 11:35 amMarta Cascante (University of Barcelona)
"The robust metabolic adaptations that enable tumor progression are potential targets for combination therapy"
11:35 am - 11:45 am Discussion
11:45 am - 12:15 pmDouglas Kell (University of Manchester)
"Systems biology of community metabolic network reconstructions: principles, praxis and the role of transporters in drug uptake"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
Moderators: Paul Insel & Pedro Mendes
6:00 pmDinner
7:30 pm - 9:30 pm COMPARTMENTATION OF CELL SIGNALING
7:30 pm - 7:35 pmDiscussion Leader: Paul Insel (University of California San Diego)
7:35 pm - 8:05 pmDermot Cooper (University of Cambridge)
"Organisation of cAMP microdomains"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmHemal Patel (UCSD)
"Caveolae, caveolins and mitochondria: a subcellular symbiotic relationship"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmMary Kennedy (Caltech)
"Compartmental signal transduction of dendritic spines"
9:20 pm - 9:30 pm Discussion
TUESDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm COMPUTATIONAL APPROACHES TO PROTEIN FOLDING, BINDING AND FUNCTION
9:00 am - 9:05 amDiscussion Leader: Ruth Nussinov (NCI and Tel Aviv University)
9:05 am - 9:35 amAndrej Sali (UCSF)
"Integrating diverse data for Structure Determination of Macromolecular Assemblies"
9:35 am - 9:50 am Discussion
9:50 am - 10:20 am Rob Russell (EMBL)
"Predicting and modelling protein-protein interactions: from large complexes to tiny peptides"
10:20 am - 10:35 am Discussion
10:35 am - 10:50 am Coffee Break
10:55 am - 11:25 am Janet Thornton (University of Cambridge)
"Protein-Ligand Interactions"
11:25 am - 11:40 am Discussion
11:40 am - 12:10 pmRuth Nussinov (NCI and Tel Aviv University)
"Modeling Alzheimer Amyloid Conformations and toxic Ion Channels"
12:10 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm FUTURE TRENDS IN FLUORESCENCE MICROSCOPY
7:30 pm - 7:40 pmDiscussion Leader: Simone Baltrusch (University of Hannover)
7:40 pm - 8:05 pmAlexander Egner (Max Planck Instiute, Gottingen)
"Developments in fluorescence microscopy"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmJörg Wiedenmann (University of Southampton)
"Development of novel fluorescent proteins"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmDaniel Krüger (Olympus Soft Imaging Solutions, Germany)
"Cytometric high content data analysis: techniques and perspectives"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm GENOMIC AND PROTEOMIC ANALYSIS
9:00 am - 9:05 amDiscussion Leader: Pedro Mendes (University of Manchester)
9:05 am - 9:35 amAnna Kashina (University of Pennsylvannia)
"Posttranslational protein arginylation as a general intracellular regulator"
9:35 am - 9:45 am Discussion
9:45 am - 10:15 amFederico Katzen (Invitrogen)
"Insertion of membrane proteins into discoidal membranes using a cell-free protein expression approach"
10:15 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:55 am - 11:25 amBernhard Palsson (University of California - San Diego)
"Systems biology of human metabolism: recent developments and applications in network reconstruction"
11:25 am - 11:40 am Discussion
11:40 am - 12:10 pmAndrzej Kierzek (University of Surrey)
"Analysis of gene essentiality and expression programme in the context of genome scale metabolic networks of M. tuberculosis and S. coelicolor"
12:10 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm SUBCELLULAR ORGANIZATION OF CELL SIGNALLING EVENTS
Discussion Leader: Ron Lynch (University of Arizona)
7:30 pm - 8:00 pmRon Lynch (University of Arizona)
"Visualizing the subcellular organization of Ca2+ signalling pathways"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmEdwin Moore (University of British Columbia)
"Quantitative Analysis of Macromolecular Organization in Intact Cell Systems"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmLonny Levin (Cornell University)
"Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation"
9:20 pm - 9:30 pm Discussion
THURSDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pm PROTEIN-PROTEIN INTERACTIONS
9:00 am - 9:05 amDiscussion Leader: Carol Robinson (University of Cambridge)
9:05 am - 9:40 amCarol Robinson (Cambridge University)
"Mass spectrometry: from nanodroplets to networks"
9:40 am - 9:50 am Discussion
9:50 am - 10:25 am Brenda Winkel (Virgina Tech)
"Outside the fence: redefining the Arabidopsis flavonoid metabolon"
10:25 am - 10:35 am Discussion
10:35 am - 10:55 am Coffee Break
10:55 am - 11:30 amTom Kirkwood (Newcastle University)
"Systems Biology of age-related cellular deterioration"
11:30 am - 11:40 am Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pmReception on the Cloisters Lawn
6:00 pmFormal Dinner Banquet
7:50 pm - 8:20 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:20 pm - 9:30 pm CELL SIGNALING
8:20 pm - 8:30 pmDiscussion Leader: Steve Oliver (University of Cambridge)
"Introduction"
8:30 pm - 9:20 pmJohn Scott (University of Washington)
"Cell Signaling in Space and Time"
9:20 pm - 9:30 pm Discussion
FRIDAY
8:00 am - 9:00 amBreakfast
9:00 amDeparture

 
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