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Conference Program
 
Meiosis
June 8-13, 2008
Colby-Sawyer College
New London, NH
Chair:
Scott Keeney

Vice Chair:
Abby Dernburg

Meiosis is the widely conserved form of cell division that allows sexually reproducing organisms to produce haploid gametes. The 2008 Meiosis Gordon Conference will bring together researchers who study the cell and molecular biology, genetics, genomics, biochemistry, and evolutionary biology of meiosis. The emphasis is on chromosome dynamics, but will include substantial coverage of cytoskeletal and nuclear structure, gene regulation, gametogenesis, and evolutionary aspects. Session topics will include: control of the meiotic cell cycle; initiation and regulation of meiotic recombination; crossover control; checkpoints that regulate progression through meiosis; histone modifications, silencing, germline small RNAs and transposon suppression; chromosome pairing, formation and disassembly of the synaptonemal complex; cohesion and chromosome condensation; chromosome movements, the meiotic bouquet and the nuclear envelope; spindles, kinetochores and the dissolution of cohesion; and the evolution of meiosis and sexual reproduction.


Contributors
This conference is supported in part by grants from the March of Dimes, the National Institute of Child Health and Human Development (NICHD), and the National Science Foundation. Support was also provided by generous contributions from BASF Plant Science and Applied Precision.

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
4:00 pm - 6:00 pmOpening Reception
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEVOLUTION OF MEIOSIS, SEXUAL REPRODUCTION, & CHROMOSOME STRUCTURE
Discussion Leader: Scott Hawley (Stowers Institute)
7:40 pm - 7:55 pm Zac Cande (University of California, Berkeley)
"Diplomixis in the basal eukaryote Giardia: a parasexual precursor to meiosis"
7:55 pm - 8:02 pm Discussion
8:02 pm - 8:17 pm Mimi Zolan (Indiana University)
"Parthenogenesis, Meiosis, and Pseudo-meiosis in Daphnia pulex"
8:17 pm - 8:24 pm Discussion
8:24 pm - 8:39 pm Harmit Singh Malik (Fred Hutchinson Cancer Research Center)
"Genetic conflict during female meiosis and Drosophila speciation"
8:39 pm - 8:46 pm Discussion
8:46 pm - 9:01 pm Jeremy Wang (University of Pennsylvania)
"Regulation of male meiosis by the X chromosome-linked genes in mice"
9:01 pm - 9:08 pm Discussion
9:08 pm - 9:23 pm James Turner (MRC National Institute of Medical Research, UK)
"Meiotic Silencing and Gene Content of the Mammalian X Chromosome"
9:23 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREGULATION AND PERTURBATION OF MEIOTIC ENTRY AND PROGRESSION
Discussion Leader: Abby Dernburg (University of California, Berkeley)
9:00 am - 9:15 am Masayuki Yamamoto (University of Tokyo)
"Molecular basis to remove meiotic mRNAs selectively in mitotic fission yeast cells"
9:15 am - 9:25 am Discussion
9:25 am - 9:40 am David Page (HHMI and Whitehead Institute)
"Competence to initiate meiosis: a major transition state in germ cell development"
9:40 am - 9:50 am Discussion
9:50 am - 10:05 am Alex Bortvin (Carnegie Institution of Washington)
"Mouse Maelstrom and transposon silencing at the onset of meiosis"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break / Group Photo
10:45 am - 11:00 am Terry Orr-Weaver (Whitehead Institute and MIT)
"Developmental regulation of the meiotic cell cycle"
11:00 am - 11:10 am Discussion
11:10 am - 11:25 am Paul Burgoyne (MRC National Institute of Medical Research, UK)
"MSCI failure, unrepaired DSBs, and mid pachytene spermatocyte apoptosis"
11:25 am - 11:35 am Discussion
11:35 am - 11:50 am Angelika Amon (HHMI and MIT)
"Effects of age on meiosis in budding yeast"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Patricia Hunt (Washington State University)
"Environmental effects on recombination in mammals"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1 (posters 1-55, odd numbers presenting)
6:00 pmDinner
7:30 pm - 9:30 pmRECOMBINATION DISTRIBUTIONS: HOT (AND NOT) SPOTS
Discussion Leader: Anne Villeneuve (Stanford University)
7:30 pm - 7:45 pm Gerry Smith (Fred Hutchinson Cancer Research Center)
"Genetic control of the genome-wide distribution of meiotic DSBs and crossovers in S. pombe"
7:45 pm - 7:54 pm Discussion
7:54 pm - 8:09 pm Maria Jasin (Memorial Sloan-Kettering Cancer Center)
"Distribution of crossovers and noncrossovers within a mouse hotspot"
8:09 pm - 8:18 pm Discussion
8:18 pm - 8:33 pm Philippe Bois (Scripps Research Institute, Florida)
"Regulation of mouse recombination hotspots"
8:33 pm - 8:42 pm Discussion
8:42 pm - 8:57 pm Bernard de Massy (Institute of Human Genetics, Montpellier)
"Initiation of meiotic recombination: hidden and moving sites in the genome"
8:57 pm - 9:06 pm Discussion
9:06 pm - 9:21 pm Jeff Sekelsky (University of North Carolina, Chapel Hill)
"Crossover distribution in Drosophila on large and small scales"
9:21 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHOMOLOGOUS PAIRING AND SYNAPSIS
Discussion Leader: Doug Bishop (University of Chicago)
9:00 am - 9:15 am Abby Dernburg (University of California, Berkeley)
"Regulation of homolog pairing and synapsis by cell cycle kinases"
9:15 am - 9:25 am Discussion
9:25 am - 9:40 am Monica Colaiacovo (Harvard Medical School)
"Synaptonemal complex formation in C. elegans meiosis"
9:40 am - 9:50 am Discussion
9:50 am - 10:05 am Eva Hoffmann (University of Sussex)
"Regulation and functions of the synaptonemal complex in budding yeast"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:00 am Akira Shinohara (Osaka University)
"Control of synaptonemal complex formation by SCF ubiquitin ligase complex"
11:00 am - 11:10 am Discussion
11:10 am - 11:25 am Denise Zickler (Université Paris-Sud)
"Msh4, Mer3 and Mlh1 in Sordaria: multiple coordinate roles from homologous pairing to chiasma formation"
11:25 am - 11:35 am Discussion
11:35 am - 11:50 am Tomas Naranjo (Universidad Complutense, Madrid)
"Do terminal regions of cereal chromosomes contain specific sequences that aid homologue identification?"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Giovanni Bosco (University of Arizona)
"Drosophila condensin II subunit Cap-H2 antagonizes male meiotic chromosome pairing and interacts with the achiasmate pairing maintenance gene teflon"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2 (posters 1-55, even numbers presenting)
6:00 pmDinner
7:30 pm - 9:30 pmCHROMOSOME SEGREGATION: SPINDLES, KINETOCHORES & COHESION
Discussion Leader: Zac Cande (University of California, Berkeley)
7:30 pm - 7:45 pm Hiro Ohkura (The University of Edinburgh)
"Post-pachytene chromosome organisation and spindle assembly in Drosophila female meiosis"
7:45 pm - 7:54 pm Discussion
7:54 pm - 8:09 pm Kim McKim (Waksman Institute, Rutgers University)
"Analysis of Drosophila meiotic spindles with genetic interactions"
8:09 pm - 8:18 pm Discussion
8:18 pm - 8:33 pm Sharon Bickel (Dartmouth College)
"Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit Smc1 is reduced"
8:33 pm - 8:42 pm Discussion
8:42 pm - 8:57 pm Yoshinori Watanabe (University of Tokyo)
"Direct link between heterochromatin and centromeric protector shugoshin"
8:57 pm - 9:06 pm Discussion
9:06 pm - 9:21 pm Wolfgang Zachariae (Max Planck Institute of Molecular Cell Biology and Genetics)
"The coordination of recombination and monopolar attachment in meiosis I"
9:21 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmINITIATION OF MEIOTIC RECOMBINATION
Discussion Leader: Scott Keeney (Memorial Sloan-Kettering Cancer Center)
9:00 am - 9:15 am Alain Nicolas (Insitut Curie)
"Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites"
9:15 am - 9:25 am Discussion
9:25 am - 9:40 am Kunihiro Ohta (University of Tokyo)
"Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination"
9:40 am - 9:50 am Discussion
9:50 am - 10:05 am Franz Klein (University of Vienna)
"Protein-chromosome interactions during early meiotic recombination"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:00 am Nancy Kleckner (Harvard University)
"Integration of chromosomal events during DSB formation"
11:00 am - 11:10 am Discussion
11:10 am - 11:25 am Mathilde Grelon (INRA, Station de Génétique et d'Amélioration des Plantes)
"Identification of meiotic DSB forming proteins in Arabidopsis thaliana"
11:25 am - 11:35 am Discussion
11:35 am - 11:50 am Dan Camerini-Otero (Genetics and Biochemistry Branch, NIDDK, NIH)
"The mouse Spo11, Hop2 and Mnd1 proteins in meiotic recombination"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm John Schimenti (Cornell University)
"Novel meiotic recombination functions in mice"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3 (posters 56-110, odd numbers presenting)
6:00 pmDinner
7:30 pm - 9:30 pmCHROMOSOME DYNAMICS
Discussion Leader: Yoshinori Watanabe (University of Tokyo)
7:30 pm - 7:45 pm Yasushi Hiraoka (Osaka University)
"Movements of homologous chromosomes in fission yeast meiosis"
7:45 pm - 7:54 pm Discussion
7:54 pm - 8:09 pm Mike Dresser (Oklahoma Medical Research Foundation)
"Extremely dynamic chromosome dynamics"
8:09 pm - 8:18 pm Discussion
8:18 pm - 8:33 pm Sean Burgess (University of California, Davis)
"Cis and trans effects on homolog interaction in budding yeast"
8:33 pm - 8:42 pm Discussion
8:42 pm - 8:57 pm Anne Villeneuve (Stanford University)
"Crossover-triggered differentiation of meiotic bivalents directs chromosome behavior during the meiotic divisions"
8:57 pm - 9:06 pm Discussion
9:06 pm - 9:21 pm Scott Hawley (Stowers Institute)
"The fate of heterochromatc pairings: heterochromatic threads connect oscillating achiasmate chromosomes during meiosis"
9:21 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmMECHANISMS OF HOMOLOGOUS RECOMBINATION
Discussion Leader: Gerry Smith (Fred Hutchinson Cancer Research Center)
9:00 am - 9:15 am Doug Bishop (University of Chicago)
"Dmc1 and Recombination Partner Choice"
9:15 am - 9:25 am Discussion
9:25 am - 9:40 am Nancy Hollingsworth (SUNY Stonybrook)
"Phosphorylation and regulation of meiotic recombination"
9:40 am - 9:50 am Discussion
9:50 am - 10:05 am Simon Boulton (London Research Institute, Clare Hall Labortories)
"Regulation of meiotic recombination by the anti-recombinase SPAR1"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:00 am Neil Hunter (University of California, Davis)
"Mechanism and regulation of joint molecule formation"
11:00 am - 11:10 am Discussion
11:10 am - 11:25 am Michael Lichten (National Cancer Institute, NIH)
"Regulation of the formation and resolution of recombination intermediates during meiotic progression"
11:25 am - 11:35 am Discussion
11:35 am - 11:50 am Paula Cohen (Cornell University)
"Interactions between the MUS81 and MSH4/MSH5 recombination pathways in the mouse"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Rhona Borts (University of Leicester)
"Association of mutations in meiotic recombination genes and male infertility"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 4 (posters 56-110, even numbers presenting)
6:00 pmDinner
7:30 pm - 9:30 pmCROSSOVER CONTROL
Discussion Leader: Kim McKim (Rutgers University)
7:30 pm - 7:45 pm Jennifer Fung (University of California, San Francisco)
"Global analysis of the meiotic crossover landscape"
7:45 pm - 7:54 pm Discussion
7:54 pm - 8:09 pm Chris Franklin (University of Birmingham, UK)
"AtRPA1a an Arabidopsis replication protein A family member is required for Class I meiotic crossover formation, but is dispensable for DNA double-strand break repair"
8:09 pm - 8:18 pm Discussion
8:18 pm - 8:33 pm Judith Yanowitz (Carnegie Institution of Washington)
"GAK-1, an autosome-specific factor required for X chromosome recombination"
8:33 pm - 8:42 pm Discussion
8:42 pm - 8:57 pm Greg Copenhaver (University of North Carolina, Chapel Hill)
"Forward and Reverse Approaches for Meiotic Analysis Using Arabidopsis Tetrads"
8:57 pm - 9:06 pm Discussion
9:06 pm - 9:21 pm Barbara Meyer (HHMI and University of California, Berkeley)
"Control of crossover number and distribution"
9:21 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by Grant 1 R13 HD58316-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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