| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Julie Kovacs (University of Washington), Chair
"Welcome & Introductory Remarks" / Comments by GRC Site Staff |
| 7:45 pm - 9:30 pm | Mechanisms of Energy Conversion in Biology and Chemistry |
| Discussion Leader: Harry Gray (Cal Tech) |
| 7:45 pm - 8:45 pm | Cruickshank Lecturer: Daniel Nocera (MIT)
"Mechanisms of Energy Conversion in Biology and Chemistry" |
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:30 pm | Dick Holm, Eckard Munck & Peter Kroneck
"A Brief Tribute to Helmut Beinert" |
| 9:30 pm | Poster Session A / Chair's Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | O-O Bond Cleavage and Formation (Mn & Fe) |
| Discussion Leader: Bill Tolman (University of Minnesota) |
| 9:00 am - 9:30 am | John Groves (Princeton University)
"Reactivity and Interconversions of Oxo-, Peroxo- and Dioxo-Manganese Porphyrins" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Mike Hendrich (Carnegie Mellon University)
"Detection of Short-Lived Intermediates in the Catalytic Cycle of a Manganese Dioxygenase" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Elodie Anxolabehere-Mallart (CNRS Universite Paris-SUD)
"Intermediates of water oxidation in the OEC. Chemical and electrochemical access to Mn-oxo and Mn-peroxo model complexes" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Marlene Martinho (Carnegie Mellon University)
"Mossbauer studies of the Membrane-Associated Methane Monooxygenase from Methylococcus capsulatus bath: Evidence for a dinuclear iron center" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Masao Ikeda-Saito (Tohoku University)
"Structures of peroxo and hydroperoxo intermediates of heme proteins" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | O-O Bond Cleavage and Formation (Cu) |
| Discussion Leader: Marty Bollinger (Penn State University) |
| 7:30 pm - 8:00 pm | Shelagh Ferguson-Miller (Michigan State University)
"Energy transduction by cytochrome oxidase: Importance of conserved water and conserved lipid" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Simon de Vries (Delft University of Technology)
"Tryptophan272: The heart of the cytochrome oxidase proton pump" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Edward Solomon (Stanford University)
"O2 reduction to H2O by the trinuclear Cu cluster in the multicopper oxidases" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Poster Session A |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Sulfur's Influence on Metalloenzyme Function |
| Discussion Leader: Marty Kirk (University of New Mexico) |
| 9:00 am - 9:30 am | Charles Riordan (University of Delaware)
"Synthetic and Reactivity Studies for Understanding Organonickel Intermediates in Biocatalysis" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Sean Elliott (Boston University)
"Electrochemical Characterization of Archaeal Thioredoxins" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Mike Maroney (University of Massachusetts Amherst)
"NiSOD: A Case of Convergent Evolution" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | David Goldberg (Johns Hopkins University)
"The Impact of Thiolate |Donation on Non-Heme and Heme Synthetic Analogs: Relevance to Superoxide Reductase and Cytochrome P450" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Sulfur's Influence on Metalloenzyme Function (Clusters) |
| Discussion Leader: Marcetta Darensbourg (Texas A&M University) |
| 7:30 pm - 8:00 pm | Paul Lindahl (Texas A&M University)
"Influence of Sulfur on Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase Reactivity" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Richard Holm (Harvard University)
"Aspects of the Biomimetic Chemistry of Iron, Nickel, Molybdenum, and Tungsten" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Steve Ragsdale (University of Michigan)
"Methyl-Coenzyme M Reductase: Intermediacy of Methyl-Nickel or Methyl Radical?" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Poster Session B |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Oxidative Stress and Reactive Oxygen Species |
| Discussion Leader: Joan Valentine (UCLA) |
| 9:00 am - 9:30 am | Diane Cabelli (Brookhaven Natl. Labs)
"Functional Variations in Manganese Superoxide Dismutase" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Saltman Lecture: Chris Chang (U C Berkeley)
"Chemical Approaches to Understanding Copper and Peroxide Biology in the Brain" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Katherine Franz (Duke University)
"Inhibiting Metal-Promoted Oxidative Stress with Prochelators" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Jason Shearer (University of Nevada)
"Probing the Enzymatic Mechanism of Nickel Superoxide Dismutase Using Metallopeptide Based Models" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Microbial
Enzymes - Living on the Edge |
| Discussion Leader: Peter Kroneck (University of Konstanz) |
| 7:30 pm - 8:00 pm | Arnulf Kletzin (TU Darmstadt, Germany)
"Towards a reaction mechanism for the sulfur oxygenase reductase: Conclusions from 3D structure and mutagenesis experiments" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Fred Hagen (Delft University of Technology)
"Tungsten homeostasis in Pyrococcus furiosus" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Dianne Newman (Massachusetts Institute of Techology)
"Electron transfer in times of stress: new roles for redox active 'antibiotics'" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Poster Session B |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Bio-inspired Catalysis |
| Discussion Leader: Jonas Peters (Massachusetts Institute of Technology) |
| 9:00 am - 9:30 am | Thomas Ward (Univ of Neuchatel, Switzerland)
"Designed evolution of artificial metalloenzymes based on the biotin-avidin technology" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Dan Stack (Stanford University)
"Development of Bio-inspired Iron and Manganese Oxidation Catalysts" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Kit Cummins (Massachusetts Institute of Technology)
"New Metal-Mediated Chemistry of the Essential Elements Nitrogen and Phosphorus" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Larry Que (University of Minnesota)
"Bio-inspired Hydrocarbon Oxidations by Nonheme Iron Catalysts" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Joint Poster Session with Gordon Research Seminar |
| 6:00 pm | Dinner |
| 7:30 pm - 8:45 pm | Joint Session with Gordon Research Seminar |
| Discussion Leader: Steve Lippard (Massachusetts Institute of Technology) |
| 7:30 pm - 8:30 pm | Tom O'Halloran (Northwestern University)
"Inorganic Physiology of Cancer Cell Proliferation: Targeting Copper Receptor Chemistry" |
| 8:30 pm - 8:45 pm | Discussion |
| 8:45 pm | Joint Poster Session with Gordon Research Seminar |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |