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Conference Program
 
Microbial Toxins & Pathogenicity
July 13-18, 2008
Proctor Academy
Andover, NH

Related Meeting Information
The Microbial Toxins & Pathogenicity Gordon Research Conference was held in conjunction with the Microbial Toxins & Pathogenicity Gordon-Kenan Research Seminar. Please refer to the Microbial Toxins & Pathogenicity GKRS web page for more information.

The Microbial Toxins and Pathogenicity Gordon Conference is an exceptional forum for learning about the newest knowledge in the field of microbial pathogenesis. The focus is on basic mechanisms, primarily from bacterial systems that exemplify common themes in toxin biochemistry and biogenesis, molecular and cellular pathogenesis, and infection and immunity. New research on translating knowledge of basic mechanisms into therapeutic advances will also be presented. Speakers include established leaders in the field as well as young investigators of exceptional promise. Sessions are chaired by prominent researchers who broadly review the topic and place the speakers' work into that context. Discussions led by the session chair are lively exchanges of new ideas and perspectives stimulated by each talk. In addition to the main sessions, this meeting includes well-attended and highly interactive poster sessions. In 2008, the main conference will be preceded by the Gordon Research Seminar on Microbial Toxins and Pathogenicity. This weekend meeting, planned by and for post-doctoral and pre-doctoral trainees in the field of microbial pathogenesis, will provide an opportunity for future leaders in the field to present their work as talks and posters in a collegial and interactive environment. Attendance at the GRS will add great value to the overall GRC experience for these young investigators.


SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTOXINS AND PATHOGENICITY (KEYNOTES)
7:40 pm - 7:50 pm Discussion Leader: Vic DiRita (University of Michigan)
7:50 pm - 8:25 pm Cesare Montecucco (University of Padova)
"Toxin mechanisms and the evolution of toxigenic bacteria"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:15 pm Daniel A. Portnoy (University of California-Berkeley)
"Intracellular pathogens and innate immunity: A bacteriologist's perspective"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTOXIN MECHANISMS OF ACTION
9:00 am - 9:15 am Discussion Leader: Karla Fullner Satchell (Northwestern University)
9:15 am - 9:40 am Kim Orth (UT-Southwestern)
"Black Death, Black Spot, Black Pearl: Tales of Bacterial Effectors"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 am Claude Parsot (Institut Pasteur)
"Functional analysis of Shigella flexneri type III secretion effectors"
10:15 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:20 am Peter Sebo (Institute of Microbiology of the Academy of Sciences of the Czech Republic)
"Fooling the antigen-presenting phagocyte: Receptor binding and subversive signaling of Bordetella adenylate cyclase"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Ken Bradley (UCLA)
"Identification of host factors required for sensitivity to bacterial toxins"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:30 pm Joseph T. Barbieri (Medical College of Wisconsin)
“Carleen M. Collins: A Life in Science”
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCELLULAR MICROBIOLOGY AND PATHOGENESIS
7:30 pm - 7:45 pm Discussion Leader: Craig Roy (Yale University)
7:45 pm - 8:10 pm Ralph Isberg (Tufts University / HHMI)
"Pathway analysis of proteins translocated into host cells by Legionella pneumophila"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Alejandro Aballay (Duke University)
"Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Samuel Miller (University of Washington)
"Regulation of Rho GTPases and phagosome tubulation by Salmonella effector proteins"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREGULATORY MECHANISMS IN BACTERIAL PATHOGENS
9:00 am - 9:15 am Discussion Leader: Andrew Camilli (Tufts University / HHMI)
9:15 am - 9:40 am Matt Waldor (Harvard University)
"Cell-to-cell communication regulates Vibrio cholerae cell size and shape"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 am Heran Darwin (New York University)
"A ubiquitin-like modification for protein degradation in Mycobacterium"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:15 am Stephen Lory (Harvard University)
"Post-transcriptional regulation of virulence gene expression in Pseudomonas aeruginosa"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 am Virginia Miller (University of North Carolina, Chapel Hill)
"Yersinia enterocolitica and Yersinia pestis RovA regulons: psa and myf operons as a case history"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Eric Skaar (Vanderbilt University)
"The adaptive response of Staphylococcus aureus to growth in vertebrate blood"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPHAGE AND PATHOGEN GENOME EVOLUTION
7:30 pm - 7:45 pm Discussion Leader: John Mekalanos (Harvard University)
7:45 pm - 8:10 pm Andrew Camilli (Tufts Medical School/HHMI)
"Lytic phage and the VBNC state limit transmission of cholera"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm David Friedman (University of Michigan)
"Prophage induction and pathogenicity of enterohemorrhagic E. coli"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Jeffrey F. Miller (UCLA)
"Mutagenic retrohoming and the evolution of parasite-host interactions"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSTRUCTURAL BIOLOGY INSIGHTS INTO MICROBIAL PATHOGENESIS
9:00 am - 9:15 am Discussion Leader: Samuel Miller (University of Washington)
9:15 am - 9:40 am Partho Ghosh (University of California-San Diego)
"Virulence and crossreactivity of Group A Streptococcus M1 protein"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 am Bryan Krantz (University of California - Berkeley)
"Anthrax toxin assembly & translocation - an interplay of form & function"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:15 am Feng Shao (National Institute of Biological Sciences, Beijing)
"The MAPK-specific Phosphothreonine Lyase Activity of a Bacterial Type III Effector Family"
11:15 am - 11:25 am Discussion
11:25 am - 11:50 am Christine Szymanski (National Research Council of Canada)
"Campylobacter jejuni glycosylation - from structure to pathogenesis"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Michelle Dunstone (Monash University)
"A common fold mediates bacterial attack and vertebrate defense"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmTRANSLATING KNOWLEDGE FROM PATHOGENESIS RESEARCH
7:30 pm - 7:45 pm Discussion Leader: Harry Mobley (University of Michigan)
7:45 pm - 8:10 pm Thomas Dubensky (ANZA Therapeutics)
"Translating Pathogenesis into Vaccine Development: Harnessing the Immunologic Potency of L. monocytogenes to Address Acute Medical Needs"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Mario Feldman (University of Alberta)
"Bacterial glycoproteins and their applications in biotechnology"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm R.E.W. Hancock (University of British Columbia)
"Innate defense regulators as a new anti-infective strategy"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMICROBIAL INFECTION MECHANISMS
9:00 am - 9:15 am Discussion Leader: Andreas Baumler (University of California - Davis)
9:15 am - 9:40 am Joan Mecsas (Tufts University)
"Role of Yersinia Yops in mouse infections"
9:40 am - 9:50 am Discussion
9:50 am - 10:15 am David Hendrixson (University of Texas-Southwestern Medical School)
"Colonization dynamics of Campylobacter jejuni in the natural avian host"
10:15 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break
10:50 am - 11:10 am Manuela Raffatellu (University of California, Irvine)
"TH-17 cytokines orchestrate the mucosal barrier to Salmonella"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Padmini Salgame (UMDNJ)
"Helminth Modulation of Tuberculosis"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Karen Guilleman (University of Oregon)
"Keeping the peace: regulation of inflammatory responses to the microbiota in the zebrafish intestine"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIMMUNITY AND IMMUNOPATHOGENESIS
7:30 pm - 7:45 pm Discussion Leader: Mary O'Riordan (University of Michigan)
7:45 pm - 8:10 pm Alice Prince (Columbia University)
"Staphylococcus aureus protein A activation of epithelial signaling cascades"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Egil Lien (University of Massachusetts)
"Evasion of innate immunity and the evolution of a highly virulent pathogen"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Vojo Deretic (University of New Mexico)
"Autophagy in immunity and inflammation - from TB to Crohn's Disease"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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