Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Muscle & Molecular Motors
June 29 - July 4, 2008
Colby-Sawyer College
New London, NH
Chair:
Justin E. Molloy

Vice Chair:
David D. Thomas

The principal purpose of this conference is to discuss important recent unpublished developments in the field. This international forum for information exchange will lead to better integration of knowledge about muscle and molecular motors from atomic resolution structures to functional roles in intact systems. Our focus is on understanding molecular mechanisms from primary processes underlying energy transduction through to integrated ensembles of molecular motors. The scientific scope encompasses: targeting and regulation of motors, structure-function studies; energy transduction mechanism; development of new techniques and modalities for studying motors in vivo and in vitro and the role and mode of action of molecular motors in infectious disease and human health. The conference also aims to foster and catalyze new collaborations between international scientists who work at the leading edge of the field.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome by Justin Molloy / Introductory Comments by GRC Site Staff
7:40 pm - 8:50 pmSTRUCTURAL BIOLOGY OF MOTORS AND TRACKS I
Discussion Leader: Anne Houdusse (Institut Curie, Paris)
7:40 pm - 8:00 pm Keiko Hirose (Institute for Cell Engineering, Ibaraki, Japan)
"Cryo-EM studies of microtubule motors"
8:00 pm - 8:10 pm Charles Sindelar (Lawrence Berkeley Natl Lab, Berkeley, CA)
"A common microtubule activation mechanism for plus- and minus-end directed kinesin motors"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Anne Houdusse (Institut Curie, Paris)
"A new myosin VI state reveals how actin triggers phosphate release"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:30 pmOPENING KEYNOTE
Chair: Anne Houdusse (Institut Curie, Paris)
8:50 pm - 9:20 pm Lee Sweeney (University of Pennsylvania)
"Progress in unraveling the motor mechanism of myosin"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:45 amSTRUCTURAL BIOLOGY OF MOTORS AND TRACKS II
Discussion Leader: Anne Houdusse (Institut Curie, Paris)
9:00 am - 9:20 am David D. Thomas (University of Minnesota)
"Dynamics of the actomyosin interaction"
9:20 am - 9:30 am Chris Yengo (UNC Charlotte, Charlotte, NC)
"Structural dynamics of functional domains in myosin V examined with spectroscopic, kinetic, and computational methods"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 am Jared Cochran (Dartmouth College Hanover, NH)
"Structural and Mechanistic Analysis of the Drosophila Nod Kinesin during its Unique ATPase Cycle"
9:50 am Coffee Break / Group Photo
10:30 am - 12:00 pmKINETIC PATHWAYS AND REGULATION I
Discussion Leader: Steven Rosenfeld (Columbia Medical School, New York)
10:30 am - 10:50 am Stan Burgess (University of Leeds, UK)
"Dynein structure and power stroke"
10:50 am - 11:10 am Kazu Sutoh (University of Tokyo, Japan)
"Communication of multiple ATPase sites of the dynein motor domain"
11:10 am - 11:20 am Discussion
11:20 am - 11:40 am Susan Gilbert (Rensselaer Polytechnic Institute, New York)
"Kinesin head-head coordination"
11:40 am - 11:50 am Sarah Rice (Northwestern, IL)
"Mechanism of Kinesin Regulation by its Tail"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:20 pmKINETIC PATHWAYS AND REGULATION II
Discussion Leader: Steven Rosenfeld (Columbia Medical School, New York)
7:30 pm - 7:50 pm Steven Rosenfeld (Columbia Medical School, New York)
"How kinetics informs us about cell physiology - The story of CENP-E"
7:50 pm - 8:00 pm Enrique De La Cruz (Yale University, CT)
"ATP utilization and duplex rRNA unwinding by the DEAD-box protein, DbpA"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmMihaly Kovacs (Eotvos University, Hungary)
"Blebbistatin alters communication between functional regions of myosin"
8:30 pm - 8:40 pmChris Berger (University of Vermont, VT)
"Coordination Between the Active Site and Actin-binding Cleft in Myosin: A Role for Flexibility of the Upper 50 kD Subdomain?"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:30 pmEMERGENT PROPERTIES OF MOTOR SYSTEMS I
Discussion Leader: Peter Knight (University of Leeds, UK)
8:50 pm - 9:10 pm Peter Knight (University of Leeds, UK)
"Influences of myosin levers on motor function"
9:10 pm - 9:20 pm Ron Rock (University of Chicago, IL)
"Navigating the cytoskeleton with myosin X"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amEMERGENT PROPERTIES OF MOTOR SYSTEMS II
Discussion Leader: Peter Knight (University of Leeds, UK)
9:00 am - 9:20 am Jonathon Howard (Max-Planck, Dresden, Germany)
"Kinesin-8, a translocase and length-dependent depolymerase"
9:20 am - 9:40 am Kristen Verhey (University of Michigan)
"Road signs for kinesin motors"
9:40 am - 9:50 am Discussion
9:50 am - 10:00 am Arne Gennerich (UCSF, CA)
"Force-dependent stepping of cytoplasmic dynein"
10:00 am Coffee Break
10:30 am - 10:50 am Mike Ostap (University of Pennsylvania)
"Myosin I can act as a force sensor"
10:50 am - 11:00 am Mike Geeves (University of Kent, UK)
"Calcium regulation of mammalian myosin 1C"
11:00 am - 11:10 am Discussion
11:10 am - 12:00 pmTHEORETICAL FRAMEWORKS AND MOTOR MECHANISM I
Discussion Leader: Jonathon Howard (Max-Planck, Dresden, Germany)
11:10 am - 11:30 am Frank Julicher (Max-Planck, Dresden, Germany)
"Oscillating motor systems"
11:30 am - 11:40 am Pascal Martin (Institut Curie, Paris France)
"Spontaneous oscillations and negative friction powered by a minimal acto-myosin system"
11:40 am - 11:50 am Michael E. Fisher (University of Maryland, MD)
"What superstall and assisting loads may teach us?"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTHEORETICAL FRAMEWORKS AND MOTOR MECHANISM II
Discussion Leader: Jonathon Howard (Max-Planck, Dresden, Germany)
7:30 pm - 7:50 pm Sean Sun (John Hopkins University, Baltimore)
"A general framework for modeling dimeric processive motors"
7:50 pm - 8:00 pm Andrej Vilfan (Stefan Institute, Ljubljana, Slovenia)
"Models of myosin V"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Holly Goodson (University of Notre Dame, Indiana)
"Influence of physical constraints on microtubule dynamics"
8:30 pm - 8:50 pm Gabriella Piazzesi (University of Florence, Italy)
"Myosin structural dynamics and muscle function"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Malcolm Irving (King's College London, UK)
"Is the myosin II light-chain domain a rigid lever arm?"
9:10 pm - 9:20 pm Gerald Offer (University Bristol, UK) & Ed Taylor (Northwestern, IL)
"Recent controversy in low-angle x-ray scattering data from muscle fibers"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amPOWER-STROKES AND RATCHETS
Discussion Leader: Steven Block (Stanford University, California)
9:00 am - 9:20 am Toshio Yanagida (Osaka University, Japan)
"Thermal ratchet and its application to artificial muscle"
9:20 am - 9:40 am Hideo Higuchi (Tokyo University, Sendai, Japan)
"Step size of dynein is determined by distances of a power stroke and fluctuation"
9:40 am - 9:50 am Discussion
9:50 am - 10:00 am Kathy Trybus (University of Vermont, VT)
"Myosin V and Kinesin act as tethers to enhance each others' processivity"
10:00 am Coffee Break
10:30 am - 12:10 pmMOTORS THAT DRIVE INFECTION AND DISEASE I
Discussion Leader: James Sellers (NHLBI - NIH)
10:30 am - 10:50 am Marie-France Carlier (LEBS, CNRS, France)
"How reconstituted motility assays bring insight into actin-based motile and morphogenetic processes"
10:50 am - 11:00 am Inna Belyantsava (NIDCD - NIH)
"New insight into gamma-actin function in inner ear hair cell stereocilia"
11:00 am - 11:10 am Discussion
11:10 am - 11:20 am Yuichiro Maeda (Nagoya University Japan)
"The nature of the G- to F-actin transition"
11:20 am - 11:30 am Kenneth Holmes (MPI Heidelberg, Germany)
"F-actin revisited"
11:30 am - 11:40 am Discussion
11:40 am - 12:00 pm John Hammer (NHLBI - NIH)
"Myosin V and memory"
12:00 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:10 pmMOTORS THAT DRIVE INFECTION AND DISEASE II
Discussion Leader: James Sellers (NHLBI - NIH)
7:30 pm - 7:50 pm James Sellers (NHLBI - NIH)
"Heads to tails: how some myosins auto regulate"
7:50 pm - 8:00 pm Lois Weisman (University of Michigan)
"Direct regulation of the vacuole-specific myosin V receptor by the cyclin-dependent kinase, Cdk1"
8:00 pm - 8:10 pm Discussion
8:10 pm - 9:00 pmALEXANDER CRUICKSHANK LECTURE
Introduction: Justin E. Molloy (MRC NIMR, UK)
8:10 pm - 8:50 pm Steven Block (Stanford University, California)
"Breaking the nanometer barrier: Biophysics, one molecule at a time"
8:50 pm - 9:00 pmDiscussion
9:00 pm Posters / Social Gathering
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 amDETERMINANTS OF PROCESSIVITY AND DIRECTIONALITY
Discussion Leader: Claudia Veigel (MRC NIMR, UK)
9:00 am - 9:20 am Claudia Veigel (MRC NIMR, UK)
"Myosin kinetics under load"
9:20 am - 9:30 am Masahide Kikkawa (Kyoto University, Japan)
"What are the structural effects of load applied to motors?"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Sivaraj (Shiv) Sivaramakrishnan (Stanford University, California)
"Unusual protein structural elements involving myosin motors"
10:00 am Coffee Break
10:30 am - 10:50 am Samara Reck-Peterson (Harvard Medical School, Massachusetts)
"Regulation of cytoplasmic dynein processivity"
10:50 am - 11:10 amChristoph Schmidt (Georg-August University, Göttingen, Germany)
"Processive or diffusive: regulated motility of the mitotic Eg5 kinesin"
11:10 am - 11:20 am Discussion
11:20 am - 11:30 am Yale Goldman (University of Pennsylvania, PA)
"Navigation by myosin isoforms and dynein"
11:30 am - 11:40 am Takeshi Satamoto (NHLBI - NIH)
"Direct observation of the mechanochemical coupling in myosin-V during processive movement"
11:40 am - 11:50 am Giovanni Cappello (Institut Curie, Paris)
"Single Myosin V Beyond the Membrane"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:20 pm - 7:50 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:50 pm - 8:50 pmSUMMARY AND GENERAL
7:50 pm - 8:20 pm David D. Thomas (University of Minnesota)
"Summary and General"
8:20 pm - 8:30 pm Short Presentations
8:30 pm - 8:40 pm Short Presentations
8:40 pm - 8:50 pm Short Presentations
8:50 pm - 9:30 pmMATSUBARA LECTURE
Chair: Yale E. Goldman (University of Pennsylvania)
8:50 pm - 9:20 pm David M. Warshaw (University of Vermont)
"General Motors: Stepping into the future"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 GM084516-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter